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PH

phenylpropanolamine (Dristan SR / Histabid / Dexatrim)

✓ Approved

Lumara Health · Small Molecule · Small Molecule

What is phenylpropanolamine?

phenylpropanolamine is a small molecule developed by Lumara Health. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesDristan SR, Histabid, Dexatrim
CompanyLumara Health
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Lumara Health

Therapeutic Indications

phenylpropanolamine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersCough✓ Approved

Related Research Articles

PubMedClinical radiology2026-08-29

Assessment of image quality and radiation dose in low-dose, low-contrast computed tomography coronary angiogram: a systematic review and meta-analysis.

Naik S D SD, Visakh T T, Prakashini K K, Sharath S S

Coronary artery disease (CAD) remains a leading cause of morbidity and mortality worldwide. Computed tomography coronary angiography (CTCA), a noninvasive test, requires contrast volume and radiation dose. Low-contrast, low-dose CTCA using reduced tube potential and reconstruction minimises nephropathy and radiation exposure while maintaining quality. This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines and was registered with International Prospective Register of Systematic Reviews (PROSPERO); PubMed, Scopus, and Web of Science (2014-2025) databases were searched for studies evaluating low-contrast, low-dose CTCA. Outcomes included signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), computed tomography dose index volume (CTDIvol), dose-length product (DLP), and effective dose (ED). Leave-one-out sensitivity and within-study subgroup analyses were performed. Five studies with 353 participants were analysed. Low-dose, low-contrast CTCA maintains high image quality while reducing radiation exposure. At 80 kV, combined SNR and CNR were 27.1 (95% confidence interval [CI]: 17.85-36.26) and 31.2 (95% CI: 22.21-40.28), respectively, with CTDIvol: 2.08 mGy, DLP: 38.8 mGy·cm, and ED: 0.37 mSv. At 100 kV, combined SNR and CNR were 22.1 (95% CI: 10.89-33.25) and 24.0 (95% CI: 15.78-32.19), respectively, with CTDIvol: 5.59 mGy, DLP: 84.8 mGy·cm, and ED: 1.24 mSv. Subgroup analysis showed an 80-kV reduced radiation dose by 54-56% while keeping image quality similar, with 5-15% difference in SNR and CNR values. The leave-one-out analysis confirmed robustness of the pooled estimates. Low-dose, low-contrast CTCA using 80-100 kV with iterative or deep learning image reconstruction (DLIR) maintains image quality while reducing iodine and radiation exposure. Compared with 100 kV, 80 kV provides lower radiation dose with minimal image-quality differences, supporting use in selected patients.

PMID 42667811
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PubMedAdvanced materials (Deerfield Beach, Fla.)2026-08-29

Soft-Rigid Liquid Metal-SiC Hybrid Fillers Enable Superior Nonlinear Conductivity and Electric Field Regulation of Composite Dielectrics.

Ren Junwen J, Zeng Ruichi R, Wei Huachao H, Wang Zi Z et al.

Nonlinear dielectrics with superior electric field regulation capabilities are essential for advanced power equipment. However, traditional nonlinear dielectric materials depend on an electrical percolation mechanism, requiring high concentrations of nonlinear conductive filler that degrade insulation and mechanical properties. Herein, we propose a synergistic strategy using a hybrid filler of soft liquid metal and rigid silicon carbide particles (LM-SiCp) to develop insulating nonlinear composite dielectrics. The unique LM-SiCp structure enables a favorable network of potential barriers at low fields and steep exponential current growth at high fields, yielding an excellent "low onset, high gain" nonlinear behavior. The resulting composites exhibit an impressive nonlinear coefficient of ∼7.55 and a markedly reduced threshold field strength from 4.81 to 3.41 kV/mm. It also achieves improved toughness (2.29 MJ/m3), thermal conductivity (0.36 W/mK), high breakdown strength (∼33.4 kV/mm), and low dielectric loss (<0.03), which ensure the stable performance of the composite dielectric under practical engineering conditions. This strategy offers a novel design concept for high-performance composite dielectrics capable of effective electric field modulation in power equipment.

PMID 42666078
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PubMedApplied microscopy2026-08-28

Imaging optimization of FIB cross sections for reliable porosity analysis of PEMFC cathode catalyst layers.

Kwon Ji Hee JH, Jo Jinnyeong J, An Byeong-Seon BS

Focused ion beam-scanning electron microscopy (FIB-SEM) was used to investigate the effects of acceleration voltage, beam current, and cryogenic conditions on the cross-sectional preparation of proton exchange membrane fuel cell (PEMFC) cathode catalyst layers. Milling at 30 kV and 0.26 nA effectively minimized curtaining artifacts and produced an apparent cross-sectional pore morphology similar to that obtained by cryogenic milling, indicating that optimized room-temperature milling can provide cross sections suitable for consistent two-dimensional (2D) pore-area analysis under the conditions examined.Representative FIB-SEM cross-sectional images of PEMFC cathode catalyst layers prepared under different FIB milling conditions: (a-c) 5 kV at room temperature, (d-f) 30 kV at room temperature, and (g-i) 30 kV under cryogenic conditions (- 150 °C). The indicated voltage and current values represent the FIB acceleration voltage and ion beam current used for milling, respectively. The red dashed box in (f) highlights the optimized room-temperature milling condition (30 kV, 0.26 nA) used for comparison with the corresponding cryogenic condition in (i).

PMID 42663789
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PubMedAnnals of the ICRP2026-08-27

Development of a pragmatic methodology for measurement of dose for KV CBCT in radiotherapy: A pilot study.

Djukelic M M, Gros S S, Kron T T, Wood T T et al.

Imaging modalities such as on-board kilovoltage cone beam computed tomography (kV CBCT) on a linear accelerator (linac) are utilised daily to verify positioning in the multi-week fractionation schedule of a cancer patient undergoing treatment. There is a need for optimisation of radiological protection in kV CBCT imaging protocols to avoid unnecessarily high doses to normal tissues surrounding the target. Traditionally, a 100 mm ionisation chamber and a cylindrical PMMA phantom are used in measuring CT doses, but these are not available in many radiotherapy centres. This study explores an alternative setup using a 0.6 cc Farmer-type ionisation chamber and a 30 cm × 30 cm × 30 cm cubically shaped phantom comprising slabs of water equivalent material typically used in radiotherapy centres. The weighted dose index values determined from the alternative setup are compared with those determined from the conventional cylindrical CT phantoms. The results indicate that the alternative setup using equipment more accessible in radiotherapy facilities is a viable alternative to the use of a CT phantom to quantify kV CBCT radiation dose from linac-based image-guided radiotherapy equipment that can be used for optimisation processes. This should allow most radiotherapy centres all over the world to engage in meaningful dose measurement and optimisation for CBCT.

PMID 42658211
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PubMedSensors (Basel, Switzerland)2026-08-27

A 1 kV Compensation-Free Three-Stage Inductive Voltage Divider with Integrated-Reference Self-Calibration.

Wang Jian J, Yin Xiaodong X, Liu Hao H, Liu Junjie J et al.

Electronic compensation networks used in high-accuracy inductive voltage dividers (IVDs) can introduce temperature- and aging-dependent drift sources, complicating long-term uncertainty evaluation. This paper presents a 1 kV, 10-tap, compensation-free three-stage IVD that combines multi-stage excitation, a closed shielded core, and equipotential coaxial-cable windings to suppress excitation, magnetic-coupling, and capacitive errors. An integrated reference winding is embedded in the third-stage coaxial-cable winding, enabling a simplified bootstrap self-calibration procedure without an additional auxiliary IVD. At 50 Hz, the calibrated ratio error and phase displacement are within 0.08 μV/V and 0.08 μrad, respectively, for all taps, with expanded uncertainties of 0.04 μV/V and 0.06 μrad. Wideband measurements up to 3 kHz further show that the proposed IVD can serve as a voltage-ratio reference for harmonic voltage measurement and calibration.

PMID 42655445
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PubMedPharmaceuticals (Basel, Switzerland)2026-08-27

Targeted Sequencing and Haplotype Analysis of Voltage-Gated Potassium Channel Genes Reveal a Potential Association of KCNV2 Haplotypes with Antiseizure Medication Response in Turkish Patients with Epilepsy.

Pekkoc-Uyanik Kubra Cigdem KC, Todurga-Seven Zeynep Gizem ZG, Agay Erhan Rasit ER, Uzun Hafize H

Objective: Voltage-gated potassium channel genes are among the most frequently implicated in epilepsy and antiseizure medication (ASM) response. In this pilot study, we aimed to identify rare and common variants by sequencing voltage-gated potassium channel (Kv) genes in epilepsy patients using ASM, and to reveal the potential drug responses of these variants. Methods: To investigate the role of genetic variants in Kv genes (KCNQ1, KCNQ2, KCNQ3, KCNA1, KCNA2, and KCNV2) in response to ASMs among 31 epilepsy patients, we used targeted next-generation sequencing (tNGS). Patients were classified as responders or persistent based on seizure control status. Selected variants in the genes were annotated, filtered, and analyzed for association with ASM response. Results: We identified 181 variants in the 6 channel genes, including missense, synonymous, intronic, UTR, and stop-gained variants. Six variants of uncertain significance (VUSs) were observed, including KCNA2c.*1314C>T, KCNQ1c.*976G>A, KCNQ2 (c.2613G>T p.Arg871Ser and c.1148+62T>G), and KCNQ3 (c.*6282A>G and c.*2860T>C). Two novel variants were identified in our study group, KCNA2:c.*1314C>T and KCNQ3:c.*2860T>C. Both were located in the 3' UTR region and classified as VUSs according to ACMG guidelines. In the KCNV2 gene, the CG haplotype comprising rs7029012 and rs10967705 was observed more frequently in patients with drug-persistent epilepsy than in those with drug-responsive epilepsy (18.5% vs. 0.8%; χ2 = 6.756, p = 0.009, BH-FDR q = 0.036), suggesting a potential association with pharmacoresistant epilepsy. Conclusions: Our haplotype analysis suggests the potential pharmacogenetic contribution of the KCNV2 gene to ASM response; however, these exploratory findings require validation in larger independent cohorts and functional studies.

PMID 42653690
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