Drug Database
PH

phenylpropanolamine (Dristan SR / Histabid / Dexatrim)

✓ Approved

Lumara Health · Small Molecule · Small Molecule

What is phenylpropanolamine?

phenylpropanolamine is a small molecule developed by Lumara Health. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesDristan SR, Histabid, Dexatrim
CompanyLumara Health
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Lumara Health

Therapeutic Indications

phenylpropanolamine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersCough✓ Approved

Related Research Articles

PubMedMaterials horizons2026-10-15

Enhanced temperature stability of cross-linked polyethylene dielectrics enabled by a graftable molecule with multiple functional units.

Liu Ziyang Z, Meng Zhaotong Z, Wang Zhaoyang Z, Zhang Yiwei Y et al.

The temperature stability of semicrystalline polyolefin dielectrics is intrinsically linked to the interplay between crystalline morphology and charge transport, yet their coordinated regulation remains challenging. Here, a graftable molecule with multiple functional units, PXDP, was purpose-designed to coordinate crystallization and charge transport in XLPE. Its terminal vinyl group provides a grafting function, the urethane units provide hydrogen-bond-mediated ordering and nucleation, and the flexible polycaprolactone-derived segments regulate subsequent crystal growth. PXDP grafting further introduces deep traps that impede carrier migration. At a PXDP loading of 0.3 phr, the representative spherulite diameter decreases from 3.4 to 2.1 µm, accompanied by an increased conduction transition threshold and suppressed space-charge accumulation. XLPE-g-PXDP3 achieves a DC breakdown strength of 324.86 kV mm-1 at 90 °C and an electric-field distortion rate of 3.60% at 80 °C. This work establishes a multiscale molecular-design framework for coordinating crystallization and charge transport in semicrystalline polyolefin dielectrics, thereby reducing the temperature sensitivity of dielectric performance and highlighting its potential for HVDC submarine cable insulation.

PMID 42876277
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PubMedNanomaterials (Basel, Switzerland)2026-10-14

A Nano-Bismuth-Silicone Polymer Composite as Shielding for X-Rays in Extreme-Environment Applications: Experimental and Simulation Studies.

Vaezzadeh Seyyed Saeed SS, Rahman Mahmudur M, Kota Kalyan Raj KR, Ozmaeian Masoumeh M et al.

Radiation shielding is an important consideration in the design and protection of spacecraft electronics and equipment, where conventional metallic shields can add considerable weight and are difficult to integrate with compact or non-planar components. Flexible polymer composites containing high-Z materials offer an alternative approach by combining radiation attenuation with the conformability of an elastomeric matrix. In this work, nano-bismuth is incorporated into a silicone elastomer at loadings of 0-30 wt.% to develop a flexible X-ray shielding composite. The shielding performance of the composites is evaluated experimentally under a 160 kV X-ray source at a total dose of 1 Mrad and compared using Geant4 Monte Carlo simulations. The simulation model is then used to investigate a broader range of bismuth concentrations and composite thicknesses and develop an empirical relationship to predict X-ray attenuation. The results show a clear improvement in X-ray attenuation with increasing nano-bismuth content, demonstrating the potential of silicone/nano-Bi composites as shielding materials for extreme-environment applications, including space.

PMID 42872983
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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-10-14

Sandwich-Structured Aramid Composite Papers with Heterogeneous Dielectric Layers for Integrated Corona Resistance and Thermal Conductivity.

Ren Jun-Wen JW, Chen Jun-Xue JX, Tong Ying-Ying YY, Wang Zi Z et al.

Aramid dielectric papers are indispensable for insulation in high-performance motors for electric vehicles, aircraft, and high-speed rail. However, the ongoing electrification trend toward higher voltage, frequency, and power density imposes severe electrothermal stresses that conventional aramid papers cannot withstand. Their inherently low thermal conductivity leads to localized heat accumulation while poor corona resistance accelerates electrothermal aging, both compromising long-term motor reliability. Here, we report a sandwich-structured poly(m-phenylene isophthalamide) (PMIA) composite dielectric paper that decouples thermal conductivity from corona resistance through a functional multilayer architecture. Fluorinated graphene (FG)/PMIA surface layers provide interface passivation and charge dissipation, while boron nitride nanotube (BNNT)/PMIA core layers enable thermal conduction and dielectric reinforcement. Electrospinning followed by hot-pressing achieves spatially oriented functional filler arrangements. FG constructs continuous charge-transfer barrier to suppress surface discharge and BNNT constructs continuous thermal pathways in the bulk without compromising insulation integrity. The optimized dielectric paper achieves a thermal conductivity of 10.22 W·m- 1·K- 1 and a corona lifetime of 147.42 min, representing 1.23-fold and 14.7-fold improvements over neat PMIA paper, while maintaining a high breakdown strength of 199.52 kV/mm. This specific synergy originates from hierarchically oriented architecture rather than simple property addition, offering a universal strategy to design dielectric materials with decoupled multifunctionality.

PMID 42872470
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PubMedEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026-10-13

Improved assessment of the cochlear implant and temporal bone structures with ultra-high resolution photon-counting detector CT compared to conventional CT systems.

van der Bie Judith J, van der Eerden Anke W AW, van den Berg Aaike S AS, Dijkshoorn Marcel L ML et al.

This study evaluates the image quality of photon-counting detector CT (PCD-CT) compared to conventional CT systems in cochlear implant imaging and aims to determine optimal scan parameters. Three cochlear implant models were inserted into three post-mortem human specimen heads. Each head was scanned on three high-end CT systems: SOMATOM Edge, SOMATOM Force and NAEOTOM Alpha. A total of 192 reconstructions were obtained, including various tube voltages (120-150 kV), tin filtering, and slice thicknesses (0.2-0.6 mm). For each scanner, multiple reconstruction kernels were applied. Contrast-to-noise ratios (CNR) for bone-to-soft-tissue were calculated. Two radiologists independently assessed anatomy, implant visibility, and overall image quality on a 5-point Likert scale and scored diagnostic confidence for detecting anatomic dehiscence. PCD-CT showed significantly higher image quality scores across implant, anatomy, and general image quality compared to the Edge and Force (p < 0.001). PCD-CT also produced significantly higher CNR (mean 23.5 vs. 13.8 [Edge] and 12.7 [Force]) and greater diagnostic confidence. For PCD-CT, optimal image quality was achieved using 0.2 mm slice thickness and the Hr89 kernel at 140 kV. PCD-CT scans acquired with half dose (27.5 mGy) showed no significant difference in CNRs but led to slightly lower subjective scores compared to standard-dose imaging. PCD-CT provides superior image quality and diagnostic confidence in cochlear implant imaging compared to the Edge and Force. Optimal results are achieved using 140 kV, 0.2 mm slices, and the Hr89 kernel. Although dose reduction is feasible, it slightly compromises subjective image quality.

PMID 42867657
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PubMedPest management science2026-10-09

Demographic suppression and oxidative responses of Tribolium beetles to cold-plasma and microwave treatment in wheat flour: efficacy-quality trade-offs.

Ghorbel Mouna M, Elmenofy Wael W, El-Mogy Mohamed Mohamed MM, El-Ganainy Sherif M SM et al.

Non-chemical physical treatments may complement stored-product pest management, but acute mortality alone may underestimate their value when surviving adults reproduce poorly and post-treatment population recovery is suppressed. This study compared atmospheric cold-plasma (CP; 10-20 kV) and microwave (MW; 300-900 W) exposure against sex-balanced adult cohorts of Tribolium castaneum and Tribolium confusum in wheat flour. Mortality increased with intensity and exposure duration. At 20 min, Abbott-corrected mortality reached 59.07% and 53.65% under CP-20 kV and 59.59% and 59.38% under MW-900 W in T. castaneum and T. confusum, respectively. Despite incomplete acute mortality, F1 emergence declined from 199.4 and 163.8 adults in untreated controls to 15.0 and 20.4 after CP and to 5.0 and 1.4 after MW. Both technologies delayed adult pre-oviposition, shortened oviposition and longevity, reduced flour loss, and increased superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST) and malondialdehyde (MDA) in survivors. In independent flour-only assays at 20 min, MW-900 W caused the largest quality changes, increasing peroxide value and free fatty acids while reducing extractable oil and gelatinization enthalpy. Species-specific exploratory principal component analysis (PCA) and canonical discriminant analysis (CDA) of control and 20-min profiles identified dominant treatment gradients. Principal component one (PC1) explained 90.55% and 89.84% of variance, and mean repeated five-fold cross-validation accuracy was 85.5% and 85.9%. CP and MW substantially suppressed post-treatment population recovery beyond 24-h mortality. MW gave stronger combined suppression but larger flour-quality changes, whereas CP caused smaller measured quality shifts under the tested laboratory conditions. © 2026 Society of Chemical Industry.

PMID 42850703
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PubMedFood chemistry2026-10-09

Pulsed electric field-enhanced phenolic release, profiling, and antioxidant enhancement in cold-pressed rapeseed oil.

Rasool Arslan A, Zhang Qiqi Q, Li Yaning Y, Hu Jinling J et al.

Cell-wall sequestration intact Brassica napus seeds severely restricts phenolic recovery during conventional processing, thereby limiting cold-pressed oil quality. Fifteen Yunnan winter accessions were screened for total phenolic content, and the three highest-ranking were selected for pulsed electric field (PEF) treatment and profiling using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS-TQD), antioxidant activity, and oxidative markers. Optimal PEF-treatment (7 kV/cm; 10 Hz; 1 min) enhanced phenolic release and migration, increasing from 308.70 to 1204.52 mg GAE/100 g, with rutin and kaempferol showing cultivar-dependent, PEF-exclusive detection. PEF enhanced antioxidant activities while reducing peroxide values by up to 71.2%. Electron spin resonance (ESR) indicated reduced lipid radical signal after PEF, while proton nuclear magnetic resonance (1HNMR) and gas chromatography (GC) showed comparable fatty acid profiles. These results, limited to three accessions and a single time point, require broader validation and storage conditions. PEF is a promising clean-label, non-thermal strategy to enrich phenolic-bioactives in cold-pressed oil.

PMID 42854567
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