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Fluosol-DA (Fluosol)

✓ Approved

Mitsubishi Tanabe Pharma Corporation · Small Molecule · Small Molecule

What is Fluosol-DA?

Fluosol-DA is a small molecule developed by Mitsubishi Tanabe Pharma Corporation. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesFluosol
CompanyMitsubishi Tanabe Pharma Corporation
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Mitsubishi Tanabe Pharma Corporation

Therapeutic Indications

Fluosol-DA is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Blood and lymphatic system disordersAnaemia✓ Approved
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Neoplasm malignant✓ Approved

Related Research Articles

PubMedFrontiers in immunology2026-10-15

Activation of cytosolic DNA sensing in NCM460 intestinal epithelial cells induces antiviral factors that restrict HIV infection in macrophages.

Majid Safah S, Khan Shazheb S, Wang Xu X, Khan Raheeb R et al.

The gastrointestinal tract is an important site of HIV persistence and contains susceptible target cells, including macrophages. Crosstalk between intestinal epithelial cells and macrophages may contribute to mucosal innate defense. NCM460 human intestinal epithelial cells were transfected with poly(dA). Expression and production of interferons, interferon-stimulated genes, and CC chemokines were assessed by quantitative RT-PCR, western blotting, and ELISA. Primary human macrophages were treated with conditioned supernatants from NCM460 cells, and HIV infection was assessed using cytopathic effects, luciferase activity, and HIV Gag RNA expression. Poly(dA) induced IFN-β, IFN-λ1, IFN-λ2/3, ISG15, viperin, OAS1, RANTES, and MIP-1α in NCM460 cells. Supernatants from poly(dA)-stimulated NCM460 cells induced GBP5, viperin, and MX2 in primary macrophages and significantly inhibited HIV infection. Activation of cytosolic DNA sensing in intestinal epithelial cells induces soluble antiviral factors that enhance innate antiviral responses in macrophages and may contribute to mucosal defense against HIV.

PMID 42876517
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PubMedFrontiers in robotics and AI2026-10-15

A new hybrid optimization intelligence for cable-driven continuum robot motion: two-obstacle simulation and real-data assessment.

Djeffal Selman S, Ghoul Abdelhamid A, Morakchi Mohamed Razi MR, Bendriss Badreddine B et al.

Cable-driven continuum robots enable dexterous motion in confined spaces, but inverse kinematics remains difficult because different internal shapes and cable states can produce the same end-effector position. This study presents a design-aware hybrid optimization framework, DA-IHHO-DELS, for inverse kinematics of a three-section continuum robot. A piecewise-constant-curvature forward model generates physically consistent section positions, cable-length estimates, and feasibility terms. The optimizer combines geometry-consistent seeding, opposition learning, improved Harris hawks search, differential-evolution exploitation, grey-wolf leader guidance, Cauchy/Levy perturbations, and bounded local refinement. Its multi-objective score includes the arc-length consistency residual, orientation error, cable-length dispersion, inter-section smoothness, actuation effort, and constraint violation, and it is compared with GA, ABC, ACO, DE, HHO, TLBO, BOA, GWO, WOA, and POA. In the regenerated obstacle-constrained simulation, DA-IHHO-DELS achieved a median F 1 residual of 0.00491 mm, a median reconstructed Cartesian error of 0.00255 mm, 100% success under the strict F 1 < 0.01 criterion, the lowest median aggregate score, and a mean runtime of 0.56883 s. A secondary benchmark using measured CBHA/Robotino XT actuator lengths further assessed transfer of the geometry-guided optimization consistency to real measured continuum-robot data. The results show that design-aware hybrid optimization can combine analytical continuum-robot kinematics with robust search to obtain accurate, feasible, and smooth inverse-kinematic solutions. The real-data benchmark supports consistency transfer while remaining distinct from a direct hardware test of the same three-section cable-driven robot.

PMID 42876628
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PubMedPhysics in medicine and biology2026-10-15

Practical considerations in measuring out-of-field neutron dose for pulsed and gantry-mounted proton therapy machines.

Zhang Hailei H, Mazur Thomas R TR, Zorloni Gabriele G, Darafsheh Arash A

Objective.Synchrocyclotrons deliver radiation in distinct macro pulses with high instantaneous dose rate that distinguish them from isochronous cyclotrons and synchrotrons. The relatively high instantaneous dose rates associated with synchrocyclotrons require special consideration in measurement of the neutron dose. The objective of this work is to measure the out-of-field neutron ambient dose equivalent (H*(10)) as a conservative operational surrogate to assess the fetal dose due to secondary neutrons for a gantry-mounted synchrocyclotron proton therapy system when an intensity modulated proton therapy (IMPT) brain treatment is delivered with the dynamic aperture (DA), static aperture (SA), and no aperture (NA).Approach.A pencil beam scanning (PBS) gantry-mounted synchrocyclotron was used for beam delivery. IMPT plans employing the DA, SA, and NA, each with 3 fields (vertex, lateral, and posterior-anterior (PA)) were optimized using the treatment planning system to treat a left-sided spherical brain target with 6 cm diameter to a total dose of 66 Gy (weighted by radiobiological effectiveness [RBE] 1.1) in 33 fractions. The plans were delivered to an anthropomorphic phantom and the neutron H*(10) was measured using two commercial rem-meters, a WENDI-II and a LUPIN-BF3-NP counter at 43, 53, 61, and 71 cm distance from the isocenter intended to mimic distances to a fetus at various gestational periods. To investigate the influence of the couch angle for the PA field, the neutron dose from the PA field was measured at several couch angles including 0°, 180°, and 270°.Main results.WENDI-II suffers from dead-time associated issues and underestimated the dose by a factor of ∼1.7-2.7 compared to LUPIN-BF3-NP. H*(10) showed dependence on the measurement location and the use of field shaping system. The total H*(10) for 66 Gy-equivalent proton dose was estimated to be 10.7 mSv (9.7 mSv) and 4.9 mSv (4.5 mSv) at 43 and 71 cm distance from the isocenter, respectively, when the SA (DA) was used. Without an aperture the corresponding values were 11.8 mSv and 5.3 mSv. The 270°-couch-angle resulted in the highest neutron dose from the PA field by ∼15% relative to the 0°-couch-angle, resulting in an increase in the neutron dose by ∼5% for the whole treatment.Significance.WENDI-II is not a reliable device for in-room neutron dose measurement for synchrocyclotrons with high instantaneous dose rates. Employing appropriate use of the aperture system as well as avoiding the 270° couch angle for the PA field can minimize the neutron dose in the gantry-mounted system studied in this work.

PMID 42876248
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PubMedBMC musculoskeletal disorders2026-10-15

Factors associated with 1-year health-related quality of life after neck-specific exercise in chronic whiplash-associated disorders: an exploratory secondary analysis of a randomized controlled trial.

Peolsson Anneli A, Ljunggren Stefan S, Peterson Gunnel G

Factors associated with changes in health-related quality of life (HRQoL) outcomes in neck disorders have not been investigated after internet-based support for exercise. The purpose of the study was to investigate baseline and short-term outcome factors associated with changes in HRQoL (EQ-5D-3L and EQ-VAS) at 3 and 15 months, respectively, after a neck-specific exercise programme (NSE) for individuals with chronic whiplash-associated disorders grades 2 and 3. This was a secondary analysis of a prospective randomized controlled multi-centre trial with concealed allocation. Participants (n = 140) were randomized to NSE at a physiotherapy clinic or internet-based NSE with four physiotherapy visits (NSEIT). Assessor-blinded investigators obtained measurements at baseline and at 3- and 15-month follow-up. Orthogonal partial least square (OPLS) and OPLS discriminant statistical analyses (OPLS-DA) were used. There were no significant differences between the exercise programmes. Improvement in psychosocial measures, pain, disability and several objective measures were associated with improvements in HRQoL in OPLS models (R2 = 0.20 to 0.27, Q2 = 0.06 to 0.12, p < 0.05 to < 0.001). Higher baseline score on adverse psychosocial measures and disability, together with lower dizziness, self-efficacy, and neck-muscle endurance in extension, were associated with clinically relevant improvement in EQ-5D-3L at 15-month follow-up (R2 = 0.26, Q2 = 0.13, p < 0.01). The other models were non-significant. Several factors, including adverse psychosocial measures, may be clinically relevant for HRQoL after neck-specific exercise interventions. Given the models' weak predictive ability, the findings should be regarded as exploratory and hypothesis-generating. The study was registered before data collection started, ClinicalTrials.gov Protocol ID: NCT03022812, initial release 12/20/2016. The study was approved by the regional ethical review board in Linköping, Sweden (Dnr 2016/135-31; 2016/526-32; 2017/45-32).

PMID 42875773
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PubMedScandinavian journal of trauma, resuscitation and emergency medicine2026-10-14

Preselection of stable children limits inference about DA-PEWS transport safety.

Yılmaz Ercan E, Koker Özer Nezihe N, Topal Erdem E

PMID 42870291
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PubMedTranslational andrology and urology2026-10-14

Comparative outcomes of KangDuo and da Vinci robot-assisted ureteral reimplantation: a retrospective cohort study.

Bao Han H, Yang Qian Q, Wang Xiang X, Zhang Yu Y et al.

Ureteral reimplantation is central to distal ureteral reconstruction, but evidence comparing emerging robotic platforms with the established da Vinci system remains limited. We compared the perioperative safety and mid-term outcomes of KangDuo Surgical Robot-01 (KD-SR-01)-assisted and da Vinci-assisted ureteral reimplantation. We retrospectively analyzed 153 patients who underwent robot-assisted ureteral reimplantation between January 2024 and December 2025. Platform allocation was nonrandom and reflected patient choice after standardized counseling. The primary outcome was mid-term surgical failure, defined as persistent symptoms or radiographic obstruction requiring continued urinary drainage or further intervention; secondary outcomes were operative time, estimated blood loss, postoperative hospital stay, postoperative renal function, and complications. The primary analysis was multivariable regression adjusted for baseline differences in case complexity, with Firth penalized models used for the rare binary outcomes. Propensity score matching was retained as a sensitivity analysis. Before adjustment, the da Vinci group had longer strictures [5.0 (3.0-10.0) vs. 4.0 (3.0-5.0) cm; P=0.01] and more previous failed reconstructions (31.4% vs. 13.7%; P=0.03). All procedures were successfully completed without conversion. KD-SR-01 was associated with a longer operative time [adjusted difference, 13.91 minutes; 95% confidence interval (CI): 1.94-25.88; P=0.02]. No significant differences were observed in estimated blood loss, postoperative hospital stay, postoperative serum creatinine, or postoperative estimated glomerular filtration rate. Complications occurred in 3/51 (5.9%) KD-SR-01 and 7/102 (6.9%) da Vinci cases (adjusted odds ratio, 0.91; 95% CI: 0.20-3.49); surgical failure occurred in 1/51 (2.0%) and 2/102 (2.0%), respectively (adjusted odds ratio, 1.20; 95% CI: 0.09-10.93). Results were consistent in the propensity score-matched sensitivity analysis. KD-SR-01-assisted ureteral reimplantation is safe and feasible, with perioperative safety and mid-term clinical outcomes comparable to those of da Vinci-assisted surgery. Although the longer operative time with KD-SR-01 may reflect the surgeon's early learning curve and a more methodical operative workflow, these data suggest that the platform may be a feasible alternative in selected reconstructive cases.

PMID 42871620
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