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Fluosol-DA (Fluosol)

✓ Approved

Mitsubishi Tanabe Pharma Corporation · Small Molecule · Small Molecule

What is Fluosol-DA?

Fluosol-DA is a small molecule developed by Mitsubishi Tanabe Pharma Corporation. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesFluosol
CompanyMitsubishi Tanabe Pharma Corporation
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Mitsubishi Tanabe Pharma Corporation

Therapeutic Indications

Fluosol-DA is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Blood and lymphatic system disordersAnaemia✓ Approved
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Neoplasm malignant✓ Approved

Related Research Articles

PubMedMarine life science & technology2026-08-30

Marine phycotoxins repurposed as bioresource: their antiviral potentials and molecular mechanisms in aquatic organism.

Cao Cheng C, Ma Baofu B, Show Pau Loke PL, Ngo Huu Hao HH et al.

Marine phycotoxins produced by microalgae have traditionally been regarded as water pollutants or hazardous substances. Most studies have focused on their toxicity, with limited exploration of their therapeutic potential. In this study, we demonstrated that domoic acid (DA) exerts antiviral roles against largemouth bass ranavirus (LMBV). Mechanistic analyses revealed that DA disrupts the extracellular structure of LMBV and inhibits intracellular viral assembly. This may be attributed to the ATP depletion caused by the suppression of mitochondrial oxidative phosphorylation. In vivo, DA treatment reduced fish mortality by 12.5% and significantly alleviated pathological lesions in splenic and telencephalic tissues, thereby further confirming its protective effect. Additionally, transcriptomic analysis of liver tissue showed that DA enhanced digestive enzyme activity and activated the complement immune response in LMBV-infected fish. This study uncovers previously unappreciated antiviral activity of marine phycotoxin-DA and elucidates its underlying mechanisms preliminary, laying a foundation for developing marine phycotoxins as antiviral lead compounds. The online version contains supplementary material available at https://doi.org/10.1007/s42995-026-00412-2.

PMID 42668748
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PubMedFood chemistry2026-08-30

Effects of different drying methods on the drying characteristics and flavour profiles of Shanxi Da Huang apricots.

Wu Tingxuan T, Li Huaiqi H, Li Zhuo Z, Wei Yuewei Y et al.

Shanxi Da Huang apricot is highly susceptible to postharvest deterioration, restricting its utilization and commercial development. This study evaluated the effects of hot-air drying (AD), microwave drying (MD), vacuum heating drying (HD), and freeze drying (FD) on drying behavior and flavor quality. Low-field nuclear magnetic resonance (LF-NMR), headspace solid-phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS), gas chromatography-ion mobility spectrometry (GC-IMS), electronic nose, and electronic tongue were employed to characterize water distribution, volatile compounds, sensory attributes, and flavor profiles. Multivariate analyses integrating variable importance in projection (VIP), odor activity value (OAV), orthogonal partial least squares-discriminant analysis (OPLS-DA), and partial least squares regression (PLSR) identified 34 differential volatile compounds and 12 key aroma-active compounds, elucidating their potential biochemical origins and relationships with sensory properties. β-Cyclocitral, β-Ionone, and Linalool were identified as characteristic aroma contributors of Shanxi Da Huang apricot. These findings provide a basis for flavor regulation and drying-process optimization of dried apricot products.

PMID 42669277
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PubMedOphthalmology science2026-08-30

Symmetry in the Enlargement Rates of Large Hypertransmission Defects between Eyes in Age-Related Macular Degeneration.

Beqiri Sara S, Herrera Gissel G, Shen Mengxi M, Berni Alessandro A et al.

The symmetry of macular atrophy growth rates between eyes of patients with bilateral nonexudative age-related macular degeneration (AMD) was assessed to determine if both eyes could be used in clinical trials to test therapies that might slow the growth of atrophy. Retrospective review of prospectively collected swept-source OCT angiography images. Patients with bilateral nonexudative AMD with ≥1 large hypertransmission defect (hyperTD) in both eyes were included. All large hyperTDs, defined by a greatest linear dimension ≥250 μm, were identified by 2 independent graders and annotated using a semiautomated algorithm. Growth rates were assessed using the area, square root (sqrt) area, and the perimeter-adjusted growth-rate strategies. Baseline lesion sizes were stratified using a size breakpoint of 0.9 disc area (DA). Intereye comparisons of annual hyperTD growth rates were performed. Power analyses were calculated to determine the sample sizes needed for different clinical trial designs. Intereye concordance of growth rates was evaluated using Lin concordance correlation coefficients, and inter eye growth-rate agreement was evaluated using Bland-Altman analyses. Sample sizes for a 2-arm clinical trial design were calculated to detect a 30% reduction in growth rates in the treatment arm with 80% power and a 2-sided α = 0.05. Sixty-four subjects (128 eyes) were followed for a mean of 4.2 ± 1.9 years, providing 942 annualized growth-rate intervals. Prior to stratification by baseline size of 0.9 DA, intereye concordance was high (rc = 0.76) for the total area growth rate, but lower for the sqrt and perimeter-adjusted growth rates (rc = 0.51, rc = 0.60, respectively). Upon stratification, lesions <0.9 DA showed low correlation (0.39-0.46) across the 3 growth rates, but lesions ≥0.9 DA showed high correlation regardless of the transformation strategy (0.73-0.78). High intereye concordance in hyperTD growth rates was observed for lesions ≥0.9 DA using 3 different growth-rate strategies. Regardless of the growth-rate strategy used, recruitment of fellow eyes in a paired-eye study for localized treatments or both eyes for systemic treatments resulted in a marked reduction in sample sizes, with improved clinical trial efficiency. Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

PMID 42668661
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PubMedFood chemistry: X2026-08-30

Analysis of characteristic flavor compounds in coffee peels subjected to different thermal processing treatments based on GC-IMS and HS-SPME-GC-MS combined with chemical pattern recognition.

Meng Congyan C, Wu Jie J, Yan Chunrong C, Wei Jianqiang J et al.

This study investigated the effects of microwave thermal processing treatment (MD) and hot-air thermal processing treatment (HAD) on the volatile flavor compounds of coffee peel, using sun-dried (SG) samples as the control. GC-IMS and HS-SPME-GC-MS were combined with multivariate analyses (PCA and PLS-DA) and ROAV evaluation. A total of 62 and 56 volatile organic compounds (VOCs) were tentatively identified by GC-IMS and GC-MS, respectively, with ketones, aldehydes, alcohols, and esters representing the predominant classes. The two analytical methods exhibited complementary detection capabilities. PCA and PLS-DA clearly differentiated the three thermal drying treatments. Aroma-related compounds (VIP > 1 and ROAV ≥ 1) included 2-furanmethanethiol, 3-methylbutanal, (E)-2-decenal, ethyl heptanoate, hexanal, benzyl alcohol, linalool and β-ionone. Based on the nine core coffee flavor categories, SG exhibited a complex aroma profile characterized by herbal/vegetable, fruity, and nutty/cocoa notes; HAD was distinguished by highly pronounced floral notes; whereas MD presented both floral and roasted characteristics. The integrated analytical strategy effectively discriminated among different thermal processing treatments and identified putative aroma markers, which require further validation through olfactometry or sensory evaluation. This study provides a scientific basis for elucidating the flavor profile of coffee peel and supports the further development of coffee cascara tea products.

PMID 42668484
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PubMedEuropean archives of psychiatry and clinical neuroscience2026-08-30

Untargeted plasma metabolomics identifies metabolite signatures associated with suicidality status in chronic schizophrenia.

Wang Lijun L, Lu Chenghao C, Sun Xiaochun X, Sun Wenjie W et al.

Suicide contributes substantially to mortality in schizophrenia, yet metabolic signatures associated with suicidality remain poorly understood. We applied untargeted plasma metabolomics with multivariate modeling to identify plasma metabolic signatures associated with suicidality status and clinical features. We enrolled 146 frequency-matched psychiatric inpatients with chronic schizophrenia: 73 in the suicide-risk (SR) group, defined by current suicidal ideation or suicidal behavior/attempt history at admission, and 73 in the non-suicide-risk (NSR) group. Plasma samples underwent untargeted metabolomic profiling. Discriminating metabolites were identified using orthogonal partial least squares discriminant analysis (OPLS-DA) and Benjamini-Hochberg-adjusted Mann-Whitney U testing (variable importance in projection [VIP] >1.0 and adjusted p <0.05). Stepwise logistic regression with forced clinical covariates generated an exploratory metabolite-based classification model, and Spearman correlations examined associations with Positive and Negative Syndrome Scale (PANSS) and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) scores. OPLS-DA identified 70 discriminating metabolites (R2Y = 0.938, Q2Y = 0.650), with nominal enrichment of lysine degradation, glutathione metabolism, phenylalanine/tyrosine/tryptophan biosynthesis, and sphingolipid metabolism. Stepwise regression retained six metabolites associated with SR status (area under the curve [AUC] = 0.774): Sphingosine, 3-OH-TML, Ile-Leu+Leu-Ile, TML, Taurine, and 12-HETE. Gamma-Glu-Thr showed the highest VIP (5.003) and broad clinical correlations. Plasma metabolic differences involving sphingolipid, lysine/carnitine, neuroinflammatory, amino-acid, and glutathione-related pathways were associated with suicidality status in chronic schizophrenia. These exploratory cross-sectional findings require validation in larger longitudinal cohorts using dedicated suicidality assessments.

PMID 42669098
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PubMedHealthcare quarterly (Toronto, Ont.)2026-08-30

Thank God He Lived: Always, Do No Harm.

Seeman Neil N

This paper critiques an expansion of Medical Assistance in Dying for psychiatric illnesses in Canada, utilizing Orlando Da Silva's memoir, Thank God I Failed, as a central case study. It argues that severe depression impairs cognitive autonomy, making consent impossible and exposing patients to structural coercion within an underfunded healthcare system. By analyzing the intersection of physical and mental suffering, the text challenges health system utilitarianism and the artificial segregation of pain. Ultimately, it calls for rigorous evidentiary standards in healthcare policy, emphasizing the system's fundamental obligation to protect vulnerable patients and prioritize comprehensive care over expedited assisted death.

PMID 42669636
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