Drug Database
HU

human normal immunoglobulin G (NPB01)

✓ Approved

Nihon Pharmaceutical · Polyclonal Antibodies · Polyclonal Antibodies

What is human normal immunoglobulin G?

human normal immunoglobulin G is a polyclonal antibodies developed by Nihon Pharmaceutical. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesNPB01
CompanyNihon Pharmaceutical
Drug ClassPolyclonal Antibodies, Antibody
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, Nihon Pharmaceutical

Therapeutic Indications

human normal immunoglobulin G is developed for 11 unique indications across 5 therapeutic areas.

Therapeutic AreaConditionPhase
Skin and subcutaneous tissue disordersErythema multiforme✓ Approved
Nervous system disordersGuillain-Barre syndrome✓ Approved
Skin and subcutaneous tissue disordersPemphigoid✓ Approved
Skin and subcutaneous tissue disordersPemphigus✓ Approved
Infections and infestationsSalmonellosis✓ Approved

+6 more indications available with a free account

Sign up free to view all indications →

Related Research Articles

PubMedBrain and behavior2026-10-15

Naoxueshu Oral Liquid Attenuates Early Radiation-Induced Brain Injury in Rats.

Li Fuguang F, Qu Xiaolong X, Li Kuiyuan K, Li Guosong G et al.

To investigate the effect of Naoxueshu Oral Liquid on rats with radiation-induced brain injury. A total of 108 male Sprague-Dawley rats were randomly assigned to a control group, an irradiated + normal saline group (RBI+NS), and an irradiated + Naoxueshu Oral Liquid group (RBI+NXS). A radiation-induced brain injury model was established by single-dose whole-brain high-energy X-ray irradiation (30 Gy). After irradiation, rats received Naoxueshu Oral Liquid (0.5 mL/100 g/day, gavage) or normal saline for 14 days. Body weight was monitored, cerebral edema was assessed by brain tissue water content on Days 3, 7, and 14, histopathology was evaluated by hematoxylin-eosin (H&E) staining, and Morris water maze training was conducted from Day 8 to Day 13 post-irradiation, followed by the probe trial on Day 14 post-irradiation. Body weight differed significantly among groups after irradiation (Day 3/6/9/12: all p < 0.01). Specifically, at Day 12, body weight was 328.17±20.10 g (control), 258.50±18.87 g (RBI+NS), and 302.83 ± 10.87 g (RBI+NXS); RBI+NXS was higher than RBI+NS (p < 0.01), while control versus RBI+NS remained different (p < 0.01). H&E staining showed widened perineuronal and perivascular spaces after irradiation, which were attenuated by Naoxueshu. In the Morris water maze, RBI+NS rats exhibited prolonged latency and fewer platform crossings; these impairments were improved after Naoxueshu treatment. Naoxueshu Oral Liquid reduced cerebral edema and improved Morris water maze performance in rats after whole-brain irradiation. Because behavioral outcomes were assessed only using the Morris water maze, the cognitive-related findings should be interpreted cautiously.

PMID 42875996
Read full article →
PubMedFrontiers in immunology2026-10-15

Mycophenolate mofetil as salvage therapy for refractory acute-onset CIDP associated with rheumatoid arthritis: a case report.

Tan Jinhui J, Huang Hai H, Tan Linghua L, Li Bo B

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated neuropathy that rarely co-occurs with rheumatoid arthritis (RA). When CIDP proves refractory to first-line therapies, management becomes particularly challenging, especially in patients with multiple autoimmune conditions. A 43-year-old Chinese male with a 3-year history of seropositive RA in sustained remission presented with acute progressive quadriparesis, bilateral ptosis, and facial diplegia. Cerebrospinal fluid analysis revealed albuminocytologic dissociation, and nerve conduction studies demonstrated evolving demyelinating features, consistent with a diagnosis of acute-onset CIDP (A-CIDP). The patient responded inadequately to sequential treatment with intravenous immunoglobulin, high-dose corticosteroids, and the neonatal Fc receptor (FcRn) antagonist efgartigimod, experiencing repeated relapses during corticosteroid tapering. Mycophenolate mofetil (MMF) was subsequently introduced as a steroid-sparing agent at 0.75 g twice daily, enabling further prednisone tapering from 20 mg to 10 mg daily without relapse; MMF was later up-titrated to 1 g twice daily. Under a combined, multi-target immunosuppressive regimen of MMF, prednisone, methotrexate, iguratimod, and hydroxychloroquine, the patient achieved sustained neurological improvement, with prednisone successfully tapered to 10 mg daily by October 2025 and maintained thereafter. By April 2026, only residual mild ptosis persisted, and no infectious complications occurred. This case suggests that MMF-based multi-target immunosuppression may be a therapeutic option for RA-associated, treatment-refractory A-CIDP, potentially enabling successful glucocorticoid tapering even after an inadequate response to a short course of FcRn-targeted therapy.

PMID 42876587
Read full article →
PubMedFrontiers in cardiovascular medicine2026-10-15

Pathogenicity assessment of a bicuspid aortic valve-associated ELASTIN variant using a zebrafish model.

Bernard Victor G VG, Théron Alexis A, Drouard Aurélien A, Avierinos Jean-François JF et al.

Bicuspid aortic valve (BAV) is one of the most common congenital heart defects but its genetic basis remains incompletely defined. Extracellular matrix components play key roles in outflow tract (OFT) and valve development, but their contribution to BAV is not fully established. Following the analysis of a cohort of BAV patients, we identified a family harbouring a rare human ELASTIN (ELN) variant (p.Gln691X). Here, we investigated the pathogenicity of this variant using an in vivo zebrafish model. We generated a zebrafish elna/b double knockout (KO) using an RNAless CRISPR Cas9 strategy to avoid genetic compensation. Cardiovascular morphology and function were assessed in mutant embryos. To evaluate pathogenicity of the human ELN p.Gln691X variant, mutant and control embryos were rescued by mRNA injection encoding either WT human ELN or the p.Gln691X variant. elna/b double KO zebrafish exhibited cardiovascular defects including OFT anomalies, reduced stroke volume and dysmorphic aortic valves, highlighting Elastin's critical role in cardiac development. We then used this model to test the ELN variant identified in the BAV family. We found that wild-type ELN mRNA was able to restore normal cardiac function and morphology, whereas the variant ELN mRNA failed to do so. Our study establishes a robust in vivo model to assess ELN variant pathogenicity and provides evidence linking ELASTIN to BAV, opening new avenues for uncovering the genetic mechanisms underlying BAV.

PMID 42876768
Read full article →
PubMedFrontiers in cognition2026-10-15

Brain mechanics and cognition: the role of rodent MR elastography in identifying cellular mechanisms.

Milbocker Katrina A KA, Vander Wiele Sabrina S SS, Johnson Curtis L CL

Magnetic resonance elastography (MRE) non-invasively quantifies brain tissue mechanical properties and has revealed an intriguing relationship between regional viscoelasticity and cognitive function across the lifespan. However, the biological basis of this relationship remains poorly understood as it is not yet clear which microstructural features generate the mechanical signal, whether brain mechanics are primarily structural or also dynamic on cognitive timescales, or how generalizable the current relationships observed in humans are across different brain regions and functions. We argue that resolving these questions requires preclinical MRE in rodents, where mechanical measurements can be linked directly to complementary analyses of cellular components and where structure and function can be experimentally perturbed. Although rodent MRE is well-established and has been productively applied to disease models, it has been little used in the contexts in which the human MRE-cognition findings are most concentrated including normal development and aging and cognitive variation in the otherwise-healthy brain. We review the human MRE-cognition literature, summarize what preclinical MRE has revealed to date, and outline experimental frameworks organized around the open questions through which rodent MRE could begin to clarify why brain mechanics relate to brain function.

PMID 42876515
Read full article →
PubMedFrontiers in immunology2026-10-15

Case Report: Multiple brain abscess-like lesions with concurrent detection of Nocardia amamiensis and Leishmania infantum in cerebrospinal fluid.

Liang Jiahao J, Wang Gang G, Shen Ruile R

Central nervous system nocardiosis is rare and potentially life-threatening, and human infection due to Nocardia amamiensis has seldom been reported; central nervous system involvement in visceral leishmaniasis is likewise uncommon. We report a 69-year-old man who developed progressive impairment of consciousness and coma after recurrent fever. Brain magnetic resonance imaging revealed multiple abscess-like lesions in both cerebral hemispheres, the cerebellum, and the brainstem, accompanied by acute or subacute cerebral infarctions. The cerebrospinal fluid opening pressure was 300 mmH2O. The white blood cell count was 285 × 106/L, with 81.9% polymorphonuclear cells; protein was 1.977 g/L and glucose was 2.34 mmol/L. MetaCAP analysis of cerebrospinal fluid concurrently detected N. amamiensis and L. infantum, and bone marrow smear demonstrated Leishmania amastigotes within macrophages. The patient tested negative for human immunodeficiency virus, and abdominal ultrasonography showed no hepatosplenomegaly. On the available evidence, visceral leishmaniasis was established and central nervous system nocardiosis was strongly suspected. Detection of L. infantum in cerebrospinal fluid supported possible central nervous system involvement, but did not establish a direct contribution to the brain abscess-like lesions. The patient received trimethoprim-sulfamethoxazole, imipenem-cilastatin, amikacin, and liposomal amphotericin B, but his condition continued to deteriorate. He was discharged against medical advice, and follow-up revealed that he had died. This case illustrates that sequencing-based detection is an important clue but cannot replace culture, pathogen-specific polymerase chain reaction, or evidence from lesion tissue.

PMID 42876631
Read full article →
PubMedFrontiers in cellular and infection microbiology2026-10-15

Genomic and antimicrobial susceptibility characterization of a clinical Pasteurella aerogenes isolate from a human patient.

Chen Ying Y, Brandis Gerrit G, Li Hong H, Luo Yongjun Y et al.

Pasteurella aerogenes is an opportunistic zoonotic pathogen associated with reproductive disorders in animals and sporadic human infections. However, the complete genome, antimicrobial susceptibility profile, and phylogenetic relationships of clinical P. aerogenes isolates, particularly from China, remain poorly understood. We sequenced the complete genome of the clinical P. aerogenes isolate 21PA20240911 from a patient with urinary tract infection in Hainan, China, using a hybrid PacBio and Illumina sequencing approach. Comparative genomic analyses, including genome feature characterization, ANI-based species delineation, virulence gene screening, antimicrobial susceptibility testing, and cgSNP-based phylogenetic analysis, were performed to investigate the strains genomic landscape and evolutionary origin. The genome of strain 21PA20240911 was 2.3Mbp with a G+C content of 40.84%. ANI analysis confirmed its taxonomic assignment as P. aerogenes (97.61% identity with the reference strain). The strain carried 28 virulence-associated genes. Notably, tviB and wbpD were detected only in our strain and a duck-derived Sichuan isolate. The isolate was resistant only to erythromycin but showed nonsusceptibility to multiple β-lactams and tetracyclines. Resistance-associated determinants included tet (B)/tetR and a putative PBP3/FtsI-like protein variant carrying D350N and S357N substitutions. Phylogenetic analysis tentatively suggests the possibility of zoonotic transmission from local poultry for this strain. This study provides the first complete genome sequence of a clinical P. aerogenes isolate from China, offering a genomic foundation for understanding its pathogenicity and antimicrobial resistance. From a One Health perspective, enhanced surveillance in both clinical and veterinary settings is warranted.

PMID 42876705
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about human normal immunoglobulin G