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ketoprofen spray

✓ Approved

Giuliani · PTGS1 · Small Molecule

What is ketoprofen spray?

ketoprofen spray is a small molecule developed by Giuliani. It is approved for therapeutic indications via transdermal.

Drug Profile

CompanyGiuliani
Drug ClassSmall Molecule
Molecular TargetPTGS1, PTGS2
RouteTransdermal
StatusApproved
Sources: ClinicalTrials.gov, Giuliani

Mechanism of Action

Molecular Targets

ketoprofen spray acts on 2 molecular targets:

PTGS1prostaglandin-endoperoxide synthase 1 (COX3, PCOX1)
PTGS2prostaglandin-endoperoxide synthase 2 (GRIPGHS, hCox-2)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

ketoprofen spray is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Hepatobiliary disordersHepatitis✓ Approved
Musculoskeletal and connective tissue disordersMusculoskeletal pain✓ Approved

Related Research Articles

PubMedPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology2026-10-15

International survey of parental and patient perspectives on emerging adrenaline devices for community-based management of anaphylaxis: An EAACI task force report.

Gonzalez-Matamala M F MF, Patel N N, Kahn-Santoro D D, Knibb R R et al.

Intranasal adrenaline has been approved in multiple countries for anaphylaxis treatment, based primarily on pharmacokinetic/pharmacodynamic comparisons to adrenaline autoinjectors (AAIs). To assess patient and caregiver perspectives regarding emerging non-injectable adrenaline routes. Online survey of adults and caregivers of children with food allergy prescribed AAIs, with international dissemination supported by the European Academy of Allergy and Clinical Immunology (February-April 2025). We analyzed 542 responses from caregivers and 224 from adults with food allergy. Effectiveness of adrenaline nasal spray (ANS) compared to AAI was rated "extremely important" by 78% of caregivers and 71% of adults. 48% of caregivers and 42% of adults were "extremely worried" that ANS may not work as well as AAI, and 50% and 44% (respectively) that it may not work well enough. Compared with AAI, respondents were less worried about ANS being painful or difficult to carry, and about fear/embarrassment around use, but more worried about side effects and knowing how to use it. Most anticipated being more comfortable using ANS than AAI, and over half anticipated earlier use during anaphylaxis. Only 17.2% of caregivers and 23.2% of adults preferred to be prescribed ANS only. There was interest in sublingual adrenaline due to portability and reduced needle-related burden, but confidence depended on comparable speed/effectiveness and feasibility during reactions. Non-injectable adrenaline is attractive to caregivers and adults, and may improve willingness to carry and use adrenaline. However, demand for evidence of effectiveness, safety, and real-world feasibility is high, highlighting important information needs for shared decision-making.

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PubMedFrontiers in chemistry2026-10-15

Development of alkyd-based copper sorbate coatings for anti-corrosion and anti-biofouling applications.

Thiyagarajan Manikandan M, Angaiah Subramania S, Yan Chao C, Punniyakotti Parthipan P

Biofouling is a serious problem in various industrial sectors such as shipping infrastructure, cooling water systems, and aquaculture. Biofilm formation by different types of microorganisms plays a very crucial role in this biofouling process. Biofouling on metallic surfaces accelerates aggressive corrosion processes. Therefore, it is essential to develop antifouling coatings with corrosion resistance for effective protection. In the present study, copper sorbate (CS) and copper oxide (CuO) were synthesized as antifouling pigments and characterized using a UV-vis spectrometer, Fourier transform infrared spectroscopy, X-ray diffraction, and field emission scanning electron microscopy. Both pigments in different ratios were used for the formulation of antifouling and anti-corrosion paints. Salt spray test and anti-corrosion test were performed in the presence of 3.5% NaCl solution for 30 days. Electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization were recorded for all the tested specimens. The results indicate that CS-rich coatings (15%20% of CS) display higher corrosion resistance than CuO-rich coatings. The antifouling potential of the coated mild steel was evaluated by immersing them in the marine estuarine water, and surface changes were monitored at regular intervals. All coatings exhibited considerable antifouling effects up to 60 days of immersion. Notably, the CS-II coating, containing only 5% CuO with 15% of CS, showed significant fouling resistance up to 90 days. At the end of 120 days, SEM analysis confirmed that a huge number of marine microorganisms (mostly diatoms) settled on CS-I, CS-III, CS-IV, and CS-V, but minimal microorganisms were only noticed on CS-II. This could be due to the antimicrobial activity and controlled leaching behavior of both pigments in marine conditions.

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PubMedFood chemistry: X2026-10-14

Effects of ultrasound-heat pretreated egg white powder addition on the quality, gel properties, and metatranscriptomic profiles of yogurt.

Xie Yunxiao Y, Wang Xiaolin X, Shui Yuru Y, Hu Gan G et al.

Egg white powder incorporation into high-protein yogurt may interfere with starter culture performance and acid-induced gel formation. This study prepared egg white powder by ultrasound-heat pretreatment followed by spray drying (UHSD-prepared egg white powder) and evaluated its effects on set-type yogurt. Compared with fresh egg white, the UHSD-prepared egg white powder exhibited a 90.3% reduction in apparent lysozyme activity. Yogurt containing 1% UHSD-prepared egg white powder exhibited improved texture, water-holding capacity, and viscoelastic properties, whereas 4% addition increased pH, reduced titratable acidity, and decreased some texture parameters. Metatranscriptomic analysis revealed greater transcript representation of lactic acid bacteria-related taxa in the 1% group, while the 4% group exhibited reduced transcriptional representation of glycolysis/gluconeogenesis, pyruvate metabolism, glycoside hydrolases, and glycosyltransferases. UHSD-prepared egg white powder showed potential as a functional ingredient to modulate yogurt quality. Further comparison with conventional spray-dried egg white powder is needed to clarify the specific contribution of ultrasound-heat pretreatment.

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PubMedPest management science2026-10-14

On-farm comparison of aerial and chemigation application methods for Striacosta albicosta (lepidoptera: Noctuidae) management in corn using pyrethroid and diamide insecticides.

Rilaković Andrea A, Fritz Bradley B, Bipin Poudel P, Howard Reka R et al.

Application method and timing can strongly influence the efficacy and efficiency of insecticide treatments. The western bean cutworm, Striacosta albicosta, is a significant pest that can cause severe damage to corn ears through larval feeding. Management of S. albicosta frequently relies on insecticide application; however, inadequate applications or ineffective insecticides can lead to control failures. We seek to evaluate the efficacy of bifenthrin (pyrethroid) and chlorantraniliprole (diamide) for managing S. albicosta in corn using aerial and chemigation applications. In an on-farm study conducted over two growing seasons, aerial application deposition, spray coverage, and insecticide residues were greater on tassels than on ear leaves within the corn canopy. Of the total spray volume applied aerially, only 36.4% reached the tassel level, whereas 19.8% reached the ear zone. Across both application methods, chlorantraniliprole resulted in the lowest ear-feeding injury (0.1 cm-1), while bifenthrin provided moderate control (0.55 cm-1) compared to the control (1.26 cm-1). No significant differences in yield protection were detected between application methods. Effective management of S. albicosta requires delivering sufficient insecticide concentration to the target site and achieving adequate coverage throughout the corn canopy. Ensuring deposition in the ear zone is particularly important to delay resistance development and prevent larvae from being exposed to sublethal concentrations. These findings demonstrate the higher efficacy of chlorantraniliprole in reducing feeding injury and suggest that application method selection may be flexible without compromising yield protection. © 2026 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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PubMedMarine pollution bulletin2026-10-14

A multipronged approach to inform ecological risks of emerging organic contaminants in surface water and sediment in the estuarine-receiving environment of Tauranga Harbour, Bay of Plenty, New Zealand.

Stewart Michael M, Northcott Grant G, Crawshaw Josie J, Conwell Claire C

Increasing coastal urbanisation is a continuous stressor on coastal ecosystems. Emerging organic contaminants (EOCs) comprise thousands of chemicals whose environmental fate and effects are not all well understood. A study of 96 EOCs was undertaken in Tauranga Harbour, New Zealand, with surficial sediments collected and passive sampling devices (PSDs) deployed at 12 sites. Per- and polyfluorinated alkyl substances (PFAS), glyphosate/aminomethylphosphonic acid (AMPA), and chloroxylenol were detected in PSDs only, while nonylphenol, bisphenol A, ketoprofen, salicylic acid, meclofenamic acid, UV filter chemicals and antifouling agents were only detected in sediment. Methyl paraben was the only EOC detected in both phases. Lipophilic phthalate plasticisers, pyrethroid insecticides, brominated diphenyl ether flame retardants and polycyclic musk fragrances were only measured in sediment. Phthalate plasticisers were ubiquitous while pyrethroid insecticides were detected at 8 sites. Steroid estrogens, phosphate flame retardants, wastewater markers, and the anti-corrosive benzotriazole were not detected. Generally, EOC concentrations in sediment and water from Tauranga Harbour are low when compared to other countries, with higher concentrations observed closest to the city of Tauranga. A qualitative ecological risk assessment of EOCs was undertaken using a risk quotient (RQ) approach. Ecological risk from dissolved EOCs was low to negligible with concentrations several orders of magnitude lower than effects concentrations. Sediment concentrations of EOCs were generally one order of magnitude below ecological effects concentrations, however five EOCs presented potential risks with exceedances recorded across 6 sites. Highest RQs quotients were 7.7 for monobutyl phthalate acid ester and 5.0 for cis-permethrin.

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PubMedPain2026-10-14

The analgesic efficacy of opioids in different application modalities for the treatment of breakthrough cancer pain-a systematic review with network meta-analysis.

Dinges Hanns-Christian HC, Thiedmann Sophie S, Weyland Johanna J, Volberg Christian C et al.

Breakthrough cancer pain episodes often require oral immediate release opioids or parenteral opioid treatment. Different formulations and application modalities have been approved for this condition. This study aimed to identify the most effective of the available substances and applications to treat breakthrough cancer pain. We conducted a comprehensive systematic review with network meta-analysis. The database search included MEDLINE, CENTRAL, Embase, and Web of Science. Eligible were randomized controlled trials comparing opioids and application modalities for the treatment of breakthrough cancer pain episodes. Primary end points were the pain intensity difference (PID) at 15 and 30 minutes. Secondary end points were side effects and adverse events, as well as dichotomous outcomes of treatment success. Frequentist network meta-analysis was conducted using the package netmeta in R. From 5133 records initially identified by the literature review, 23 studies were eligible for quantitative analysis. Compared with placebo, the most effective interventions at 15 minutes (PID) were intravenous or subcutaneous applications of morphine, and intranasal fentanyl or sublingual fentanyl tablets. After 30 minutes (PID), the most effective interventions were still subcutaneous and intravenous morphine, but also sublingual fentanyl tablets. Intranasal fentanyl spray was equally effective as buccal and other transmucosal applications by 30 minutes. The quality of evidence on the topic is poor as most studies are phase III trials for drug approval. The risk of publication bias is therefore high. Sublingual fentanyl tablets were as effective as intravenous or subcutaneous morphine and are a practical modality for self-administration.

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