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minocycline hydrochloride

✓ Approved

PreCision Dermatology · Small Molecule · Small Molecule

What is minocycline hydrochloride?

minocycline hydrochloride is a small molecule developed by PreCision Dermatology. It is approved for therapeutic indications via oral (po).

Drug Profile

CompanyPreCision Dermatology
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, PreCision Dermatology

Therapeutic Indications

minocycline hydrochloride is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsStreptococcal infection✓ Approved

Related Research Articles

PubMedJournal of virology2026-07-17

Cyclo-C stabilizes PEX13 to inhibit porcine epidemic diarrhea virus replication by blocking pexophagy-mediated disruption of antiviral innate immunity.

Lou Jinxiu J, Guo Zhiwei Z, Chen Kang K, Tian Yuanmingyue Y et al.

The persistent threat of porcine epidemic diarrhea virus (PEDV) to the global swine industry is compounded by high neonatal piglet mortality and the absence of effective antiviral therapies. Host-directed strategies that reinforce immunity offer a promising avenue to counter viral immune evasion. Through screening of an FDA-approved compound library, we identify the small-molecule cyclocytidine hydrochloride (Cyclo-C) as a potent inhibitor of PEDV replication that acts by stabilizing the peroxisomal biogenesis factor PEX13, a previously unrecognized host restriction factor. The antiviral activity of Cyclo-C is strictly PEX13-dependent, as it is completely abrogated in PEX13 knockout cells. Mechanistically, Cyclo-C disrupts the interaction between PEX13 and the viral nonstructural protein 8 (NSP8), thereby preventing NSP8-mediated PEX13 degradation and the subsequent induction of PI3K/AKT/mTOR-driven pexophagy. Preservation of peroxisomal integrity stabilizes the peroxisome-localized pool of MAVS, leading to a robust enhancement of type III interferon (IFN-III) responses that suppress viral replication. Critically, this mechanism translates in vivo, where Cyclo-C treatment of PEDV-challenged piglets significantly reduces mortality, lowers viral loads, and protects intestinal villus architecture. Our findings establish Cyclo-C as a first-in-class host-directed therapeutic candidate and validate the concept that pharmacological preservation of peroxisome-mediated innate immunity represents an effective antiviral strategy against enteric coronaviruses. The high genetic variability of porcine epidemic diarrhea virus (PEDV) limits current vaccine efficacy, and no antiviral therapeutics exist. Host-directed therapies targeting cellular pathways that viruses exploit for immune evasion offer an alternative approach. Here, we identify the FDA-approved compound Cyclo-C as a potent inhibitor of PEDV replication. Cyclo-C acts by stabilizing PEX13, a host protein that the virus degrades to evade immunity. By blocking viral protein NSP8 from binding PEX13, Cyclo-C prevents virus-induced pexophagy, thereby preserving peroxisomal integrity. This preserves peroxisome-localized MAVS and enhances type III interferon responses. In infected neonatal piglets, Cyclo-C reduced mortality and viral loads while protecting intestinal integrity. This study provides proof of concept that targeting peroxisomal immune regulation is a viable antiviral strategy and identifies Cyclo-C as a promising candidate for treating PEDV infection.

PMID 42466851
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PubMedLuminescence : the journal of biological and chemical luminescence2026-07-16

Pioneering Novel, Green, White, and Blue Fluorescence-Based Platforms for Sustainable and Concurrent Monitoring of Ciprofloxacin With Celecoxib or Itopride in Biological Matrices.

Barakat Neamat T NT, El-Aziz Heba Abd HA, Eid Manal I MI, Ibrahim Fawzia A FA

Two innovative spectrofluorimetric techniques were developed for the first time to enable simultaneous quantification of ciprofloxacin hydrochloride in binary mixtures with either celecoxib or itopride hydrochloride in biological fluids. The first relied on synchronous spectrofluorimetry at a constant wavelength interval (Δλ = 100 nm), which effectively reduced spectral interference and allowed accurate estimation of celecoxib and ciprofloxacin hydrochloride at their zero-crossing points of 276 and 328 nm, respectively. The second technique leveraged direct spectrofluorimetric measurement of ciprofloxacin hydrochloride and itopride hydrochloride mixture, using excitation at 258 nm that yielded two discrete emission peaks at 351 nm for ITH and 441 nm for CPN. Both methods demonstrated remarkable sensitivity and selectivity, achieving excellent linearity (r = 0.9999) across broad ranges of (0.05-3.0 μg/mL and 0.05-5.0 μg/mL for ciprofloxacin hydrochloride and celecoxib, respectively, and 0.07-4.0 μg/mL for ciprofloxacin hydrochloride and 0.04-9.0 μg/mL for itopride hydrochloride. Comprehensive greenness assessment was performed, which confirmed their low environmental burden. Moreover, whiteness and blueness evaluations highlighted the favorable integration of analytical efficiency with sustainability principles. The proposed strategies combine rapidity, high sensitivity, and environmental safety, providing reliable alternatives for routine quality control of pharmaceutical formulations and accurate determination of CPN mixtures in biological matrices.

PMID 42458825
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PubMedDiseases of aquatic organisms2026-07-16

Isolation, identification, and genomic features of Proteus mirabilis from diseased Asian arowana Scleropages formosus.

Yang Han H, Wen Siyi S, Han Zhuoran Z, Sun Jingfeng J

Proteus mirabilis is a Gram-negative opportunistic pathogen increasingly reported in aquatic animals; however, its pathogenic potential and genomic features in ornamental fish remain unclear. This study isolated 3 strains (WSY-112, WSY-113, and WSY-114) from diseased Asian arowana Scleropages formosus displaying hemorrhagic and ulcerative lesions. All 3 isolates were identified as P. mirabilis through physiological and biochemical characterization as well as 16S rRNA and gyrB sequencing. Strain WSY-114 was selected for further analyses, including whole-genome sequencing, antimicrobial susceptibility testing, and experimental infection. Genomic annotation identified multiple virulence-related genes for flagellar assembly, adhesion, toxin production, iron acquisition, and type III/IV/VI secretion systems. Experimental infection in zebrafish Danio rerio showed dose-dependent mortality (LD50 = 6.6 × 104 CFU g-1) and clinical signs mirroring natural infections in the arowana. The strain exhibited resistance to multiple tested antibiotics, including tetracyclines (tetracycline, minocycline, and doxycycline), macrolides (erythromycin and azithromycin), and ampicillin, consistent with antibiotic-resistance genes detected in its genome. These results indicate that P. mirabilis exhibits pathogenic potential under experimental conditions and may represent a potential risk factor in ornamental fish.

PMID 42460755
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PubMedAnnals of hematology2026-07-16

Breast cancer risk in female survivors of Hodgkin lymphoma after exposure to non-pegylated liposomal doxorubicin at young adult and adult age: the first real-life series from Southern Italy cancer centers.

Picardi Marco M, Vincenzi Annamaria A, Giordano Claudia C, Pugliese Novella N et al.

Studies in female Hodgkin lymphoma (HL) survivors have shown that doxorubicin hydrochloride exposure at young adult and adult (YA&A) age is associated with an increased risk of breast cancer (BC) regardless of chest-radiotherapy (c-RT). Although non-pegylated liposomal doxorubicin (NPLD)-based regimens have shown efficacy and safety in the treatment of lymphoma, the association between NPLD exposure and BC risk has not been examined in HL survivors. We assessed standardized incidence ratio (SIR) and absolute excess risk (AER) of BC in a cohort of 100 female ≥ 5-year HL survivors treated between 18 and 60 years of age with NPLD-based regimen in tertiary hospitals in southern Italy between 2009 and 2020. The median cumulative liposomal doxorubicin dose was 290 mg/m²; c-RT was administered to 20% of patients. After a median follow-up of 10 years (interquartile range, 8-11 years), no women had developed BC. Compared with the Italian general population, the SIR was 0.00 (95% confidence interval, 0.00-4.29); the standardized ratio was 86.5 per 100,000 person per year according to the AIRTUM (Associazione Italiana Registri Tumori) Working Group data for women aged between 18 and 60 years. In our series, the AER was - 8.87 per 10,000 person per year. Based on data derived from the pooled summary rate of literature, HL survivors treated with doxorubicin hydrochloride-including regimens at YA&A age had an incidence rate of BC of 1.6% at 10-year median follow-up. These data, if validated in largest datasets with longer follow-up, suggest that treatment with NPLD could be not associated with increased BC risk in HL survivors, unlike conventional doxorubicin. Our findings provide a rationale for evaluating NPLD-based frontline therapy in prospective studies of YA&A patients with newly diagnosed HL.

PMID 42461398
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PubMedBMC infectious diseases2026-07-16

Rare primary small intestinal infection: a case report of Mycobacterium kansasii enteropathy in an immunocompetent patient and literature review.

Wu Lang L, Wang Jiayao J, Zhu Jin J, Li Teng T et al.

Non-tuberculous mycobacteria (NTM) are important opportunistic pathogens that most commonly infect the lungs. Primary involvement of the gastrointestinal tract-especially the small intestine-is exceedingly rare, and small-bowel infection caused by Mycobacterium kansasii (M. kansasii) has seldom been reported. We describe an extremely rare case of primary small-intestinal M. kansasii infection in an immunocompetent young man who presented with prolonged chronic diarrhea and fever. After an extensive but unrevealing diagnostic work-up, the etiology was finally established by microbial metagenomic sequencing of tissue obtained by double-balloon endoscopy. Building on the initial regimen of ethambutol hydrochloride, rifampicin, and clarithromycin-and with subsequent antibiotic adjustments tailored to the patient's evolving symptoms-clinical symptoms resolved completely, and follow-up endoscopy showed mucosal improvement. This case underscores that NTM infection should be considered in the differential diagnosis of unexplained chronic gastrointestinal symptoms and highlights the pivotal role of modern molecular techniques in reaching a precise diagnosis. Detailed analysis of the case together with a review of the literature aims to raise clinicians' awareness and improve management of this rare entity.

PMID 42458280
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PubMedAnnals of hematology2026-07-16

Peripheral blood CD8 + T-cell count at diagnosis predicts prognosis in R-CHOP-treated diffuse large B-cell lymphoma patients.

Chen Fang F, Liu Ping P, Zhao Jiajia J, Wang Demin D et al.

While the prognostic significance of peripheral blood (PB) lymphocyte counts in diffuse large B-cell lymphoma (DLBCL) patients treated with Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine Sulfate, and Prednisone (R-CHOP) is established, the specific role of CD8+ T-cell counts (CD8c) remains unclear. Methods: This retrospective study analyzed 315 newly diagnosed DLBCL patients treated at Central Hospital of Xiangtan from January 2018 to September 2023. We evaluated the prognostic significance of initial CD8c and other clinical parameters using univariate and multivariate survival analyses to identify independent predictors of outcome. An optimal CD8c cut-off value of 264.5×106/L was identified. Low CD8c correlated with significantly improved 5-year progression-free survival (PFS) (88.78% vs 49.18%, p<0.001) and overall survival (OS) (84.02% vs 31.25%, p<0.001). Multivariate analysis confirmed CD8c as an independent prognostic factor for both PFS and OS. CD8c demonstrated significant interactions with lactate dehydrogenase levels. Notably, low CD8c groups consistently exhibited superior survival outcomes, even in the presence of other poor prognostic factors. Initial PB CD8c serves as an independent predictor for R-CHOP-treated DLBCL patients. These findings suggest CD8c may be a candidate for enhancing existing prognostic models, particularly when combined with established risk factors, underscoring the potential importance of host immune status in DLBCL prognosis and treatment outcomes. Independent validation in external cohorts is needed.

PMID 42458006
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