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minocycline hydrochloride

✓ Approved

PreCision Dermatology · Small Molecule · Small Molecule

What is minocycline hydrochloride?

minocycline hydrochloride is a small molecule developed by PreCision Dermatology. It is approved for therapeutic indications via oral (po).

Drug Profile

CompanyPreCision Dermatology
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, PreCision Dermatology

Therapeutic Indications

minocycline hydrochloride is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsStreptococcal infection✓ Approved

Related Research Articles

PubMedNeuromolecular medicine2026-08-30

AMBMP Hydrochloride Reverses STZ-Induced Alzheimer-Type Dementia Associated with Wnt/β-catenin/TLR4 Signaling.

Kalra Palak P, Chaturvedi Deepak D, Kumar Amit A, Grewal Amarjot Kaur AK et al.

Alzheimer's disease (AD) is a debilitating neurodegenerative disorder with progressive cognitive decline and neuronal loss. This study investigated the neuroprotective effects of AMBMP Hydrochloride, a Wnt/β-catenin agonist, in a streptozotocin (STZ)-induced mice model of AD, elucidating the interplay between dysregulated Wnt/β-catenin signaling and Toll-Like Receptor 4 (TLR4)-mediated inflammation, with Palmitic acid used as a TLR4 pathway modulator. Mice received bilateral intracerebroventricular (i.c.v.) injections of STZ (3 mg/kg) on Day 1 and Day 3, followed by administration of Donepezil (3 mg/kg)/ AMBMP Hydrochloride (5 mg/kg and 10 mg/kg)/Palmitic acid (TLR4 agonist, 20 mg/kg) via the intraperitoneal (i.p.) route from Day 4 to Day 22. STZ-treated mice exhibited significant cognitive dysfunction, characterized by impaired performance in the Morris Water Maze (MWM) task along with increase in acetylcholinesterase (AChE) activity, oxidative stress (thiobarbituric acid reactive substances; TBARS), neuroinflammation [tumor necrosis factor alpha (TNF-α)/Interleukin-6 (IL-6)/Interleukin-1 beta (IL-1β) and nuclear factor kappa B (NF-κB)] and decreased reduced glutathione (GSH) levels. However, AMBMP Hydrochloride significantly improved behavioral and biochemical alterations possibly through modulation of Wnt/β-catenin signaling and attenuation of TLR4-mediated inflammation. Interestingly, Palmitic acid co-treatment was found to counteract these protective effects, further pointing to a role of TLR4 in the pharmacological effect of AMBMP Hydrochloride. In summary, we confirmed that AMBMP Hydrochloride exhibits potent neuroprotective effects associated with modulating Wnt/β-catenin/TLR4 signaling, offering a promising therapeutic approach against Alzheimer-Type Dementia. Future studies should delve deeper into the molecular mechanisms and translational promise of AMBMP hydrochloride, paving the way for its development as a potential candidate for AD management.

PMID 42668333
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PubMedBrain, behavior, and immunity2026-08-30

Spatial synaptic pruning mechanism of NAC microglia in differential regulation of PTSD- and depression-like behaviors.

Zhao Mingyue M, Tian Wenyu W, Hu Xinyu X, Dai Jiajie J et al.

Post-traumatic stress disorder (PTSD) comorbid with depression is a prevalent, treatment-refractory clinical syndrome. Emerging evidence indicates shared microglial alterations in PTSD and depression, suggesting it may represent a common pathological substrate. However, the underlying neuroimmune mechanisms remain unclear. PTSD- and depression-like behaviors were induced in rats by using single prolonged stress combined with foot shock (SPS&S). Cellular activity, spatial distribution, and morphology were assessed using qPCR, immunofluorescence, and Golgi-Cox staining. Microglial activity was inhibited using clodronate liposomes (CDSlip) and minocycline. Bulk RNA sequencing was performed to profile neuroimmune-related signaling molecules. Stress induced PTSD- and depression-like behaviors, accompanied by region-specific enhanced microglial activity in the anterior-medial NAC core (amNACc) and lateral NAC shell (LNACsh). Selective depletion of microglia in amNACc and LNACsh via CDSlip specifically alleviated stress induced PTSD- and depression-like behaviors, respectively. Morphological and functional analyses in each region revealed that microglia reshaped the spatial pattern of neuronal structure and function, manifested by enhanced in amNAC and inhibited in LNACsh, via differentially pruning adjacent inhibitory synapses in corresponding region. Further transcriptomic analysis of synaptic pruning relevant signaling pathway showed upregulated expression of "Eat me" signal molecules (particularly Mertk) in the amNAC and downregulated expression of "Find me" signal molecules (particularly Cx3cr1) in the LNACsh, consistent with the observed spatial synaptic pruning profiles. Minocycline administration reversed stress-induced PTSD and depression-like behaviors while normalizing the region-specific alterations in synaptic pruning signaling molecules. Stress may elicit two regionally heterogeneous microglial subpopulations within NAC: phagocytosis-enhanced and recognition-impaired, which remodel the structure and function of local neural networks by differential pruning of inhibitory synapses, thereby driving the manifestation of PTSD- and depression-like behaviors, separately. These findings deepen our understanding of the neuroinflammatory mechanisms underlying trauma-related psychiatric disorders and identify novel targets for immunomodulation-based targets for transdiagnostic interventions .

PMID 42669315
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PubMedPakistan journal of medical sciences2026-08-30

Efficacy of Bromhexine hydrochloride combined with bronchoalveolar lavage under fiberoptic bronchoscopy in the treatment of mild to moderate community-acquired pneumonia.

Hu Feiyan F, Lin Li L, Lv Feijing F, Xu Yanan Y et al.

To evaluate the clinical efficacy of bromhexine hydrochloride (BRH) combined with fiberoptic bronchoalveolar lavage (BAL) under fiberoptic bronchoscopy (FOB) in the treatment of patients with community-acquired pneumonia (CAP). This retrospective cohort study included clinical data from 126 patients with mild-to-moderate CAP treated at Yongkang First People's Hospital from March 2023 to March 2025. Of them, patients treated with BRH alone (BRH group, n=63) were matched 1:1 to a cohort treated with BRH combined with fiberoptic bronchoscopic BAL under FOB (BRH & BAL group, n=63). The primary outcome was clinical efficacy. Secondary outcomes included clinical symptoms, levels of inflammatory factors, and incidence of adverse reactions. After treatment, the efficacy of the BRH & BAL group (95.2%) was significantly higher than that of the BRH group (84.1%) (P<0.05). Post-treatment duration of fever, time to cough relief, time to resolution of pulmonary rales, and hospital length of stay in the BRH & BAL group were all shorter than those in the BRH group (P<0.05). After treatment, the levels of IL-6, CRP, and PCT in both groups were considerably lower than pre-treatment and significantly lower in the BRH & BAL group than in the BRH group (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). BRH combined with BAL under FOB for the treatment of mild-to-moderate CAP is associated with improved therapeutic efficacy, alleviation of clinical symptoms, reduction of the inflammatory response, and good safety.

PMID 42668875
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PubMedMedical mycology journal2026-08-30

A Case of Kerion Celsi due to Trichophyton rubrum Successfully Treated with Fosravuconazole.

Une Chisato C, Ikutama Risa R, Kano Rui R, Kimura Utako U et al.

A male in his seventies presented with multiple erythematous follicular papules on the back, followed by lesions in the occipital region and posterior neck. Fungal examination revealed kerion celsi caused by Trichophyton rubrum. The patient was treated with fosravuconazole 100 mg/day for 8 weeks, and the brush method was negative 1 month later. The oral antifungal medicines approved for treatment of tinea capitis in Japan are limited to itraconazole and terbinafine hydrochloride. However, itraconazole has many contraindicated drugs, and antifungal resistance has recently become a major concern.As the challenge of drug-resistant fungi is expected to become more significant in the future, the clinical benefits of using fosravuconazole L-lysine ethanolate (F-RVCZ) for treating kerion celsi may increase. Our experience suggests that F-RVCZ could be a valuable therapeutic option.

PMID 42669480
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PubMedFrontiers in medicine2026-08-29

Effects of fractional laser combined with amorolfine hydrochloride cream on fungal clearance rate and nursing outcomes in patients with onychomycosis: a retrospective clinical study.

Wang Dan D, Wu ZhuoYan Z, Jia Fei F

To investigate the clinical efficacy, fungal clearance rate, and impact on quality of life of fractional laser combined with amorolfine hydrochloride cream in the treatment of onychomycosis. This study retrospectively analyzed 90 patients diagnosed with onychomycosis who were admitted to our hospital between November 2023 and November 2024. According to the treatment strategies received during routine clinical practice, patients were assigned to either the conventional group or the study group, with 45 cases in each group. The conventional group received amorolfine hydrochloride cream alone combined with routine nursing care, whereas the study group additionally received fractional laser therapy and targeted comprehensive nursing intervention on this basis. Comparative analyses were conducted between the two groups with respect to the fungal clearance rate, overall clinical intervention efficacy, quality-of-life scores before and after the intervention, incidence of adverse events, and nursing satisfaction. After the intervention, the overall clinical effective rate and fungal clearance rate in the study group (95.56 ± 3.5, 95.56 ± 3.2%) were both significantly higher than those in the conventional group (82.22 ± 4.2, 77.78 ± 4.9%) (p < 0.05). The degree of improvement in quality of life among patients in the study group was significantly better than that in the conventional group (p < 0.05). In addition, the incidence of adverse events in the study group was significantly lower than that in the conventional group (p < 0.05), and the overall patient satisfaction with nursing care was significantly higher than that in the conventional group (p < 0.05). Compared with amorolfine hydrochloride cream alone, fractional laser combined with amorolfine hydrochloride cream is safer and more effective in the treatment of onychomycosis, improves nursing outcomes, increases the fungal clearance rate, enhances quality of life, and reduces adverse events.

PMID 42666669
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PubMedArchives of microbiology2026-08-29

Comparative evaluation of glucosamine derivatives for enhanced microbial hyaluronic acid production by Streptococcus zooepidemicus and Streptococcus pyogenes.

Girgin Öz Hilal H, Aydın Yıldırım Pınar P, Öğüt Hamdi H

The extraction of hyaluronic acid (HA) from animal tissues such as rooster combs or bovine vitreous humor is limited by complex purification steps and contamination risks. Microbial fermentation has therefore become a sustainable alternative for HA production. This study aimed to optimize the temperature and pH conditions for Streptococcus pyogenes using the Taguchi method and to investigate the effects of three glucosamine derivatives D-(+)-glucosamine hydrochloride, N-acetyl-D-glucosamine, and D-glucosamine 3-sulfate on HA synthesis by Streptococcus pyogenes and Streptococcus zooepidemicus. The optimal temperature and pH conditions for S. pyogenes HA production were identified as 32 °C and pH 8.0. Among the glucosamine derivatives tested, supplementation with 1.3 g N-acetyl-D-glucosamine and 2 g D-glucosamine 3-sulfate significantly increased HA production in S. zooepidemicus, reaching 1018.9 mg/L and 739.0 mg/L, respectively, whereas glucosamine hydrochloride showed no significant effect. In contrast, the highest mean HA concentrations in S. pyogenes were 773.7 mg/L with 0.8 g D-(+)-glucosamine hydrochloride and 540.5 mg/L with 2 g D-glucosamine 3-sulfate, although these differences were not statistically significant. No significant differences were observed among the tested concentrations of N-acetyl-D-glucosamine. These results demonstrate that the type and dosage of glucosamine precursors exert strain-specific effects on HA biosynthesis. This work provides a comparative analysis of glucosamine derivatives in Streptococcus species, offering new insights into microbial HA production strategies.

PMID 42667334
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