Drug Database
DI

diosmin + hesperidine (Daflon / Capiven / Detralex)

✓ Approved

Servier · therapeutic agent

What is diosmin + hesperidine?

diosmin + hesperidine is a therapeutic agent developed by Servier. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesDaflon, Capiven, Detralex
CompanyServier
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Servier

Therapeutic Indications

diosmin + hesperidine is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Gastrointestinal disordersAbdominal pain✓ Approved
Vascular disordersPeripheral venous disease✓ Approved

Related Research Articles

PubMedMolecular diversity2026-08-29

Machine learning-driven drug repurposing and computational validation for Nipah virus.

Sharma Shivangi S, Yadav Pragya D PD, Cherian Sarah S

The recurring Nipah virus outbreaks and the lack of effective antiviral therapies, emphasize the urgent need for effective therapeutic interventions. Given the sporadic and unpredictable nature of NiV outbreaks, drug repurposing offers a time-efficient alternative to the development of novel antivirals. In this study, we leveraged machine learning (ML) techniques to accelerate the process of identifying potential therapeutic candidates. Several supervised ML models such as Support Vector Machines, Random Forest, Logistic Regression, Decision Tree, k-Nearest Neighbors, Artificial Neural Networks, and Ridge Classifier were implemented using publicly available NiV inhibitor datasets (viz. Anti-Nipah, NVIK, PubChem) as well as literature review (n = 211 compounds). Among these, the Random Forest model demonstrated highest predictive performance, achieving high accuracy on both training (95%) and testing (86%) datasets. The optimized model was subsequently applied to screen FDA-approved, preclinical, clinical, and antiviral drug libraries (comprising 9021 compounds) to identify potential anti-NiV candidates. The shortlisted compounds underwent further validation through molecular docking to evaluate binding affinity and molecular dynamics simulations to assess structural stability and interactions with key viral targets, including the glycoprotein and RNA-dependent RNA polymerase (RdRp). Based on docking scores and molecular dynamics stability, we identified three and five promising candidates: 2,3,4,5,6-Pentagalloylglucose, Echinacoside, Parishin A, and Neohesperidin dihydrochalcone, Naringin dihydrochalcone, Diosmin, Orientin, Amikacin, against the glycoprotein and RdRp respectively. This integrative approach, combining ML, drug repurposing, and computational validation, aims to expedite the discovery of effective therapeutic agents against the Nipah virus and strengthen preparedness for future outbreaks.

PMID 42665761
Read full article →
PubMedFoods (Basel, Switzerland)2026-08-27

Diosmin Attenuates Age-Associated Vascular Oxidative Stress and Endothelial Dysfunction in Aged Rats.

Valdiserra Giulia G, Di Salvo Clelia C, Fornai Matteo M, Pellegrini Carolina C et al.

Vascular aging is driven by a self-sustaining interplay between oxidative stress and chronic low-grade inflammation, collectively referred to as inflammaging. Diosmin, a citrus-derived flavonoid with antioxidant and anti-inflammatory properties, has not previously been investigated in this context. Young (10-week-old) and aged (40-week-old) male Sprague-Dawley rats received diosmin (50 mg/kg/day) or vehicle for 3 months. Vascular function was assessed in mesenteric resistance arteries using pressure myography, while oxidative stress was evaluated by dihydroethidium and mitoSOX staining. Circulating malondialdehyde (MDA), tumor necrosis factor (TNF), lipopolysaccharide-binding protein (LBP) vascular expression of Nos3, Gpx1, Sod2 and Xdh were measured. Aging was associated with impaired endothelium-dependent vasorelaxation, increased vascular DHE and MitoSOX fluorescence and elevated circulating MDA and LBP levels. Chronic diosmin supplementation partially restored endothelial function. The improvement in endothelial function was consistent with a partial preservation of NO-dependent endothelial function, although NO production and bioavailability were not measured directly. Diosmin also significantly reduced vascular DHE and MitoSOX fluorescence in aged animals. These effects were accompanied by decreased plasma MDA and LBP levels, whereas TNF remained unchanged. Diosmin did not significantly affect Nos3, Gpx1 or Sod2 gene's expression, but it attenuated the age-related upregulation of Xdh. Overall, diosmin attenuated age-associated vascular oxidative stress and partially improved endothelial function in aged rats. Although the reduction in circulating LBP suggests a possible effect on selected systemic signals associated with endotoxin exposure, additional inflammatory markers and mechanistic studies will be required to determine whether diosmin modulates vascular inflammaging.

PMID 42650473
Read full article →
PubMedAntioxidants (Basel, Switzerland)2026-08-27

Tissue-Specific Bioactive Metabolites and Antioxidant Activity in Minicitrus (Fortunella hindsii) and Responses to a Fruit-Associated Weissella Strain.

Yang Han H, Wu Manxi M, Huang Xinlin X, Cao Hujing H et al.

Minicitrus (Fortunella hindsii) is a wild kumquat with potential nutritional and medicinal value, but its tissue-specific bioactive metabolites, antioxidant activity, and endophytes remain poorly characterized. Here, we integrated LC-MS profiling, HPLC quantification, chemical and cellular antioxidant assays, 16S rRNA gene sequencing, bacterial isolation, and treatment experiments across five tissues. Among all the metabolites determined by HPLC, 13 were quantified using authentic standards and 24 were semi-quantified as linarin equivalents. Leaves, stems, and fruits accumulated abundant flavone glycosides, with phloretin-3',5'-di-C-glucoside reaching 1823.19 ± 278.71 μg/g FW in leaves and 847.11 ± 27.28 μg/g FW in fruits, while roots and seeds showed distinct coumarin- and furanocoumarin-rich profiles, respectively. Leaf extracts showed the strongest chemical and cellular antioxidant activities, followed by fruit extracts. Isoorientin 2″-O-rhamnoside and diosmin exhibited strong chemical antioxidant capacity, and several flavone glycosides showed protective effects in cellular assays. Endophytic bacterial communities differed markedly among tissues, with fruit harboring a distinct community dominated by Weissella and Pantoea, which accounted for 65.64% and 19.13% of the relative abundance, respectively. Among two culturable fruit-associated isolates, Weissella sp. SJG-1 treatment was associated with 32.92-104.45% increases in six HPLC-quantified metabolites and higher antioxidant activity of fruit extracts. These findings highlight minicitrus as a source of bioactive metabolites and suggest a potential association between fruit-associated bacteria and fruit functional properties.

PMID 42650301
Read full article →
PubMedJournal of robotic surgery2026-08-19

Prevention of lymphedema after extended pelvic lymphadenectomy using diosmin, bromelain, melilotus, and hesperidin: results from a prospective randomized study (PRELYNE trial).

Montanaro Francesca F, Pettenuzzo Greta G, Malandra Sarah S, Veccia Alessandro A et al.

Extended pelvic lymph node dissection (ePLND) during robot-assisted radical prostatectomy (RARP) may impair lymphatic drainage, causing lower-limb and genital lymphedema with a potential negative impact on postoperative recovery and quality of life. This prospective randomized study evaluated whether an oral formulation containing diosmin, bromelain, melilotus, and hesperidin (Meliven Top®) could reduce postoperative lymphatic morbidity after RARP with ePLND. One hundred patients undergoing RARP with ePLND for prostate cancer were randomized 1:1 to standard postoperative care alone or standard care plus oral Meliven Top® for one month. Lower-limb volumes were assessed preoperatively and at 1 and 3 months postoperatively using circumferential measurements and truncated-cone volume estimation. Secondary endpoints included genital swelling, genital pain, and lymphocele formation. Multivariable ANCOVA models adjusted for baseline limb volume, body mass index, and number of lymph nodes removed were applied.Ninety-eight patients completed follow-up. No significant differences in lower-limb volumetric changes were observed between groups at 1 or 3 months. However, genital pain at 1 month was significantly lower in the treatment group (2% vs. 18%; p = 0.008), and persistent genital swelling at 3 months was absent in treated patients compared with controls (0% vs. 8%; p = 0.041). Lymphocele rates were similar between groups. In conclusion, Meliven Top® did not significantly reduce postoperative lower-limb volume changes after RARP with ePLND, but it was associated with improved genital symptom recovery. Larger studies with longer follow-up are warranted.Clinical trial registration This study was not registered in a public clinical trial registry.

PMID 42616207
Read full article →
PubMedJournal of clinical medicine2026-08-13

Effectiveness of Diosmin, Cumarin and Arbutin in Reducing Edema and Pain After Hip or Knee Arthroplasty.

Saini Andrea A, Gramaglia Marco M, Piano Simonetta S, Mattioda Alberto A

Background/Objectives: To assess the efficacy of a product containing Diosmine, Cumarin and Arbutin (Linfadren®) in reducing edema and pain and improving specific symptomatology in patients undergoing rehabilitation treatment after hip or knee arthroplasty. Methods: In this monocentric prospective study, fifty consecutive patients, hospitalized for rehabilitation, were administered Linfadren® twice a day for 20 days. Limb circumference, pain and specific symptomatology were assessed at baseline and at the end of the treatment; the specific symptomatology was evaluated by means of the Western Ontario and McMaster Universities Arthritis Index (WOMAC), self-administered. Results: Baseline and final limb circumference showed a statistically significant difference with 60.42 ± 6.77 cm vs. 53.7 ± 6.37 cm; p < 0.0001. Baseline and final pain showed a statistically significant difference with NRS 4.0 ± 1.01 vs. 0.4 ± 0.70-p < 0.0001. Baseline and final specific symptomatology differed in a statistically significant manner with the respective scores 37.1 ± 14.4 vs. 18.1 ± 11.4; p < 0.0001. Correlations between the decrease in limb circumference, pain and specific symptomatology showed statistical significance. Conclusions: The product containing Diosmine, Cumarin and Arbutin demonstrates efficacy in reducing edema and pain and in improving specific symptomatology in patients undergoing rehabilitation treatment after hip or knee arthroplasty. This can translate to patients' better ability to perform intensive physiotherapy protocols, thus enhancing the recovery.

PMID 42589977
Read full article →
PubMedAnnals of surgical treatment and research2026-08-12

A preliminary experimental study of venoactive compounds on human lymphatic endothelial cells: cellular response and therapeutic potential.

Ko Hyunmin H

Lymphedema is a common complication following surgical procedures, particularly in breast cancer patients. However, no effective medical treatment has been clearly established. Venoactive compounds (venoactive drugs, VADs) are frequently used as an alternative option, despite limited supporting evidence. This study aimed to evaluate their potential therapeutic role in lymphedema. Human lymphatic endothelial cells (HLECs) were used to assess the effects of diosmin, calcium dobesilate, and Vitis vinifera extract. Cell viability was evaluated using the MTT assay to determine non-cytotoxic concentrations. Lymphangiogenesis was assessed using Transwell migration and Matrigel-based tube formation assays (Corning). Western blot analysis was performed to examine the activation of protein kinase B (AKT), extracellular signal-regulated kinase (ERK), and p38 mitogen-activated protein kinase (MAPK) signaling pathways. Treatment with VADs showed an overall tendency to suppress cell migration compared to the control. On the other hand, there was no significant difference in the tube formation. Western blot analysis revealed that Vitis vinifera extract significantly inhibited the activation of AKT, ERK, and p38 MAPK pathways. Diosmin increased p38 activation without affecting AKT or ERK, while calcium dobesilate did not induce any significant changes in these signaling pathways. VADs did not directly promote lymphangiogenesis in HLECs. Their therapeutic effects in lymphedema may instead be mediated by microvascular stabilization through anti-inflammatory, antioxidant, and permeability-reducing mechanisms. Further experimental and clinical studies are needed to validate these findings.

PMID 42582538
Read full article →

+772 more articles available with a free account

Sign up free to view all articles →

Ask about diosmin + hesperidine