Drug Database
LA

lamivudine + raltegravir (MK 0518B / Dutrebis / MK0518B)

✓ Approved

Merck & Co. · · Small Molecule

What is lamivudine + raltegravir?

lamivudine + raltegravir is a small molecule developed by Merck & Co.. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesMK 0518B, Dutrebis, MK0518B
CompanyMerck & Co.
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Merck & Co.

Mechanism of Action

Molecular Targets

lamivudine + raltegravir acts on 1 molecular target:

gag-pol, HIV-1 (gag-pol)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

lamivudine + raltegravir is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsAcquired immunodeficiency syndrome✓ Approved

Related Research Articles

PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-10-15

Product-Reshaped Gas-Phase Hydrodynamics Govern CO2 Electrolysis in Gas Diffusion Electrodes.

Alyahya Abdullah A AA, Tovar-Oliva Mayra S MS, Malimusi Blessings G BG, Murcia-López Sebastián S et al.

High-rate CO 2 electrolysis is commonly assessed using current density, single-pass conversion and Faradaic efficiency, but these global metrics do not indicate whether the local reaction environment required for selective multicarbon formation is preserved during scale-up. Using an experimentally validated, flow-direction-resolved continuum model of a Cu-based gas-diffusion-electrode (GDE) flow-cell system, we demonstrate that gas-fed CO 2 electrolysers behave as reacting-flow electrochemical reactors in which electrochemical conversion transforms the gas phase in the cathode compartment and makes it part of the reactor response. As cathode potential becomes more negative, CO 2 consumption, CO formation and consumption, and gaseous product evolution progressively dilute the CO 2 -rich reacting gas phase, altering gas composition, density and velocity and feeding back into reactant delivery and intermediate availability. This reaction-induced hydrodynamic response creates an operating window favoring ethylene formation and reveals a conservation-driven feedback that becomes unavoidable during scale-up: as electrode length, conversion and gaseous product formation increase, extended electrodes must preserve the spatial overlap between CO 2 delivery, CO generation, controlled CO consumption and limited dilution of the reacting gas phase.

PMID 42875864
Read full article →
PubMedChemistry (Weinheim an der Bergstrasse, Germany)2026-10-15

Synthesis, Electrochemical Behavior, and Catalytic Activity of Cobalt Complexes of 5,15-Diazaporphyrin and 5-Monoazaporphyrin Derivatives Bearing Meso-Aryl Groups.

Kaneko Momo M, Wakasa Yui Y, Minoura Mao M, Furukawa Ko K et al.

Cobalt (Co) complexes of porphyrin derivatives possess distinctive redox properties, and hence, their development has attracted significant interest across a wide range of fields. Herein, we report the new examples of the Co complexes of 5,15-diazaporphyrin (DAP) and 5-monoazaporphyrin (MAP) derivatives bearing meso-aryl groups. These Co complexes were prepared by metal-templated cyclization of Co-bis(dipyrrin) complexes, complexation of azaporphyrin freebases with a Co salt, and meso-N-functionalization of the Co complexes of DAP and MAP with diphenyliodonium hexafluorophosphate or methyl triflate. The structures as well as the optical and redox properties of these new Co complexes were elucidated by X-ray crystallography, spectroscopic and voltammetric measurements, and density functional theory calculations. The introduction of a positive charge to the DAP and MAP rings via meso-N-functionalization considerably altered the frontier-orbital energies, resulting in redshifts of the Q bands and anodic shifts of the ligand-centered redox processes. The addition of axial ligands also had notable effects on the metal-centered and ligand-centered redox processes. All the CoII complexes catalyzed the intramolecular radical cyclization and 1,2-H-shift reactions of N-benzyl-N-Boc-3-diazopropane-1-amine in the presence of Cs2CO3 to yield two kinds of products via the corresponding σ-bonded alkyl Co-azaporphyrin intermediates.

PMID 42875956
Read full article →
PubMedNature communications2026-10-15

Early coconut oil exposure suppresses chronic experimental Crohn's disease via myristic acid and enhanced regulatory T cells.

Rodriguez-Palacios Alex A, Raffner Basson Abigail A, Menghini Paola P, Ezeji Jessica J et al.

Public health advisory guidelines caution against the consumption of saturated fats, especially coconut oil (CO), yet CO is widely consumed in regions with low inflammatory bowel disease prevalence (IBD) and is often perceived as beneficial by IBD patients. CO is rich in medium-chain saturated fatty acids, notably lauric acid (C12:0) and myristic acid (C14:0) which are negligible in mammalian tissues without dietary intake. Because IBD is linked to saturated fats consumption, here we tested and unexpectedly found that CO and its saturated fatty acids are beneficial suppressing intestinal inflammation in SAMP1/YitFc mice, a chronic IBD model of Crohn's disease-like ileitis. In young mice, the early exposure to a high-dose CO-based diet prevented ileitis in 63.64% of animals (95%CI = 30.79-to-89.07%). Importantly, comparable protection was observed at lower doses amenable for human translation. Although CO did not reverse established disease in adult mice, when combined with steroids, it prolonged the period of steroid-induced remission illustrating its therapeutic benefits in IBD. Disease prevention was associated with myristic acid and correlated with anti-inflammatory microbiota shifts and enhanced regulatory T-cell responses, without adverse effects. Findings challenge current dietary advisories against CO and support reevaluation of CO and myristic acid as anti-inflammatory dietary adjuvants for the prevention and management of established IBD.

PMID 42875437
Read full article →
PubMedBehavior research methods2026-10-15

Inclusive electroencephalography practices for Black and Muslim participation in a White non-Muslim-majority country: A co-produced tutorial.

Cruse Damian D, Razaie Ilham I, Abbey Nyamesumpa N, Bradbury Natasha N et al.

Most electroencephalography (EEG) research is conducted in White-majority Western countries by White researchers. EEG practices therefore often explicitly and implicitly exclude minoritised groups, leading to low diversity in EEG data samples that deepens biases in interpretation and clinical utility. Because EEG electrodes must contact the scalp, Black people and Muslim women who wear a hijab (or, Hijabis) are two systematically excluded groups. As a group of EEG researchers, Black people, and Hijabis, here we describe co-produced practical approaches to overcoming EEG participation barriers, from recruitment to data collection, and provide co-produced text, photographs, and videos designed to break down these barriers. These approaches provide further tools for the EEG community to tackle systemic exclusion and foster better, more representative neuroscience.

PMID 42875624
Read full article →
PubMedFrontiers in veterinary science2026-10-15

Polystyrene nanoplastics potentiate cadmium-induced pyroptosis and apoptosis in primary duck hepatocytes: differential responses to N-acetylcysteine.

Chen Zhixuan Z, Chen Yan Y, Yu Zhili Z, Xu Qingqing Q et al.

Nanoplastics (NPs) can act as carriers for heavy metals, and co-exposure to NPs and co-pollutants may produce greater toxicity than single exposure. However, the combined toxicity of nanoplastics and heavy metals in poultry liver cells remains poorly understood. Primary duck embryonic hepatocytes (PDEH) were used as an in vitro model. Cells were exposed to polystyrene nanoplastics (PS-NPs, 80 nm, 10 μg/mL) and/or cadmium chloride (CdCl2, 4 μg/mL) for 12 h. Pyroptosis- and apoptosis-associated endpoints were assessed by brightfield microscopy, PI staining, SEM, flow cytometry, qRT-PCR, and Western blotting. The antioxidant N-acetylcysteine (NAC, 5 μg/mL) was used to evaluate the responses of these pathways. Co-exposure to PS-NPs and Cd potentiated cadmium-induced pyroptosis-associated morphological changes, including cell swelling, rounding, membrane blebbing, and surface pore formation. Mechanistically, co-exposure activated the NLRP3/Caspase-1/GSDMD signaling axis, as indicated by increased NLRP3, cleaved Caspase-1 (P20/P10), GSDMD-NT, and intracellular IL-1β maturation. Co-exposure also exacerbated apoptosis-associated changes, including an increased Bax/Bcl-2 ratio and a higher Annexin V-positive cell population. NAC effectively reversed the apoptosis-associated endpoints but did not significantly alter the selected pyroptosis-associated markers under the present in vitro exposure conditions. These findings suggest that PS-NPs potentiate Cd-induced hepatotoxicity in primary duck hepatocytes, with concurrent activation of pyroptosis- and apoptosis-associated signaling. The differential responses to NAC indicate that antioxidant intervention may preferentially attenuate apoptosis-associated injury under the present in vitro exposure conditions, while pyroptosis-associated signaling may require alternative targeted interventions. These results provide new insights into the combined toxicity of nanoplastics and heavy metals in avian hepatocytes.

PMID 42876470
Read full article →
PubMedFrontiers in microbiology2026-10-15

Construction of an infectious clone of tomato leaf curl New Delhi virus and development of a duplex assay through recombinase polymerase amplification-lateral flow dipstick to detect the virus and tomato yellow leaf curl virus simultaneously.

Qiao Ning N, Chen Yuxing Y, Meng Yao Y, Yang Xiao X et al.

The co-infection of tomato yellow leaf curl virus (TYLCV) and tomato leaf curl New Delhi virus (ToLCNDV) in the same host complicates disease diagnosis and management, not to mention that each virus alone can cause devastating losses to its respective host crops across many tomato- and cucurbit-growing areas. However, diagnosis of mixed viral infections in the same host plants can be tedious, costly and challenging. This study aims to establish a rapid, sensitive, and specific duplex recombinase polymerase amplification-lateral flow dipstick (RPA-LFD) assay to simultaneously detect TYLCV and/or ToLCNDV in co-infected samples. We constructed an infectious clone from a ToLCNDV strain of the Asian clade isolated from a diseased cucumber plant in China, and confirmed that it could co-infect Nicotiana benthamiana together with an infectious clone of the TYLCV-IL strain, providing the defined viral inoculum for method development and validation. An optimal duplex RPA-LFD assay was developed by screening specific RPA primers and probes targeting conserved sequences of both viruses and optimizing reaction parameters, which produced interpretable results directly on a test strip after 20 min at 39 °C. With the purified plasmid DNA, the analytical limits of detection of the duplex RPA-LFD for TYLCV and ToLCNDV were 102 and 101 copies/μL, respectively. No cross-reactions were detected against three other begomoviruses. Further validation using total DNA from co-inoculated N. benthamiana and field-collected samples showed high consistency with conventional PCR, and the assay effectively distinguished single-virus from mixed infections. This duplex RPA-LFD assay provides a reliable diagnostic for detecting and surveying co-infections caused by TYLCV and ToLCNDV.

PMID 42876742
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about lamivudine + raltegravir