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disopyramide

✓ Approved

Ethypharm Corp. · SCN5A · Small Molecule

What is disopyramide?

disopyramide is a small molecule developed by Ethypharm Corp.. It is approved for therapeutic indications via unknown.

Drug Profile

CompanyEthypharm Corp.
Drug ClassSmall Molecule
Molecular TargetSCN5A
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Ethypharm Corp.

Mechanism of Action

Molecular Targets

disopyramide acts on 1 molecular target:

SCN5Asodium voltage-gated channel alpha subunit 5 (CMD1E, SSS1)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

disopyramide is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Cardiac disordersArrhythmia✓ Approved

Related Research Articles

PubMedEuropean archives of psychiatry and clinical neuroscience2026-08-30

Untargeted plasma metabolomics identifies metabolite signatures associated with suicidality status in chronic schizophrenia.

Wang Lijun L, Lu Chenghao C, Sun Xiaochun X, Sun Wenjie W et al.

Suicide contributes substantially to mortality in schizophrenia, yet metabolic signatures associated with suicidality remain poorly understood. We applied untargeted plasma metabolomics with multivariate modeling to identify plasma metabolic signatures associated with suicidality status and clinical features. We enrolled 146 frequency-matched psychiatric inpatients with chronic schizophrenia: 73 in the suicide-risk (SR) group, defined by current suicidal ideation or suicidal behavior/attempt history at admission, and 73 in the non-suicide-risk (NSR) group. Plasma samples underwent untargeted metabolomic profiling. Discriminating metabolites were identified using orthogonal partial least squares discriminant analysis (OPLS-DA) and Benjamini-Hochberg-adjusted Mann-Whitney U testing (variable importance in projection [VIP] >1.0 and adjusted p <0.05). Stepwise logistic regression with forced clinical covariates generated an exploratory metabolite-based classification model, and Spearman correlations examined associations with Positive and Negative Syndrome Scale (PANSS) and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) scores. OPLS-DA identified 70 discriminating metabolites (R2Y = 0.938, Q2Y = 0.650), with nominal enrichment of lysine degradation, glutathione metabolism, phenylalanine/tyrosine/tryptophan biosynthesis, and sphingolipid metabolism. Stepwise regression retained six metabolites associated with SR status (area under the curve [AUC] = 0.774): Sphingosine, 3-OH-TML, Ile-Leu+Leu-Ile, TML, Taurine, and 12-HETE. Gamma-Glu-Thr showed the highest VIP (5.003) and broad clinical correlations. Plasma metabolic differences involving sphingolipid, lysine/carnitine, neuroinflammatory, amino-acid, and glutathione-related pathways were associated with suicidality status in chronic schizophrenia. These exploratory cross-sectional findings require validation in larger longitudinal cohorts using dedicated suicidality assessments.

PMID 42669098
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PubMedClinical & experimental optometry2026-08-30

Clinical validation of a multifunction ocular biometer in children.

Lin Rui R, Li Yong Y, Yang Yong Y, Qian Chaoxu C

Reliable ocular biometry and refraction measurements are essential for monitoring paediatric myopia in routine practice and school screening. Integrated instruments may improve clinical workflow, but measurement differences between devices can influence longitudinal interpretation. Accurate assessment of biometric and refractive parameters is essential for paediatric myopia management. The aim was to evaluate the agreement and repeatability of a multifunctional ocular biometer, the SW-9000ARK, compared with established instruments for ocular biometry and refraction. This prospective cross-sectional study included 361 children (mean age 10.7 ± 2.5 years; 49.0% girls). All subjects underwent non-cycloplegic measurements with the SW-9000ARK, IOLMaster 700, and Topcon KR-800 in random order, followed by subjective refraction (SR). Agreement was assessed using Bland-Altman analysis. Repeatability in 211 right eyes was assessed using within-subject standard deviation, test-retest repeatability, coefficient of variation and intraclass correlation coefficient (ICC). The SW-9000ARK showed excellent agreement with the IOLMaster 700 for axial length (mean difference -0.01 mm; 95% LoA -0.08 to +0.05 mm), central corneal thickness (+5.19 µm; 95% LoA -9.57 to +19.96 µm), anterior chamber depth (-0.03 mm; 95% LoA -0.11 to +0.05 mm), lens thickness, and keratometry, with ICC values ≥ 0.96. Spherical equivalent exhibited strong agreement with the Topcon KR-800 (+0.08D; 95% LoA -0.65 to +0.81D) and SR (+0.35D; 95% LoA -0.43 to +1.13D). Repeatability was high across all parameters (Sw = 0.018 mm for AL; ICC ≥0.94). The SW-9000ARK provides highly agreeable and repeatable measurements of ocular biometry and non-cycloplegic refraction in paediatric ametropia, supporting its use as a reliable single-platform tool for myopia management and large-scale screening.

PMID 42669424
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PubMedInternational journal of biological macromolecules2026-08-30

Targeted delivery of antimicrobial peptide LL-37 via ferritin fusion improves antibacterial and anti-inflammatory outcomes in a murine sepsis model.

Pan Wangyao W, Tian Changhao C, Ding Yang Y, Pei Zejun Z et al.

The antimicrobial peptide LL-37 holds considerable therapeutic potential for treating infection and inflammation; however, its clinical application is often limited by poor stability, susceptibility to proteolytic degradation, and insufficient targeting capability. In this study, we engineered a targeted fusion protein (designated as FL) based on ferritin light chain (FTL) by genetically fusing the LL-37 peptide to the C-terminus of FTL, thereby markedly enhancing the structural stability and proteolytic resistance of LL-37. This design further exploits the specific recognition of FTL by scavenger receptor A (SR-A), which is highly expressed on the macrophage surface, to achieve targeted delivery to inflammatory lesions. Both in vitro and in vivo experiments demonstrated that FL not only retained the antimicrobial activity of LL-37, but also exhibited certain anti-inflammatory capacity. In a murine sepsis model, FL exerted superior antibacterial and anti-inflammatory efficacy compared with free LL-37, and partially alleviated structural and functional damage in multiple organs. Moreover, safety evaluations confirmed that FL showed no significant hemolytic activity, immunogenicity or tissue toxicity, indicating good biocompatibility. This study presents a novel protein formulation that integrates enhanced stability, inflammation-targeting capability, and multiple biological activities, thereby providing a promising translational candidate strategy for the precise treatment of infection- and inflammation-related diseases.

PMID 42669340
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PubMedNeurosurgery practice2026-08-29

Outcomes of Laser Interstitial Thermal Therapy-Augmented Surgery in the Management of Subcortical Glioblastoma.

Chen Hsien-Chung HC, Yekula Anudeep A, Weimar Marcus W MW, Wong Eric T ET et al.

Subcortical glioblastomas present surgical challenges owing to their proximity to critical anatomy. In this study, we assessed the utility of laser interstitial thermal therapy (LITT) in the management of subcortical glioblastomas. Clinical outcomes were evaluated in 80 consecutive patients with subcortical glioblastoma (isocitrate dehydrogenase wild-type, H3K27 nonmutant) treated surgically between 2017 and 2025. During this time period, LITT was increasingly incorporated into stereotactic needle biopsy (SNB) and surgical resection (SR) workflows, enabling comparisons between SNB vs SNB + LITT and between SR only vs planned subtotal resection (STR) + LITT. Among 46 treatments involving SNB, 24 underwent SNB only and 22 SNB + LITT. Lesion size was similar between these groups (1.72 ± 0.38 vs 1.92 ± 0.36 cm, P = .07), with comparable procedural morbidity (4.2% vs 4.5%, P = 1.0). In newly diagnosed glioblastoma, SNB + LITT was associated with improved overall survival compared with SNB alone (median 375 vs 162 days, P = .0012). Thirty-four patients underwent resections (18 SR, 16 STR + LITT). Lesion size was comparable between these cohorts (3.77 ± 0.68 vs 3.74 ± 0.83 cm, P = .9) as was the extent of cytoreduction (77.8% vs 93.8%, P = .34), but STR + LITT was associated with fewer permanent postoperative deficits (0% vs 27.8%, P = .047). Survival did not differ between STR + LITT and SR (median 368 vs 289 days, P = .43). Across all patients, postoperative motor deficits were associated with worse survival (112 vs 254 days, P < .001). Our results support incorporating LITT as a staged procedure into planned STR or in conjunction with SNB in the management of subcortical glioblastoma. Postoperative motor deficit is associated with poor survival outcomes.

PMID 42667011
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PubMedJournal of experimental botany2026-08-29

Deep seeding resistance in maize: selected after domestication or a strategy of its wild ancestors to escape underground animal burrowing?

Vázquez Leopoldo L, Cruz Alberto A, Alonso-Hernández Raymundo R, Sanjuan Francisco F et al.

Buried seeds avoid predation ensuring their survival until conditions are suitable for germination. The ability of seedlings to emerge from the soil depends on soil characteristics, burial depth, and the skotomorphogenic program of each species. This process is of interest to agriculture, as deep planting is practiced in wheat, sorghum, oats, and maize crops in certain arid and semi-arid regions of the world. In maize, deep planting can range from 10 to 40 cm, and only certain landraces are competent for this practice. It is known that deep-planting resistant varieties exhibit exaggerated mesocotyl elongation, but it is unclear whether resistance to deep planting has selected positively or negatively the growth capacity and/or development of other seedling organs and whether deep-planting resistance is an ancestral trait in Zea or evolved after maize domestication. To determine the skotomorphogenic patterns in the subtribe Tripsacinae, deep planting trials were conducted with representatives belonging to the genera Zea and Tripsacum and the length or number of seedling organs measured. The majority of maize seedlings grown in darkness exhibited features that we refer to as quasi-photomorphogenic (i.e., rupture of the coleoptile tip by the first plumular leaf and development of adventitious roots at the coleoptilar node [ARCN]), unlike teosintes that displayed a small proportion of individuals with the quasi-photomorphogenic phenotype or species of Tripsacum that maintained a strict skotomorphogenic phenotype prior to emergence. Moreover, ARCN were absent in Tripsacum and rare in teosintes, while seminal roots were uncommon in both Tripsacum and teosintes. In Tripsacinae, relative deep sowing depth (RDSD) for seedling emergence correlated positively with mesocotyl and stem lengths. Moreover, RDSD correlated negatively with the number of ARCN and SR and the length of the primary root and, to a lesser extent, of the coleoptile. In maize, SR development primordia ensued both embryonically and post-embryonically. These findings indicate that emergence from deeper soil depths has influenced the growth and development of all seedling organs, not just the mesocotyl, and that deep planting resistance is a characteristic that appeared within the Zea genus prior to maize domestication. Further, we report that Tripsacum caryopses are dispersed by myrmecochory and teosinte caryopses by seed-caching rodents. The ecological significance of skotomorphogenic development programs that aid in the escaping of wild Tripsacinae seedlings, from underground caches made by their animal dispersers, is discussed.

PMID 42667687
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PubMedJournal of medicinal food2026-08-28

Attenuation of Fasting and Postprandial Glucose Exposure by Standardized Salacia reticulata Extract in Adults with Prediabetes: A Randomized, Double-Blind, Placebo-Controlled Trial.

Baek Hyang-Im HI, Gwon Yuri Y, Park Soo Jung SJ

Clinical evidence for Salacia reticulata extract (SR) in prediabetes remains limited, particularly with respect to its effects on comprehensive glucose exposure across multiple oral glucose tolerance test (OGTT)-derived intervals. This randomized, double-blind, placebo-controlled trial evaluated the effects of a standardized SR administered for 12 weeks on fasting and postprandial glucose exposure in adults with prediabetes. One hundred participants meeting prediabetes criteria (fasting plasma glucose [FPG] 100-139 mg/dL and postprandial plasma glucose [PPG] 140-199 mg/dL) were selected. Participants with dual fasting and postprandial glycemic impairments were randomly assigned to receive SR (500 mg/day, n = 50) or placebo (n = 50). Efficacy and safety outcomes were assessed at baseline and after the intervention. Compared with placebo, SR significantly reduced FPG and PPG to 90 and 120 min after supplementation (all P < .05). Glucose areas under the curve at 0-30, 0-60, 0-90, and 0-120 min were significantly lower in the SR group compared with placebo, with significant percent reductions in postprandial glucose spikes from baseline to week 12 (all P < .05). Additionally, HbA1c and triglycerides were significantly reduced, while 1,5-anhydroglucitol was significantly increased compared with placebo. Total glucagon-like peptide-1 (GLP-1) levels showed a significant between-group difference. No clinically meaningful safety concerns were observed. Twelve weeks of supplementation with standardized SR attenuated fasting and postprandial glucose concentrations, including significant reductions in OGTT-derived glucose spikes. These findings extend clinical evidence of S. reticulata to early-stage dysglycemia and support its potential role in glycemic stabilization in prediabetes.

PMID 42663504
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