Drug Database
AD

AD-220 (AD 220A / AD 220 / AD220)

✓ Approved

Addpharma · Small Molecule · Small Molecule

What is AD-220?

AD-220 is a small molecule developed by Addpharma. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesAD 220A, AD 220, AD220
CompanyAddpharma
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Addpharma

Therapeutic Indications

AD-220 is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Metabolism and nutrition disordersHyperlipidaemia✓ Approved
Metabolism and nutrition disordersHypercholesterolaemiaPreclinical

Related Research Articles

PubMedJournal of Alzheimer's disease reports2026-10-15

Genetic instrumental variable analysis reveals multivariate dietary patterns beneficial to patients with Alzheimer's disease.

Xu Hong H, Nie Yutong Y, Li Siying S, Ye Junman J et al.

Dietary patterns (DPs) are important in the modulation of the pathogenesis of Alzheimer's disease (AD) and progression of neurodegeneration. However, literature reports are inconsistent in studies examining how DPs benefit AD patients. To assess potential causal links between diets and AD risk occurrence. Based on comprehensive genome-wide association studies data, potential links between diets and AD risk were assessed by conventional and advanced Mendelian randomization and sensitivity analyses using single nucleotide polymorphisms as genetic instruments. Protein (95% CI: -0.280 to -0.250), fat (95% CI: -0.091 to -0.042), and carbohydrates (95% CI: -0.048 to -0.021) displayed protective roles in AD. The role of sugar, one component of carbohydrates, was ambiguous in development of AD. 24 DPs derived from daily diet habits were negative in the association with AD and 24 DPs of daily diet habits positively associated with AD. Many single diet factors such as beer, decaffeinated coffee, non-oily fish, lamb/mutton, and biscuit cereal were found to display harmful or protective roles in AD development and progress. However, their roles were varied in DPs of individual diet habits and showed significant positive or negative loadings to AD risks dependent on DPs, not dependent on single diet factors themselves. Significantly detrimental or protective loadings to AD risks are dependent on DPs of individuals, not dependent on the single diet factor itself. Data here suggests that, for principles, daily DPs should balance protein, fat, including saturated fatty acids and unsaturated fatty acids, and carbohydrates to prevent AD development and progress.

PMID 42876848
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PubMedJournal of digestive diseases2026-10-15

Single Jaundice in Cirrhosis: A Neglected Acute Decompensation of Acute-on-Chronic Liver Failure and Mortality.

Zhang Xin X, Wang Xian Bo XB, Zheng Xin X, Tan Wen Ting WT et al.

To compare the risk of acute-on-chronic liver failure (ACLF) and short-term outcomes among cirrhotic patients with single jaundice, acute decompensation (AD) (including ascites, variceal bleeding, hepatic encephalopathy, and/or bacterial infection), and non-AD non-jaundice. We analyzed cirrhotic inpatients without obstructive jaundice enrolled from two large multicenter prospective cohorts. Patients were divided at admission into classical AD, single jaundice, or non-AD non-jaundice groups. Baseline characteristics, ACLF development, and short-term outcomes were compared between groups. Among 2645 cirrhotic patients, classical AD, single jaundice, and non-AD non-jaundice were observed in 2163 (81.78%), 267 (10.09%), and 215 (8.13%), respectively. The 90-day liver transplant (LT)-free mortality was comparable between single jaundice patients and classical AD patients (15.09% vs. 17.81%, p = 0.266), but significantly higher than non-AD non-jaundice patients (2.45%; p < 0.01). The prevalence of ACLF (16.10% vs. 16.09%, p = 1.000) and pre-ACLF (9.36% vs. 6.43%, p = 0.094) were comparable between the single jaundice and classical AD groups. Intrahepatic precipitants, particularly hepatitis B flare with hepatitis B virus (HBV) reactivation (odds ratio [OR] 2.69; p = 0.002), spontaneous hepatitis B flare with high HBV-DNA load (OR 23.75; p < 0.001), superimposed hepatitis A/E virus infection on HBV infection (OR 13.40; p < 0.001) and hepatotoxic drug usage (OR 3.64; p < 0.001) were associated with single jaundice. Cirrhotic inpatients with single jaundice show comparably high short-term mortality and ACLF risk to those with classical AD. Single jaundice shall be considered as an AD event and is predominantly triggered by intrahepatic insults, warranting surveillance equivalent to classical AD and prioritized management of the precipitants.

PMID 42876334
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PubMedSpinal cord series and cases2026-10-15

Surgery to treat autonomic dysreflexia due to cubital tunnel syndrome in cervical spinal cord injury: a case report.

He Kevin K, Chin Brian B, Orr Jonah P JP, Rohrer Lucas L et al.

Autonomic dysreflexia (AD) is a potentially fatal syndrome in people with spinal cord injury (SCI) marked by episodic hypertension with flushing, diaphoresis, and bradycardia. Common etiologies include bladder distension and bowel impaction. Compressive neuropathies lack attention as a potential precipitant of AD. This report describes an individual with cervical SCI and with recurrent AD treated with ulnar nerve decompression surgery. A 74-year-old woman with a remote history of C6 SCI (American Spinal Injury Association Impairment Scale Grade B) presented to clinic with recurrent episodes of AD that had been refractory to standard treatment measures. History and clinical examination were suggestive of ulnar nerve compressive neuropathy at the elbow - cubital tunnel syndrome. The diagnosis was confirmed with electrodiagnostic studies and neuromuscular ultrasound. Treatment with surgery successfully resolved her episodes of AD. This case identifies compressive neuropathy as a treatable cause of AD in individuals with cervical SCI. When more common etiologies of AD are excluded, clinicians should consider compressive peripheral neuropathies as potential causes of AD. Surgical decompression may alleviate symptoms of AD in select cases. Further research should investigate the prevalence and optimal management of compressive neuropathy in people with SCI.

PMID 42875417
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PubMedJournal of Alzheimer's disease reports2026-10-15

Smaller pineal volume in Alzheimer's disease than in dementia with Lewy bodies.

Matsuoka Teruyuki T, Kobayashi Ryota R, Imai Ayu A, Sakamoto Kazutaka K et al.

Pineal gland volume reduction in Alzheimer's disease (AD) has been reported. Recent findings also indicate an association between pineal volume reduction and dementia with Lewy bodies (DLB). This study aimed to compare pineal volume between two major neurodegenerative disorders: AD and DLB. This cross-sectional analysis included patients with AD or DLB who underwent brain magnetic resonance imaging (MRI) and Mini-Mental State Examination (MMSE). AD was diagnosed based on the National Institute on Aging-Alzheimer's Association criteria and confirmed by positive amyloid positron emission tomography. DLB was diagnosed per McKeith et al.'s clinical criteria and confirmed by dopamine transporter single-photon emission computed tomography or 123I-metaiodobenzylguanidine myocardial scintigraphy. Pineal parenchymal volume (PPV) was manually measured using MRI data. The Mann-Whitney U test was used for group comparisons, and analysis of covariance (ANCOVA) was performed with logarithmic transformation since PPV was not normally distributed. Covariates included total intracranial volume, age, sex, MMSE score, use of antidementia drugs, use of psychotropic medications, and MRI magnetic field strength. Seventy-five patients (AD, 41; DLB, 34; 35 women) were analyzed. PPV was significantly smaller in the AD group than in the DLB group (74.7 ± 18.8 versus 96.0 ± 31.6 mm3, U = 1024, p < 0.001). ANCOVA confirmed a significant diagnostic effect (F = 11.9, p < 0.001). Pineal volume was smaller in AD than in DLB; this difference may reflect the neuropathological characteristics specific to AD.

PMID 42876878
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PubMedJournal of Alzheimer's disease reports2026-10-15

The characteristic patterns of dynamic network reconfiguration underlying subjective cognitive decline.

Ke Zhihong Z, Yang Dan D, Zhou Zhixin Z, Gao Wenqian W et al.

Although dynamic network reconfiguration is altered in Alzheimer's disease (AD), its pattern in subjective cognitive decline (SCD), an early preclinical stage, remains unclear. This study aims to identify the characteristics of dynamic network reconfiguration in SCD individuals compared to healthy controls (HCs) and AD patients. Time-varying multilayer network models were built for AD (n = 111), SCD (n = 115), and HC (n = 111) groups using the GenLouvain algorithm. We compared dynamic reconfiguration features across groups and examined how abnormal reconfiguration affects the relationship between amyloid-β (Aβ) pathology and cognition. SCD individuals showed higher global recruitment and lower global integration than AD patients, and lower integration than HCs. At the nodal level, SCD was marked by increased recruitment and reduced integration in regions mainly within the default mode network (DMN) and somatomotor network (SMN). In SCD, recruitment in the left anterior insula and ventral frontal cortex linked Aβ pathology to memory performance. In AD, integration in the left superior frontal gyrus mediated the effects of Aβ on memory and verbal fluency. The combination of differences in nodal recruitment and integration across groups helped distinguish between healthy, SCD, and AD individuals. SCD individuals show distinct patterns of dynamic network reconfiguration, high recruitment, and low integration in DMN and SMN, offering new insights into early AD pathophysiology.

PMID 42876884
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PubMedFrontiers in medicine2026-10-15

Case Report: Clinical manifestations of retinal detachment in patients with atopic dermatitis: two cases and potential immunopathogenic mechanism.

Zhang Conghui C, Liao Xin X, Cui Hongping H, Jin Haiying H

Retinal detachment (RD) represents a sight-threatening ocular sequela among individuals affected by atopic dermatitis (AD). Chronic habitual eye rubbing may impair the structural stability of the ocular tissues. Here, we report two patients with AD-associated RD, emphasizing both surgical characteristics and potential immune-mediated mechanisms. Two cases of AD-associated RD were included. For each one, the clinical picture, intraoperative findings, and potential immune pathway hypotheses were taken into account. Our first patient was a 15-year-old boy with a history of toric intraocular lens implantation who initially presented with elevated intraocular pressure and vitreous hemorrhage, later developing RD characterized by retinal dialysis, retinal tear, and ciliary epithelium detachment. Patient two was a man of 43, in whom RD coexisted with posterior subcapsular cataract as well as astigmatism. Severe systemic AD was present in both, and both had a long history of rubbing their eyes. Each underwent vitrectomy with internal tamponade. In one of them, recurrence ensued because of proliferative vitreoretinopathy. This series illustrates the typical features and surgical challenges of RD in AD, which arise from chronic eye rubbing-induced mechanical damage and astigmatism. Timely ophthalmic evaluation and systemic AD control aid visual preservation. Our findings propose a preliminary hypothesis of interactive immune and mechanical mechanisms underlying AD-associated RD, which warrants further experimental validation.

PMID 42876813
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