Drug Database
SI

sitagliptin phosphate + ipragliflozin L-proline (Sujanu / MK0431J)

✓ Approved

Kotobuki Pharmaceutical Co., Ltd. · DPP4 · Small Molecule

What is sitagliptin phosphate + ipragliflozin L-proline?

sitagliptin phosphate + ipragliflozin L-proline is a small molecule developed by Kotobuki Pharmaceutical Co., Ltd.. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesSujanu, MK0431J
CompanyKotobuki Pharmaceutical Co., Ltd.
Drug ClassSmall Molecule
Molecular TargetDPP4, SLC5A2
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Kotobuki Pharmaceutical Co., Ltd.

Mechanism of Action

Molecular Targets

sitagliptin phosphate + ipragliflozin L-proline acts on 2 molecular targets:

DPP4dipeptidyl peptidase 4 (CD26, DPPIV)
SLC5A2solute carrier family 5 member 2 (SGLT2)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

sitagliptin phosphate + ipragliflozin L-proline is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Metabolism and nutrition disordersType 2 diabetes mellitus✓ Approved

Related Research Articles

PubMedKidney medicine2026-08-30

Calcium Crystal Deposits in Kidney Allografts: The Interplay of PTH Levels and Phosphaturia.

Barbuto Simona S, Vischini Gisella G, Magagnoli Lorenza L, Provenzano Michele M et al.

Hyperparathyroidism is common in kidney transplant recipients and may contribute to graft injury through calcium crystal deposition. We investigated the association between pretransplant parathyroid hormone (PTH) levels and calcium crystal deposits (CCDs) and whether fractional excretion of phosphate (FePi) mediates this relationship. Retrospective single-center observational study. Forty-one kidney transplant recipients undergoing protocol biopsies at 3 and 12 months posttransplantation. Pretransplant PTH levels. Presence of calcium crystal deposits in graft biopsies. Logistic regression models and mediation analysis were used to evaluate associations between PTH levels, FePi, and CCDs. CCDs were detected in 33% of biopsies at 3 months and 45% at 12 months. Higher pretransplant PTH levels were associated with increased odds of CCDs. Mediation analysis showed that approximately 72% of this effect was explained using FePi levels. At 24 months posttransplantation, no meaningful difference in estimated glomerular filtration rate was observed between patients with and without CCDs. Retrospective design, small sample size, absence of fibroblast growth factor 23 level measurements, and limited adjustment for potential confounders. Elevated pretransplant PTH levels are associated with calcium crystal deposition in kidney allografts, largely mediated by phosphate wasting. However, no clear impact on graft function was observed within the first 2 years posttransplantation.

PMID 42668546
Read full article →
PubMedThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale2026-08-30

Tackling Drug Resistance and Virulence in Proteus mirabilis Infections: Evaluating Rosemary Extract as a Complementary Therapeutic Agent.

Mirzaei Arezoo A, Wagemans Jeroen J, Moghim Sharareh S

The rising antimicrobial resistance in Proteus mirabilis, a primary contributor to catheter-associated urinary tract infections, underscores the urgent need to explore alternative therapeutic approaches. In this study, we evaluated the antibacterial and antivirulence potential of Rosmarinus officinalis L. extract (ROE) against P. mirabilis and concurrently assessed clinical isolates for the presence of key resistance and virulence genes. Forty multi-drug-resistant (MDR) P. mirabilis isolates were analyzed using multiplex PCR to detect carbapenemase genes (b l a NDM, b l a OXA family, b l a SIM-1, b l a VIM-1) and uniplex PCR to identify virulence determinants (mrpA, pmfA, rsbA, rsmA, luxS). ROE was extracted and analyzed using high-performance liquid chromatography (HPLC). The antibacterial, antibiofilm, and antiswarming effects of the extract were assessed. All isolates carried all five virulence genes. Carbapenemase gene profiling revealed b l a VIM-1in 20% of isolates, while b l a OXA-23, b l a OXA-24, and b l a OXA-58 were detected in 10%, 2.5%, and 2.5% of isolates, respectively. Neither b l a SIM-1 nor b l a NDM was identified. HPLC analysis of ROE identified rosmarinic acid as the predominant compound. Although the agar well diffusion assay indicated no bactericidal activity, the broth microdilution method determined a minimum inhibitory concentration (MIC) of 8 mg/mL for both reference and MDR strains. At sub-MIC levels, ROE significantly inhibited swarming motility (up to 86% at 250 μg/mL) and biofilm formation (up to 78% in the reference strain and 76% in MDR isolates at 15.6 μg/mL) in a dose-dependent manner. Notably, biofilm eradication activity was observed only against preformed biofilms of the reference strain, achieving up to 53% reduction. MTT cytotoxicity assays confirmed that ROE in low concentrations (1000-15.6 μg/mL) was nontoxic to Vero cells. These results highlight the concerning prevalence of carbapenemase genes among clinical P. mirabilis isolates and identify ROE as a promising, nontoxic candidate for targeting motility and biofilm formation. These findings suggest ROE may offer a viable strategy for managing drug-resistant P. mirabilis infections.

PMID 42668901
Read full article →
PubMedPlant science : an international journal of experimental plant biology2026-08-30

Brassinosteroid regulates thermotolerance through affecting the antioxidant capacity and the auxin pathway under heat stress in Brassica rapa ssp. pekinensis.

Huang Yunshuai Y, Zheng Meina M, Wang Yanbing Y, Xu Li L et al.

Heat stress threatens the yield and quality of plants. Brassinosteroid (BR) is widely used in agricultural production and plays important roles in regulating plant growth and stress response, but it is rarely reported on its function in thermotolerance in Chinese cabbage. In this study, we found that BR improves thermotolerance by alleviating the inhibition of leaf growth, and the BR biosynthesis inhibitor brassinazole (BRZ) treatment significantly reduced thermotolerance and plant growth in Chinese cabbage. Under heat stress, the accumulation of malondialdehyde and H2O2 was inhibited, and antioxidant-related enzyme activities and the contents of soluble protein and free proline were increased under BR treatment. Multiple transcriptome assays showed that BR may affect the expression levels of some BrSAUR genes in the auxin pathway, and ABA biosynthesis and metabolism genes to improve heat tolerance. Dual-luciferase reporter assay and VIGS assay showed that BrBZR1 can activate BrSAUR9 expression and the BrSAUR9-silenced plants inhibit plant growth. Furthermore, BR alleviated photosynthetic system damage and increased the fresh weight under heat stress. Our results provide new insights about the function of BR in conferring thermotolerance and biomass increase under heat stress in Chinese cabbage.

PMID 42669332
Read full article →
PubMedRevista espanola de medicina nuclear e imagen molecular2026-08-30

Duration of levothyroxine discontinuation and pre-radioiodine TSH levels in thyroid cancer.

Mintegui G G, Martínez Z Z, Basantes M M, Ferrando R R

Radioiodine treatment in differentiated thyroid carcinoma requires elevated TSH levels to optimize the uptake of [131I]NaI. Levothyroxine suspension is the usual strategy for inducing endogenous TSH elevation, although the optimal duration of this suspension remains controversial. To evaluate the effect of the duration of levothyroxine suspension on TSH levels achieved prior to radioiodine treatment. Retrospective cohort study that included 104 patients with differentiated thyroid carcinoma treated at a reference university center. Patients were classified according to the time of discontinuation of levothyroxine prior to radioiodine treatment: three weeks (group A, n = 21) and four weeks (group B, n = 83). TSH levels between groups and their distribution by categories (<30, 30-49, 50-69, 70-99 y ≥100 mIU/L) were analyzed. The proportion of patients who reached the recommended TSH threshold (≥30 mIU/L) was also evaluated. The mean age (SD) was 46.7 (10.3) years and 87 patients were women. The mean TSH was 70.9 mIU/L (95% CI: 54.5-87.2) in group A and 88.7 mIU/L (95% CI: 84.8-92.6) in group B. The proportion of patients who achieved TSH ≥ 30 mIU/L was significantly higher in group B (100% vs 76.2%; p < 0.001). The distribution of TSH levels by category differed significantly between both groups (p < 0.001). On the other hand, the proportion of patients with TSH ≥ 100 mIU/L did not show significant differences (60.2% vs 47.6%; p = 0.42). In multivariate analysis adjusted for age, sex, and radioiodine dose, levothyroxine discontinuation time was not independently associated with the likelihood of TSH ≥ 100 mIU/L. Three weeks of levothyroxine suspension allowed TSH levels ≥30 mIU/L to be reached in most patients, although a proportion did not reach the recommended threshold. Four weeks were associated with adequate TSH elevation in all patients in this cohort. TSH monitoring during preparation could allow for more individualized strategies that optimize thyroid stimulation, minimizing unnecessary exposure to hypothyroidism.

PMID 42669345
Read full article →
PubMedPhysical chemistry chemical physics : PCCP2026-08-30

Elucidating the electronic origins of a halide-dependent inversion of magnetic anisotropy in tetravalent uranium amidinate complexes.

Näder Adrian A, Hong Boseok B, Fichter Sebastian S, Patzschke Michael M et al.

Recent synthesis and characterization of tetravalent U and Np complexes [AnIVX((S)-PEBA)3] and [AnIVX(iPr2BA)3] (X = F, Cl) bearing the (S,S)-N,N'-bis(1-phenylethyl)benzamidinate ((S)-PEBA) and the N,N'-bis(isopropyl)benzamidinate (iPr2BA) ligands, respectively, have revealed a characteristic inversion of paramagnetic 1H NMR shifts for both [UF(L)3] representatives compared to the [UCl(L)3] compounds. The same effect is not observed for [NpF(L)3] and [NpCl(L)3], with currently no satisfactory explanation for these observations. Using straightforward CASSCF-SOC-NEVPT2 calculations and point-group-optimized geometries, in combination with the Kuprov model approach [G. T. P. Charnock and I. Kuprov, Phys. Chem. Chem. Phys., 2014, 16] for the calculation of pseudo-contact shifts (PCS), the experimentally derived 1H paramagnetic shifts could be reproduced qualitatively and in most cases also quantitatively. The good agreement for most signals allowed for a first evaluation of the contribution of Fermi-contact shifts (FCS) for more strongly deviating data points, which could be supported by unrestricted DFT spin densities and spin populations. To finally gain a deeper understanding as to where the differing magnetic anisotropy for the [UF(L)3] compounds stems from, the magnetic sublevels of the ground atomic multiplet |J,mJ〉 were investigated for all complexes. These revealed that only for the [UF(L)3] compounds a high |mJ〉 (pseudo) doublet showing sufficient isolation is stabilized in the ground state, whose high axiality in the end enables the realization of a prolate χ tensor responsible for the inverse PCS field.

PMID 42669213
Read full article →
PubMedPediatric research2026-08-30

Serum and urinary D-lactate in pediatric intestinal failure: clinical associations and reference values.

Halašová Rita R, Ibrahim Rana R, Balogová Stanislava S, Štichhauer Radek R et al.

D-lactate, produced by intestinal microbiota or derived from the methylglyoxal pathway and diet, is converted by D-lactate dehydrogenase (LDHD) to pyruvate, with several known pathogenic variants of the gene. This study compared serum and urinary D-lactate concentrations across five patient groups and established reference values in healthy children. In this cross-sectional study, 341 serum and urine samples from 129 pediatric patients were analyzed. The cohort comprised patients receiving home parenteral nutrition (PN, n = 19), after bowel adaptation (ADAPT, n = 28), with gastrostomy feeding (PEG, n = 13), other gastrointestinal disorders (GI, n = 14), and healthy controls (HC, n = 55). D-lactate was measured via enzymatic spectrophotometric assay. A genetic sub-analysis assessed pathogenic LDHD variants. Median serum and urinary D-lactate concentrations in healthy controls were 28.5 μmol/L (IQR 25-34.25) and 400 μmol/L (IQR 193-722), respectively. Both serum (p < 0.001) and urine (p = 0.011) D-lactate concentrations were higher in the ADAPT group compared to healthy controls. No pathogenic LDHD variants were identified. Children after bowel adaptation have higher serum and urine D-lactate concentrations compared to healthy controls. Reference values for serum and urinary D-lactate were defined. This is the first study to provide reference values for serum and urinary D-lactate concentrations in healthy children (serum: 28.5 µmol/L (IQR: 25-34.25 µmol/L); urine: 400 µmol/L (IQR: 193-722 µmol/L)). Children after bowel adaptation exhibited higher D-lactate concentrations in both serum and urine compared to healthy controls. Higher serum and urinary D-lactate levels were associated with the presence of an intestinal anastomosis.

PMID 42668282
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about sitagliptin phosphate + ipragliflozin L-proline