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calcium carbonate + vitamin D3 (Ideos)

✓ Approved

Innothera · VDR · Small Molecule

What is calcium carbonate + vitamin D3?

calcium carbonate + vitamin D3 is a small molecule developed by Innothera. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesIdeos
CompanyInnothera
Drug ClassSmall Molecule
Molecular TargetVDR
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Innothera

Mechanism of Action

Molecular Targets

calcium carbonate + vitamin D3 acts on 1 molecular target:

VDRvitamin D receptor (NR1I1, PPP1R163)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

calcium carbonate + vitamin D3 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Musculoskeletal and connective tissue disordersOsteoporosis✓ Approved

Related Research Articles

PubMedFrontiers in medicine2026-10-15

Hypercalcemia and acute kidney injury caused by occupational inhalation of vitamin D3: a case report.

Zhu Shan S, Chen Luping L, Ying Jun J, Ye Hongying H et al.

Vitamin D intoxication is a rare but potentially life-threatening condition that can lead to severe hypercalcemia and serious complications. Most reported cases are associated with long-term or high-dose oral vitamin D preparations, dietary supplement use, or inappropriate iatrogenic prescribing. In contrast, occupational inhalation exposure remains exceedingly uncommon. We report the case of a 25-year-old man who developed parathyroid hormone (PTH)-independent hypercalcemia and acute kidney injury (AKI) due to excessive exogenous vitamin D3 exposure in the workplace. Following prompt treatment, his clinical condition improved and he was discharged. This case underscores the importance of actively eliciting a history of occupational exposure in patients with PTH-independent hypercalcemia, particularly when there is no clear history of oral supplement use, to reduce missed diagnoses and facilitate prompt recognition and treatment.

PMID 42876639
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PubMedDevelopmental medicine and child neurology2026-10-15

Vitamin D deficiency in early pregnancy and the risk of developing cerebral palsy: A case-control study.

Bergman Ebba E, Rylander Lars L, Lindh Christian C, Thacher Jesse D JD

To investigate whether maternal deficiency of vitamin D in early pregnancy increases the risk of cerebral palsy (CP) in offspring. This registry and biobank-based case-control study consisted of mother-child pairs from Scania, Sweden. Cases (n = 322) were identified from a nationwide CP-register born between 1995 and 2014. Random population controls (n = 343) and preterm controls (n = 258) were identified from a birth registry. Serum samples taken during pregnancy were obtained from a biobank and 25(OH)D3 concentrations were categorized into three groups: sufficient (≥ 75 nmol/L), insufficient (50-74.9 nmol/L), and deficient (< 50 nmol/L). Logistic regression was used to investigate associations between 25(OH)D3 concentrations and CP. Separate analyses were completed among children born preterm and at term, as well as for subtypes of CP. Deficiency of 25(OH)D3 was not associated with a significantly higher risk of CP compared with sufficient values in the studied groups of all children (odds ratio [OR]: 1.34; 95% confidence interval [CI]: 0.86-2.10), children born at term (OR: 1.48; 95% CI: 0.89-2.44), and children born preterm (OR: 0.74; 95% CI: 0.37-1.46). No apparent association between 25(OH)D3 and CP was observed; however, the relatively small sample size and reliance on a single vitamin D measurement may have limited the detection of modest effects.

PMID 42875866
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PubMedFrontiers in medicine2026-10-15

Partial attenuated PTH suppression of calcimimetics may be due to the resulting hypocalcemia or a significant decrease in serum calcium levels within the normal reference range without adequate calcium supplementation.

Kong De-Ru DR, Kong De-Ya DY, Mu Li-Yuan LY, Qu Xiu-Quan XQ et al.

Certain dialysis patients with secondary hyperparathyroidism (SHPT) show partial insensitivity to calcimimetics. These agents are allosteric activators of the calcium-sensing receptor (CaSR) and enhance their sensitivity to extracellular calcium, thereby inhibiting parathyroid hormone (PTH) secretion and eliciting a decrease in serum calcium levels. We hypothesize that the partial attenuated PTH suppression of calcimimetics may be due to the resulting hypocalcemia or a significant decrease in serum calcium levels within the normal range without adequate calcium supplementation. Effective suppression of PTH by calcimimetics inevitably lowers serum calcium levels, which may be further aggravated by ongoing bone mineralization following PTH suppression. This hypocalcemic state or decreased extracellular ionized calcium, if not adequately corrected, acts as a strong trigger for excessive PTH secretion through reducing CaSR activation and stimulating parathyroid chief cells and causing hypertrophy and hyperplasia of parathyroid glands, and then establishing a counter-regulatory feedback circuit that diminishes the therapeutic effect of calcimimetics. High incidence of hypocalcemia, observed in clinical trials of calcimimetics, also bolsters the validity of this hypothesis. Such adverse outcomes may be partially alleviated by timely and adequate calcium and vitamin D supplementation.

PMID 42876689
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PubMedFood science & nutrition2026-10-15

Effect of Alkalization With Potassium Carbonate and Ammonium Bicarbonate on the Chemical and Physical Properties of Cocoa Butter: A Factorial and Central Composite Design Approach.

Sadeghzadeh Afghan A, Taghinezhad Maryam M, Pirsa Sajad S

This study investigated the effects of cocoa butter alkalization using potassium carbonate and ammonium bicarbonate (0%-6%) on acidity, peroxide value, iodine value, saponification value, moisture content, slip melting point, pH, and lead content. A factorial design and central composite design (CCD) were employed. The highest peroxide value (0.1 meq O2/kg) was observed in samples containing 3% potassium carbonate +3% ammonium bicarbonate and 6% potassium carbonate +6% ammonium bicarbonate. The highest acidity was related to the control sample (1.77), while the lowest was found in the sample with 6% of both alkalis (0.77). The control sample also showed the lowest saponification value (189.61 mg KOH/g fat), whereas the highest was recorded for the 6% + 6% sample (199.04 mg KOH/g fat). The highest iodine value (35.91 g I2/100 g fat) belonged to the 6% + 6% sample, and the lowest (32.42 g I2/100 g fat) to the sample containing 6% ammonium bicarbonate alone. Minimum moisture content (0.053%) was observed in the sample with 6% potassium carbonate +3% ammonium bicarbonate, and maximum (0.077%) in the sample with 3% + 3%. The lowest pH (5.05) was for the control, and the highest (9.87) for the 6% + 6% sample. The highest slip melting point (30.23°C) was recorded for the control, and the lowest (26°C) for the sample with 3% potassium carbonate +6% ammonium bicarbonate. All samples complied with Iranian national standards for lead content. The results indicated that 3% potassium carbonate alone, 3% ammonium bicarbonate alone, and 3% potassium carbonate +6% ammonium bicarbonate are suitable for cocoa alkalization. Finally, mathematical models were developed using response surface methodology to establish quantitative relationships between the chemical properties of cocoa butter and the concentrations of the alkaline agents, enabling the achievement of desired product characteristics.

PMID 42876929
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PubMedJournal of the science of food and agriculture2026-10-15

Cerasus humilis proanthocyanidins alleviate osteoporosis by regulating renal calcium metabolism.

Li Xinran X, Shu Yanxia Y, Yu Chao C, Feng Weiran W et al.

Postmenopausal osteoporosis is associated with disturbed calcium homeostasis and renal calcium handling. Although Cerasus humilis proanthocyanidins (PA) show anti-osteoporotic activity, their effects on renal calcium metabolism remain unclear. We hypothesized that C. humilis PA could alleviate ovariectomy (OVX)-induced bone loss by improving renal calcium reabsorption. Compared with untreated OVX rats, 12 weeks of PA treatment increased bone mineral density from 125.5 to 232.8 mg cm-3 and improved trabecular microarchitecture (P < 0.05). PA reduced β-C-terminal telopeptide and tartrate-resistant acid phosphatase-5b levels, increased bone-specific alkaline phosphatase levels, decreased 24 h urinary calcium excretion, and increased apparent calcium absorption from 50.4% to 87.8% (all P < 0.05). Renal histopathological alterations were attenuated, with increased renal bone morphogenetic protein-7 and urinary Klotho levels and decreased serum fibroblast growth factor 23 levels. Renal protein expression of transient receptor potential vanilloid 5 (TRPV5) and Calbindin-D28k increased by 53.0% and 45.6%, respectively (P < 0.05), with corresponding mRNA upregulation. C. humilis PA alleviated OVX-induced bone loss and calcium metabolic disturbances. The effects were associated with reduced urinary calcium loss and increased renal TRPV5 and Calbindin-D28k expression. Renal calcium handling may therefore contribute to the anti-osteoporotic effect of C. humilis PA in OVX rats, and the potential as a dietary ingredient for bone health warrants further investigation. © 2026 Society of Chemical Industry.

PMID 42875697
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PubMedThe Egyptian journal of immunology2026-10-15

Assessment of serum levels of vitamin D and tumor necrosis factor alpha in ulcerative colitis patients at Egyptian Military Hospitals: Cross-sectional observational study.

Eldahan Wedad W, Hassan Mohamed Z H MZH, Asaad Ahmed M AM, Salaheldin Mohamed M et al.

Ulcerative colitis (UC) is a chronic inflammatory disorder confined to the colonic and rectal mucosa. The disease is marked by infiltration of immune cells, leading to excessive production of inflammatory mediators. A key pro-inflammatory cytokine that plays a vital role in the pathophysiology of ulcerative colitis is tumor necrosis factor alpha (TNF-alpha). Low levels of vitamin D have been associated with several autoimmune disorders. This study aimed to assess vitamin D serum levels in UC patients as regard TNF-alpha serum levels and the Severity of UC (UCDAI). This cross-sectional observational research was carried out at Military healthcare facilities in Cairo, Egypt, over six months, from 1 July 2025 to 31 December 2025. Utilizing a convenience sample of 50 adults aged 15 to 70 years with a confirmed diagnosis of ulcerative colitis, newly diagnosed. They were divided into two groups according to disease severity (UCDAI or Mayo score): 26 patients in the mild group & 24 patients in the moderate/severe group. Demographic data were collected from patients' interviews. Colonoscopy for ulcerative colitis disease activity index (UCDAI) score, CBC, ESR, CRP, and Fecal calprotectin (FC) were investigated at Egyptian Military hospitals. Serum levels of 25-hydroxyvitamin D (using CLIA) and TNF-alpha (using ELISA) were measured at central laboratories of the armed forces and blood bank. Correlation analysis showed Serum Vitamin D had a moderate negative correlation with UCDAI (r = -0.466, p-value= 0.001), and a strong negative correlation with serum TNF-alpha (r = -0.669, p-value <0.001). Serum TNF-alpha showed a moderate positive correlation with UCDAI (r = 0.472, p-value= 0.001). Fecal calprotectin had a strong positive correlation with UCDAI (r = 0.704, p-value <0.001) and a weak positive correlation with serum TNF-alpha (r = 0.388, p-value= 0.005). In conclusion, this study demonstrates that patients with moderate to severe ulcerative colitis had pronounced mucosal and systemic inflammation, reflected by markedly elevated fecal calprotectin and TNF-alpha levels, concomitant with significantly lower vitamin D concentrations compared with those in mild disease.

PMID 42875905
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