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calcium carbonate + vitamin D3 (Ideos)

✓ Approved

Innothera · VDR · Small Molecule

What is calcium carbonate + vitamin D3?

calcium carbonate + vitamin D3 is a small molecule developed by Innothera. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesIdeos
CompanyInnothera
Drug ClassSmall Molecule
Molecular TargetVDR
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Innothera

Mechanism of Action

Molecular Targets

calcium carbonate + vitamin D3 acts on 1 molecular target:

VDRvitamin D receptor (NR1I1, PPP1R163)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

calcium carbonate + vitamin D3 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Musculoskeletal and connective tissue disordersOsteoporosis✓ Approved

Related Research Articles

PubMedFrontiers in endocrinology2026-07-17

Efficacy and safety of parathyroid hormone analogs therapy on hypoparathyroidism: a meta-analysis.

Li Siting S, Zhang Yuanfang Y, Zhao Li L, Ma Chao C

To assess the efficacy and safety of parathyroid hormone(PTH) analogs alone as compared with the conventional therapy on HypoPTH, and assess its emphasis on patients' health-related quality of life (HRQoL). Database (PubMed, Web of Science, Embase and Cochrane Library) were systematically searched until February 30, 2026. The primary outcomes were serum calcium and serum phosphate, while the secondary outcomes included 24-hour urinary calcium excretion, serum 25(OH)D, serum 1,25-dihydroxyvitamin D, calcium phosphate product, estimated glomerular filtration rate (eGFR), adverse events, and HRQoL. Meta-analysis was conducted using RevMan 5.4 and STATA 17.0. Eleven studies were included. Compared to conventional therapy, PTH analogs therapy showed no difference in serum calcium (MD = -0.02 mmol/L; 95% CI, -0.14 to 0.11 mmol/L), serum phosphorus (MD = 0.08 mmol/L; 95% CI, -0.05 to 0.20 mmol/L) and 24-hour urinary calcium excretion (MD = 1.00 mmol; 95% CI, -1.84 to 3.84 mmol). PTH analogs decreased 25(OH) vitamin D, increased 1,25(OH)2 vitamin D and eGFR. Additionally, PTH analogs therapy significantly improved HRQoL as measured by the Short Form 36 (SF-36) Health Survey Questionnaire (MD = -7.35; 95% CI, -8.37 to -6.33). In addition to the comparable control of serum calcium and serum phosphorus levels to conventional therapy, limited data indicate that PTH analogs treatment may be better in regulating the serum vitamin D and maintaining the eGFR for patients with HypoPTH. PTH analogs therapy also improves patients' HRQoL. https://www.crd.york.ac.uk/PROSPERO/, identifier CRD420251089112.

PMID 42466353
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PubMedHealth science reports2026-07-17

The Association of Micro- and Macro-Nutrient Patterns With the Risk of Rheumatoid Arthritis in Newly Diagnosed Cases: A Case-Control Study.

Jandari Sajedeh S, Shadmand Foumani Moghadam Mohammad Reza MR, Shahraki Jazinaki Mostafa M, Rastegarmoghadam-Ebrahimian Arezoo A et al.

This study aims to explore the nutrient patterns of macronutrients and micronutrients in healthy people and individuals newly diagnosed with rheumatoid arthritis (RA) and their associations with the risk of RA. This case-control study involved 50 RA patients and 100 matched healthy controls. Dietary intakes were obtained using valid food frequency questionnaires (FFQ). Factor analysis was performed to identify nutritional patterns. Multivariable analysis was performed to assess the relationship between each detected nutrient pattern and the risk of RA. Weight, BMI, waist circumference, physical inactivity, and prevalence of individuals with a familial history of RA were significantly higher in RA patients than in individuals without RA (p < 0.05). Four nutrient patterns were identified, accounting for 71.65% of the total variance. The first (high intake of vitamin D, protein, selenium, and cholesterol), third (high intake of vitamin C, calcium, and dietary fiber), and fourth (high intake of iron and vitamin E) identified patterns were inversely associated with the risk of RA, in contrast to the second pattern (high intake of total fat, trans fatty acids, saturated fatty acids (SFA), higher dietary serving score (DSS) and a higher dietary inflammatory index (DII)), which was directly related to the RA risk (p < 0.05). This study revealed that dietary patterns that are high in DSS and DII scores, total fat, SFA, and trans fatty acids may be related to the risk of RA. Also, it was shown that dietary contents of protein, cholesterol, fiber, vitamin D, vitamin C, vitamin E, selenium, and calcium could be associated with the RA pathogenesis. To reach a definitive finding regarding the association of each nutrient with the risk of RA, conducting more high-quality cohort studies with a large sample size is needed.

PMID 42466377
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PubMedOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2026-07-17

Dietary and supplemental calcium intake and bone changes during antiresorptive osteoporosis treatment in older women: a longitudinal observational study.

Papageorgiou Maria M, Gugler Yvan Y, Ferrari Serge S, Rizzoli René R et al.

Calcium supplements are often prescribed with osteoporosis medications without considering dietary adequacy. In calcium-replete older women, calcium supplements had little effect on the response to antiresorptives, whereas low protein intake blunted their benefits. Calcium supplementation may be unnecessary when intake is adequate, and nutrition should be optimized for osteoporosis treatment. Osteoporosis medications (OM) are commonly prescribed with calcium supplements (CaS) without considering dietary adequacy. We investigated whether calcium and protein intakes influence the effect of OM on total hip bone mineral density (BMD) and strength in calcium-replete women. Data from 586 women (median age 67 years) from the Geneva Retirees Cohort were analyzed: 101 on menopausal hormone therapy (MHT), 67 on antiresorptives (AR) (bisphosphonates, denosumab or raloxifene), and 418 without OM. Annual changes in total hip BMD, strength, and structure were assessed over a median 3.5 years using 2D/3D-DXA and finite element analysis. Calcium and protein intakes were assessed by food frequency questionnaire; CaS use was recorded at baseline and follow-up. Total calcium intake (diet + supplements) was 1503 mg/day; 71% women met recommendations (≥ 1200 mg/day), 51% used CaS, and 70% vitamin D. MHT or AR increased total hip BMD and strength versus no OM. Neither total calcium intake (above or below 1200 mg/day) nor CaS use significantly affected bone outcomes. However, in women with low calcium intake (< 800 mg/day), no difference in changes of BMD or bone strength was observed between women with and without OM in the absence of CaS. In women with protein intake < 0.8 g/kg/day, AR effects were blunted, with reduced improvements in trabecular BMD (P = 0.009) and total hip strength (P = 0.040). In calcium-replete older women, protein intake rather than CaS influences total hip bone changes with OM. These findings question routine CaS in women with adequate calcium intake and emphasize the importance of sufficient protein intake for optimal osteoporosis management. GERICO http://www.isrctn.com/ISRCTN11865958.

PMID 42463975
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PubMedJournal of chromatography. A2026-07-17

Alternative solvents in liquid chromatography and supercritical fluid chromatography for the separation of phenolic compounds.

Gregson Maud M, Batteau Magali M, Faure Karine K

Regarding the growing interest in evaluating and reducing the environmental impact in analytical chemistry laboratories - particularly in chromatography - we investigated the use of six alternative, greener solvents: ethanol, isopropanol, acetone, dimethyl carbonate, propylene carbonate and Cyrene for the separation of phenolic compounds using LC × SFC. These solvents were assessed based on key criteria including elution range, peak width, resolution and selectivity. Their cost, toxicity, biodegradability and hazard potential were also considered. Our findings indicate that several of these greener alternatives show promising results comparable or complementary to the conventional solvents acetonitrile and methanol used in both dimensions. This work contributes to the ongoing evolution toward more sustainable laboratory practices and supports the necessary adoption of environmentally friendly solvents in analytical method development and routine chromatographic applications.

PMID 42462407
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PubMedAnnali italiani di chirurgia2026-07-17

Pre- and Postoperative Nutritional Deficiencies in Patients Undergoing Bariatric Surgery: A Retrospective Cohort Study.

Algethami Mohammed R MR, Jamal Wisam W

To assess the changes in biochemical indicators of nutritional deficiencies before and after bariatric surgery. This retrospective cohort study included 480 adult patients who underwent bariatric surgery between June 2016 and June 2019 at a tertiary care center in Saudi Arabia. Demographic data, comorbidities, and pre- and postoperative biochemical parameters, including hemoglobin, iron profile, Vitamin D, Vitamin B12, albumin, calcium, and parathyroid hormone levels, were extracted from the medical records. These biochemical parameters were used to assess micronutrient status and identify clinically relevant nutritional deficiencies based on established laboratory thresholds. Paired t- and McNemar tests were used to compare the pre- and postoperative values. Statistical significance was set at p < 0.05. We found a high prevalence of pre- and postoperative nutritional deficiencies among patients. The mean hemoglobin decreased from 13.09 to 12.34 g/dL (mean difference -0.75 g/dL; 95% CI -0.89 to -0.61; p < 0.001). We observed a significant association between ferritin and gender pre- and postoperatively, which was lower in women than in men preoperatively and decreased in both sexes postoperatively. The prevalence of 25-hydroxyvitamin D deficiency was 88.0% preoperatively and 72.7% postoperatively in patients with available laboratory data. A high prevalence of pre- and postoperative nutritional deficiencies was observed among patients undergoing bariatric surgery in Saudi Arabia. Although certain parameters improved after surgery, others remained prevalent or worsened postoperatively. These findings highlight the importance of structured nutritional assessments and regular biochemical monitoring before and after bariatric surgery.

PMID 42464830
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PubMedJournal of physiological anthropology2026-07-17

An exploratory study on the association between vitamin D intake or synthesis and sleep health in young adult women: an observational study.

Yoshizu Rika R, Sasaki Toru T, Nakajima Hideaki H, Eto Hiromi H et al.

Vitamin D deficiency, which is highly prevalent in modern society, is associated with health issues, including sleep-wake disorders and depression. This pilot study aimed to examine the relationship between dietary vitamin D intake or vitamin D synthesis from ultraviolet exposure and serum 25-hydroxyvitamin D (25[OH]D) levels as an indicator of vitamin D status, as well as their association with sleep health and depressive symptoms. Twenty-nine young adult women participated in two surveys conducted in spring and summer. Vitamin D intake was estimated based on responses to a dietary questionnaire. The amount of vitamin D synthesized in the skin through ultraviolet exposure was calculated by estimating ultraviolet exposure over a 2-week period. Serum 25(OH)D concentrations were measured using liquid chromatography-tandem mass spectrometry. Sleep habits were assessed using a 2-week sleep diary, and depression and insomnia symptoms were evaluated using questionnaires. The mean (SD) serum 25(OH)D concentrations in spring and summer were 8.9 (2.9) and 15.5 (4.8) ng/mL, respectively. The median (IQR) dietary vitamin D intake adjusted for energy expenditure based on dietary surveys was 8.5 (6.6, 9.2) μg/day in spring and 6.2 (4.3, 10.2) μg/day in summer (P = 0.40). The median (IQR) amount of vitamin D produced from ultraviolet exposure increased from 10.5 (4.6, 17.4) μg/day in spring to 17.0 (10.1, 34.5) μg/day in summer (P = 0.009). Among those with low serum 25(OH)D concentrations or low vitamin D intake in summer, the delayed midpoint of sleep was observed. No significant correlation was found between changes in serum 25(OH)D concentrations from spring to summer and changes in depression or insomnia symptoms. All participants exhibited vitamin D deficiency during the spring term. In contrast, during the summer term, serum 25(OH)D levels increased, primarily due to enhanced vitamin D synthesis resulting from ultraviolet exposure of the skin. However, the observed increase in serum 25(OH)D levels from spring to summer did not correlate with any improvement in depression or insomnia symptoms.

PMID 42464419
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