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calcium carbonate + vitamin D3 (Ideos)

✓ Approved

Innothera · VDR · Small Molecule

What is calcium carbonate + vitamin D3?

calcium carbonate + vitamin D3 is a small molecule developed by Innothera. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesIdeos
CompanyInnothera
Drug ClassSmall Molecule
Molecular TargetVDR
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Innothera

Mechanism of Action

Molecular Targets

calcium carbonate + vitamin D3 acts on 1 molecular target:

VDRvitamin D receptor (NR1I1, PPP1R163)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

calcium carbonate + vitamin D3 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Musculoskeletal and connective tissue disordersOsteoporosis✓ Approved

Related Research Articles

PubMedACS applied materials & interfaces2026-08-30

Degradation Mechanisms of Fluorinated Disordered Rocksalt Cathodes: Effects of Electrolyte Chemistry and Discharge Voltage.

Ahmed Ridwan A RA, Lee Gi-Hyeok GH, Hershkovitz Eitan E, Li Tianyu T et al.

Cation-disordered rock-salt (DRX) oxides have emerged as a promising class of high energy density cathodes for next-generation lithium-ion batteries. Fluorination has been widely employed to tune the redox chemistry and structural stability of these materials, leading to enhanced electrochemical performance. However, the degradation mechanisms of fluorinated DRX (F-DRX) cathodes during electrochemical cycling remain poorly understood. Here, we investigate the degradation behavior of an F-DRX cathode cycled in a conventional carbonate-based electrolyte and a localized high-concentration electrolyte (LHCE). By correlating electrochemical performance with interfacial and bulk structural evolution, we elucidate the role of electrolyte chemistry and deep discharge voltage in governing structural transformation and degradation. The results reveal more pronounced surface and bulk structural changes in the conventional LiPF6-carbonate electrolyte relative to LiFSI-LHCE, indicating accelerated degradation in the former. Lowering the discharge cutoff voltage from 2.0 to 1.5 V further promotes interfacial degradation in both electrolyte systems. This work demonstrates that the LHCE offers superior compatibility with F-DRX cathodes, enabling stable cycling by mitigating surface and bulk structural degradation. These insights clarify the interplay between electrolyte chemistry and voltage window in F-DRX degradation and highlight the critical importance of advanced electrolyte designs for unlocking the full potential of DRX cathodes.

PMID 42669203
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PubMedCureus2026-08-30

Association of Vitamin D Deficiency With Cardiometabolic and Renal Outcomes in Patients With Autoimmune Rheumatic Diseases: A Systematic Review and Meta-Analysis.

Imran Adnan A, Waris Hafiz Abdul HA, Khan Tanoli Sikander S, Raza Muhammad Tabish MT et al.

Autoimmune rheumatic diseases (ARDs) are chronic immune-mediated diseases associated with increased cardiovascular and renal morbidity. Vitamin D deficiency is common in these disorders and may coexist with inflammation, immune dysregulation, endothelial dysfunction, and impaired vascular and renal homeostasis. This systematic review and meta-analysis evaluated the association of vitamin D deficiency with adverse cardiometabolic and renal outcomes in ARDs. PubMed/MEDLINE, Scopus, Embase, Web of Science, and Google Scholar were searched from inception through March 31, 2026, without language restrictions. Observational studies that measured serum 25-hydroxyvitamin D (25(OH)D) and reported cardiometabolic, cardiovascular, renal, or cardiorenal outcomes were eligible. Two reviewers independently conducted study selection, data extraction, and quality assessment. Compatible outcome-specific estimates were pooled using constrained maximum-likelihood random-effects models with Hartung-Knapp inference. Hazard ratios (HRs) and correlation coefficients were examined independently. Eighteen studies met the eligibility criteria, and four independent cohorts contributed to at least one quantitative synthesis. Vitamin D deficiency was associated with higher all-cause mortality (pooled HR 1.95, 95% confidence interval (CI) 1.36-2.79). The pooled association with cardiovascular events was imprecise (HR 2.20, 95% CI 0.52-9.25). Serum 25(OH)D was inversely but inconclusively correlated with proteinuria in pediatric systemic lupus erythematosus (r = -0.47, 95% CI -0.98 to 0.85). Cardiometabolic studies generally reported adverse metabolic and vascular findings but could not be pooled because of incompatible effect measures. Vitamin D deficiency was associated with higher mortality and greater cardiometabolic and renal disease burden; however, cardiovascular-event and proteinuria estimates remained inconclusive. Observational designs, residual confounding, heterogeneous definitions, and few compatible studies precluded causal conclusions. Prospective studies and randomized trials are required to determine whether correcting vitamin D deficiency improves clinical outcomes.

PMID 42668756
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PubMedPediatric health, medicine and therapeutics2026-08-30

Vitamin D Supplementation and Serum 25-Hydroxyvitamin D Response in Infants and Children: A Narrative Review.

Vieth Simon S

Vitamin D deficiency remains common among infants and young children, particularly in higher latitudes and among exclusively breast-fed infants. Although routine supplementation is widely recommended, variability in achieved serum 25-hydroxyvitamin D [25(OH)D] concentrations has been reported across pediatric populations. Understanding the consistency of biochemical response across diverse pediatric settings remains clinically relevant for both research and supplementation practice. To summarize evidence from pediatric clinical studies utilizing a standardized vitamin D formulation and to assess the magnitude and consistency of serum 25(OH)D response across independent investigator-initiated studies. Relevant studies were identified through company-supported research records and a supplementary PubMed search. Eligible publications were published between 2010 and 2020 and included infants or children ≤18 years receiving vitamin D supplementation with reported baseline and follow-up 25(OH)D concentrations. Studies were required to explicitly identify the study formulation and report serum 25(OH)D outcomes. A narrative synthesis approach was applied. Seven studies (Canada, Australia, Vietnam, and Mongolia; total n ≈ 3,800) met inclusion criteria. Supplementation doses ranged from 400 IU/day to 14,000 IU/week across study durations of 1-12 months. Mean baseline 25(OH)D concentrations (≈53 nmol/L) increased to ≈75 nmol/L (mean Δ ≈22 nmol/L). Daily supplementation at 400 IU achieved sufficiency in the majority of infants, while higher-dose regimens produced proportionally greater increases. No study reported clinically significant adverse events attributable to supplementation. Vitamin D supplementation produced consistent and clinically meaningful increases in serum 25(OH)D concentrations across diverse pediatric populations. The approximately 20-25 nmol/L increase observed across the included studies was broadly consistent with published pediatric vitamin D supplementation literature. These findings support current supplementation practices while highlighting the reproducibility of biochemical response across independent pediatric research settings.

PMID 42668848
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PubMedBiomechanics and modeling in mechanobiology2026-08-30

Calcium-mediated force-interval relationship drives post-extrasystolic potentiation in premature ventricular complexes: a computational study.

Vossen Sjoerd S, van Osta Nick N, Lourenço Guilherme Pedro Carvalho GPC, Laranjo Sérgio Matoso SM et al.

Premature ventricular complexes (PVCs) are common cardiac arrhythmias that can lead to cardiomyopathy when frequent. Post-extrasystolic potentiation (PESP), which is the transient increase in contractility following a PVC, may serve as a predictive marker for heart failure risk; yet, the underlying calcium-mediated mechanisms and their relative contribution compared to loading conditions remain poorly understood. We integrated a mechanochemical model coupling intracellular calcium dynamics to sarcomere mechanics within the CircAdapt closed-loop cardiovascular framework. A novel calcium source model incorporating the force-interval relationship was calibrated using experimental canine data. We simulated single PVCs across varying coupling intervals and systematically investigated the contributions of calcium dynamics versus loading conditions to PESP, quantified as changes in systolic blood pressure (∆SBP), maximum rate of left ventricular pressure rise (∆max(dPLv/dt)), and left ventricular ejection fraction (∆LVEF). The calcium-based force-interval relationship reproduced experimental mechanical restitution curves with high accuracy (RMSE 9.59 ± 0.08%). Shorter coupling intervals reduced premature beat contractility while enhancing PESP in subsequent beats. Systematic variation of preload, afterload, and intrinsic contractility revealed that calcium dynamics reproduce the observed PESP patterns, with loading conditions as modulators. Notably, ∆max(dPLv/dt) and ∆SBP responded differently, with ∆SBP exhibiting complex non-monotonic behavior. The model qualitatively reproduced pressure-volume patterns from a single clinical quadrigeminy case. This study demonstrates that a calcium-based force-interval formulation reproduces the qualitative features of PESP within this framework, with preload and afterload modulating the pattern of beat-to-beat pressure response. The divergent behavior among contractility metrics emphasizes the need for multimetric assessment. This framework enables distinguishing intrinsic myocardial dysfunction from extrinsic loading effects, facilitating patient-specific risk stratification in PVC-induced cardiomyopathy.

PMID 42669085
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PubMedInternational journal of cardiology. Cardiovascular risk and prevention2026-08-30

Comment on "Tocotrienol-rich fraction of vitamin E in diabetes and cardiovascular disease: From molecular mechanisms to clinical application".

Mi Shiting S, Guo Xinru X, Chen Tielong T

PMID 42668495
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PubMedPeerJ2026-08-30

Optimizing drip irrigation density enhances growth, yield, physiology, and antioxidant capacity of Korean strawberry 'Kuemsil' in recycling hydroponics.

Jeong Youngae Y, Zebro Mewuleddeg M, Kim Minkyung M, Rabbani Md Golam MG et al.

Efficient irrigation management is crucial for improving water-use efficiency and maintaining high productivity in controlled-environment strawberry cultivation. This study evaluated how different drip irrigation densities influence the growth, physiological responses, yield, fruit quality, mineral uptake, and antioxidant activity of the 'Kuemsil' strawberry cultivar grown in a recycling hydroponic system. Three irrigation densities, D3 (three drippers at 25 cm spacing), D6 (six drippers at 15 cm spacing), and D9 (nine drippers at 10 cm spacing) were compared under coir-substrate cultivation from October 2024 to May 2025. Increasing dripper density generally improved plant performance, with D6 (moderate) and D9 (high) irrigation densities promoting better vegetative growth, photosynthetic efficiency, water status, and nutrient balance compared with the D3 (low-density) treatment. Plants under low irrigation distribution showed reduced physiological performance and greater energy dissipation, indicating higher stress levels. Although the highest irrigation density increased total fruit production, the moderate irrigation density provided the best balance between marketable yield and fruit quality by reducing the proportion of unmarketable fruits and enhancing the production of larger fruits. In addition, the moderate irrigation density improved antioxidant capacity and membrane stability, suggesting enhanced physiological resilience under recycling hydroponic conditions. The findings demonstrate that optimizing drip irrigation density is critical for maximizing strawberry productivity and fruit quality while supporting efficient water and nutrient use in sustainable hydroponic production systems. The moderate irrigation density was identified as the most effective strategy for achieving balanced growth, yield, and physiological performance in 'Kuemsil' strawberry cultivation.

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