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Factor X + Factor IX (Factor X P Behring)

✓ Approved

CSL Behring · F9 · Cell-based Therapies

What is Factor X + Factor IX?

Factor X + Factor IX is a cell-based therapies developed by CSL Behring. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesFactor X P Behring
CompanyCSL Behring
Drug ClassCell-based Therapies
Molecular TargetF9, F10
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, CSL Behring

Mechanism of Action

Molecular Targets

Factor X + Factor IX acts on 2 molecular targets:

F9coagulation factor IX (P19, F9 p22)
F10coagulation factor X (FXA, FX)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

Factor X + Factor IX is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Congenital, familial and genetic disordersFactor IX deficiency✓ Approved
Congenital, familial and genetic disordersFactor X deficiency✓ Approved

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Reactive oxygen species-dependent regulation of hypoxia-inducible factor 1α/C-X-C motif chemokine receptor 4 signaling promotes ozone-induced cancer metastasis.

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Air pollutants, including vehicle emissions and photochemical smog such as ozone, have become a significant health concern in most industrialized nations. Inhaling ozone has repeatedly been linked to increased lung inflammation, immune responses, and cancer development, ultimately speeding up lung cancer metastasis and leading to higher death rates. However, the direct connection between ozone exposure and tumor cell migration has not yet been definitively established. This study aims to investigate the effects of ozone exposure on cancer spread and its underlying mechanisms, focusing on the hypoxia-inducible factor 1α (HIF-1α)/C-X-C motif chemokine receptor 4 (CXCR4) pathway, which influences cancer cell migration and epithelial-mesenchymal transition (EMT). Using B16F10 melanoma and LL2 Lewis lung carcinoma cells, we examined how 1 ppm ozone exposure affects reactive oxygen species (ROS) production and its subsequent impact on the HIF-1α/CXCR4 pathway. Our results show a significant increase in HIF-1α/CXCR4 expression and EMT-related proteins after ozone exposure. Additionally, the use of arbutin, a known ROS scavenger, significantly reduced HIF-1α/CXCR4 levels and cell migration, confirming the role of ROS in ozone-induced metastasis. In summary, our research suggests that ozone promotes cancer spread by activating the HIF-1α/CXCR4 signaling pathway, highlighting an environmental factor that could facilitate cancer progression.

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[This corrects the article DOI: 10.3389/fbinf.2025.1674791.].

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In a nutshell: Explaining joint and muscle bleeding in individuals with haemophilia A and B.

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Motivation and attributional beliefs are critical for adolescents' academic participation and performance, yet validated tools capturing these constructs are limited in occupational therapy contexts. This study aimed to develop and standardize the Strengths and Difficulties Self-Perception Scale for Adolescent Students (StreDi-SPeS). A cross-sectional design was used with 539 adolescents (ages 13-18) in Cyprus. Psychometric evaluation included item-total correlations, exploratory factor analysis, and reliability testing. Analyses supported a four-factor structure explaining 40.3% of variance. Internal consistency was acceptable for the overall scale (α = .814) and three factors, with one factor requiring refinement. The StreDi-SPeS demonstrates preliminary validity and reliability as a measure of adolescents' attributional and motivational self-perceptions. It offers occupational therapy practitioners and researchers a tool for assessing academic participation and guiding interventions.

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