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Factor X + Factor IX (Factor X P Behring)

✓ Approved

CSL Behring · F9 · Cell-based Therapies

What is Factor X + Factor IX?

Factor X + Factor IX is a cell-based therapies developed by CSL Behring. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesFactor X P Behring
CompanyCSL Behring
Drug ClassCell-based Therapies
Molecular TargetF9, F10
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, CSL Behring

Mechanism of Action

Molecular Targets

Factor X + Factor IX acts on 2 molecular targets:

F9coagulation factor IX (P19, F9 p22)
F10coagulation factor X (FXA, FX)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

Factor X + Factor IX is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Congenital, familial and genetic disordersFactor IX deficiency✓ Approved
Congenital, familial and genetic disordersFactor X deficiency✓ Approved

Related Research Articles

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Unmasking Factor XIII Deficiency: Recurrent Intracranial Hemorrhage Despite Normal Coagulation Studies.

Ramesh Karthik K, Hui Gavin G, Shodiya Michael M, Palaskas Nicolaos J NJ

Factor XIII (FXIII) deficiency is a rare bleeding disorder that can be easily missed because routine coagulation tests remain normal. We report a 32-year-old Nicaraguan man who carried a childhood diagnosis of von Willebrand disease and was inadvertently managed with cryoprecipitate for 25 years, a treatment that incidentally corrected his true underlying deficiency due to its high FXIII content. After immigrating and transitioning to von Willebrand factor/Factor VIII concentrate, he developed recurrent life-threatening intracranial hemorrhages. FXIII activity testing ultimately revealed a level of less than 5%, confirming severe FXIII deficiency. He was started on FXIII concentrate prophylaxis with no further bleeding events. This case highlights how diagnostic anchoring and inadvertent treatment with cryoprecipitate can mask FXIII deficiency for decades. Furthermore, it underscores the importance of considering FXIII testing in patients with severe or recurrent bleeding and normal standard coagulation studies.

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PubMedCochlear implants international2026-08-30

Translation and validation of the extended version of the effort assessment scale for adults with cochlear implant in Turkish language.

Kartal Özcan Ahsen A, Çiprut Ayça A, Aktaş Selman S

Although assessing listening effort is clinically essential, no validated Turkish self-report measure currently exists. This study aimed to translate and culturally adapt the Extended version of the Effort Assessment Scale (EEAS) into Turkish and to evaluate the validity and reliability of the Turkish EEAS (T-EEAS) in adults with typical hearing (TH) and cochlear implant (CI) users. A standardized cross-cultural adaptation protocol was followed. Psychometric properties were evaluated in 567 adults (463 TH and 104 CI users). Construct validity was examined using confirmatory factor analysis. Reliability was assessed using Cronbach's alpha, test-retest correlation, intraclass correlation coefficient (ICC), and Bland-Altman agreement analysis. Discriminant validity was evaluated by comparing T-EEAS scores between groups. Confirmatory factor analysis supported a two-factor structure with good model fit. The T-EEAS showed high internal consistency (Cronbach's alpha = 0.938) and excellent test-retest reliability (Spearman's r = 0.867; ICC = 0.877). CI users reported higher listening effort than the TH group (P < 0.001), with a large effect size (Cliff's δ = 0.838). The T-EEAS captures subjective listening effort in Turkish-speaking populations. The two-factor structure distinguishes effort in quiet versus noise, which may support outcome monitoring in audiological rehabilitation. The higher scores observed in CI users support the discriminant validity of the scale. The T-EEAS is a valid and reliable measure of subjective listening effort in Turkish-speaking adults and can distinguish between TH adults and CI users, supporting its use in clinical and research settings.

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Advancing the Longitudinal Measurement of Physical Aggression from Age 3 to 15: Applications of Moderated Non-Linear Factor Analysis.

Fix Rebecca L RL, Raghunathan Radhika S RS, Iris Luo Xiaoshuang X, Geller Amanda A

Physically aggressive behavior among children and adolescents is a longstanding concern, as documented in a large body of literature examining trajectories of aggressive behavior. However, aggression has been shown to present differently across the life course and is also likely to present differently across population subgroups, complexity that challenges the understanding and prevention of, and intervention in, problem behaviors. We therefore created covariate-informed trajectories of aggressive behaviors and identified subgroups representing heterogeneity in the development of girls' and boys' physically aggressive behaviors from ages 3 to 15 years. We used data from 3,263 families in the Future of Families and Child Well-being Study (waves 3-6, ages 3-15 years), a longitudinal birth cohort study following children born in large cities between 1998 and 2000 to mostly unmarried mothers. We used moderated non-linear factor analysis to generate factor scores of physically aggressive behaviors over time, separately for boys and girls, and then ran sex-separated latent growth models using the covariate-informed factor scores. Both girls and boys had three-class change trajectories. For adolescent girls, there is just one trajectory toward physically aggressive behavior (with the third classification as Desistors). For adolescent boys, there are two trajectories toward aggressive behavior (including Adolescent Onset). While universal programming that is not gender-responsive can meet the needs of young people who were classified as Persistors or in the Low Aggression group, we observed unique possible points of intervention and sex-specific needs. In response, we advise on interventions for young people, adults in youth-serving organizations, and structural-level considerations.

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Cantaert Gabriël Rafaël GR, Lauwerier Emelien E, Reinders Jan-Jaap JJ, Robijn Lenzo L et al.

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A Cross-Sectional Methodological Study to Validate Authentic Leadership Questionnaire (ALQ) Among Selected Latin American Nursing Staff.

Periañez Carlos Alberto Henao CAH, Trejos Serrato Jhovana J, Castillo-Díaz Marcio Alexander MA

Authentic leadership has been associated with work-related well-being, job satisfaction, and quality of nursing care. However, psychometric evidence supporting instruments used to assess this construct remains limited across Latin American nursing contexts, highlighting the need for further validation studies. To evaluate evidence of validity for the Authentic Leadership Questionnaire (ALQ) among nursing staff in a Latin American context. This cross-sectional methodological study included 418 nursing staff members-registered nurses and nursing assistants-selected through proportional stratified sampling from a public high-complexity hospital in Cali, Colombia, between May and October 2025. SELF and RATER versions of the ALQ were evaluated using confirmatory factor analysis. Four measurement models were compared for each version: unidimensional, correlated four-factor, second-order, and bifactor models. The final model was assessed through standardized loadings, internal consistency (McDonald's omega, ordinal alpha, composite reliability), measurement invariance (configural, metric, scalar) between nursing staff members, and correlations with job satisfaction. The revised correlated four-factor model (excluding item 9) showed the best fit (ALQ-RATER: CFI= 0.998, TLI= 0.997, SRMR= 0.045, RMSEA= 0.079; ALQ-SELF: CFI= 0.996, TLI= 0.995, SRMR= 0.047, RMSEA= 0.050). Factor loadings were significant (RATER λ = 0.661-0.945; SELF λ = 0.671-0.897). Reliability was adequate (ALQ-RATER: ω = 0.883-0.938, ordinal α = 0.887-0.952, CR = 0.899-0.957; ALQ-SELF: ω = 0.801-0.847, ordinal α = 0.846-0.880, CR = 0.850-0.880). Configural, metric, and scalar invariance were supported. Registered nurses demonstrated significantly higher latent means across all authentic leadership dimensions than nursing assistants. All ALQ dimensions were positively associated with intrinsic job satisfaction (r = 0.287-0.550) and satisfaction with supervision (r = 0.336-0.633). The ALQ demonstrated evidence of structural validity, reliability, measurement invariance, and external validity among Colombian nursing staff. The instrument can be used to assess authentic leadership in healthcare settings, support leadership development initiatives, and facilitate research examining its relationship with job satisfaction.

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Validation of a Turkish Translation of the Stress in Emergency Healthcare Professionals: The Stress Factors and Manifestations Scale.

Alsancak Halil H, Birgili Fatma F

The primary duties of emergency healthcare professionals (EHPs) are to provide emergency patient care to acutely ill and injured individuals. Due to the nature of their work, EHPs operate under constant stress, often requiring rapid decision-making, swift action, and the delivery of necessary medical care in life-or-death situations, sometimes under inadequately safe conditions. Therefore, the aim of this study is to determine the validity and reliability of the Emergency Healthcare Professional Stress Factors and Symptoms (SEHP:SFMS) Scale in Turkish for identifying stress factors and symptoms in emergency medical care professionals providing emergency patient care services. A methodological study design was used in this study. The study was conducted with the participation of 211 EHPs from employees working in emergency care institutions affiliated with the Muğla Provincial Health Directorate between November 2023 and June 2024. Data were collected via a face-to-face survey. Data were analysed using Lawshe content validity ratio, Kaiser-Meyer-Olkin coefficient, Bartlett test, exploratory factor analysis, principal component analysis, Varimax factor rotation method, confirmatory factor analysis, Cronbach's α internal consistency coefficient, convergent validity, discriminant validity, test-retest, and Spearman correlation coefficient tests. The linguistic translation and cultural adaptation of the SEHP:SFMS showed strong performance. The scope validity index of the scale is 0.83. The item-total correlation values of the scale were found to be between 0.486 and 0.794, and the factor loadings were between 0.474 and 0.816. Confirmatory factor analysis fit indices: χ2 = 248.727; df = 101; n = 211; p = 0.000; χ2/df = 2.463; RMSEA = 0.083; CFI = 0.914, SRMR = 0.052, which was found to be compatible and acceptable with the proposed 3-factor model. The Cronbach's α reliability coefficient of the scale was 0.931, and the total variance was 61.97%. SEHP:SFMS is a valid and reliable tool to assess stress factors and symptoms of Turkish emergency healthcare professionals. Its use improves the quality of emergency care. These study findings have been used to create a tool with Turkish validity and reliability that allows for the examination of stress factors among healthcare professionals working in emergency and critical services. Identifying and reducing stress factors among healthcare professionals is crucial for the delivery of quality healthcare services. It can also be used to develop targeted interventions and ongoing strategies to facilitate improved clinical supervision and mentoring. Nurses in emergency departments, which are among the most stressful, dynamic, intense, life-saving, and critical environments in healthcare institutions, and where life-saving treatment is administered, are at high risk of experiencing psychological trauma. Trauma experienced in the work environment is a significant problem for nursing. The consequences of trauma negatively affect nurses and institutions. Studies show that post-traumatic stress, anxiety, depression, and burnout are commonly observed in emergency department nurses. In this sense, understanding the stress and stress factors experienced by nurses can guide future interventions. The results of this study are considered important in making visible the stress and stress factors experienced by nurses in the emergency department, and also in guiding managers and nurses working in this field in terms of preventive and protective measures.

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