Drug Database
RA

rabies antiserum

✓ Approved

Shanghai Serum Biotechnology · Polyclonal Antibodies · Polyclonal Antibodies

What is rabies antiserum?

rabies antiserum is a polyclonal antibodies developed by Shanghai Serum Biotechnology. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection.

Drug Profile

CompanyShanghai Serum Biotechnology
Drug ClassPolyclonal Antibodies, Antibody
RouteInjectable (Others), Intramuscular (IM) Injection
StatusApproved
Sources: ClinicalTrials.gov, Shanghai Serum Biotechnology

Therapeutic Indications

rabies antiserum is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsRabies✓ Approved

Related Research Articles

PubMedBMC public health2026-10-15

Rabies and rabies prophylaxis in Egypt: a nationwide cross-sectional study that calls for action.

Helal Mohamed Basyouni MB, Saeda Mohamed Ahmed MA, Elshaar Ahmed Gamal AG, Zayed Mohamed Elsayed ME et al.

Rabies is a fatal but preventable viral disease that poses a global health threat, especially in developing countries. Despite the high incidence of animal bites reported annually in Egypt, limited data exist regarding the knowledge, attitudes, and practices (KAP) of the general population toward rabies and rabies prophylaxis. We conducted a nationwide cross-sectional study using a structured interview-based survey targeting individuals aged 18 years or older who attended outpatient clinics at nine university hospitals across Egypt. The survey assessed participants' KAP toward rabies and rabies prophylaxis and identified barriers to prophylaxis uptake. Among 1,777 participants who responded to the survey, only 42.8% (n = 760) had good knowledge about rabies and rabies prophylaxis, while the majority, 88.5% (n = 1,572), exhibited a positive attitude toward rabies prophylaxis. Knowledge was higher among those who reported awareness of rabies campaigns in their geographic areas (69.1% vs. 40.5%, p < 0.001) and those who had previously been bitten or attacked by animals (56.1% vs. 41.3%, p < 0.001). Overall, 9.7% (n = 173) of participants reported a history of animal bites or attacks; however, 18.5% (n = 32) of these participants did not receive post-exposure prophylaxis (PEP), and 17% (n = 24) did not complete the vaccine schedule. Pre-exposure prophylaxis (PrEP) uptake was low, with only 4.3% (n = 23) of high-risk individuals receiving it. Key barriers to rabies prophylaxis included lack of knowledge about the rabies vaccine, reported by 82.4% of participants, lack of knowledge about rabies, reported by 81.7%, and inadequate hospital facilities, reported by 43.1%. Despite a generally positive attitude toward rabies prophylaxis, knowledge and adherence to prophylactic measures, including pre-exposure and post-exposure prophylaxis, remain relatively inadequate in Egypt. Public health interventions, such as educational campaigns and improved accessibility to vaccination services, are needed to address these gaps and mitigate the public health burden of rabies.

PMID 42875760
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PubMedTropical animal health and production2026-10-14

Pasture area increases livestock rabies risk in Rio de Janeiro, Brazil: a geospatial analysis of neurological syndrome cases (2020-2024).

Monteiro Rafael Veríssimo RV, da Costa Renata Falcão Rabello RFR, Kimura Leda Maria Silva LMS, de Oliveira Glenda Ribeiro GR et al.

Animal rabies poses a risk to livestock in Brazil due to transmission by hematophagous bats. The Brazilian sanitary surveillance system mandates rabies testing for any livestock exhibiting signs of neurological syndrome. This geospatial, retrospective, longitudinal, observational study analyzed rabies test results for 204 cattle and 56 horses presenting with neurological syndrome in Rio de Janeiro State, Brazil, from 2020 to 2024. We calculated correlations and linear models between rabies results and municipal land-use types, as well the population of herbivores. Most neurological syndrome cases and positive rabies results occurred in cattle. The final linear model for the number of neurological syndrome cases and positive rabies results incorporated pasture area, shrub area and cattle population. Pasture area was positively correlated with higher numbers (p = 0.011 and p = 0.005, respectively). Larger shrub area was associated with fewer neurological syndrome reports and fewer positive results (p = 0.009 and p = 0.010, respectively). Greater cattle population showed a negative association with neurological syndrome notifications and positive detections (p = 0.085 and p = 0.046, respectively).A higher proportion of positive rabies tests was associated with larger pasture areas (p = 0.019) and with lower equine populations (p = 0.115). These findings indicate that the lower animal diversity in pasture areas provides few alternative feeding options for Desmodus rotundus besides livestock, leading to more neurological syndrome cases and animal rabies infections. A larger shrub area offer feed alternatives other than cattle to the bats and a larger cattle population dilutes the frequency of bat meals across individuals, reducing both neurological syndrome notifications and positive rabies detections.

PMID 42873394
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PubMedOne health (Amsterdam, Netherlands)2026-10-14

A mixed-methods study of community dog management and rabies awareness in Thailand.

Thichumpa Weerakorn W, Wiratsudakul Anuwat A, Pan-Ngum Wirichada W, Rawson Thomas T et al.

Rabies elimination requires coordinated interventions across the human-animal-environment interface, yet sustained progress is often hindered by systemic gaps between dog population management, community engagement, and governance. This study investigated community perceptions and challenges related to rabies prevention and control across high-endemic areas in Thailand. Using a mixed-methods design, secondary provincial quantitative data were integrated with qualitative thematic analysis from 57 stakeholders in high endemic areas, including public health officials, policymakers, NGOs, animal-welfare liaisons, and community members. The findings indicated standard rabies awareness, 98.2% of participants demonstrated good preventive practices, recognized post-exposure prophylaxis (PEP) as essential, and 68.4% possessed good knowledge. Although most supported dog sterilization (59.6%) and vaccination (63.2%), only 19.3% perceived existing control campaigns as effective. Main challenges included constrained operational resources (57.9%) and limited local government budgets (40.4%). Free-roaming community dogs were prevalent, with 54.4% of participants identifying abandonment as the primary driver of population growth. Informal feeding networks provided localized care for community dogs. While public willingness to fund management was relatively low (33.3% willing to pay; 19.3% supporting co-payment), reflecting an expectation of local authority responsibility. Qualitatively, unclear boundaries between public health mandates and animal welfare legal frameworks added complexity to rabies outbreak response and sometimes introduced institutional challenges among local government and non-governmental sectors. Nevertheless, stakeholders strongly supported sustained sterilization and intersectoral collaboration. Addressing policy-practice gaps, stabilizing financing, and integrating community social dynamics into formal One Health governance are crucial for achieving sustainable rabies elimination.

PMID 42872006
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PubMedBMJ (Clinical research ed.)2026-10-14

Bat-borne zoonoses: transmission, impact, prevention, and management.

Stanhope Jessica J, Boardman Wayne S J WSJ, Burrell Christopher C, Bi Peng P et al.

Climate change and biodiversity loss are global environmental crises driving emerging infectious diseases, including bat-borne pathogens of public health significance: Ebola, Marburg, Nipah, Hendra, classic rabies virus, and Australian bat lyssavirus, as well as the fungus Histoplasma This review presents the evidence on the mechanisms of transmission, impact, and prevention and management strategies relevant to each of these pathogens. Transmission pathways vary between pathogens but often involve exposure to body fluids or excreta of a bat or other infected animal or human. The diseases associated with these infections have high mortality rates, and survivors may continue to experience a range of long term effects, including neurological and neuropsychiatric signs and symptoms. Prevention strategies may be implemented to reduce the risk of zoonotic spillover and human-to-human transmission of these pathogens, including better ecological stewardship, reducing exposure of domestic animals and humans to bats, isolation of infected people, and, where possible, vaccination of humans and animals. The mainstay of treatment for these conditions is supportive care; however, specific drugs are now available for histoplasmosis and Ebolavirus infection. In the face of climate change and further loss of biodiversity, developing more effective strategies to prevent and manage these conditions will be critical.

PMID 42875048
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PubMedPLoS neglected tropical diseases2026-10-13

Delay in initiation of rabies post-exposure vaccination and influencing factors in Gondar zones of Ethiopia.

Hailu Bezawit Kassaw BK, Demessie Yitayew Y, Berihun Asnakew Mulaw AM, Bitew Abebe Belete AB et al.

Rabies is a viral zoonotic disease of warm-blooded animals, which is preventable through proper administration of post-exposure prophylaxis (PEP). In controlling rabies, delays in initiating post exposure vaccination (PEV) are a challenge in endemic regions. A study was conducted to assess the delay in initiation of PEV and identify associated factors in Ethiopia. Data was collected by face-to-face interviews from 260 dog bite victims or their guardians between January and June, 2025 using a questionnaire. Post exposure vaccination was considered delayed if it was initiated after 48 hours of the exposure incident. The prevalence of delayed initiation of PEV was calculated as a percentage from the number of individuals who initiated PEV after 48 hours and the total number of individuals exposed to rabies. Factors associated with delay were identified using logistic regression models. The prevalence of delayed in initiation of rabies PEV was 86.1% (224/260); 13.9% (36/260) of participants commenced vaccination within 48 hours of exposure. Severity of bite and ownership of biting animal were factors associated with the outcome. Deep bite (OR = 0.22, 95% CI: 0.07 - 0.66, P = 0.008) and bitten by stray dogs (OR = 0.51, 95% CI = 0.27 - 0.95, P = 0.033) reduced delay in initiation of PEV. Majority of respondents (88.5%) are aware of the existence, the signs (71.5%), the way of transmission (75.4%), and the fatal nature (96.5%) of rabies, and the need for PEV (95.4%). Another majority believe that the cost of the vaccine is fair and PEV is effective (95%), and and costs of the vaccination (76.2%) was not a reason for delay. In conclusion, the study outlined that respondents know many aspects of rabies control and had fewer barriers to uptake the PEV; however, the delay in initiating PEV was high. This underscores that respondents may not be aware of the risk of delay. Therefore, interventions focusing on the risk of delayed PEV initiation are needed.

PMID 42868155
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PubMedInfectious diseases & clinical microbiology2026-10-12

Rabies: A Timeless Zoonotic Threat.

Tülek Necla N

PMID 42861348
Read full article →

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