Drug Database
RA

rabies antiserum

✓ Approved

Shanghai Serum Biotechnology · Polyclonal Antibodies · Polyclonal Antibodies

What is rabies antiserum?

rabies antiserum is a polyclonal antibodies developed by Shanghai Serum Biotechnology. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection.

Drug Profile

CompanyShanghai Serum Biotechnology
Drug ClassPolyclonal Antibodies, Antibody
RouteInjectable (Others), Intramuscular (IM) Injection
StatusApproved
Sources: ClinicalTrials.gov, Shanghai Serum Biotechnology

Therapeutic Indications

rabies antiserum is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsRabies✓ Approved

Related Research Articles

PubMedFrontiers in public health2026-08-29

Temporal trends and determinants of delayed care-seeking after rabies exposure: a 27,930-patient analysis in Tianjin.

Li Shuai S, Liu Shuangyan S

Prompt care-seeking after rabies exposure is essential for effective post-exposure prophylaxis (PEP). This study aimed to identify independent factors associated with care-seeking delay and to map the full PEP pathway. We retrospectively enrolled 27,930 patients attending the rabies PEP clinic at Santan Hospital, Tianjin, between February 2022 and January 2026. Delay was defined as >12 h from exposure to registration. Multivariable logistic regression, combined with XGBoost and SHAP, identified independent factors for delay and quantified their relative importance. Restricted cubic splines examined the non-linear relationship between age and delay. Subgroup analysis assessed the stability of the association of grade III exposure with more prompt care-seeking. A Sankey diagram traced the PEP pathway. The delay rate was 29.7%. Eight independent factors were identified. Adults had a 34% higher risk of delay than children (aOR = 1.34, 95% CI: 1.22-1.47, P < 0.001). Grade III exposure was associated with more prompt care-seeking (aOR = 0.69, 95% CI: 0.65-0.73, P < 0.001). Previous rabies vaccination (aOR = 1.17, 95% CI: 1.11-1.23, P < 0.001) and inadequate wound management (aOR = 1.57, 95% CI: 1.31-1.88, P < 0.001) were associated with higher delay risk. Age showed a non-linear relationship with delay risk, with adults at highest risk. The Sankey diagram showed that inadequate wound management was rare in the PEP pathway, and the two-dose booster schedule achieved a much higher completion rate than the standard schedule. Our findings suggest that adults may face the highest risk of care-seeking delay, and that improving healthcare access for adults and promoting simplified vaccination schedules may be key to improving PEP quality.

PMID 42666512
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PubMedRadiology case reports2026-08-28

Atypical neuroimaging in rabies encephalitis: A case report of concurrent cerebral venous sinus thrombosis in a nine-year-old patient.

Doughmi Djoudline D, Akammar Amal A, Daoudi Imad I, Benlamkaddem Said S et al.

Human rabies is a fatal viral encephalitis that presents a profound diagnostic challenge in the absence of a known history of animal exposure. We report the case of a 9-year-old boy from Morocco who presented with fever, seizures, psychomotor agitation, hypersalivation and hydrophobia, despite no reported history of an animal bite or scratch. Brain magnetic resonance imaging (MRI) served as a critical diagnostic tool, strongly suggesting rabies encephalitis by revealing classic bilateral symmetric grey matter hyperintensities in the thalami and temporal lobes. Concurrently, MRI revealed an atypical and rare macrovascular finding: extensive cerebral venous sinus thrombosis of the right transverse and sigmoid sinuses, which likely accounted for additional asymmetric white matter changes. A nuchal skin biopsy analyzed via reverse transcription polymerase chain reaction confirmed the presence of rabies virus RNA. Despite aggressive neurocritical care and therapeutic anticoagulation, the patient's condition deteriorated, and he passed away on day 9 of admission. This case underscores the dual role of MRI in acute encephalitis: guiding early etiological diagnosis of rabies and identifying concurrent, clinically significant macrovascular complications like cerebral venous sinus thrombosis.

PMID 42662867
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PubMedOne health (Amsterdam, Netherlands)2026-08-28

School-based one health education shapes young minds and households to prevent zoonoses: A comparison of four teaching strategies.

Maia Lorena Diniz Macedo Silva LDMS, Ramos Breno Oliveira Lima BOL, Paiva Marcelo Teixeira MT, Araújo Érica Lorenza Martins ÉLM et al.

Health education initiatives have received increasing attention in public policy; however, empirical evidence on the comparative efficacy of different teaching strategies remains limited. This study evaluated four educational approaches: group discussion, theater, board games, and traditional board-based instruction, among 166 elementary school students participating in activities focused on zoonoses, including rabies, sporotrichosis, Rocky Mountain spotted fever, and leishmaniasis. Adjusted exploratory analyses showed higher knowledge gain for board game than for group discussion, while no statistically significant differences were detected among the other strategies. Post-intervention scores were significantly higher than pre-intervention scores, indicating knowledge gains after the educational activities. The proportion of correct responses related to zoonoses increased from 15.7% to 56.6% (p < 0.05), while knowledge of One Health concepts rose from 38.2% to 55.7% (p < 0.05). Overall, the findings indicate that the educational interventions showed efficacy in enhancing students' knowledge and fostering behavioral changes within their family environments. These results highlight the potential of structured school-based health education to promote awareness and prevention of zoonotic diseases.

PMID 42661958
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PubMedBiotechnology letters2026-08-28

5' untranslated region (5' UTR) of bovine β-globin in the mRNA constructs translates different types of antigenic proteins.

Sajjanar Basavaraj B, Gopinath Shreya S, Nadarajan Prasanth P, Marreddy Vishnu Kiran VK et al.

Synthetic messenger RNA (mRNA) is emerging as next generation vaccine platform. As natural 5'UTRs of particular genes do not work for other than its own mRNA, it is essential to identify an ideal 5'UTR supporting higher translation efficiency for different antigens. Six natural 5'UTRs derived from α, β-globin genes of host animals and other viral genes were cloned upstream to the coding sequences of reporter proteins. The corresponding capped mRNA were produced through in vitro transcription and the translation efficiency was assessed using flow cytometry, bioluminescence, immunofluorescence and western blot experiments. The results revealed higher translation of reporter proteins by bovine β-globin 5'UTR in different cell lines. Further, the chosen 5'UTR supported mRNA translation to produce different antigenic proteins such as rabies virus glycoprotein (RVG), major structural protein of foot and mouth disease virus (VP1) and bacterial epsilon toxoid protein (Eptx). Bovine -globin 5'UTR not only increased the translation efficiency of reporter proteins but also supported the expression of different antigenic proteins. Hence, bovine -globin 5'UTR can be used in the mRNA vaccine designs against animal diseases.

PMID 42661014
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PubMedComparative biochemistry and physiology. Part A, Molecular & integrative physiology2026-08-28

Female-biased 26RFa/QRFP peptide content and transcript levels in the zebra finch (Taeniopygia guttata) diencephalon.

Matsumura Moeka M, Hamasaki Sumire S, Moto Kanaho K, Abe Yurika Y et al.

Sex differences in the neural mechanisms underlying energy balance are a fundamental aspect of avian integrative physiology, yet remain poorly understood. The 26RFamide/pyroglutamylated RFamide peptide (26RFa/QRFP) is a hypothalamic orexigenic neuropeptide whose precise role and regulation in songbirds are unknown due to the lack of species-specific analytical tools. To investigate the 26RFa/QRFP system in the zebra finch (Taeniopygia guttata), we developed and validated a novel, high-affinity rabbit antiserum directed against a specific fragment of zebra finch 26RFa/QRFP. The specificity of this reagent was rigorously confirmed through a competitive enzyme-linked immunosorbent assay and cross-validated by the neuroanatomical colocalization of 26RFa/QRFP-like immunoreactive cell bodies and mRNA transcripts in the ventromedial and lateral hypothalamic areas. Using this validated platform, we identified striking female-biased dimorphism in the zebra finch diencephalon, with approximately 3.9-fold higher mature peptide content and 1.5-fold higher mRNA expression in females than in males (P < 0.05). These findings suggest that zebra finches employ sex-specific neuroendocrine strategies for metabolic regulation.

PMID 42665123
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PubMedViruses2026-08-27

Using Lateral Flow Devices to Enhance Molecular Epidemiology and Evaluating the Rabies Surveillance System on Unguja Island, Zanzibar.

Bosch Cayla C, Moh'D Ali Z AZ, Ramadhan Ramadhan J RJ, Coetzer Andre A et al.

Dog rabies remains a neglected tropical disease in many resource-limited endemic regions, including Unguja Island, Zanzibar. Classically, in such resource-limited settings, an underestimation of the impact of rabies, which directly correlates with insufficient diagnostic capabilities and surveillance efforts, leads to poor investment in effective rabies control. This study combined molecular epidemiology with retrospective analyses of surveillance data from 2016 to 2024 to better understand the transmission dynamics and assess the effectiveness and reliability of the rabies surveillance system on Unguja Island. Towards this goal, rabies RNA was extracted from used lateral flow devices for further molecular phylogenetic analyses of the partial nucleoprotein gene. From this analysis, we were able to conclude that the rabies lyssaviruses presently circulating on Unguja Island represent a distinct endemic cycle in comparison to rabies viruses from elsewhere in Tanzania. In addition, space-time analysis and the evaluation of testing rates identified high-risk rabies areas with particularly inadequate surveillance. These findings allow better understandings of the disease's impact, which will support improved surveillance and the implementation of targeted control strategies, and will pave the way for, hopefully, the elimination of dog rabies in the longer run.

PMID 42655655
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