Drug Database
RH

rhIFN-alpha (ReliFeron)

✓ Approved

Reliance Life Sciences Private Limited · IFNAR2 · Recombinant Proteins

What is rhIFN-alpha?

rhIFN-alpha is a recombinant proteins developed by Reliance Life Sciences Private Limited. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection or intravenous (iv) or subcutaneous injection.

Drug Profile

Brand NamesReliFeron
CompanyReliance Life Sciences Private Limited
Drug ClassRecombinant Proteins
Molecular TargetIFNAR2
RouteInjectable (Others), Intramuscular (IM) Injection, Intravenous (IV), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, Reliance Life Sciences Private Limited

Mechanism of Action

Molecular Targets

rhIFN-alpha acts on 1 molecular target:

IFNAR2interferon alpha and beta receptor subunit 2 (IFNARB, IFN-alpha-REC)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

rhIFN-alpha is developed for 8 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Hairy cell leukaemia✓ Approved
Infections and infestationsHepatitis B✓ Approved
Infections and infestationsHepatitis C✓ Approved
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Kaposi's sarcoma✓ Approved
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Non-Hodgkin's lymphoma✓ Approved

+3 more indications available with a free account

Sign up free to view all indications →

Related Research Articles

PubMedPeerJ2026-08-30

Methomyl resistance in Musca domestica: mechanisms and inheritance.

Khan Hafiz Azhar Ali HAA

Methomyl resistance is a documented problem in Musca domestica field strains worldwide, including Pakistan, where the insecticide is commonly used. To address this, a methomyl-resistant near-isogenic line (Meth-R) was created specifically to determine its resistance inheritance mode and cross-resistance profile. Analysis of reciprocal F1 and F1' crosses demonstrated autosomal inheritance of methomyl resistance in the Meth-R strain, as evidenced by similar median lethal dose (LD50) values and the absence of sex linkage or maternal effects. Resistance expression was incompletely dominant, with dominance values of 0.7 (F1) and 0.6 (F1'). Significant deviations between observed and expected mortality in self-bred (F2 and F2') and backcross (BC1-BC4) progenies (chi-square analyses) indicate resistance is likely controlled by multiple genes. The Meth-R strain showed no cross-resistance to alpha-cypermethrin, fluralaner, pirimiphos-methyl, or clothianidin. Additionally, observing significant synergism of methomyl with both piperonyl butoxide (PBO; oxidase inhibitor) and S,S,S-tributyl phosphorotrithioate (DEF; esterase inhibitor) implicates metabolic detoxification as a key mechanism of methomyl resistance. The Meth-R strain exhibits methomyl resistance inherited as an autosomal, incompletely dominant trait under polygenic control. Although there was cross-resistance in the Meth-SEL strain to alpha-cypermethrin, fluralaner, pirimiphos-methyl, and clothianidin versus the lab susceptible strain, selection with methomyl did not increase the level of cross-resistance. These results offer a foundation for combating methomyl resistance.

PMID 42668966
Read full article →
PubMedCochlear implants international2026-08-30

Translation and validation of the extended version of the effort assessment scale for adults with cochlear implant in Turkish language.

Kartal Özcan Ahsen A, Çiprut Ayça A, Aktaş Selman S

Although assessing listening effort is clinically essential, no validated Turkish self-report measure currently exists. This study aimed to translate and culturally adapt the Extended version of the Effort Assessment Scale (EEAS) into Turkish and to evaluate the validity and reliability of the Turkish EEAS (T-EEAS) in adults with typical hearing (TH) and cochlear implant (CI) users. A standardized cross-cultural adaptation protocol was followed. Psychometric properties were evaluated in 567 adults (463 TH and 104 CI users). Construct validity was examined using confirmatory factor analysis. Reliability was assessed using Cronbach's alpha, test-retest correlation, intraclass correlation coefficient (ICC), and Bland-Altman agreement analysis. Discriminant validity was evaluated by comparing T-EEAS scores between groups. Confirmatory factor analysis supported a two-factor structure with good model fit. The T-EEAS showed high internal consistency (Cronbach's alpha = 0.938) and excellent test-retest reliability (Spearman's r = 0.867; ICC = 0.877). CI users reported higher listening effort than the TH group (P < 0.001), with a large effect size (Cliff's δ = 0.838). The T-EEAS captures subjective listening effort in Turkish-speaking populations. The two-factor structure distinguishes effort in quiet versus noise, which may support outcome monitoring in audiological rehabilitation. The higher scores observed in CI users support the discriminant validity of the scale. The T-EEAS is a valid and reliable measure of subjective listening effort in Turkish-speaking adults and can distinguish between TH adults and CI users, supporting its use in clinical and research settings.

PMID 42668441
Read full article →
PubMedInternational journal of microbiology2026-08-30

Microbial Communities Vary by Body Region but Remain Consistent Across Color Morphs in the Solitary Ascidian Rhopalaea abdominalis.

Hutchings Brenna B, López-Legentil Susanna S, Stefaniak Lauren M LM, Nydam Marie L ML et al.

Ascidians are filter-feeding marine invertebrates that display inter- and intraspecific color variation and host diverse microbiomes. Although color variation has been used as an indicator of speciation and correlated with distinct microbiome structure in some colonial species, there is limited research on microbiome variation across color morphs and body regions in solitary ascidians. To address these knowledge gaps, three color morphs (purple, orange, and intermediate shades of pink) of the solitary Belizean ascidian Rhopalaea abdominalis were collected for phylogenetic analysis using the Cytochrome Oxidase I (COI) gene and for microbial characterization via sequencing the V4 region of the 16S rRNA gene. Microbial sequences derived from the ascidian branchial sac, gut, and tunic body regions were processed using both operational taxonomic unit (OTU) and amplicon sequence variant (ASV) pipelines to determine the resolution and consistency of sequence processing methods using mothur and QIIME 2 software, respectively. COI sequencing revealed two clades that were independent of color morphs. Microbiome characterization showed no significant differences in alpha- or beta-diversity across ascidian color morphs or COI clades but distinct microbiomes within each body region. The branchial sac harbored a higher number of core members (i.e., detected across all host individuals) that included known ascidian symbionts (e.g., Endozoicomonas), whereas the gut and tunic were colonized by taxa identified in seawater and across multiple classes of marine invertebrates. Results were highly congruent between OTU- and ASV-based pipelines, yielding statistically equivalent alpha-diversity metrics, consistent beta-diversity patterns, and similar core membership profiles. These findings reinforce the validity of both methods for studying microbial symbiont communities and corroborate previous research showing distinct microbiomes by body region and overall conservation when color morphs lack genetic differentiation.

PMID 42668720
Read full article →
PubMedNeurobiology of stress2026-08-30

PKCα-deficient mice show altered synaptic signaling and impaired fear extinction.

An Lulu L, Yang Miyoung M, Ding Qi Q, Wang Hongbing H

Protein kinase C alpha (PKCα), encoded by Prkca, has been implicated in neuronal signaling, plasticity, and memory. Human genetic studies identify PRKCA as a candidate locus relevant to memory and posttraumatic stress disorder (PTSD), but the physiological functions of PKCα remain incompletely defined. Here, we examined the anatomical distribution, signaling function, and behavioral phenotypes associated with constitutive global PKCα deficiency in Prkca -/- mice. PKCα was enriched in forebrain regions, including the hippocampus and prefrontal cortex. It was detected in MAP2-positive neurons and was not detected in GFAP-positive astrocytes. In cultured hippocampal neurons, PKC activation induced redistribution of PKCα to dendritic and membrane-associated compartments, including PSD95-positive postsynaptic sites. PKCα deficiency did not alter gross hippocampal morphology or the basal abundance of major neuronal and synaptic marker proteins, but it reduced basal phosphorylation of pan-PKC, CaMKIIα, and the AMPA receptor subunit GluR1 at Ser831. Male Prkca -/- mice showed impaired hippocampus-dependent spatial memory, increased anxiety-like behavior, and a marked deficit in contextual fear extinction. These findings identify PKCα as part of a signaling program associated with synaptic function and support a role for PKCα-dependent processes in adaptive updating of learned fear.

PMID 42668616
Read full article →
PubMedOrvosi hetilap2026-08-30

[Modern treatment of androgenetic alopecia].

Rózsa Petra P, Kemény Lajos L, Gyulai Rolland R

Androgenetic alopecia is the most common hair loss, characterized by a chronic and progressive course and a significant psychosocial burden. The aim of this study was to provide a comparative analysis of current international guidelines and expert consensus statements on the treatment of androgenetic alopecia and to summarize their applicability in clinical practice. A literature search was performed in the PubMed database to identify English-language guidelines and expert recommendations published between 2015 and 2025. The included documents were analyzed narratively and compared based on therapeutic approaches. Conventional treatments, including topical minoxidil and 5-alpha-reductase inhibitors, remain the cornerstone of therapy. More recent recommendations increasingly support the use of low-dose oral minoxidil and dutasteride; however, their position varies across guidelines. The role of procedural therapies also differs, mainly due to limited evidence. Differences between recommendations are primarily driven by variability in levels of evidence and the evolving new therapies. In clinical practice, an individualized, multimodal treatment strategy combined with regular follow-up is essential. The management of androgenetic alopecia is a rapidly evolving field requiring personalized therapeutic decisions. In clinical practice, a personalized combined treatment strategy and regular follow-up are of paramount importance. Orv Hetil. 2026; 167(35): 1385-1393.

PMID 42669143
Read full article →
PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-08-30

IFI27 and BAX are Essential for GSDME-Mediated Myeloma Cell Pyroptosis.

Cui Yaoli Y, Sun Yuening Y, Liu Ziyang Z, Lai Xuntao X et al.

Induction of pyroptosis is a novel strategy for multiple myeloma (MM) treatment, but the underlying mechanism remains elusive. In the analysis of the transcriptomic profile in pyroptotic MM cells, we find the interferon-alpha inducible protein IFI27 is strikingly upregulated. IFI27 is downregulated in MM cells in association with poor prognosis, but its overexpression displays great potency to trigger pyroptosis in both MM cell lines and newly diagnosed MM cells in a GSDME-dependent manner. Moreover, ectopic IFI27 impairs mitochondrial structure and function. Interestingly, when mitochondria are depleted, IFI27 almost fails to induce MM cell pyroptosis. Mechanistic studies show that IFI27 recruits N-GSDME to mitochondria via BAX, therefore triggering pyroptosis. When IFI27 is knocked down, MM cells hardly undergo pyroptosis even when triggered by N-GSDME, BAX, or chemotherapeutic agents. Although GSDMD induces cell pyroptosis independent of BAX, BAX is required for IFI27- and N-GSDME-induced cell pyroptosis. Lastly, ectopic IFI27 promotes GSDME activation and triggers MM cell pyroptosis in vivo and strikingly prolongs the survival of mice with MM. In summary, the present study finds that IFI27 and BAX are essential for GSDME-mediated cell pyroptosis, and induction of IFI27 may represent a promising strategy for the treatment of MM expressing GSDME.

PMID 42669156
Read full article →

+9996 more articles available with a free account

Sign up free to view all articles →

Ask about rhIFN-alpha