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Ortho-ACI

✓ Approved

Orthocell Pty, Ltd. · Cell-based Therapies · Cell-based Therapies

What is Ortho-ACI?

Ortho-ACI is a cell-based therapies developed by Orthocell Pty, Ltd.. It is approved for therapeutic indications via surgical implantation.

Drug Profile

CompanyOrthocell Pty, Ltd.
Drug ClassCell-based Therapies
RouteSurgical Implantation
StatusApproved
Sources: ClinicalTrials.gov, Orthocell Pty, Ltd.

Therapeutic Indications

Ortho-ACI is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Musculoskeletal and connective tissue disordersChondropathy✓ Approved

Related Research Articles

PubMedNational science review2026-08-30

Tetraboron MR framework with ortho-B-π-B pattern enables high-efficiency yellow narrowband OLEDs.

Zhang Shuqi S, Yang Yongliu Y, Cheng Zhangli Z, Zhang Tongyuan T et al.

Multiple resonance (MR) frameworks with ortho-boron-π-boron (B-π-B) patterns are promising alternatives to those with para-B-π-B ones for realizing bathochromic narrowband emission, but such cases have been rarely reported, and suffer from significant synthetic challenges. Here, a novel tetraboron MR framework ICZ4B incorporating an ortho-B-π-B pattern was constructed by using indolo[2,3-c]carbazole as the central building block. The well-defined borylation active sites facilitate an efficient one-shot quadruple borylation. ICZ4B not only exhibits bright yellow emission with a small full width at half maximum of 24 nm, but also achieves an improved reverse intersystem crossing rate of 4.7 × 104 s-1. The non-sensitized device realizes an outstanding external quantum efficiency of 36.5%, representing one of the highest results at long wavelengths. This study not only presents a feasible pathway for realizing MR frameworks with ortho-B-π-B patterns via delicate selection of key precursors, but also offers insights for optimizing synthetic strategies for complex MR frameworks.

PMID 42668809
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PubMedJournal of visualized experiments : JoVE2026-08-29

Retrospective Cohort Study of Peripheral Blood miR-486-3p Levels in Patients with Acute Cerebral Infarction and Obstructive Sleep Apnea Syndrome.

Liu Zhihan Z, Hong Yu Y, Cheng Yanbo Y, Du Bo B et al.

Acute cerebral infarction (ACI) complicated with obstructive sleep apnea syndrome (OSAS) confers a high risk of stroke recurrence and death, yet effective biomarkers for this comorbid condition remain limited. This retrospective cohort study enrolled 270 patients with ACI between November 2020 and December 2023, who were classified into the ACI group (n = 100, apnea‑hypopnea index [AHI] < 5) and the ACI with OSAS group (n = 170, AHI ≥ 5), with the latter further stratified into mild (5 ≤ AHI < 15, n = 60), moderate (15 ≤ AHI < 30, n = 75), and severe (AHI ≥ 30, n = 35) subgroups. Serum miR‑486‑3p expression was measured by RT‑qPCR, and inflammatory markers, including tumor necrosis factor‑α (TNF‑α), C‑reactive protein (CRP), and hypoxia‑inducible factor‑1α (HIF‑1α), were quantified by ELISA. The diagnostic value of miR‑486‑3p was evaluated using receiver operating characteristic curve analysis, and its prognostic significance was assessed through Kaplan‑Meier survival analysis and Cox regression models. miR-486-3p was markedly lower in the comorbid group and demonstrated strong diagnostic ability (AUC = 0.927). Notably, a clear dose‑dependent trend was observed across OSAS severity subgroups, with miR‑486‑3p decreasing progressively and TNF‑α and CRP increasing stepwise from mild to severe OSAS. Spearman correlation analyses revealed that miR‑486‑3p was negatively correlated with AHI, NIHSS score, TNF‑α, and CRP. At 1‑year follow‑up, patients with low miR‑486‑3p expression had significantly worse functional outcomes compared with those with high expression. Multivariate Cox regression confirmed miR‑486‑3p as an independent protective factor for 1‑year prognosis. These findings suggest that miR‑486‑3p may serve as a novel diagnostic and prognostic biomarker for ACI patients with OSAS, potentially through its regulatory role in systemic inflammation, and warrant further validation in larger prospective cohorts.

PMID 42667237
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PubMedJournal of visualized experiments : JoVE2026-08-29

Orthokeratology Plus Traditional Chinese Medicine Fumigation in Children with Unilateral Myopic Anisometropia.

Zhang Chang C, Hu Zhenxian Z, Zhang Xin X, Ding Yu Y et al.

This retrospective, nonrandomized cohort study evaluated whether monocular orthokeratology (Ortho-K) combined with Traditional Chinese Medicine (TCM) fumigation was associated with longitudinal ocular outcomes in children with unilateral myopic anisometropia. A total of 101 eligible children were analyzed: 33 in the Ortho-K + Fumigation group, 33 in the Ortho-K group, and 35 in the Spectacle group. The primary outcome was change in axial length (ΔAL) of the initially non-myopic fellow eye. All available post-baseline measurements were analyzed using generalized estimating equations (GEE), with linear mixed-effects and complete-case analyses used to assess robustness to missing follow-up. Fellow-eye ΔAL showed a significant group-by-time interaction (P < 0.001). Compared with Ortho-K alone, the combination group had lower ΔAL at 3, 6, 12, and 18 months (all Bonferroni-adjusted P < 0.001), and both sensitivity analyses supported the primary finding. In the myopic eye, smaller differences between the Ortho-K + Fumigation and Ortho-K groups were significant in the primary GEE at all four visits but were not fully stable in sensitivity analyses. Baseline-adjusted 18-month analyses of secondary dry-eye outcomes showed group differences in tear film break-up time (TBUT), Schirmer I test, and Ocular Surface Disease Index (OSDI), but not corneal fluorescein staining (CFS). Myopia onset did not differ significantly overall, whereas rapid myopic shift showed a modest overall difference; no categorical pairwise comparison remained significant after Bonferroni correction. These results are hypothesis-generating and do not establish causality, prevention, generalized ocular-surface benefit, or long-term safety.

PMID 42667198
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PubMedRSC advances2026-08-29

Structure-activity relationship study on the antibacterial properties of B-ring brominated 1,3-dithiolium flavonoids.

Bahrin Lucian G LG, Rosca Irina I, Sandu Isabela A IA, Jones Peter G PG et al.

The synthesis of twelve new tricyclic flavonoids, with a bromine substituent at the ortho, meta or para position of the B ring, from the corresponding flavanones is described. Four structures were unambiguously proven by X-ray analysis. An SAR study of the antibacterial properties against Staphylococcus aureus, Escherichia coli, Enterococcus faecalis, and Klebsiella pneumoniae was performed and revealed compound- and strain-dependent activity, with 5h showing the most promising broad-spectrum antibacterial profile, while 5f, 5i and 5j also exhibited strong activity against selected strains. Cytotoxicity assays showed high cell viability (>90%) at 0.001 mg mL-1 for all compounds, indicating dose-dependent cytotoxicity. These findings highlight 5h as a promising candidate for further investigation.

PMID 42666773
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PubMedChemical science2026-08-29

Controlling phosphorus(v)-stereogenicity via organocatalytic acylative desymmetrisation of bisphenols.

Platt Ffion M FM, Prindl Martha I MI, Zhou Zhanyu Z, Cordes David B DB et al.

The enantioselective construction of phosphorus(v)-stereogenic centres is of broad importance due to the utility of these compounds both as ligands in catalysis and as scaffolds in medicinal chemistry. This manuscript demonstrates the effective acylative desymmetrisation of ortho-bisphenols to access P(v)-stereogenic products using low 1 mol% loadings of the chiral isothiourea HyperBTM as a Lewis base catalyst and readily available anhydride feedstock starting materials. The scope and limitations of this method have been investigated (24 examples, up to 95% yield, 98 : 2 er). Control experiments reveal the role of bis-acylation in the amplification of stereocontrol through a chiroablative kinetic resolution of the monoester product. A chromatography-free process towards the standard starting material has been developed on decagram scale, facilitating the catalytic application of the process on multigram scale, with 98% catalyst recovery. Synthesis of a polymer-supported isothiourea catalyst facilitated transfer of the catalytic reaction into continuous flow in a packed-bed reactor.

PMID 42666532
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PubMedAngewandte Chemie (International ed. in English)2026-08-29

Synthesis of Isoquinolines Through Isochromenylium Intermediates Captured by Nitriles and a CO-to-CN Switch.

Hu Xu-Dong XD, Ding Gui-Feng GF, Zheng Yu-Qing YQ, Liu Wen-Bo WB

Isochromenylium ions have emerged as versatile intermediates for the rapid construction of molecular complexity through cascade reactions. However, their application in catalytic annulation processes with nitriles to form isoquinolines remains largely unexplored, despite the prevalence of nitrile motifs and isoquinoline frameworks in bioactive molecules and functional materials. Here we report a catalytic cascade strategy for the efficient synthesis of isoquinolines, including enantioenriched variants, from readily available substrates. The reaction includes palladium-catalyzed cyclization of ortho-alkynylaryl aldehydes to generate an isochromenylium palladium species, which is captured by indium-promoted 1,2-addition of nitriles. Subsequent water-assisted ring opening furnishes a Zincke-type intermediate, followed by intramolecular condensation to deliver the isoquinoline products. This cascade process achieves a net conversion of a carbonyl (CO) unit into a nitrile-derived carbon-nitrogen (CN) linkage at an intermediate-stage in a single operation. Notably, the use of malononitrile-tethered substrates enables the synthesis of enantioenriched isoquinolines with high enantioselectivity. Mechanistic studies indicate a cooperative role of palladium and indium in promoting the 1,2-addition of isochromenylium palladium species to the nitrile. The method exhibits excellent atom economy, good functional group tolerance, and scalability, highlighting its potential application for heterocycle synthesis.

PMID 42666004
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