Drug Database
ID

idoxuridine (idoxuridine, APR / Apridin C / Apridin)

✓ Approved

Pierre Fabre S.A. · · Small Molecule

What is idoxuridine?

idoxuridine is a small molecule developed by Pierre Fabre S.A.. It is approved for therapeutic indications via topical.

Drug Profile

Brand Namesidoxuridine, APR, Apridin C, Apridin
CompanyPierre Fabre S.A.
Drug ClassSmall Molecule
Molecular Target,
RouteTopical
StatusApproved
Sources: ClinicalTrials.gov, Pierre Fabre S.A.

Mechanism of Action

Molecular Targets

idoxuridine acts on 2 molecular targets:

(UL30)
(UL30)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

idoxuridine is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Infections and infestationsHerpes simplex✓ Approved
Congenital, familial and genetic disordersCongenital herpes simplex infection✓ Approved

Related Research Articles

PubMedDiscover mental health2026-07-17

Prevalence and factors associated with depression among junior police officers in Kampala metropolitan area.

Kabanda Enock E, Kyeyune Jemimah J, Opito Ronald R

Police officers in Uganda are at higher risk of depression due to the exceptionally stressful nature of their work and exposure to trauma, yet there is paucity of evidence on depression and its associated factors among police officers in Uganda. This study, therefore, aimed to determine the prevalence of depression and associated factors among junior police officers in Kampala Metropolitan area (KMP). This was a cross-sectional study which involved 266 junior police officers in KMP sampled using multi-stage sampling technique and interviewed using a structured questionnaire. Patient Health Questionnaire (PHQ-9) was used to assess depression, and participants with PHQ-9 scores ≥ 10 were considered to have depressive symptoms. Data was entered into Stata version 16.0 for management and analysis. Descriptive statistics were conducted and presented as means, frequencies and percentages while bivariate and multivariate analysis were conducted using Modified Poisson regression and presented as prevalence ratios (PR) with a 95% interval and a P < 0.05 for statistical significance. The mean age of the 266 participants was 36 (SD = 8) years, with prevalence of depression being 31.2% (95% CI 25.9-37.1). The sociodemographic factor significantly associated with depression was working in the field force department, aPR = 2.28 (95%CI 1.17-4.42). The environmental and occupational factors significantly associated with depression were working in rural areas, aPR = 2.11 (95%CI 1.08-4.14) and history of experiencing traumatic incidents, aPR = 2.56 (95%CI 1.45-4.53). This study found the prevalence of depression among junior police officers in KMP to be higher compared to the global prevalence of depression among police officers, and to findings from several studies in other population settings. Working in the field force unit, rural areas and history of experience trauma were significantly associated with depression among the junior police officers. There is a need for the Uganda police force to create friendly working environment with flexible work schedules and put in place mechanisms to support officers experiencing trauma at workplace.

PMID 42463575
Read full article →
PubMedJournal of gastrointestinal cancer2026-07-17

Neoadjuvant Imatinib Therapy in Rectal Gastrointestinal Stromal Tumors: A Comprehensive Narrative Review of Tumor Downsizing, Sphincter Preservation, Transanal Surgical Platforms, Functional Outcomes, and Survival.

Raja Naga Praneeth NP, Kandagari Nagapavani N

Rectal gastrointestinal stromal tumors (GISTs) represent approximately 5-8.5% of all GISTs and pose unique surgical challenges due to the confined pelvic anatomy and proximity to the anal sphincter complex. Historically, radical surgery - including abdominoperineal resection (APR) or pelvic exenteration - was frequently required for complete tumor clearance, resulting in permanent colostomy and significant functional morbidity. The introduction of imatinib mesylate, a selective tyrosine kinase inhibitor (TKI) targeting KIT and PDGFRA, has fundamentally transformed the management of rectal GIST. Neoadjuvant imatinib therapy achieves significant tumor downsizing (25-46% reduction), reduces mitotic activity, and enables sphincter-preserving surgery in patients who would otherwise require radical resection. The concurrent evolution of transanal endoscopic platforms - including transanal endoscopic microsurgery (TEM), transanal minimally invasive surgery (TAMIS), and robotic TAMIS (R-TAMIS) - has further expanded the possibilities for organ preservation, achieving R0 resection rates of 89-100% with favorable functional outcomes and preserved fecal continence. Emerging evidence also suggests improvements in distant recurrence-free survival, disease-specific survival, and overall survival compared with upfront surgery. This comprehensive narrative review examines the rationale, efficacy, response assessment, surgical implications, the role of transanal surgical platforms, functional outcomes, quality of life, survival outcomes, and current guideline recommendations for neoadjuvant imatinib in rectal GIST.

PMID 42467291
Read full article →
PubMedJournal of gastrointestinal cancer2026-07-16

Quality‑of‑Life Outcomes of Appendicostomy-Colostomy Integration in Abdominoperineal Resection: A Multicenter Prospective Cohort Study.

Alvandipour Mina M, Mortazavi Milani Atousa A, Khodabakhsh Asal A, Masoud Bahnamiri Masoudeh M et al.

Abdominoperineal resection (APR) for very low rectal cancer often causes long-term QoL issues due to a permanent colostomy and pelvic morbidity. Dual-stoma techniques, like appendicostomy-enabled irrigation, might enhance bowel control and psychosocial recovery, but these methods need more study in large prospective cohorts. Appendicostomy with abdominal colostomy during APR improves long-term QoL without increasing complications. A ten-year prospective cohort study across three Iranian colorectal centers involved 130 participants undergoing standardized APR with dual-stoma formation, including a permanent colostomy and appendicostomy. QoL was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) and the colorectal cancer-specific module (QLQ-CR29) at 12, 18, and 24 months. Missing responses were addressed through multiple imputation. Nonparametric methods like Mann-Whitney, Kruskal-Wallis, and Spearman's correlation evaluated trends and disparities across domains and sociodemographic variables. The mean QoL score was 81.5 ± 11.3. Functional domains, including cognitive (94.6 ± 12.5), role (89.5 ± 13.5), and physical (85.0 ± 12.1), remained consistently high. CR29 scores indicated strong body image (75.9 ± 16.0), minimal stoma-related embarrassment (29.5 ± 21.0), and maintained sexual function (74.9 ± 24.6 among active respondents). Issues concerning appendicostomy management were minimal, with 91.5% of participants reporting ease of use; no severe complications were observed. Persistent concerns included financial burden (35.6 ± 23.2) and mild peri-stomal symptoms. Dual-stoma APR with appendicostomy is a safe, feasible, and associated with favorable physical, psychosocial, and functional QoL outcomes.

PMID 42461514
Read full article →
PubMedXenobiotica; the fate of foreign compounds in biological systems2026-07-16

An LC-MS/MS method for simultaneous quantification of six components of Angelicae pubescentis radix and systematic evaluation of Angelicae pubescentis radix as a potential inhibitor of multiple cytochrome P450 enzymes.

Yao Jia J, Yang Shunjun S, Liu Ying Y, Ye Rong R et al.

1. Quantitative analytical method was developed for six coumarin constituents in Angelicae pubescentis radix (APR), and the inhibitory effect of the herb's extract on cytochrome P450 enzymes was investigated.2. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for the simultaneous quantification of six coumarins (imperatorin, 8-methoxypsoralen, isopimpinellin, isoimperatorin, bergapten, and cnidilin) in APR. Concurrently, the inhibitory effects of its aqueous extract on multiple P450s were evaluated in rat liver microsomes using a 'Pittsburgh cocktail' approach.3. The method demonstrated excellent linearity (R2 > 0.999), precision, stability, repeatability (RSD < 3.0%), and recovery (95.15-102.36%). The extract exhibited significant time-dependent inhibition of CYP1A2 (residual activity 58.2%), with weaker effects on other P450s.4. A robust LC-MS/MS method was successfully established. The extract of APR was identified as a potent time-dependent inhibitor of CYP1A2 in rat liver microsomes (RLMs), suggesting a potential risk for metabolism-based drug interactions in rats that warrants further investigation in human systems.

PMID 42461003
Read full article →
PubMedJournal of occupational medicine and toxicology (London, England)2026-07-16

Perceived employment vulnerability in Latin America in the context of a potential new pandemic: a multicountry cross-sectional study.

Mejía Christian R CR, Serna-Alarcón Víctor V, Cedillo-Balcázar Jamil J, Vega-Useche Leonel L et al.

Emerging infectious disease threats may reactivate concerns about employment instability and economic disruption, particularly in regions marked by labor informality, social inequality, and limited social protection. Although the effects of COVID-19 on employment have been widely documented, less is known about how workers perceive the potential labor consequences of future health emergencies. This study aimed to assess perceived labor-related repercussions of a potential new pandemic among workers in Latin America. An analytical cross-sectional study was conducted using secondary data from an online survey administered to workers from more than ten Latin American countries between June and July 2022, during the early phase of the 2022 mpox outbreak. Participants were asked about the expected impact of a potential new pandemic on their employment, salary, and overall work situation. Associations between perceived labor-related repercussions and sociodemographic and occupational factors were evaluated using Poisson generalized linear models with a log link and robust variance, adjusted for country of residence. Among 850 surveyed workers, 64.2% perceived that a potential new pandemic would have a considerable or very strong impact on their work. In the adjusted analysis, men reported a lower perceived impact than women (aPR: 0.87; 95% CI: 0.78-0.97; p = 0.009). Lower perceived impact was also observed among those engaged in virtual work (aPR: 0.64; 95% CI: 0.44-0.93; p = 0.018) and hybrid work (aPR: 0.84; 95% CI: 0.73-0.97; p = 0.017), compared with in-person workers. No occupational sector showed a statistically significant difference compared with healthcare workers in the revised adjusted model, although the food sector had a higher, non-significant point estimate. Perceived labor-related vulnerability in the context of a potential new pandemic was substantial among workers in Latin America. Perceptions differed mainly according to sex and work modality, while occupational-sector estimates should be interpreted cautiously because of subgroup heterogeneity and limited precision.

PMID 42458529
Read full article →
PubMedFrontiers in plant science2026-07-16

QTL mapping for leaf rust resistance in bread wheat using PBW343/W8627 RIL population.

Vindhya K S KS, Sharma Renu R, Kumar Satish S, Prasad Pramod P et al.

Leaf rust, caused by Puccinia triticina, inflicts 10-50% yield losses in bread wheat, with newly emerging virulent pathotypes overcoming major Lr genes and rendering the cultivars susceptible. The identification of genetic loci conferring resistance to wheat leaf rust, coupled with the development of molecular markers and the incorporation of resistant alleles into breeding programs, represents the most sustainable and cost-effective strategy for disease management. The present study, employed a recombinant inbred line population derived from (PBW343/W8627) was utilized to map QTLs for leaf rust resistance at seedling and adult plant stages. The RIL population along with its parents was evaluated at seedling and adult plant stages against most prevalent and virulent pathotypes at seedling and adult plant stages for the two crop seasons (2021-22 and 2022-23). Analysis of variance revealed significant differences among the RILs across years. For QTL mapping, genotyping was conducted using 3.9K DArT SNPs leading to the identification of two QTLs: QLr.iiwbr.2B.1 (2B) explaining phenotypic variance of 13.26% with a LOD score 8 and QLr.iiwbr.5B.1 (5B) explaining 14.91% with LOD score 3.91 for all stage resistance (ASR) as well as one QTL for adult plant resistance (APR), QLr.iiwbr.6B.1 (PVE 14.21%). Further, in silico analysis revealed a putative candidate gene encoding for Annexin (TraesCS5B02G201700) which plays an important role in disease resistance in wheat. The study identified new QTLs associated with leaf rust resistance, providing valuable sources to accelerate the development of durable rust resistant sources. Further, characterization of these QTLs will strengthen their utility in rust resistance breeding.

PMID 42459374
Read full article →

+8631 more articles available with a free account

Sign up free to view all articles →

Ask about idoxuridine