Drug Database
BL

blood substitute (Volplex / Volplex)

✓ Approved

Sinclair · Cell-based Therapies · Cell-based Therapies

What is blood substitute?

blood substitute is a cell-based therapies developed by Sinclair. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesVolplex, Volplex
CompanySinclair
Drug ClassCell-based Therapies
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, Sinclair

Therapeutic Indications

blood substitute is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresAdjuvant therapy✓ Approved

Related Research Articles

PubMedBMC pediatrics2026-07-17

Association between elevated blood glucose level and brain injuries (IVH/WMI) in preterm infants.

Lampe Renée R, Felderhoff-Müser Ursula U, Sidorenko Irina I, Krüger Marcus M et al.

The likelihood of developing preterm brain injury such as intraventricular hemorrhage (IVH) or cystic white matter injury (cWMI) largely depends on gestational age. However, its pathogenesis is multifactorial, and accounting of additional risk factors is important for preventing brain injury. Glucose is one of the most important energy sources for the brain. Both high and low blood glucose level may be associated with the onset and progression of brain disorders. To evaluate the relation between preterm brain injury (IVH/cWMI) and blood glucose level, univariate statistical analyses of retrospective data of 109 extremely and very preterm infants was performed. The analyzed data included 14 prenatal and infant diagnoses and 32 regularly measured parameters. Mean values of whole blood glucose levels in preterm infants diagnosed with IVH or cWMI was higher than in controls indicating that elevated blood glucose level is associated with development of preterm brain injury. Mean values were higher both before and after diagnosis of IVH or cWMI, and even significantly exceeded the hyperglycemia threshold of 125 mg/dL following IVH diagnosis. Furthermore, a significant or moderate association was revealed between elevated blood glucose level and 8 medical diagnoses, as well as 21 routinely measured parameters. Our study emphasizes the importance of regularly monitoring blood glucose levels in preterm infants and keeping it within a safe range.

PMID 42464181
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PubMedAmerican journal of industrial medicine2026-07-17

Association of Noise Exposure, Arterial Stiffness, and Blood Pressure in Chinese Adults.

Zhang Hong H, Zhang Haozhe H, Xiao Yang Y, Chen Zhaomin Z et al.

Occupational noise is considered one of the most common occupational hazards all over the world. We aimed to explore the association between occupational noise exposure and blood pressure in Chinese adults, and the mediating role of arterial stiffness in the above-mentioned association. We surveyed machinery manufacturing company workers in Wuhan, China. Occupational noise was assessed using cumulative noise exposure (CNE). Brachial-ankle pulse wave velocity (baPWV) was detected by a BP-203RPE III net-worked arteriosclerosis detection device. Generalized linear models and bootstrap mediating analyses were conducted. A total of 839 participants were included in the study. In the analysis between cumulative noise exposure (CNE) and blood pressure, the β value for systolic blood pressure (SBP) was 0.119 (95% confidential interval [CI]: 0.010, 0.227) and the β value for diastolic blood pressure (DBP) was 0.162 (95% CI: 0.083, 0.241). CNE was positively associated with baPWV (β = 0.002, 95% CI = 0.001, 0.003), and baPWV was positively associated with SBP (β = 51.080, 95% CI = 44.726, 57.433) and DBP (β = 35.927, 95% CI = 31.253, 40.602). baPWV mediated the associations between CNE and blood pressure; the mediation proportion was 62.41% for SBP and 37.14% for DBP, respectively. Our study suggests that occupational noise exposure is associated with elevated blood pressure, and that arterial stiffness mediated the positive association between occupational noise and blood pressure. Appropriate measures should be implemented to control for occupational noise exposure and to protect workers from cardiovascular diseases in the workplace.

PMID 42464580
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PubMedbioRxiv : the preprint server for biology2026-07-17

The Blood RNA Stability Atlas: defining temporal structure and trait-state programs in the human whole-blood transcriptome.

Baltazar Will C WC, Messing Robert O RO, Ferguson Laura B LB

Whole-blood RNA biomarkers are widely used for diagnosis and disease monitoring, but their utility depends not only on abundance but also on temporal stability, a property that is not routinely incorporated into biomarker design. We analyzed 968 longitudinal whole-blood transcriptomes from 165 healthy individuals across eight independent studies spanning diverse platforms, time scales (50 minutes to 16 weeks), and common environmental exposures. Using a cross-study analytical framework integrating variance partitioning, repeatability, and time-associated differential expression, we quantified temporal stability for 6,064 RNAs and classified transcripts into "trait" (stable) and "state" (dynamic) categories representing the extremes of longitudinal changes in transcript abundance. We identified 1,118 trait RNAs exhibiting stable within-individual levels of abundance but substantial inter-individual variability, enriched for whole-blood eGenes (P = 6.0 × 10⁻²⁰), supporting a genetic basis for stability. In contrast, 1,504 state RNAs showed context-dependent temporal variation and were enriched for translation and RNA-binding pathways. Integration with genetic datasets revealed that 4,395 (72%) blood transcripts were linked to at least one whole-blood eQTL, collectively associated with 18,358 GWAS trait relationships, providing disease-relevant context for transcript stability. We developed the Blood RNA Stability Atlas to integrate these features and demonstrate both top-down (disease-to-gene) and bottom-up (gene-to-context) applications for biomarker prioritization and interpretation. These findings establish temporal stability as a defining property of the blood transcriptome and provide a practical, publicly accessible framework for distinguishing stable baseline abundance levels from context-dependent transcriptional responses, informing biomarker selection, study design, and hypothesis generation.

PMID 42465362
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PubMedChemistry of materials : a publication of the American Chemical Society2026-07-17

From Cation Order to Disorder: Unlocking Ion Transport Pathways in Li-Zn-Zr-Cl Halospinels.

Cardoza Abby M AM, Case Tyler B TB, Rom Christopher L CL, Davis Karina K et al.

Lithium metal chloride halospinels of the general formula Li2 MCl4 are a promising class of earth-abundant ion conductors for all-solid-state batteries. However, poor room-temperature ionic conductivity has historically limited their use in practical applications. Here, we substitute Zr4+ into Li2ZnCl4 along the series Li2-2x/3Zn1-x Zr2x/3Cl4 (x = 0, 0.1, 0.3, 0.4, 0.6, 0.9, and 1.0) to understand how cation disorder and vacancy tuning impact ion transport in "normal" halospinels. Aliovalent Zr4+ substitution increases ionic conductivity by nearly 5 orders of magnitude, from 1.320(3) × 10-9 S cm-1 in Li2ZnCl4 to 6.74(1)× 10-5 S cm-1 for x = 0.6. Average and local structure characterization through synchrotron X-ray diffraction (SXRD) and neutron pair distribution function (nPDF) analysis reveal that Zr4+ redistributes the Zn2+ and Li+ sublattices into previously unoccupied interstitial sites, which form new low-energy hopping pathways that facilitate ion transport. We rationalize the dramatic rearrangement of the cation local structure by considering the coordination preferences of the cations and the potential electrostatic penalties incurred by the higher-valent Zr4+ cations. This work delivers an atomistic understanding of substitution-induced cation disorder and ion transport properties in a new family of earth-abundant halospinels.

PMID 42465218
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PubMedWater environment research : a research publication of the Water Environment Federation2026-07-17

The Microbiota of Evaporative Cooling Systems and the Impact of Rainwater as an Alternative Water Source.

van Leuven Nicole N, Tewes Thomas J TJ, Lucassen Ralf R, Lipski André A et al.

Climate change and an increasing global population are supposed to cause progressive water shortages in the future. Using rainwater in water tanks for evaporative cooling systems as a substitute might help reduce water consumption needed for cooling. Therefore, our study identified the present microbiota in evaporative cooling systems (ECS) and used an ex situ approach to identify effects of the substitution of tap water with rainwater. Culturable cell counts (CCC) based on colony-forming units for total counts or selected pathogens, total biofilm masses based on crystal violet staining, and the bacterial composition (16S rRNA sequencing) of biofilms sampled in different ECS were considered. Data suggest that rainwater does not enhance biofilm growth, since both culturable cells and total biofilm mass tended to decrease when using rainwater instead of tap water. Interestingly, biocide treatment slightly enhanced the total biofilm mass and CCC. Sequencing data revealed differences in the microbiota when using the different water types; yet, the community shift did not include an enrichment of typical pathogens in both cases. Overall, our results suggest that a substitution of tap water with rainwater for ECS creates no disadvantage with regard to the microbial safety and might allow a reduction of financial and resource investments.

PMID 42464668
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PubMedCommunications biology2026-07-17

Plasmodium chabaudi malaria parasites adjust liver stage development to synchronise egressing blood stages with host daily rhythms.

Herbert-Mainero Alejandra A, Schneider Petra P, O'Donnell Aidan J AJ, Reece Sarah E SE

Synchronised multiplication of Plasmodium parasites within red blood cells causes periodic malaria fevers. Aligning blood stage development with the feeding-fasting rhythm of the vertebrate host facilitates within-host survival and between-host transmission. We use the rodent model Plasmodium chabaudi to test when, following development in the liver, the blood stage of infection begins. We find egress from the liver into the blood is aligned with the time of day of rhythmic host feeding, but only in wild type hosts, with egress occurring after a fixed period of pre-erythrocytic development in hosts without a canonical circadian clock. However, perturbing the duration over which parasites enter the bloodstream does not affect their multiplication rate in the first five intraerythrocytic development cycles, suggesting that the expected fitness benefits from timing egress anticipates rhythmic challenges or opportunities (e.g. rhythmic nutrient limitation or nutrient availability) later in the infection when parasite densities increase.

PMID 42463916
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