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lansoprazole + amoxicillin + clarithromycin (Lansap)

✓ Approved

Takeda · ATP4A · Small Molecule

What is lansoprazole + amoxicillin + clarithromycin?

lansoprazole + amoxicillin + clarithromycin is a small molecule developed by Takeda. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesLansap
CompanyTakeda
Drug ClassSmall Molecule
Molecular TargetATP4A
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Takeda

Mechanism of Action

Molecular Targets

lansoprazole + amoxicillin + clarithromycin acts on 1 molecular target:

ATP4AATPase H+/K+ transporting subunit alpha (ATP6A)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

lansoprazole + amoxicillin + clarithromycin is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Gastrointestinal disordersGastric ulcer✓ Approved
Infections and infestationsHelicobacter infection✓ Approved

Related Research Articles

PubMedAntimicrobial agents and chemotherapy2026-07-17

Insights into amoxicillin pharmacokinetics using physiology-based pharmacokinetic modelling.

Darlow Christopher A CA, Dubey Vineet V, Reza Nada N, Hope William W

Amoxicillin is the most commonly used antibiotic globally. However, there is a relatively poor understanding of its pharmacokinetics, pharmacodynamics, and clinical pharmacology. We constructed a physiology-based pharmacokinetic (PBPK) model of amoxicillin to gain deeper insights into the adequacy of amoxicillin regimens for the treatment of infections relevant to global health. We constructed an amoxicillin PBPK model in PK-Sim using known ADME and physicochemical parameters, in vitro characterized transporter kinetics of amoxicillin with OAT3, and time-concentration data from the published literature. Unknown parameters were fitted using a subset of available clinical pharmacokinetic data for training, before final validation with a holdout data set. Population simulations were performed using the final model for a range of amoxicillin regimens and contexts. The final amoxicillin PBPK model was high performing by fold-error metrics for both plasma and urinary concentrations. Simulations demonstrated all regimens achieved the 40%T>minimum inhibitory concentration (MIC) target for Streptococcus pneumoniae up to 1 mg/L and all except p.o. 500 mg amoxicillin q8h for the wild-type Haemophilus influenzae MIC distribution. The simulations also demonstrated high urinary amoxicillin exposures and evaluated the effects of inadequate active ingredient content, missed doses, and probenecid co-administration. This PBPK model gives the following insights into amoxicillin pharmacokinetics: i) the adequacy of amoxicillin for infections caused by S. pneumoniae and H. influenzae; ii) the impact of non-compliance and loss of active ingredients on antimicrobial coverage; iii) the effect of probenecid co-administration to improve coverage; and iv) the characterization of high urinary amoxicillin exposure with consequences for use in urinary tract infections.

PMID 42467065
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PubMedBMC microbiology2026-07-17

Synergistic biofilm formation by the coexistence of nontypeable Haemophilus influenzae and Moraxella catarrhalis reduces amoxicillin efficacy.

Umar Nafisa Khamis NK, Ueda Ryo R, Shiga Tatsuya T, Fujishiro Taku T et al.

Nontypeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis are recognized as the key pathogens that cause respiratory tract infections, and both are capable of forming biofilms. Although interspecies biofilm formation has been described, the impact of co-culture conditions on antimicrobial responsiveness remains incompletely defined. In this study, we examined biofilm formation by co-culturing NTHi and M. catarrhalis and evaluated their antimicrobial responsiveness to amoxicillin and alternative clinically relevant antibiotics, including sequential exposure following initial amoxicillin treatment, in an in vitro model. Biofilm formation was quantitatively evaluated using the crystal violet staining method with a 96-well pin replicator. Twenty clinical isolates of M. catarrhalis were first cultured for 24 h to assess their biofilm-forming capacities, which varied considerably among strains, with some producing robust biofilms. To further examine interspecies interactions, M. catarrhalis and NTHi were co-cultured at different CFU ratios, revealing that increasing the proportion of M. catarrhalis in the inoculum enhanced overall biofilm production compared with either species alone. Additionally, exposure to selected antibiotics showed that respiratory quinolones were associated with greater reductions in biofilm biomass and viable bacteria within co-culture-derived biofilms compared with amoxicillin, both during direct treatment and following prior amoxicillin exposure, under the experimental conditions tested. Co-culture of NTHi and M. catarrhalis was shown to significantly enhance biofilm formation compared with either culture species alone. In particular, a higher proportion of M. catarrhalis was associated with increased biofilm production. These findings suggest that polymicrobial coexistence may contribute to reduced antimicrobial responsiveness through enhanced biofilm formation.

PMID 42464116
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PubMedBMC microbiology2026-07-17

Carriage and susceptibility of Enterobacteria isolated from the local chickens at markets and peri-urban areas of Bobo-Dioulasso, Burkina Faso.

Zon Drissa D, Yaméogo Victorien V, Meda Roland Nâg-Tiero RN, Sanou Soufiane S et al.

Salmonella and Escherichia coli are among the main causes of foodborne illness and negatively impact poultry industry. The aim of this study is to determine the carriage rate and sensitivity of Enterobacteria isolated from the cloacae of chickens. Samples were taken only from healthy local chickens of markets (55 samples) and outlying areas (45 samples) using the swabbing technique. The swabs were pre-enriched and inoculated onto Hektoen agar at 37 °C for 24 h. Bacteria and resistance genes were identified through molecular biology. Antimicrobial susceptibility was tested by Kirby Bauer method. The overall prevalence was 65% for Escherichia coli and 27% for Salmonella sp. after biochemical tests and these carrying rates of these strains were 10% for Salmonella and 53% for Escherichia coli after molecular confirmation tests. E. coli isolates (n = 53), 91.43% (32/35) originated from farms, while 75% (21/28) were collected from markets. The detection of the 16S rRNA gene was higher in market samples (25%) compared to farm samples (8.57%). Antibiotic susceptibility testing showed extremely high resistance rates to amoxicillin (> 93%) and tetracycline (> 80%) in both bacterial species. In contrast, high susceptibility rates were recorded to ceftriaxone (> 90%) and norfloxacin (> 89%). Moderate resistance levels were observed to cotrimoxazole and amoxicillin-clavulanic acid Augmentin (> 41%). Comparative statistical analysis between bacterial species showed no statistically significant difference for most antibiotics (p > 0.05). Among Escherichia coli isolates, 58.49% (31/53) exhibited a penicillinase phenotype, compared with 60% (6/10) of Salmonella spp. and ESBL phenotypes were detected in 35.80% (19/53) of E. coli isolates and 40% (4/10) of Salmonella spp. isolates. No statistically significant difference was observed between the species. The blaTEM gene was detected in 41.5% (22/53) of E. coli isolates and in 60% (6/10) of Salmonella spp. isolates. Similarly, the blaCTX-M-9 gene was identified in 35.58% (19/53) of E. coli isolates and 30% (3/10) of Salmonella spp. isolates although this difference was not statistically significant (p > 0.05). This study highlighted the presence of strains Enterobacteria resistant to many antimicrobials of therapeutic importance in healthy chickens. For the well-being of consumers, it is necessary to strengthen surveillance and prevention systems.

PMID 42464141
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PubMedCureus2026-07-17

Unravelling the Allergy Label: A Case of Successful Multi-drug Allergy De-labelling in a Patient.

Vassila Angeliki A, Teo Ying Y, Jones Michael A MA

We report the case of a 23-year-old woman with a pre-existing penicillin allergy label from childhood who presented with severe bilateral conjunctivitis and oral mucositis following a prodromal respiratory illness. Her symptoms worsened shortly after receiving doxycycline, raising concern for a drug reaction. Her condition progressed with significant ocular involvement requiring bilateral amniotic membrane grafting and subsequent immunosuppressive therapy. Investigations confirmed Mycoplasma pneumoniae infection, supporting a diagnosis most consistent with Mycoplasma-induced rash and mucositis (MIRM), although Stevens-Johnson syndrome (SJS) could not be fully excluded. Following recovery, a structured allergy work-up was undertaken, including patch testing, intradermal testing and graded oral provocation in accordance with established guidance. All tests were negative, and the patient successfully tolerated amoxicillin, doxycycline and ibuprofen without adverse reactions. This case demonstrates how a structured, multidisciplinary approach to drug allergy evaluation can facilitate de-labelling in patients with complex mucocutaneous presentations, restore access to first-line therapies and improve patient care.

PMID 42465146
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PubMedAntonie van Leeuwenhoek2026-07-17

Stenotrophomonas maltophilia in a Rhipicephalus linnaei tick cell culture: detection, antibiotic resistance and multi-locus sequence typing.

Husin Nurul Aini NA, Loong Shih Keng SK, Lee Hai Yen HY, Sahimin Norhidayu N et al.

Ticks harbour diverse microbial communities, but opportunistic and environmentally associated bacteria within these systems remain poorly understood. During attempts to establish primary cell cultures from surface-sterilized embryos of the dog tick Rhipicephalus linnaei, we detected the presence of Stenotrophomonas maltophilia, a multidrug-resistant environmental bacterium and emerging opportunistic pathogen. Microscopic examination of Giemsa-stained smears showed abundant extracellular rod-shaped bacteria closely associated with degenerating tick cells, with no evidence of intracellular infection. Molecular identification based on 16S and 23S rRNA gene sequencing confirmed the bacteria as S. maltophilia, and antibiotic susceptibility testing revealed resistance to amoxicillin-clavulanic acid, imipenem, cefoxitin, and nitrofurantoin, but susceptibility to meropenem. Multi-locus sequence typing (MLST) identified the isolate as sequence type 948 (ST948), which is a single-locus variant of ST408 and a double-locus variant of ST144, both of which are representatives of environmental and clinical S. maltophilia strains from diverse geographic origins. These findings provide the first evidence of S. maltophilia occurring in a tick-derived cell culture system and highlight the need to consider opportunistic bacteria when interpreting tick microbiome and cell culture-based studies, particularly those involving veterinary-relevant tick species.

PMID 42467116
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PubMedItalian journal of pediatrics2026-07-17

Clinical features and outcomes associated with macrolide resistance - associated mutations in pediatric Mycoplasma pneumoniae pneumonia.

Huang Yilan Y, Zhang Zili Z, Liang Ming M, Xu Jiaxing J et al.

To investigate the clinical characteristics of macrolide resistance - associated mutations in hospitalized children with Mycoplasma pneumoniae pneumonia (MPP) and to evaluate their associations with severe Mycoplasma pneumoniae pneumonia (SMPP) and prolonged cough. A total of 1,094 hospitalized children with MPP were retrospectively enrolled. Among them, 1,069 underwent A2063G/A2064G mutation testing, whereas 25 were not tested. Patients were classified into mutation-positive, mutation-negative, and untested groups according to mutation testing results. Clinical features, laboratory parameters, treatment profiles, and outcomes were compared among groups. Logistic regression and receiver operating characteristic (ROC) curve analyses were performed to identify risk factors for SMPP and prolonged cough. The proportion of SMPP was higher in the mutation-positive group than in the mutation-negative group. In addition, patients in the mutation-positive group exhibited a more pronounced inflammatory response and greater immune imbalance, as reflected by increased neutrophil percentage and D - dimer levels, along with decreased CD4 and CD8 counts. Univariate analysis showed that A2063G/A2064G mutation status was associated with both SMPP and prolonged cough. However, multivariable analysis identified fibrinogen and AST as independent factors associated with SMPP, while prolonged cough was additionally associated with the duration of azithromycin and clarithromycin therapy, as well as CD8 levels. Children with macrolide resistance-associated mutations exhibited a higher inflammatory burden and a higher unadjusted proportion of SMPP. However, after adjustment, A2063G/A2064G mutation status was not independently associated with SMPP or prolonged cough. Clinical management should integrate inflammatory markers, oxygenation status, and clinical presentation for individualized monitoring and treatment.

PMID 42464300
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