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lansoprazole + amoxicillin + clarithromycin (Lansap)

✓ Approved

Takeda · ATP4A · Small Molecule

What is lansoprazole + amoxicillin + clarithromycin?

lansoprazole + amoxicillin + clarithromycin is a small molecule developed by Takeda. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesLansap
CompanyTakeda
Drug ClassSmall Molecule
Molecular TargetATP4A
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Takeda

Mechanism of Action

Molecular Targets

lansoprazole + amoxicillin + clarithromycin acts on 1 molecular target:

ATP4AATPase H+/K+ transporting subunit alpha (ATP6A)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

lansoprazole + amoxicillin + clarithromycin is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Gastrointestinal disordersGastric ulcer✓ Approved
Infections and infestationsHelicobacter infection✓ Approved

Related Research Articles

PubMedClinical case reports2026-08-30

Rapid-Onset Amoxicillin-Clavulanate Liver Injury Requires Stronger Exclusion of Alternative Causes and Fuller Causality Reporting in Atypical DILI Case Reports.

Awan Muhammad Abdullah MA, Raza Hammad-Ud-Din HU

Rapid-onset drug-induced liver injury after amoxicillin-clavulanate is clinically important, but atypical latency requires particularly careful exclusion of alternative causes. Future reports should provide complete exposure chronology, infectious and autoimmune exclusion, concomitant-drug assessment, RUCAM itemization, and longer biochemical follow-up before assigning strong causality to amoxicillin-clavulanate.

PMID 42668824
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PubMedRespiratory medicine case reports2026-08-29

Successful management of fistulous empyema caused by Mycobacterium avium complex in an advanced-age patient: A case report.

Kuze Yusuke Y, Enomoto Yuri Y, Sekinada Daisuke D, Nakano Yoshio Y et al.

Herein, we report the case of an 87-year-old woman who presented with acute chest pain, fever, and cough. Imaging revealed a right pneumothorax, pleural effusion, and bronchiectasis. Pleural fluid was exudative with elevated adenosine deaminase levels, and Mycobacterium avium complex (MAC) was confirmed. Thoracoscopic plication and empyema cavity curettage were performed. Postoperatively, clarithromycin, rifampicin, ethambutol, and amikacin were initiated, leading to clinical improvement, smear and culture negativity, and discharge. Pleuritis caused by nontuberculous mycobacteria (NTM) is rare, occurring in only 1.4% of patients with NTM pulmonary disease; however, pneumothorax has been reported in 41% of these patients. NTM pleural disease with empyema is associated with a poor prognosis, with a 1-year mortality rate of 14-37%. In our report, early diagnosis enabled timely surgical and pharmacological intervention. This report highlights that even in advanced-age patients with preserved performance status, early multidisciplinary management may achieve favorable outcomes in MAC-associated pneumothorax and pleuritis.

PMID 42667095
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PubMedCureus2026-08-29

Suspected Group A Streptococcal Urethritis Following Orogenital Exposure in a Young Adult Male.

Zhou Calvin C, Tran James J, Leung Whinkie W, Laconsay Gerard G et al.

Streptococcus pyogenes, also known as group A Streptococcus (GAS), commonly causes pharyngitis and skin infection but rarely causes male genitourinary disease. We describe an uncircumcised man in his early twenties who developed progressive dysuria one day after receiving oral sex from his long-term, mutually monogamous partner, who reportedly had symptomatic GAS pharyngitis and was taking antibiotics. Examination documented urethral meatal erythema and tenderness without discharge. Leukocyte esterase was negative; urine microscopy showed 0-5 white blood cells and 5-10 red blood cells per high-power field, and urine culture yielded 20,000 colony-forming units per milliliter (CFU/mL) of beta-hemolytic GAS. Urine nucleic acid amplification tests (NAATs) for Neisseria gonorrhoeae and Chlamydia trachomatis were negative; several other causes of nongonococcal urethritis were not tested. Available records documented a 10-day course of oral amoxicillin, although the dose and timing relative to the culture result were unavailable. Symptoms improved within 48 hours and resolved within several days. The close timing between orogenital exposure and symptom onset, focal meatal findings, and quantitative GAS growth support the possible clinical relevance of the GAS isolate. However, the absence of a urethral specimen and incomplete pathogen testing prevent definitive classification as urethritis; the absence of paired isolates also prevents confirmation of direct transmission. This case emphasizes site-specific sexual history and targeted bacterial culture when initial testing is unrevealing.

PMID 42666895
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PubMedFood microbiology2026-08-29

Antimicrobial resistance patterns differ amongst Salmonella enterica recovered from synanthropic flies captured across multiple livestock production systems.

Shahanaz Eshita E, Montemayor Alicia A, Lyons Brandon B, Kaufman Phillip P et al.

Synanthropic flies are recognized as mobile reservoirs of enteric foodborne pathogens, yet their utility as antimicrobial resistance (AMR) sentinels within livestock production systems remains under-explored. This study aimed recovered the enteric foodborne pathogen Salmonella enterica from whole-body fly homogenates and characterized phenotypic AMR patterns across sampled Texas counties differing by livestock production intensity groups (low, medium, and high). Each livestock intensity group consisted of two counties. Flies were collected from five sampling locations throughout each county at multiple distances (0-15 km) from a designated epicenter. Collected flies were identified to at least family level, homogenized and then screened for Salmonella. Pathogens were biochemically presumptively confirmed molecularly. Confirmed pathogens were subjected to serotyping and phenotypic AMR screening. Besides descriptive statistical analyses, logistic regression evaluated associations between individual counties, Salmonella serovar, and AMR patterns. Overall, 89/230 samples (38.7%) yielded confirmed Salmonella. Elevated AMR frequencies for isolated Salmonella were observed for tetracycline (77.5%), streptomycin (61.8%), amoxicillin/clavulanic acid (56.2%), azithromycin (39.3%), and cefoxitin (41.6%) across sampled counties. Heatmaps revealed clear spatial differences in AMR patterns. Generalized estimating equations (GEE) analysis showed counties Go and S, both belonging to the high livestock intensity group, and the antimicrobial tetracycline were strongly associated (FDR p < 0.05) with the occurrence of AMR in Salmonella isolated from flies. Synanthropic flies demonstrated the presence of variability in Salmonella AMR patterns, and thus may be a useful sentinel for surveiling localized differences in AMR patterns of human pathogens in food animal production environments.

PMID 42668176
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PubMedInternational journal of microbiology2026-08-29

Genotypic Profiling of Virulence and Antibiotic Resistance Genes of Escherichia coli Isolates Derived From Bovine Milk in the Dr. Kenneth Kaunda District, South Africa.

Sizana Lydia C LC, Thekisoe Oriel O, Lekota Kgaugelo E KE, Ramatla Tsepo T

The growing threat of antimicrobial resistance (AMR) among foodborne pathogens poses a significant public health risk in South Africa, largely driven by excessive antibiotic use in dairy farming practices. This study investigated the virulence and AMR profiles of Escherichia coli isolated from bovine quarter milk samples in the Dr. Kenneth Kaunda District, North West Province, South Africa. Sixty-five E. coli isolates were confirmed using the automated identification Sensititre ARIS 2X ID/AST System and PCR targeting the uidA gene. Serogrouping revealed a predominance of non-O157 strains, with O128 (50.8%) as the dominant serogroup, followed by O145 (9.2%), whereas 40% of isolates were nontypable, highlighting serotype diversity. The fliC gene encoding flagellin was the most prevalent virulence marker (62.5%), whereas stx1 was detected in 9.2% of isolates, and stx2 was absent. Phenotypic testing demonstrated high resistance to amoxicillin/clavulanic acid and cephalothin (58.9% each), tetracycline (37.8%), and trimethoprim-sulfamethoxazole (3.3%). However, no isolates exhibited phenotypic multidrug resistance (MDR), despite 98.5% harboring one or more resistance genes: ermB (92.3%), vanB (90.8%), tetM (56.9%), and ampC (10.8%). The high prevalence of ermB and vanB may indicate coselection of resistance determinants and suggests their potential association with mobile genetic elements that facilitate dissemination among bacterial populations. These findings indicate that E. coli from bovine milk in the region serve as silent reservoirs for virulence and resistance genes. These findings are vital for managing E. coli isolates in dairy farming and taking proactive measures to limit AMR in animals.

PMID 42666668
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PubMedArab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology2026-08-28

Antimicrobial resistance, bacterial density, and eradication outcomes of Helicobacter pylori infection in Egyptian patients: A prospective cohort study.

Zaky Saad S, Zaghloul Nariman N, Hetta Helal F HF, Badary Dalia M DM et al.

Helicobacter pylori is a widespread pathogen linked to gastritis, peptic ulcers, and gastric cancer. Increasing antimicrobial resistance is making eradication more difficult. The aim is tostudy how clinical symptoms, endoscopic and histopathological findings, bacterial density, and antimicrobial resistance patterns of H. pylori are related in Egyptian patients. In our study, 100 treatment-naïve patients with gastrointestinal symptoms suggestive of H. pylori infection and positive stool antigen tests underwent endoscopy, gastric biopsy, histopathology, and culture with antimicrobial susceptibility testing. All patients received 14-day levofloxacin-based triple therapy. Treatment response was assessed clinically and by stool antigen testing.. Epigastric pain was the most common symptom, reported by 83% of patients, followed by nausea and vomiting in 58%. Weight loss and pallor were less frequent, at 24% and 18%, respectively. Abnormal upper gastrointestinal endoscopy findings were present in 97% of patients, with 53% showing erosive or ulcerative lesions, indicating significant mucosal involvement. Higher H. pylori bacterial density was associated with gastric ulcers, erosions, mucosal atrophy, and duodenal lesions (p < 0.001). Higher bacterial density was significantly associated with severe mucosal lesions and increased the risk of ulcerative disease, resulting in more severe epigastric pain and gastrointestinal bleeding. Histopathology revealed chronic inflammation in 95% of patients and active inflammation in 80%, indicating ongoing mucosal activity. Treatment failed in 43% of cases and was closely associated with higher bacterial density, confirming the impact of bacterial load on treatment outcomes. Antimicrobial testing showed high resistance to common first-line drugs, including amoxicillin (53.5%), clarithromycin (46.5%), and amoxicillin-clavulanic acid (50.7%). In contrast, meropenem, doxycycline, and rifampicin showed no detected resistance, indicating potential utility against infections with resistance. Bacterial density is an important predictor of mucosal damage and treatment failure. The high rate of resistance to standard first-line antibiotics highlights the need for new treatment strategies and region-specific guidelines.

PMID 42665498
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