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DKB-19002 (DKB 19002 / DKB19002)

✓ Approved

DongKoo Bio & Pharma · Small Molecule · Small Molecule

What is DKB-19002?

DKB-19002 is a small molecule developed by DongKoo Bio & Pharma. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesDKB 19002, DKB19002
CompanyDongKoo Bio & Pharma
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, DongKoo Bio & Pharma

Therapeutic Indications

DKB-19002 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Metabolism and nutrition disordersType 2 diabetes mellitus✓ Approved

Related Research Articles

PubMedAnnals of biomedical engineering2026-05-12

Relative Motion of Cementless Tibial Trays: Time-Elapsed Micro-CT and DVC Analysis During Stair Descent and Deep-Knee-Bend.

Wearne L S LS, Rapagna S S, Keene G G, Awadalla M M et al.

An interference fit is employed for cementless tibial total knee arthroplasty components to ensure stability post-operatively. Relative motion between implant and underlying bone should be minimised, facilitating osseointegration. Previous experimental limitations have prevented quantification of this motion across the entire bone-implant interface. Furthermore, the intended (nominal) interference fit differs to that actually achieved. This study aimed to 1) experimentally quantify the relative motion across the entire interface of a commercially available cementless tibial component and underlying bone, for cadaveric tibiae through micro-computed tomography (micro-CT) imaging and digital volume correlation (DVC); and 2) assess the relationship between relative motion, actual interference fit, post-impaction strain and bone volume fraction (BV/TV).Seven cadaveric tibiae were micro-CT scanned when intact, following resection and, once implanted with a cementless titanium tibial component (Attune, DePuy Synthes), during two time-elapsed mechanical loading sequences that replicated stair descent (SD, 0.0 - 2.5 bodyweight) and deep knee bend (DKB, 0.0-3.5 bodyweight). Actual interference fit was quantified from micro-CT datasets. DVC was employed to extract the post-impaction strain field and, for each load case, the relative motion at the bone-implant interface.A sagittal rocking motion of the tray was detected in both SD and DKB, that increased with increased load applied. Tray lift-off was enhanced in the central- and lateral-anterior regions during DKB. Reduced relative motion was significantly related to higher interference in most cases, whilst it was not related to post-impaction strain or BV/TV. This study provides a comprehensive insight into the mechanical environment surrounding a cementless tibial tray in the immediate post-implantation period.

PMID 42118232
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PubMedScientific reports2026-02-17

Multiple AMMI models investigation to decipher the genotype by environment (G×E) interaction in sugarcane interspecific hybrids for yield and quality traits.

Durai A Anna AA, Kona Praveen P, Pazhany Adhini S AS, Gopinath K K

Genotype × Environment interaction for yield and quality traits was studied in 19 sugarcane (Saccharum spp.) genotypes, including 16 test entries and three varieties, assessed using a Randomized Block Design with three replications at Ponni Sugars, Erode, during 2023-24 and 2024-25 as first plant, second plant and ratoon crops. Combined ANOVA revealed significant genotype and environmental effects, with notable G × E interactions for Single Cane Weight (SCW), Cane Yield (CY), Number of Millable canes (NMC), Cane length (CL), and Commercial cane sugar yield (CCSY). CY had significant positive association with NMC (r = 0.49**), CCSY (r = 0.89**) and CL (r = 0.31*). Among different AMMI models, R-AMMI-LM model provided better data analysis, showing lower residuals and RMSE, with yielding higher variance explanation for traits under study. Biplot analysis revealed that Co 15002, Co 19002, Co 15017, and Co 20010 were stable for cane yield, while Co 20010, Co 20005, and Co 21004 were identified for CCS yield stability at 360 days. The stability parameters, MASI, MASV and SIPC values revealed genotypes Co 15020, Co 19002, Co 15017 and Co 20010 with highest stability for cane yield whereas Co 20010, Co 20005, Co 21004 and Co 15020 were recognized as stable for CCSY. Considering stability and yield for each trait, SSI identified Co 15017, Co 14012, and Co 15020 for higher cane yield with stability and Co 20010, Co 86032, and Co 15017 for higher CCS yield with stability. Co 11015, Co 15020, Co 20009, Co 20011, and Co 21007 are highly stable with higher mean value for sucrose % and CCS % at 300 days and identified as early maturing group. Multiple analysis revealed clones, Co 15017 and Co 14012 are as highly stable with good cane and CCS yields and found comparable to local standard, Co 86032 for 12th month cultivation.

PMID 41698962
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PubMedJournal of eating disorders2025-12-02

Reflective functioning in anorexia nervosa: does it differ from healthy controls and what is its relation to psychopathology?

Kanstinger Lara Maria LM, Zeeck Almut A, Hartmann Armin A, Eyschen Anne Marie AM et al.

Previous studies found an impairment in the capacity to mentalize (operationalized as "reflective functioning", RF) in patients with anorexia nervosa (AN), but only few studies used a validated interview procedure. The aim of this study was an assessment of RF in patients with anorexia nervosa in comparison to healthy controls (HCs), using both an expert-rated measure as well as a self-report measure. Further, the study aimed to explore the relationship between RF and various aspects of psychopathology. 30 female patients with AN (mean age: 26.2 ± 10.1 years) and 30 matched HCs (mean age: 27.4 ± 9.9 years) were assessed and compared regarding their level of RF using the Brief Reflective Functioning Interview (BRFI) and the Mentalization Questionnaire (MZQ). The interrelations between RF values and eating disorder psychopathology (BMI, EDI, EDE-Q), body experience (DKB-35), general psychopathology (PHQ-9, PHQ-15, GAD-7) and impairment in personality functioning (OPD-SQS) were explored using correlation coefficients. On the RF-Scale (RF-BRFI), RF was M = 3.63 (SD = 0.67) in the AN group and M = 4.13 (SD = 0.94) in the HC group. It was significantly lower for patients with AN than for HCs (t(52.5) = 2.38; p = 0.011). Mentalizing in the AN group as assessed with the MZQ was M = 3.24 (SD = 0.71), demonstrating significantly worse self-reported mentalizing capacities compared to HCs (M = 1.73; SD = 0.45; p < 0.0001). RF as measured with the BRFI was only correlated to the EDI-subscale "weight concern", while RF values of the MZQ were correlated with various aspects of psychopathology except depressive symptoms and BMI. The study confirmed the finding that patients with AN show impaired mentalizing. Strengthening the ability to mentalize might therefore be a relevant focus in treatment. However, associations of RF with psychopathology depend on the RF-measure used. Therefore, a better understanding of which aspects of mentalizing are captured by the RF-measures available would be an important basis for further research. Trial registration DRKS00031108.

PMID 41327418
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PubMedPsychotherapie, Psychosomatik, medizinische Psychologie2025-04-04

[Health-related quality of life and psychological abnormalities in patients with lipedema compared to healthy and chronically ill populations].

Kreidel Yannic Y, Himmelreich Viktoria V, Klaus Anna-Maria AM, Franke Gabriele Helga GH et al.

Lipedema is a chronical progressive disease mostly found in women, characterized by an unproportional increase of fat in the limbs and pain. So far mental perspectives are not acceptably resolved. This study examines patients' aspects in health-related quality of life.733 women with lipedema were asked to answer the questionnaires SF-36, Mini-SCL, EFK, DKB-35 and RSES which were compared with normative data. Additional questions for continuative analysis were appended.Depending on the comparison sample, statistical calculation showed significant differences of means in all collected aspects of health-related quality of life. Affected people reported consistently more impairment. Investigations in coping showed that 'depressive processing' is used most frequently. Furthermore, there were significant saliences in SF-36 scales regarding to the stadium and the use of conservative therapies. Analyses of answers to additional questions showed that most patients feel insufficient understood by fellow men. Also, nearly the half feels inadequately informed about the disease.The outcome exposes clear restrictions in quality of life in patients with lipedema. Previous publications can be confirmed and supplemented. However, the study design of an open online survey makes distortions (e. g. selection of highly informed patients) within the sample possible.The resulting need of psychological interventions is obvious. In addition, enlightenment and sensitization in science and public are important to reduce stigmatization, to relieve patients' everyday life and increase the quality of life.

PMID 40179894
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PubMedJournal of biomechanical engineering2024-10-24

Impact of Surgical Alignment, Bone Properties, Anterior-Posterior Translation, and Implant Design Factors on Fixation in Cementless Unicompartmental Knee Arthroplasty.

Yang Huizhou H, Marras Daniele D, Clary Chadd W CW, Zumbrunn Thomas T et al.

Micromotion exceeding 150 μm at the implant-bone interface may prevent bone formation and limit fixation after cementless knee arthroplasty. Understanding the critical parameters impacting micromotion is required for optimal implant design and clinical performance. However, few studies have focused on unicompartmental knee arthroplasty (UKA). This study assessed the impacts of alignment, surgical, and design factors on implant-bone micromotions for a novel cementless UKA design during a series of simulated daily activities. Three finite element models that were validated for predicting micromotion of cementless total knee arthroplasty (TKA) were loaded with design-specific kinematics/loading to simulate gait (GT), deep knee bending (DKB), and stair descent (SD). The implant-bone micromotion and the porous surface area ideal for bone ingrowth were estimated and compared to quantify the impact of each factor. Overall, the peak tray-bone micromotions were consistently found at the lateral aspect of the tibial baseplate and were consistently higher than the femoral micromotions. The femoral micromotion was insensitive to almost all the factors studied, and the porous area favorable for bone ingrowth was no less than 93%. For a medial uni, implanting the tray 1 mm medially or the femoral component 1 mm laterally reduced the tibial micromotion by 19.3% and 26.3%, respectively. Differences in tray-bone micromotion due to bone moduli were up to 59.8%. A 5 mm more posterior femoral translation increased the tray-bone micromotion by 35.8%. The presence of the tray keel prevented the spread of the micromotion and increased the overall porous surface area, but also increased peak micromotion. The tray peg and the femoral anterior peg had little impact on the micromotion of their respective implants. In conclusion, centralizing the load transfer to minimize tibial tray applied moment and optimizing the fixation features to minimize micromotion are consistent themes for improving cementless fixation in UKA. Perturbation of femoral-bone alignment may be preferred as it would not create under/overhang on the tibia.

PMID 39445747
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PubMedPeerJ2024-10-07

PotatoG-DKB: a potato gene-disease knowledge base mined from biological literature.

Xie Congjiao C, Gao Jing J, Chen Junjie J, Zhao Xuyang X

Potato is the fourth largest food crop in the world, but potato cultivation faces serious threats from various diseases and pests. Despite significant advancements in research on potato disease resistance, these findings are scattered across numerous publications. For researchers, obtaining relevant knowledge by reading and organizing a large body of literature is a time-consuming and labor-intensive process. Therefore, systematically extracting and organizing the relationships between potato genes and diseases from the literature to establish a potato gene-disease knowledge base is particularly important. Unfortunately, there is currently no such gene-disease knowledge base available. In this study, we constructed a Potato Gene-Disease Knowledge Base (PotatoG-DKB) using natural language processing techniques and large language models. We used PubMed as the data source and obtained 2,906 article abstracts related to potato biology, extracted entities and relationships between potato genes and related disease, and stored them in a Neo4j database. Using web technology, we also constructed the Potato Gene-Disease Knowledge Portal (PotatoG-DKP), an interactive visualization platform. PotatoG-DKB encompasses 22 entity types (such as genes, diseases, species, etc.) of 5,206 nodes and 9,443 edges between entities (for example, gene-disease, pathogen-disease, etc.). PotatoG-DKP can intuitively display associative relationships extracted from literature and is a powerful assistant for potato biologists and breeders to understand potato pathogenesis and disease resistance. More details about PotatoG-DKP can be obtained at https://www.potatogd.com.cn/.

PMID 39372719
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