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grass pollen vaccine (DepiQuick)

✓ Approved

Laboratorios LETI · therapeutic agent

What is grass pollen vaccine?

grass pollen vaccine is a therapeutic agent developed by Laboratorios LETI. It is approved for therapeutic indications via injectable (others) or oral (po) or subcutaneous injection or sublingual (sl)/oral transmucosal.

Drug Profile

Brand NamesDepiQuick
CompanyLaboratorios LETI
RouteInjectable (Others), Oral (PO), Subcutaneous Injection, Sublingual (SL)/Oral Transmucosal
StatusApproved
Sources: ClinicalTrials.gov, Laboratorios LETI

Therapeutic Indications

grass pollen vaccine is developed for 3 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersAsthma✓ Approved
Immune system disordersHypersensitivity✓ Approved
Immune system disordersSeasonal allergy✓ Approved

Related Research Articles

PubMedAnnals of botany2026-10-16

Grass silica short cell phytoliths in Pyrenean subalpine grasslands: taxonomy and palaeoecological relevance.

Lara-Recuero Javier J, García-Granero Juan José JJ, Gil-Romera Graciela G, Gómez Daniel D et al.

Subalpine grasslands of the Central Pyrenees (1600-2300 m a.s.l.) are semi-natural ecosystems shaped by millennia of pastoral land use. Reconstructing their long-term dynamics requires proxies with higher taxonomic resolution than Poaceae pollen. Grass silica short cell phytoliths (GSSCPs) offer this potential. We aim to build a taxonomically broad, ecologically grounded reference collection and assess the diagnostic value of GSSCP assemblages across grass lineages and habitats. We inventoried 251 grass species and selected 66 native taxa to maximize phylogenetic breadth (five subfamilies, 14 tribes, 49 genera) and capture pastoral relevance. Leaf phytoliths were extracted from multiple individuals per species, classified under ICPN 2.0, and counted to ≥300 GSSCPs per sample, yielding 29 sub-morphotypes. Multivariate ordinations explored taxonomic and ecological structure. Phytolith assemblages revealed strong taxonomic signals and clear ecological patterns. In Pooideae, specific sub-morphotypes were identified in mesic subalpine pastures dominated by Avenula pratensis and Bromus spp., in open, stress-prone grasslands characterized by Stipa spp. and Achnatherum calamagrostis, and on xerophilous calcareous slopes characterized by Koeleria vallesiana. PACMAD grasses also showed strong diagnostic value: Setaria viridis in low-elevation, warm, nutrient-rich, disturbed habitats; Danthonia decumbens in acidophilous uplands; Eragrostis minor in disturbed dry soils; and Molinia caerulea in hydromorphic meadows. These taxa occur mainly in habitats warmer, drier or more disturbed than the core humid subalpine grasslands, which show more conservative profiles. Ordination analyses confirmed that morphotype-habitat associations structure assemblages along elevational gradients. This first GSSC phytolithotheque for the Central Pyrenees provides an ICPN-compliant framework that enhances the taxonomic and ecological resolution of phytolith-based palaeoecology, improving reconstructions of past vegetation and pastoral dynamics in mountain landscapes.

PMID 42885874
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PubMedInternational journal of molecular sciences2026-10-16

Arabinogalactan Proteins in Pollen-Pistil Interactions: Molecular Regulators of Reproductive Barriers and Compatibility.

Muratova Oksana Alekseevna OA, Natyrov Alexei Nikolaevich AN, Molchanova Tatiana Petrovna TP, Fedoreyeva Larisa Ivanovna LI et al.

Arabinogalactan proteins (AGPs) are a family of highly glycosylated proteins that play an important role in the reproductive process of flowering plants. This review summarizes current knowledge of arabinogalactan proteins at various stages of male and female gametophyte development and in the regulation of their interactions-from pollen grain contact with the stigma, through pollen tube (PT) germination and its guided growth toward the embryo sac, to sperm cell delivery to the egg cell. Particular attention is given to the involvement of AGPs in pollen-pistil recognition, pollen tube growth and guidance, self-incompatibility, and reproductive barriers associated with distant hybridization. By integrating recent findings, we highlight the diverse structural and functional roles of AGPs in reproductive processes and discuss current limitations in understanding their molecular mechanisms. The review also identifies key open questions and promising directions for future research on AGP-mediated regulation of reproductive interactions in angiosperms.

PMID 42883981
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PubMedPlants (Basel, Switzerland)2026-10-16

Do Botanical Gardens Pose a Pollen Allergenicity Risk? A Multi-Method Assessment Integrating Species-Specific Values of Potential Allergenicity and Pollen Concentration Monitoring.

Li Mengxia M, Tang Qi Q, Zong Hua H, Li Xiu X et al.

Botanical gardens serve dual functions of species conservation and public education. In these open-air recreational environments, the pollen allergy risk associated with the garden's structure may impose considerable impacts on public health, yet this risk is often overlooked in landscape design. In this study, we conducted a comprehensive assessment of pollen allergy risk posed by landscape trees in the Chengdu Botanical Garden through landscape tree species composition surveys, flowering phenology observations, potential allergenicity values (VPA) estimation, and year-round pollen concentration monitoring. Six functional zones with decreasing disturbance intensity were designated in the garden. A total of 114 species (42 families, 84 genera) and 1582 individual trees were recorded, of which 76.32% are native to China. The diversity of the garden is moderately high (richness 44.8, Shannon-Wiener 3.13, evenness 0.82). A low VPA profile was observed in the garden. Low-VPA species accounted for 71.93% of species and 75.60% of individuals, while medium-VPA species represented 21.93% of species and 18.65% of individuals. High-VPA species comprised only 6.14% of species and 5.75% of individuals. Despite this low-VPA composition, pollen concentration remained unexpectedly high. Pollen monitoring showed that mean spring pollen concentrations in March and April reached 207.47 and 243.56 grains/cm2, respectively, corresponding to an extremely high risk level (Level 5). Moreover, an early peak appeared in late February (104.90 grains/cm2, Level 3). These elevated concentrations were primarily attributed to a highly concentrated flowering phenology, with 91.22% of landscape tree species flowering from February to May, among which 50.87% bloomed in March and April. Furthermore, sunshine duration exhibited the strongest negative association with spring pollen concentration, while mean wind speed exerted an independent positive effect after controlling for confounders, indicating that meteorological conditions significantly modulate actual exposure risk. These findings indicate that pollen allergy risk assessment should integrate both pollen concentration monitoring and tree VPA classification. Based on a risk framework coupling these two dimensions, the ecological conservation area (habitat protection, no public access) was identified as a high-risk core zone, the themed specialized garden area (specialist taxa display) and ecological recreation area (nature recreation, limited public access) as concentration-dominated secondary risk zones, and the educational leisure area (exhibitions and leisure), as a year-round safe zone. Given its dual mission, management should balance conservation and health through visitor guidance, physical barriers, and phenological regulation, rather than by removing allergenic species.

PMID 42884927
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PubMedAnimals : an open access journal from MDPI2026-10-16

Integrated Assessment of Pollen Substitute Diets in Honey Bees Based on Transcriptional Responses, Immune-Derived Predicted Biological Age, and Survival.

Kim Hyunjee H, Frunze Olga O, Han Sang Mi SM, Woo Soon Ok SO et al.

Heat events and nutritional stress threaten honey bee health, but how pollen substitute formulation shapes responses to acute heat remains unclear. Newly emerged Apis mellifera workers received three pollen substitute diets or two beebread-based reference diets for five days before exposure to 45 °C for 4 h. Expression of 12 genes related to nutrition, endocrine regulation, immunity, oxidative defense, and cellular stress was examined using mixed-effects and multivariate analyses. Immune-derived predicted biological age was estimated before and after heat exposure. Apparent consumption and survival were evaluated in an independent 18-day feeding assay without heat. Significant diet × heat interactions occurred for 10 genes, whereas tor and dome showed no significant interactions. At baseline, Diet2(M) exhibited a transcriptional profile similar to the control and a lower predicted biological age than Diet1(S) and Diet3(O). Diet2(M) also supported higher survival than Diet1(S), despite similar apparent consumption among substitute diets. These findings indicate that pollen substitute composition, rather than apparent consumption alone, can shape physiology and survival. Diet2(M) is therefore a priority candidate for colony-level evaluation, although improved heat tolerance was not demonstrated. These findings may guide the development of supplemental feeds supporting honey bee health under climate-related pollen scarcity and heat risk.

PMID 42883116
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PubMedPlants (Basel, Switzerland)2026-10-16

Caspase-Like Proteases as Contributors in the Functioning of Reproductive Barriers During Distant Hybridization in Solanaceae.

Ulianov Alexej I AI, Golivanov Yaroslav Yu YY, Molchanova Tatiana P TP, Muratova Oksana A OA et al.

Distant hybridization is an important breeding strategy that can effectively expand the genetic pool for developing new, high-yielding, and stress-resistant cultivars. However, reproductive isolation often hinders the application of this approach. Intergeneric reproductive barriers (IRBs) manifest during pollen-pistil interactions in plants belonging to different genera, yet the mechanisms underlying these barriers remain largely unknown. In this study, we investigated pollen-pistil interactions during the progamic phase of fertilization in three Solanaceae species using several intergeneric cross combinations. Pollen of all tested species germinated on the stigma surface, grew through the stylar transmitting tissue, and ceased elongation at a distance of 300-920 µm therefrom due to the action of a reproductive barrier. We suggest that programmed cell death (PCD) is a factor contributing to IRBs in Solanaceae. The obtained data indicate that, in all cross combinations, the rejection of incompatible pollen tubes (PTs) is accompanied by increased activity of caspase-like proteases (CLPs), as confirmed by in vivo visualization of active CLPs and spectrophotometric measurement of their activity. Specifically, incompatible PT growth in stylar tissues during the first 4 h after pollination was accompanied by a five- to six-fold increase in caspase-3-like protease activity. Notably, the arrest of PT growth in distant hybridization shows striking similarity to that observed during S-RNase-based self-incompatibility (SI) in Solanaceae. We anticipate that further research will ultimately provide insights into the regulation of reproductive barriers during distant hybridization.

PMID 42884912
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PubMedFoods (Basel, Switzerland)2026-10-16

Integrated Multi-Omics Analysis Reveals Associations Between Flavor Variation, Bacterial Communities, Metabolites, and Lipids in Commercial Dry-Cured Grass Carp.

Zhang Tianxiao T, Wang Ji J, Huang Xuhui X, Zhang Lili L et al.

Commercial dry-cured grass carp products exhibit considerable flavor variation, but the microbial and biochemical characteristics associated with this variation remain unclear. In this study, six commercial products were comparatively characterized using electronic nose and tongue analyses, GC-MS, full-length 16S rRNA gene sequencing, metabolomics, and lipidomics. Among the six sampled products, Group F exhibited distinct aroma and taste profiles and showed a greater diversity and higher measured levels of volatile compounds on a wet-weight basis, with 1-octen-3-ol, hexanal, nonanal, and (E)-4-decenal among its prominent aroma-active compounds. Bacterial community structures differed significantly among the sampled products, with distinct species-level profiles; notably, Edwardsiella piscicida predominated in Group D, whereas Staphylococcus equorum and Staphylococcus xylosus were abundant in Groups E and F. Metabolomic and lipidomic analyses further revealed pronounced product-specific differences, particularly in organic acid- and amino acid-related metabolites and in glycerolipid and glycerophospholipid profiles. Exploratory correlations suggested potential product-level associations among bacterial taxa, lipid and metabolite profiles, and aroma-active volatiles, although none remained statistically significant after FDR correction. Overall, the results reveal coordinated differences in flavor, bacterial communities, metabolites, and lipids among the six commercial dry-cured grass carp products examined in this study and provide a compositional basis for further investigation of flavor formation.

PMID 42883654
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