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grass pollen vaccine (DepiQuick)

✓ Approved

Laboratorios LETI · therapeutic agent

What is grass pollen vaccine?

grass pollen vaccine is a therapeutic agent developed by Laboratorios LETI. It is approved for therapeutic indications via injectable (others) or oral (po) or subcutaneous injection or sublingual (sl)/oral transmucosal.

Drug Profile

Brand NamesDepiQuick
CompanyLaboratorios LETI
RouteInjectable (Others), Oral (PO), Subcutaneous Injection, Sublingual (SL)/Oral Transmucosal
StatusApproved
Sources: ClinicalTrials.gov, Laboratorios LETI

Therapeutic Indications

grass pollen vaccine is developed for 3 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersAsthma✓ Approved
Immune system disordersHypersensitivity✓ Approved
Immune system disordersSeasonal allergy✓ Approved

Related Research Articles

PubMedPlanta2026-07-17

Scientific approach to reveal the conception indistinct fertilization barriers in interspecific Lilium hybridization: cytological insights.

Basit Abdul A

Lilium belonging to the Liliaceae family, is known as one of the most primitive cut flowers produced commercially in diverse regions of the Northern Hemisphere with almost 110 species. Pre- and post-fertilization hurdles cause problems in the development of interspecific Lilium hybrids due to pollen germination and stigma incompatibility, leading to improper pollen tube growth and seeds with a small embryo and no endosperm. Internal genetic and physiological factors, as well as external climatic factors, strongly influence pollen viability and germination. We linked pistillate analyses as a new way to look deeper into the stylar pollen germination capability and compatibility. Robust pollen staining and in vitro germination serve as indicators for predicting in vivo pollen vigor in interspecific Lilium breeding. Pollen tube growth was determined by how successfully the pollen was received by the pistil, pollen tube growth behavior, the ratio of successfully fertilized ovules, and embryo formation. Some issues in pollen tube behavior during normal pollination, like no germination, abnormal tube growth, and callose deposits, and some unusual growth patterns of pollen tubes, either twisted and swollen, have been encountered. During diakinesis, chromosomes are normally paired into bivalents, allowing segregation during gamete formation. However, in some cases, meiotic abnormalities such as asymmetric division, laggard chromosomes, or chromosome bridges can lead to meiotic polyploidization, forming 2n gametes. On the other hand, irregular homoeologous chromosomes could underlie poor fertility or sterility in hybrid combinations due to improper pairing. Extensive cytological analyses play a significant role in identifying the key barriers encountered at pre- and post-fertilization stages. For successful interspecific hybridization, it is necessary to thoroughly assess pre- and post-fertilization barriers to avoid breeding obstruction.

PMID 42467267
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PubMedThe Analyst2026-07-17

Pollen-stigma biomimetic framework: a CuCo2O4 nanozyme-based electrochemical aptasensor for ultrasensitive aflatoxin B1 detection.

Long Yanyi Y, Zhang Ruiming R, Zhang Lujie L, Peng Ruixue R et al.

Inspired by the highly specific recognition and signal amplification of pollen germination on a stigma, we propose a biomimetic electrochemical sensing strategy for ultrasensitive aflatoxin B1 (AFB1) detection. In this pollen-mimetic system, CuCo2O4 nanoflowers serve as "pollen-mimetic grains", with their bimetallic Cu/Co centers functioning as an internal "energy conversion system" for robust signal output. AFB1 acts as the "stigmatic secretion", triggering the release of CuCo2O4 nanoprobes from the aptamer complex via target-induced strand displacement. The released nanoprobes are subsequently captured by a hairpin probe on the electrode, which mimics the "stigmatic receptor", through specific DNA hybridization. Finally, the captured CuCo2O4 nanozyme catalyzes the oxidation of TMB, mimicking "pollen germination and tube growth" to amplify the recognition event into a measurable electrochemical signal. Under optimized conditions, this biomimetic sensor achieves a wide linear range (10-11 to 10-4 mg mL-1) and an ultralow detection limit of 2.59 fg mL-1, with excellent reproducibility, stability, and selectivity. Recovery rates in real food samples range from 97.61% to 101.53%. This pollen-stigma biomimetic framework not only provides a highly sensitive platform for AFB1 detection but also establishes a new paradigm for designing high signal-to-noise ratio biosensors for complex matrices.

PMID 42464934
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PubMedScientific reports2026-07-17

Comparative reproductive biology and fitness tradeoffs across reproductive phenotypes in dioecious and gynodioecious papaya.

Nagar Sonu S, Pathak Anshuman A, Patra Suvrajit S, Kumar Ajay A et al.

Papaya (Carica papaya L.) exhibits a polymorphic sexual system encompassing both dioecious and gynodioecious cultivars, yet the quantitative reproductive fitness consequences of its multiple sex forms remain insufficiently characterised. The present investigation provides a comprehensive evaluation of pre- and post-fertilisation reproductive traits across six floral phenotypes such as staminate, pistillate, reduced elongata, elongata, pentandria, and carpelloid pentandria, in four commercially important cultivars representing dioecious ('Ranchi Local' and 'TNAU Papaya CO-8') and gynodioecious ('F₁ Red Lady' and 'Arka Prabhat') breeding systems. Pollen production per anther, viability, in vitro germination, pollen size, time of anthesis, anther dehiscence, and stigmatic receptivity duration were quantified, along with post-fertilisation parameters including ovule maturation period, ovule degeneration percentage, fruit-set duration, and viable seed-set. Staminate flowers produced the highest pollen output (11,396-11,802 grains per anther) with superior viability (71-75%) and germination (63-68%), whereas reproductive fitness declined progressively across hermaphroditic forms in the order RE > EL > PA > CP. Carpelloid pentandria flowers exhibited 39-45% lower pollen output, 66-68% reduced viability, the highest ovule degeneration (24-26%), and the lowest viable seed-set (46-51%). Pistillate flowers maintained extended stigmatic receptivity (66-73 h), minimal ovule degeneration (16-18%), and the highest seed-set (59-69%). Correlation analysis revealed strong positive associations among pollen attributes and seed production, while ovule degeneration and delayed reproductive timing were negatively associated with reproductive success. The findings establish a clear reproductive fitness gradient among papaya sex forms and provide quantitative reference data for breeding, cultivar selection, and clarifying the evolutionary implications of sexual-system diversity in papaya.

PMID 42463862
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PubMedJournal of veterinary pharmacology and therapeutics2026-07-17

Residue Kinetics and Dietary Risk Assessment of Diazepam and Its Metabolites in Grass Carp (Ctenopharyngodon idella): Implications for Aquaculture Safety.

Shan Qi Q, Xu Feng F, Wu Mingyuan M, Zhou Hao H et al.

Diazepam (DZP), a benzodiazepine sedative, has been increasingly detected in various aquatic products including fish, shrimp, and crab in recent surveillance studies, raising public health concerns. This study systematically investigates the residue behavior, metabolite profile, and dietary risk of DZP in grass carp (Ctenopharyngodon idella) following oral administration at a dose of 500 μg/kg body weight. Concentrations of DZP and its metabolites in plasma and tissues were determined using ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), and the drug concentration-time data were fitted using a non-compartmental model embedded in WinNonLin 6.1 pharmacokinetic software. The results indicate that DZP exhibits prolonged elimination kinetics, with tissue elimination half-lives (T1/2λz) ranging from 309.44 to 509.75 h, and residues in skin-on muscle did not fall below the limit of quantification until 98 days. Metabolite analysis identified nordiazepam as the primary metabolite, with its concentration surpassing that of the parent compound by Day 21 post-administration, establishing it as a reliable residue marker for DZP in grass carp. The peak human health risk index (HRI) value was 0.392 on Day 4, remaining above the alert threshold (HRI ≥ 0.1) for 21 days, though all values remained below the safety limit (HRI < 1). These findings provide critical data to support the regulation of aquaculture practices and the assessment of dietary exposure risks associated with DZP-contaminated aquatic products.

PMID 42466529
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PubMedClinical infectious diseases : an official publication of the Infectious Diseases Society of America2026-07-17

Artificial Intelligence Across the Vaccine Clinical Trial Lifecycle: Evidence, Readiness, and Guardrails.

Idriss Jad J, Kalash Suha S, Faraj Jana Abu JA, Nolan Lauren L et al.

Artificial intelligence (AI) is increasingly being used to support clinical research, but its value in vaccine clinical trials requires careful evidence-based assessment. Vaccine trials pose distinctive challenges, including high safety expectations in healthy participants, evolving pathogen exposure and baseline immunity, incomplete correlates of protection, applicability of findings to intended-use populations, and intense public scrutiny. We conducted a structured, vaccine-focused narrative review of AI applications across the vaccine trial lifecycle, supplemented by targeted clinical trial and vaccine pharmacovigilance studies with directly transferable methods. In the combined evidence base, evidence is strongest for operational uses, particularly recruitment, eligibility screening, trial matching, and risk-based monitoring. Applications to immune-response interpretation, correlates of protection, and vaccine safety surveillance are promising but remain less prospectively validated. Responsible adoption should be guided by intended tool use, evidence of strength, data governance, regulatory expectations, and preservation of human scientific and safety judgment.

PMID 42464875
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PubMedIranian journal of nursing and midwifery research2026-07-17

Investigate the Relationship Between Receiving the COVID-19 Vaccine and Menstrual Disorders among Females of Reproductive Age in Jeddah, Saudi Arabia.

Esheaba Ola M OM, Fouly Howieda A HA, Kassem Fathia K FK

There are many physical side effects of the COVID-19 vaccine, including unexpected changes occurring in menstrual bleeding. This study aimed to assess the relation between the COVID-19 vaccine and disorders in menstruation among females of reproductive age. Participants were recruited from a nonprobability snowball sampling targeted at females who are living in Jeddah city between March 2022 and August 2022, Kingdom of Saudi Arabia (KSA). A quantitative cross-sectional design was utilized to conduct the study, a nonexperimental design based on a single observation point. The sample size is estimated by the G*Power software to be 180, considering missed cases, it increased to 197. Regarding menstrual changes, n = 86 (43.65%) experienced a delay, and about one-third reported an earlier menstruation cycle. A significant relationship is observed between nationality, occupation, and changes in period (t = 3.89, P < 0.001 and t = -2.94, P < 0.004). There is no significant difference in the occurrence of complications among the different vaccine types. Receiving the COVID-19 vaccine was strongly linked with unexpected disturbance in menstruation among the studied group, from simple menstrual irregulates to reported amenorrhea after receiving the booster doses. However, the occurrence of menstrual cycle delays was not linked to the vaccine type. Further studies should be done to investigate each type of vaccine specifically to determine if the type of vaccine affects the reproductive function generally not only the menstrual cycle, in a larger survey for more generalizability.

PMID 42466287
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