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DTwP-HepB-Hib-IPV vaccine (Easysix)

✓ Approved

Panacea Biotec Limited · Recombinant Proteins · Recombinant Proteins

What is DTwP-HepB-Hib-IPV vaccine?

DTwP-HepB-Hib-IPV vaccine is a recombinant proteins developed by Panacea Biotec Limited. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection.

Drug Profile

Brand NamesEasysix
CompanyPanacea Biotec Limited
Drug ClassRecombinant Proteins, Vaccine
RouteInjectable (Others), Intramuscular (IM) Injection
StatusApproved
Sources: ClinicalTrials.gov, Panacea Biotec Limited

Therapeutic Indications

DTwP-HepB-Hib-IPV vaccine is developed for 5 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Infections and infestationsDiphtheria✓ Approved
Infections and infestationsHepatitis B✓ Approved
Infections and infestationsPertussis✓ Approved
Infections and infestationsTetanus✓ Approved
Surgical and medical proceduresPolio immunisation✓ Approved

Related Research Articles

PubMedSSM. Mental health2026-07-17

Adverse childhood experiences, intimate partner violence, and postpartum depressive symptoms in a pregnancy cohort in Central Vietnam.

Tran Dinh Trung DT, Tran Binh Thang BT, Vo Van Thang VT, Nguyen Vu Quoc Huy VQH et al.

Adverse Childhood Experiences (ACEs), intimate partner violence (IPV), and maternal depression are prevalent globally. IPV mediates the association between ACEs and depressive symptoms. However, the effects of ACEs and IPV on postpartum depressive symptoms have primarily been examined using cross-sectional designs. This cohort study explored pathways linking ACEs, IPV during pregnancy (p-IPV), and postpartum IPV (IPV-12) with depressive symptoms at 6 and 12 months postpartum. This prospective cohort study recruited 942 pregnant women in their last trimester in Da Nang, Vietnam, and followed them up to 12 months postpartum. ACEs were assessed using the Adverse Childhood Experiences Questionnaire at baseline. IPV was measured using the Revised Conflict Tactics Scale during pregnancy (p-IPV) and 12 months postpartum (IPV-12). Postpartum depressive symptoms (PPDS) was assessed using the Patient Health Questionnaire-9 at 6 (PPDS-6) and 12 (PPDS-12) months postpartum. Mediation analysis using the Karlson-Holm-Breen method was performed to examine direct and indirect path coefficients. Loss to follow-up was 20.0% at 6 months (n = 753) and 15.3% at 12 months (n = 638). Mediation analysis indicated that ACEs influenced PPDS-12 (total path coefficient = 0.536). p-IPV, PPDS-6, and IPV-12 fully mediated this relationship, accounting for 85.44% of the total effect. IPV-12 was the strongest mediator (71.74%), followed by PPDS-6 (7.77%) and p-IPV (5.93%). IPV types (psychological, physical, sexual) demonstrated significant mediating roles. Exposure to IPV is critical for the ACE-PPDS relationship. IPV exposure at 12 months postpartum may strongly mediate the cumulative relationship between adversity and violence exposure. Community-based ACE and IPV screening is recommended to identify risk for higher depressive symptoms in postpartum women.

PMID 42465561
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PubMedEuropean journal of psychotraumatology2026-07-17

Body dysmorphic disorder symptom severity and intimate partner violence: the role of PTSD and DSO symptom domains.

Lahav Yael Y, Avidor Sharon S

Background: Body dysmorphic disorder (BDD) is common among survivors of interpersonal trauma. However, the relationship between BDD symptoms and intimate partner violence (IPV), as well as the roles of posttraumatic stress disorder (PTSD) symptom domains and disturbances in self-organization (DSO) symptom domains, remain unclear.Objective: This longitudinal study, which included three waves of data collection (T1, T2, T3), examined: (1) BDD symptom severity as a concomitant of IPV; (2) associations between PTSD and DSO symptom domains and BDD symptom severity in IPV survivors; and (3) the mediating roles of PTSD and DSO symptom domains in the relationship between the degree of IPV exposure and BDD symptoms, while controlling for age, history of childhood abuse, and IPV polyvictimization.Method: An online survey was completed by a convenience sample of 422 adult women, 76.8% (n = 324) of whom reported IPV exposure. PTSD symptom domains, DSO symptom domains, and BDD symptom severity and covariates were assessed via self-report measures.Results: Analyses indicated higher BDD symptom severity and a greater proportion of clinically significant BDD symptoms at T3 among participants exposed to IPV at T1. A sense of threat, negative self-concept, and disturbed relationships at T2 were associated with elevated BDD symptom severity at T3. However, only negative self-concept mediated the relationship between the degree of IPV exposure and BDD symptom severity; greater IPV exposure at T1 was associated with increased negative self-concept at T2, which, in turn, was associated with higher BDD symptom severity at T3.Conclusions: The current findings suggest that IPV survivors are at heightened risk for BDD symptoms and highlight negative self-concept, a component of DSO, as a potential mechanism underlying this vulnerability.

PMID 42464755
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PubMedGlobal mental health (Cambridge, England)2026-07-17

Intimate partner violence and the dual burden of anxiety and depression among women in Zambia: Spatial inequalities and implications for the sustainable development goals.

Miah Md Salek MS, Uddin Mohammad Shahab MS

This study evaluated the association between Intimate Partner Violence (IPV) and mental health indicators, providing evidence to inform maternal health policy. This study used the first nationally representative cross-sectional data on mental health symptoms from the 2024 Zambia Demographic and Health Survey (ZDHS), including 13,951 women aged 15-49 years. Anxiety and depression were assessed using the GAD-7 and PHQ-9 scales, with a score of ≥10 indicating the presence of symptoms. Stepwise, survey-weighted multivariable logistic regression was employed to examine the associations of mental health indicators and various dimensions of IPV, reporting adjusted odds ratios (aORs) and 95% confidence intervals (CIs). Physical IPV was significantly associated with higher odds of Depression aOR= 3.89; 95% CI: 2.16-6.95; p < 0.001), while Emotional IPV was also associated with higher odds of Depression aOR = 3.50; 95% CI: 2.09-5.86; p < 0.001). Similarly, Any IPV was associated with substantial higher odds with Depression aOR = 2.90; 95% CI: 1.80-4.67, p < 0.001) and Anxiety aOR = 2.05; 95% CI: 1.20-3.50, p = 0.008). These findings provide evidence-based, actionable insights for policymakers to integrate mental health and IPV prevention in high-burden provinces to meet the targets of SDG 3 and SDG 5.

PMID 42466270
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PubMedTrauma, violence & abuse2026-07-17

Barriers to Accessing Intimate Partner Violence Resources Among Latina Immigrants: A Scoping Review.

Buturla Tiffany T, Almodóvar Samuel S, Frasso Rosemary R

Intimate partner violence (IPV) is a leading cause of morbidity and mortality among women in the United States. Although intervention services exist, resources are limited, and barriers persist for many. These challenges are particularly pronounced among the growing population of Latina immigrants, who face significant obstacles to accessing such services. We conducted a scoping review to identify and synthesize research focusing on barriers to accessing IPV resources among Latina immigrants. We searched PubMed, Scopus, CINAHL, and SocINDEX. Two authors independently screened each article by title and abstract, followed by a full-text review for those that met the inclusion criteria. Additionally, the reference lists of identified studies were reviewed to identify additional studies that met the inclusion criteria. Thirty studies were included in the final analysis. Two authors independently extracted data from each article. Language inaccessibility, cultural norms, and immigration status were commonly identified barriers to accessing IPV resources. Study participants were often isolated due to a complex combination of coercive control, fear of authorities, separation from community, and lack of knowledge about resources and rights. These barriers were related to and further exacerbated by low socioeconomic status. Latinas who attempted to access resources were met with institutional and structural barriers. To our knowledge, this is the first scoping review examining barriers to accessing IPV resources among Latina immigrants. The identified barriers highlight the need for culturally competent and linguistically accessible interventions. Given the rapidly changing environment surrounding immigration in the United States, research-informed advocacy work is urgently needed.

PMID 42464034
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PubMedGlobal mental health (Cambridge, England)2026-07-17

Resilience among women survivors of intimate partner violence: Coping, meaning-making, and well-being.

Tini Çiğdem Ç, Sakiz Halis H

This qualitative study explores how women survivors of intimate partner violence (IPV) cope with abuse and reconstruct well-being and meaning in their lives. The study was conducted with 16 women aged between 27 and 51 living in three cities in the southeastern region of Türkiye. Participants were recruited through women's shelters and non-governmental organizations (NGOs) using purposive and snowball sampling. Data were collected through semi-structured interviews and analyzed using thematic analysis. The findings indicate that women's experiences of violence were shaped by sociocultural gender norms and included physical, psychological, sexual, and economic abuse. Participants described multiple coping strategies, including seeking social support, emotional expression, religious coping, and resisting stigmatization. Women's pathways toward well-being involved gaining economic independence, developing healthier communication patterns, and investing in personal development. Meaning-making processes included redefining self-identity, motherhood, reconnecting with positive experiences, and interpreting survival as a source of strength. The findings highlight survivors' agency and resilience and underline the importance of social, psychological, and economic support mechanisms in facilitating recovery following IPV.

PMID 42466263
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PubMedClinical infectious diseases : an official publication of the Infectious Diseases Society of America2026-07-17

Artificial Intelligence Across the Vaccine Clinical Trial Lifecycle: Evidence, Readiness, and Guardrails.

Idriss Jad J, Kalash Suha S, Faraj Jana Abu JA, Nolan Lauren L et al.

Artificial intelligence (AI) is increasingly being used to support clinical research, but its value in vaccine clinical trials requires careful evidence-based assessment. Vaccine trials pose distinctive challenges, including high safety expectations in healthy participants, evolving pathogen exposure and baseline immunity, incomplete correlates of protection, applicability of findings to intended-use populations, and intense public scrutiny. We conducted a structured, vaccine-focused narrative review of AI applications across the vaccine trial lifecycle, supplemented by targeted clinical trial and vaccine pharmacovigilance studies with directly transferable methods. In the combined evidence base, evidence is strongest for operational uses, particularly recruitment, eligibility screening, trial matching, and risk-based monitoring. Applications to immune-response interpretation, correlates of protection, and vaccine safety surveillance are promising but remain less prospectively validated. Responsible adoption should be guided by intended tool use, evidence of strength, data governance, regulatory expectations, and preservation of human scientific and safety judgment.

PMID 42464875
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