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MF

MF-59 (MF59)

✓ Approved

Novartis AG · Small Molecule · Small Molecule

What is MF-59?

MF-59 is a small molecule developed by Novartis AG. It is approved for therapeutic indications via injectable (others).

Drug Profile

Brand NamesMF59
CompanyNovartis AG
Drug ClassSmall Molecule
RouteInjectable (Others)
StatusApproved
Sources: ClinicalTrials.gov, Novartis AG

Therapeutic Indications

MF-59 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresOral appliance application✓ Approved

Related Research Articles

PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-10-15

Yoda1-Functionalized Nanozymes Coordinate Piezo1 Activation and Mitochondrial Protection to Reprogram the Diabetic Osteoimmune Micromilieu and Promote Vascularized Bone Repair.

Deng Qing-Song QS, Wang Ang A, Zhang Ren R, Li Xu-Ran XR et al.

Despite advances in bone tissue engineering, repairing diabetic bone defects remains a formidable challenge. Here, we present an innovative strategy for diabetic bone regeneration, the BCPG-MF@Y scaffold, which features diamond lattices of 3D-printed biphasic calcium phosphate (BCP) integrating porous gelatine methacryloyl (pGelMA) hydrogels embedded with Yoda1-functionalized manganese dioxide-ferritin (MF@Y) biomimetic nanozymes. Our comprehensive analyses revealed that the MF@Y nanozyme orchestrates mitochondrial homeostasis in bone mesenchymal stem cells (BMSCs), effectively scavenges mtROS, maintains mitochondrial membrane potential, modulates mitochondrial permeability transition pore dynamics, and prevents mitochondrial DNA leakage into the cytosol. This leads to inhibition of cGAS‒STING pathway activation, rejuvenation of senescent cells, reduced inflammation, and control of BMSC differentiation. Yoda1-mediated activation of Piezo1 mimics mechanical stimulation, promoting osteogenic differentiation while inhibiting adipogenic and osteoclastic differentiation. The BCPG-MF@Y scaffold synergistically reprograms the osteoimmune micromilieu by protecting mitochondria and activating Piezo1, showing significant promise for vascularized bone repair in diabetic conditions and potential applications in chronic inflammatory disorders.

PMID 42875724
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PubMedFrontiers in veterinary science2026-10-15

Case Report: Epitheliotropic cutaneous presentation of multicentric diffuse large B-cell lymphoma in a dog.

Kim Gyu-Hyun GH, Ko Byung-Gee BG, Kim Se-Hoon SH, Seo Kyoung-Won KW et al.

Diffuse large B-cell lymphoma (DLBCL) is the most common histological subtype of canine multicentric lymphoma, whereas epitheliotropism is classically associated with cutaneous T-cell lymphoma. A 9-year-old neutered male Chihuahua was diagnosed with stage IVb multicentric lymphoma and achieved complete remission with a UW-25 L-CHOP protocol. However, an upper lip mass, cytologically consistent with lymphoma, developed during remission. Electrochemotherapy was performed for local control and resulted in marked reduction of the lesion. The dog later developed recurrent peripheral lymphadenopathy and multiple progressive cutaneous masses despite various chemotherapy protocols and was euthanized at week 59 because of progressive clinical deterioration. Histopathology confirmed diffuse large cell lymphoma in the submandibular lymph node, whereas the cutaneous lesions showed neoplastic lymphoid infiltration with multifocal epidermal invasion, mimicking epitheliotropic T-cell lymphoma. Immunohistochemistry (IHC) confirmed diffuse CD20 expression in both sites, with CD3 labeling limited to scattered background lymphocytes. These findings supported the interpretation of secondary cutaneous involvement of DLBCL with a highly unusual epitheliotropic pattern and emphasize the importance of IHC for accurate immunophenotypic classification of cutaneous lymphoma lesions.

PMID 42876514
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PubMedEuropean heart journal. Case reports2026-10-15

Modified balloon-assisted shoehorn technique for transcatheter aortic valve implantation in functionally horizontal anatomy: a case report.

Patil Nilkanth N, Menon Rajeev R, Anne Uday Kiran UK, Gurram Pragathi P et al.

Transcatheter aortic valve implantation (TAVI) in bicuspid aortic valve (BAV) poses unique challenges. We report a case in which an apparently benign anatomy resulted in failure of conventional delivery strategies and required a novel balloon-assisted bailout technique. A 59-year-old man with a background history of liver cirrhosis presented with severe aortic stenosis due to type 1 BAV. The patient was in Child-Pugh class A with model for end-stage liver disease (MELD) score of 14; hence, he was planned for TAVI in view of high surgical risk. Pre-procedural computed tomography showed a favourable left ventricular (LV)-aortic angle, but the fused non-coronary and right-coronary cusp behaved like functional horizontal anatomy. Various previously described wire and balloon-assisted techniques failed to deliver the valve. A novel balloon-assisted modified 'shoe-horn' technique, by inflating a 16 mm balloon in non-coronary sinus, altered the delivery trajectory and enabled successful valve delivery. BAV with right non-coronary cusps fusion may behave like horizontal anatomy, despite favourable LV-aortic angle. A modified balloon-assisted shoe-horn technique can facilitate valve delivery when conventional methods fail. This case highlights an under-recognized mechanism of valve delivery failure in BAV and emphasizes the importance of preparedness for advanced bailout strategies.

PMID 42876890
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PubMedGerontology & geriatrics education2026-10-15

Multidisciplinary perspectives on geriatric mental health service delivery: a mixed-method survey study in a large integrated healthcare system.

Wyman Mary F MF, Sorocco Kristen K, Punshon Sarah S, Lennon Danielle B DB et al.

To guide training development efforts within the context of the geriatric mental health (MH) workforce shortage, we examined provider perspectives on serving older adults in the Veterans Health Administration (VA), the largest integrated health care system in the U.S. For this mixed-method observational study, 489 multidisciplinary VA MH clinicians across five sites responded to an e-mail invitation to complete a survey assessing confidence in serving older adults with and without cognitive disorders, perceived barriers to providing services, and importance of training in geriatric MH. Text comments from a subset of participants (N = 59) were analyzed using thematic consensual qualitative analysis. Quantitative results indicate that most respondents (n = 418, 92.3%) endorsed the importance of having skills for serving older adults but reported modest self-efficacy, especially for delivering treatments and for serving patients with cognitive disorders. Barriers related to clinic systems were most frequently endorsed. Perceived need for training was high, with few differences by provider or setting characteristics. Qualitative data integration provided convergent evidence for the main findings. Our study contributes to the growing literature on providing MH services for older adults, including those with dementia, and can inform efforts to address the geriatric workforce shortage.

PMID 42875734
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PubMedCardiovascular toxicology2026-10-15

Impact of Dimethyl Sulfoxide on Early Cardiotoxicity After Allogeneic Hematopoietic Stem Cell Transplantation.

Lábska V V, Mladosievičová B B, Dúbrava J J, Žiaková B B et al.

During the COVID-19 pandemic, the use of cryopreserved grafts in allogeneic hematopoietic stem cell transplantation (HSCT) increased substantially. Dimethyl sulfoxide (DMSO), used as a cryoprotective agent, is well recognized for its infusion-related toxicity; however, its impact on cardiac function remains unclear. This prospective study included 96 consecutive patients (median age 46 years) undergoing allogeneic HSCT. Patients were divided according to graft type into cryopreserved (n = 59, 61.5%) and non-cryopreserved (n = 37, 38.5%) groups. Comprehensive echocardiographic assessment was performed before and after transplantation. Significant changes were observed in diastolic parameters (E/A, and E/E'), structural parameters (left ventricular mass and left ventricular mass index), global longitudinal strain (GLS), and right ventricular ejection fraction following HSCT. In the cryopreserved group, E/A ratio decreased below the normal range and E/E' ratio increased significantly, whereas no such changes were observed in the non-cryopreserved group. During the 30-day follow-up period, symptomatic cardiovascular toxicity occurred in 5 patients (5.2%), while subclinical cancer therapy-related cardiac dysfunction was detected in 16 patients (16.7%). Receiver operating characteristic (ROC) analysis demonstrated that GLS predicted cardiotoxicity with an area under the curve (AUC) of 0.88 (95% CI, 0.79-0.98; p < 0.0001). At a cut-off value of - 16.8%, sensitivity was 100% and specificity was 79%. Cryopreserved graft administration may be associated with early alterations in left ventricular diastolic function, potentially reflecting DMSO-related cardiotoxicity. GLS appears to be a sensitive marker for the early detection and prediction of cardiotoxicity in patients undergoing allogeneic HSCT.

PMID 42875553
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PubMedZhonghua er ke za zhi = Chinese journal of pediatrics2026-10-15

[Clinical analysis of 5 cases of pediatric respiratory viral sepsis].

Long Y Y, Yuan T Y TY, Zhao L L, Xu J J et al.

Objective: To analyze the clinical characteristics of pediatric respiratory viral sepsis and to improve clinicians' awareness of this disorder. Methods: Case series study. The study retrospectively reviewed the clinical data of 5 children with respiratory viral sepsis treated at Department of Pulmonary and Critical Care Medicine, Kunming children's hospital between March 2023 and January 2026, analyzing their clinical manifestations, laboratory findings, treatment courses, and outcomes. Results: Among the 5 cases of respiratory viral sepsis, there were 2 males and 3 females, and the ages were 3 years and 8 months, 4 years, 4 years and 7 months, 5 years and 2 months, and 8 years and 10 months respectively. All 5 cases had fever, 3 cases had cough, 2 cases had breathing difficulties and 1 each case of skin mottling, thrombocytopenia, and convulsions and consciousness disorder. Laboratory tests showed that the white blood cell count was (2.06-11.86)×109/L, platelet count (26-262)×109/L, C-reactive protein 0.62-68.15 mg/L, procalcitonin 0.09-0.35 μg/L and interleukin-6 0.50-19.64 ng/L. Pathogen examination showed 3 cases of influenza A virus infection, 1 case of adenovirus infection, and 1 case of adenovirus combined with parainfluenza virus infection. All 5 patients recovered and were discharged after comprehensive treatment including antiviral therapy, respiratory support, and immunomodulation, with a hospital stay of 8-59 d. Conclusions: Respiratory viral infections can cause multiple organ dysfunction in children and meet the diagnostic criteria for sepsis. Greater clinical attention should be paid to the diagnosis, recognition, and management of viral sepsis in children.

PMID 42876102
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