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DTwP-HB-Hib vaccine (Pentavac SD, SSI / Pentavac PFS, SSI)

✓ Approved

Serum Institute of India Pvt. Ltd. · Vaccine · Vaccine

What is DTwP-HB-Hib vaccine?

DTwP-HB-Hib vaccine is a vaccine developed by Serum Institute of India Pvt. Ltd.. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection.

Drug Profile

Brand NamesPentavac SD, SSI, Pentavac PFS, SSI
CompanySerum Institute of India Pvt. Ltd.
Drug ClassVaccine
RouteInjectable (Others), Intramuscular (IM) Injection
StatusApproved
Sources: ClinicalTrials.gov, Serum Institute of India Pvt. Ltd.

Therapeutic Indications

DTwP-HB-Hib vaccine is developed for 4 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsDiphtheria✓ Approved
Infections and infestationsHepatitis B✓ Approved
Infections and infestationsPertussis✓ Approved
Infections and infestationsTetanus✓ Approved

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Textbook Outcome After Hepatoblastoma Resection: Definition, Failure Modes, and Risk-Adjusted Benchmarking in a Tertiary European Center.

Fuchs Juri J, Rabaux-Eygasier Lucas L, Hery Géraldine G, Fouquet Virginie V et al.

Textbook Outcome (TO) has emerged as a composite quality metric for benchmarking perioperative performance in adult hepatobiliary surgery. Its role in pediatric oncologic liver surgery remains insufficiently explored and TO has never been defined for hepatoblastoma resection. Single-center cohort study including children undergoing curative-intent liver resection for hepatoblastoma. Textbook Outcome after hepatoblastoma resection (TO-HB) was defined as an all-or-none composite comprising: (i) no postoperative complications (CCI = 0), (ii) no prolonged length of stay (≤ procedure-specific 75th-percentile), (iii) no reoperation within 90 days, (iv) no unplanned readmission within 90 days, and (v) no 90-day mortality. Case-mix adjustment was performed using ridge-penalized logistic regression with pre-specified covariates. Model performance was evaluated in terms of overall accuracy and calibration, including the Brier score and calibration-in-the-large, with bootstrap internal validation, to support risk-adjusted benchmarking analyses. TO-HB was achieved in 60/108 patients (55.6%). Failure to achieve TO-HB was predominantly driven by postoperative complications (38/48; 79%) and prolonged length of stay (18/48; 38%). TO-HB rates decreased with increasing surgical complexity, including higher PRETEXT stage and more extensive hepatectomy types. Risk-adjusted predictions were narrowly distributed around the overall TO rate (mean predicted probability 0.556), with preserved population-level calibration. The observed-to-expected ratio for TO-HB was 1.00, corresponding to a risk-standardized TO-HB rate of 55.6% (95% CI 42.4-71.5%). TO-HB is a feasible and stringent benchmark for perioperative quality in hepatoblastoma surgery. Failure to achieve TO-HB is predominantly driven by postoperative morbidity rather than mortality or reintervention, highlighting postoperative complications as target for quality improvement.

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PubMedBiosensors & bioelectronics2026-07-17

A methylene blue based electrochemical assay to quantify haemoglobin in blood for point-of-care anaemia diagnosis.

de Mariscal-Molina Nerea N, Hernández Gonzalo G, Piper Andrew A, Rossetti Marianna M et al.

Anaemia is a blood disorder that affects individuals of all ages, genders, and ethnicities. It results from a decrease in the number or functionality of erythrocytes or haemoglobin (Hb), leading to a deficit in oxygen transport. Anaemia can be classified into different phenotypic groups, such as haemolytic, microcytic, macrocytic, hypochromic, aplastic, and Iron Deficiency Anaemia (IDA). Its diagnosis and classification rely on the measurement of several biomarkers, where Hb is ubiquitous in all of them. Current methods for anaemia diagnosis rely on a complete haemogram, which usually requires larger volumes of sample and hinders its integration into a Point-of-Care (PoC) device. Herein, we developed an analytical method based on the interaction between methylene blue (MB) and Hb on screen printed carbon electrodes (SPCE). The system has been optimized in PBS and subsequently evaluated in whole blood real samples. Different chemical lysing buffers for erythrocytes have been studied, and the erythrocyte's lysing buffer has been chosen as the most suitable for this analytical test. An evaluation of the calibration curves is presented, giving a LOD, LOQ, and sensitivity of 664 nM, 2.8 μM, and 0.22 μM-1, respectively, allowing the clinically relevant quantification of Hb in only 1 μL of a neat blood sample. This detection method is feasible for the development of a cost-effective multiplexed PoC device with the integration of biosensors for other anaemia biomarkers, providing a fuller view to patients and clinicians of anaemia status and classification.

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Artificial Intelligence Across the Vaccine Clinical Trial Lifecycle: Evidence, Readiness, and Guardrails.

Idriss Jad J, Kalash Suha S, Faraj Jana Abu JA, Nolan Lauren L et al.

Artificial intelligence (AI) is increasingly being used to support clinical research, but its value in vaccine clinical trials requires careful evidence-based assessment. Vaccine trials pose distinctive challenges, including high safety expectations in healthy participants, evolving pathogen exposure and baseline immunity, incomplete correlates of protection, applicability of findings to intended-use populations, and intense public scrutiny. We conducted a structured, vaccine-focused narrative review of AI applications across the vaccine trial lifecycle, supplemented by targeted clinical trial and vaccine pharmacovigilance studies with directly transferable methods. In the combined evidence base, evidence is strongest for operational uses, particularly recruitment, eligibility screening, trial matching, and risk-based monitoring. Applications to immune-response interpretation, correlates of protection, and vaccine safety surveillance are promising but remain less prospectively validated. Responsible adoption should be guided by intended tool use, evidence of strength, data governance, regulatory expectations, and preservation of human scientific and safety judgment.

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Investigate the Relationship Between Receiving the COVID-19 Vaccine and Menstrual Disorders among Females of Reproductive Age in Jeddah, Saudi Arabia.

Esheaba Ola M OM, Fouly Howieda A HA, Kassem Fathia K FK

There are many physical side effects of the COVID-19 vaccine, including unexpected changes occurring in menstrual bleeding. This study aimed to assess the relation between the COVID-19 vaccine and disorders in menstruation among females of reproductive age. Participants were recruited from a nonprobability snowball sampling targeted at females who are living in Jeddah city between March 2022 and August 2022, Kingdom of Saudi Arabia (KSA). A quantitative cross-sectional design was utilized to conduct the study, a nonexperimental design based on a single observation point. The sample size is estimated by the G*Power software to be 180, considering missed cases, it increased to 197. Regarding menstrual changes, n = 86 (43.65%) experienced a delay, and about one-third reported an earlier menstruation cycle. A significant relationship is observed between nationality, occupation, and changes in period (t = 3.89, P < 0.001 and t = -2.94, P < 0.004). There is no significant difference in the occurrence of complications among the different vaccine types. Receiving the COVID-19 vaccine was strongly linked with unexpected disturbance in menstruation among the studied group, from simple menstrual irregulates to reported amenorrhea after receiving the booster doses. However, the occurrence of menstrual cycle delays was not linked to the vaccine type. Further studies should be done to investigate each type of vaccine specifically to determine if the type of vaccine affects the reproductive function generally not only the menstrual cycle, in a larger survey for more generalizability.

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PubMedFrontiers in public health2026-07-17

Reframing vaccine narrative: a co-production study of a media campaign intervention to address childhood vaccine hesitancy among Nigerian parents and caregivers.

Ike Tarela Juliet TJ, Jidong Dung Ezekiel DE, Obi Callistar Kidochukwu CK, Ntaji Maureen Iru MI et al.

Childhood vaccine hesitancy is a public health concern. Nigeria is one of the countries with the highest rates of zero-dose childhood vaccination. This study makes an original contribution by adopting a co-production approach underpinned by interpretative phenomenological analysis (IPA) to meaningfully inform the co-production of a media campaign intervention with Nigerian parents/ caregivers whose child(ren) are not, or only partially, up to date with routine immunizations aimed at reducing childhood vaccine hesitancy and promoting uptake. A total of 10 parents or caregivers whose children were not up to date with their vaccinations were recruited for the study and participated in a focus group discussion. Data were analyzed using IPA. The findings reveal that hostility, misinformation, and the breakdown of trust in vaccines, alongside faith, tradition, and the lived logic of alternative protection, intersect to exacerbate hesitancy. The findings also reveal that clarity, reassurance, and empowerment in vaccine communication, underpinned by gendered voices, can build trust in vaccine messaging and encourage uptake. The study offers important insights for policymakers and public health communication strategies, underscoring the need for culturally appropriate media campaign interventions that address vaccine-related concerns and foster uptake.

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Redox implications of oxygen binding in hemoglobin and myoglobin: Thermodynamics of the (Fe3+/Fe2+) oxidation-reduction of heme-bound fluoride complexes versus fluoride binding.

Flanders Kayla K, Mathew Annie A, Lockwood Mary M, Frankenfield Ashley A et al.

In this study, the thermodynamics of the one-electron (Fe2+/Fe3+) oxidation-reduction of the heme-bound fluoride complexes of adult hemoglobin (Hb-F) and horse heart myoglobin (Mb-F) were addressed to interpret the molecular changes these proteins undergo during the redox reactions. We measured the enthalpy (ΔHo') and entropy (ΔSo') of these reactions at pH 5 and pH 7, and also for the oxidation-reduction reactions of the metaquo complexes and for fluoride binding. The temperature dependence of the reduction potentials (Em) of Hb-F and Mb-F showed two redox pathways with distinct thermodynamic properties in the 5 to 45 °C temperature range, but only at pH 5. The Em-T plots of Hb-F and Mb-F were complementary to each other, with opposing signs in their ΔHo' and ΔSo'. The redox reactions of the metaquo heme complexes and the heme-bound fluoride complexes (at pH 7) show no evidence of a bifurcated redox pathway. Given the similarities of the heme-ligand structures of oxy- and fluoride-bound complexes and comparable thermodynamics between oxidation and oxygen binding equilibrium, we theorize that one of the thermodynamic pathways is for stabilization of the heme-bound fluoride complex upon the redox change and the other is associated to a redox pathway that stabilizes the heme ferrous state, a route presumably associated to the unligated heme ferric-to-ferrous equilibrium. The serendipitous mixing of these redox pathways in the heme-bound fluoride complexes highlights the specificity of the heme proteins for oxygen binding and the possible use of these pathways for their respective physiological roles of storage and transport. The thermodynamics of the redox reactions of the heme-bound fluoride complexes of hemoglobin and myoglobin exhibit properties similar to those of their oxygen binding equilibria, which govern transport and oxygen storage.

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