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erythromycin (erythromycin, KV)

✓ Approved

Lumara Health · therapeutic agent

What is erythromycin?

erythromycin is a therapeutic agent developed by Lumara Health. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand Nameserythromycin, KV
CompanyLumara Health
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Lumara Health

Therapeutic Indications

erythromycin is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsSalmonellosis✓ Approved

Related Research Articles

PubMedClinical radiology2026-08-29

Assessment of image quality and radiation dose in low-dose, low-contrast computed tomography coronary angiogram: a systematic review and meta-analysis.

Naik S D SD, Visakh T T, Prakashini K K, Sharath S S

Coronary artery disease (CAD) remains a leading cause of morbidity and mortality worldwide. Computed tomography coronary angiography (CTCA), a noninvasive test, requires contrast volume and radiation dose. Low-contrast, low-dose CTCA using reduced tube potential and reconstruction minimises nephropathy and radiation exposure while maintaining quality. This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines and was registered with International Prospective Register of Systematic Reviews (PROSPERO); PubMed, Scopus, and Web of Science (2014-2025) databases were searched for studies evaluating low-contrast, low-dose CTCA. Outcomes included signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), computed tomography dose index volume (CTDIvol), dose-length product (DLP), and effective dose (ED). Leave-one-out sensitivity and within-study subgroup analyses were performed. Five studies with 353 participants were analysed. Low-dose, low-contrast CTCA maintains high image quality while reducing radiation exposure. At 80 kV, combined SNR and CNR were 27.1 (95% confidence interval [CI]: 17.85-36.26) and 31.2 (95% CI: 22.21-40.28), respectively, with CTDIvol: 2.08 mGy, DLP: 38.8 mGy·cm, and ED: 0.37 mSv. At 100 kV, combined SNR and CNR were 22.1 (95% CI: 10.89-33.25) and 24.0 (95% CI: 15.78-32.19), respectively, with CTDIvol: 5.59 mGy, DLP: 84.8 mGy·cm, and ED: 1.24 mSv. Subgroup analysis showed an 80-kV reduced radiation dose by 54-56% while keeping image quality similar, with 5-15% difference in SNR and CNR values. The leave-one-out analysis confirmed robustness of the pooled estimates. Low-dose, low-contrast CTCA using 80-100 kV with iterative or deep learning image reconstruction (DLIR) maintains image quality while reducing iodine and radiation exposure. Compared with 100 kV, 80 kV provides lower radiation dose with minimal image-quality differences, supporting use in selected patients.

PMID 42667811
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PubMedAdvanced materials (Deerfield Beach, Fla.)2026-08-29

Soft-Rigid Liquid Metal-SiC Hybrid Fillers Enable Superior Nonlinear Conductivity and Electric Field Regulation of Composite Dielectrics.

Ren Junwen J, Zeng Ruichi R, Wei Huachao H, Wang Zi Z et al.

Nonlinear dielectrics with superior electric field regulation capabilities are essential for advanced power equipment. However, traditional nonlinear dielectric materials depend on an electrical percolation mechanism, requiring high concentrations of nonlinear conductive filler that degrade insulation and mechanical properties. Herein, we propose a synergistic strategy using a hybrid filler of soft liquid metal and rigid silicon carbide particles (LM-SiCp) to develop insulating nonlinear composite dielectrics. The unique LM-SiCp structure enables a favorable network of potential barriers at low fields and steep exponential current growth at high fields, yielding an excellent "low onset, high gain" nonlinear behavior. The resulting composites exhibit an impressive nonlinear coefficient of ∼7.55 and a markedly reduced threshold field strength from 4.81 to 3.41 kV/mm. It also achieves improved toughness (2.29 MJ/m3), thermal conductivity (0.36 W/mK), high breakdown strength (∼33.4 kV/mm), and low dielectric loss (<0.03), which ensure the stable performance of the composite dielectric under practical engineering conditions. This strategy offers a novel design concept for high-performance composite dielectrics capable of effective electric field modulation in power equipment.

PMID 42666078
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PubMedApplied microscopy2026-08-28

Imaging optimization of FIB cross sections for reliable porosity analysis of PEMFC cathode catalyst layers.

Kwon Ji Hee JH, Jo Jinnyeong J, An Byeong-Seon BS

Focused ion beam-scanning electron microscopy (FIB-SEM) was used to investigate the effects of acceleration voltage, beam current, and cryogenic conditions on the cross-sectional preparation of proton exchange membrane fuel cell (PEMFC) cathode catalyst layers. Milling at 30 kV and 0.26 nA effectively minimized curtaining artifacts and produced an apparent cross-sectional pore morphology similar to that obtained by cryogenic milling, indicating that optimized room-temperature milling can provide cross sections suitable for consistent two-dimensional (2D) pore-area analysis under the conditions examined.Representative FIB-SEM cross-sectional images of PEMFC cathode catalyst layers prepared under different FIB milling conditions: (a-c) 5 kV at room temperature, (d-f) 30 kV at room temperature, and (g-i) 30 kV under cryogenic conditions (- 150 °C). The indicated voltage and current values represent the FIB acceleration voltage and ion beam current used for milling, respectively. The red dashed box in (f) highlights the optimized room-temperature milling condition (30 kV, 0.26 nA) used for comparison with the corresponding cryogenic condition in (i).

PMID 42663789
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PubMedInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2026-08-28

Streptococcus pneumoniae Invasive and Bronchoalveolar Lavage Isolates in Adult Patients in Türkiye (2019-2025): Serotype Distribution, Antibiotic Resistance, and Serotype Coverage of Pneumococcal Vaccine.

Hascelik Gülsen G, Ozakin Cuneyt C, Hazirolan Gulsen G, Hasdemir Ufuk U et al.

To determine the serotype distribution, antibiotic susceptibility, and vaccine serotype coverage of Streptococcus pneumoniae isolates from adult patients in Türkiye. This laboratory study included pneumococcal isolates collected during routine procedures between 2019-2025 in 27 tertiary hospitals across 17 cities in Türkiye. Identification was performed using the optochin test and bile lysis test. Serotyping was performed by the Quellung test. Antibiotic susceptibilities were tested according to the Clinical Laboratory Standards Institute (CLSI) criteria. Among 462 pneumococcal isolates, 72.7% were from male patients, and 43.9% were from patients aged ≥65 years. The most common diagnosis was bacteremia (55.8%), followed by pneumonia (24%) and meningitis (10.6%). The most frequent serotypes were serotype 3 (17.3%), 9N (9.1%), and 19F (5.4%). Vaccine serotype coverage rates were 34.6%, 35.9%, 47.8%, and 59.5% for PCV13, PCV15, PCV20, and PPSV23, respectively; with significantly higher coverage among patients aged ≥65 years. Most isolates were susceptible to penicillin (96.3%) and cefotaxime (97.8%) using non-meningitis breakpoints. Moxifloxacin susceptibility was 99.1%. Erythromycin resistance increased from 33.3% in 2019 to 57.5% in 2025. Serotype 3 was the predominant serotype. PCV20 may provide broader coverage than PCV13, particularly in older adults. Ongoing pneumococcal surveillance and rational antibiotic use remain essential.

PMID 42660407
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PubMedJournal of infection and public health2026-08-28

Genomic epidemiology of Streptococcus pyogenes across multiple centres in China.

Liu Minglei M, Cai Yihua Y, Xu Qiaoli Q, Dong Zihao Z et al.

Streptococcus pyogenes causes a broad spectrum of invasive and non-invasive infections globally, associated with high morbidity and mortality. In mainland China, distribution of the emm genotype has shifted markedly over recent decades, with emm12 emerging as the dominant type. Meanwhile, resistance to macrolides, lincosamides, and tetracyclines has reached extremely high levels, severely limiting clinical treatment options and leading to the designation of S. pyogenes as a medium-priority pathogen by the World Health Organization. A total of 133 non-duplicate S. pyogenes isolates were collected from seven hospitals in northern and southern China, covering five provinces and one municipality, between 2022 and 2024. All isolates underwent whole-genome sequencing, emm typing, multi-locus sequence typing, resistance gene detection, virulence gene analysis, and mobile genetic element identification. All isolates were fully susceptible to penicillin, cefotaxime, levofloxacin, linezolid, vancomycin, and chloramphenicol. Resistance rates were 93.98% for erythromycin, 92.48% for clindamycin, and 81.95% for tetracycline, with erm(B) and tet(M) identified as the main resistance genes. emm12 (81.95%) and ST36 (81.20%) were the predominant types. The emm12-ST36 lineage was strongly associated with pharyngeal infections and acute suppurative tonsillitis. No M1UK lineage was detected. Distinct virulence and mobile genetic element profiles were observed between emm12 and emm1 isolates. S. pyogenes isolates analysed in this study showed extremely high resistance to macrolides, lincosamides, and tetracyclines. Penicillin remains the first-line therapy. For patients with penicillin allergy, alternative therapy should be guided by allergy severity, local susceptibility data, clinical guidelines, and antimicrobial susceptibility testing. The emm12-ST36 type was predominant among pharyngeal isolates and showed strong association with acute suppurative tonsillitis. Continuous genomic surveillance is critical for clinical treatment and infection control.

PMID 42664882
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PubMedVeterinary medicine international2026-08-28

Multidrug-Resistant Salmonella Spp. Isolated From Cloacal Swab of Healthy Layer Chickens and Egg Surface at Selected Farms in Bangladesh.

Akter Most Rafiya MR, Kallol Md Arefin MA, Alam Shanzida Binte SB, Alam Md Mahmudul MM et al.

Multidrug-resistant (MDR) Salmonella spp. is regarded as a perilous menace of public health significance. This research finding was carried out to investigate the prevalence of MDR Salmonella spp. in cloacal swabs of healthy layer birds and egg surface washing along with their resistance patterns and some associated resistance gene detection. In total, 120 samples consisting of 60 cloacal swabs and 60 eggs were collected from three different layer farms located at Mymensingh, Bangladesh, and subjected to various classical and molecular approaches. Antibiotic resistance patterns were investigated phenotypically using the Kirby-Bauer disk diffusion method and genotypically by detection of respective resistance genes. The overall prevalence rate of Salmonella spp. was 29% (95% CI: 18.077%-33.255%) and sample-wise prevalence was 23% (95% CI: 14.415%-26.918%) in cloacal swab and 35% (95% CI: 22.043%-39.956%) in egg surface washing, respectively. Antibiotic susceptibility test revealed that the highest resistance was found to ampicillin 94.29% (95% CI: 86.65%-99.96%) followed by oxytetracycline 80.00%, (95% CI: 65.23%-98.03%), and erythromycin 65.72% (95% CI: 56.73%-75.41%), 45.71%, (95% CI: 33.039%-58.08%) to streptomycin, whereas the highest sensitivity was observed against florfenicol 74.29% (95% CI: 62.91%-85.28%), followed by ciprofloxacin (68.57%, 95% CI: 62.80%-73.66%), and sulphamethoxazole (68.57%, 95% CI: 53.48%-78.97%). The isolates were also found to be MDR as 80% (28/35) isolates (95% CI: 75.80%-86.69%) possessed a MAR index ranging between 0.33 and 0.89. On average, 19 isolates (54.28%; 95% CI: 26.90%-85.17%) were resistant to 5 - 8 antibiotics of seven classes, which is really alarming for public health significance. Based on PCR results, different resistant genes blaTEM, tetA, aadA1, cat1, and flo-R were amplified from 100%, 85.71%, 77.14%, 62.86%, and 37.14% of the isolates. Due to increased drug resistance, antibiotics and other antimicrobial drugs are becoming ineffective for the medication of both human and animal infections. Further investigations are also suggested to cope with antimicrobial resistance through this research study.

PMID 42662130
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