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Fraction F (Fraction F / Ateroid / Ateroid 200)

✓ Approved

Gentium · therapeutic agent

What is Fraction F?

Fraction F is a therapeutic agent developed by Gentium. It is approved for therapeutic indications via injectable (others) or intravenous (iv) or oral (po).

Drug Profile

Brand NamesFraction F, Ateroid, Ateroid 200
CompanyGentium
RouteInjectable (Others), Intravenous (IV), Oral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Gentium

Therapeutic Indications

Fraction F is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Nervous system disordersDementia Alzheimer's type✓ Approved

Related Research Articles

PubMedDrug delivery and translational research2026-08-30

Biodegradable furylacryloyl-modified hyaluronan: in vivo evaluation and its use as a nanofibrous drug delivery system.

Brtková Barbora B, Bártová Tereza T, Piskláková Lenka L, Šimek Matěj M et al.

Furylacryloyl-modified hyaluronan (F-HA) has emerged as an appropriate material for the fabrication of UV-crosslinkable, water-stable nanofibrous scaffolds with preserved porosity. However, the safety profile and in vivo applicability of F-HA have not yet been established. In this study, we present biological assessment of F-HA, including biodegradation studies and its first in vivo evaluation in C57BL/6J mice following both intravenous and intraperitoneal administration. The results demonstrate good tolerability under the tested conditions and confirm biodegradability. Additionally, we confirm the ability of composite nanofibers consisting of F-HA with established nanofiber-forming polymers, to incorporate active pharmaceutical ingredients (API), while retaining their porous structure and favorable mechanical properties. Importantly, the incorporation of F-HA alters the release profile of embedded API. Using octenidine dihydrochloride (OCT) as a model compound, we demonstrate sustained release from F-HA/lauroyl hyaluronan (L-HA) nanofibrous scaffolds in biologically relevant protein-containing media, while retaining its structural integrity, thus supporting its suitability for biomedical applications. These findings highlight the potential of F-HA as a versatile platform for the development of advanced nanofibrous biomaterials with translational relevance in topical wound healing and drug delivery.

PMID 42668347
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PubMedMedical science monitor : international medical journal of experimental and clinical research2026-08-30

Postoperative Sexual Quality of Life and Associated Factors After Loop Electrosurgical Excision Procedure Versus Cold Knife Conization in 185 Sexually Active Women With Preinvasive Cervical Lesions.

Ozkaya Ucar Yesim Y, Turan Taner T

BACKGROUND Excisional treatment is widely used for preinvasive cervical lesions, but its effect on postoperative sexual quality of life remains uncertain. This study aimed to compare postoperative Sexual Quality of Life-Female (SQoL-F) scores and examine associated factors in women treated with cold knife conization or loop electrosurgical excision procedure (LEEP). MATERIAL AND METHODS This study included 185 sexually active women treated with cold knife conization (n=99) or LEEP (n=86) for histologically confirmed preinvasive cervical lesions during 2022-2024 and assessed at least 6 months postoperatively. The primary outcome was the total score on the validated 18-item SQoL-F questionnaire, transformed to a 0-100 scale. Between-group comparisons and multivariable linear regression with heteroskedasticity-consistent type 3 robust standard errors were performed. RESULTS Mean SQoL-F scores were similar after conization and LEEP (48.74±14.76 vs 49.70±12.76; P=0.640; Hedges' g=-0.07). In multivariable analysis, surgical technique was not associated with SQoL-F scores (ß=4.03; 95% confidence interval, -1.13 to 9.20; P=0.125). Age, marital status, weekly sexual frequency, family structure, preoperative sexual life perception, postoperative expectation, and body perception were associated with SQoL-F scores. The model explained 23.7% of the variance (R²=0.237), and internal consistency was high (Cronbach's alpha=0.886). CONCLUSIONS SQoL-F scores did not differ significantly between women who underwent cold knife conization and those who underwent LEEP. Several demographic, psychosocial, and interpersonal factors, rather than surgical technique, were associated with SQoL-F scores, although the cross-sectional design precludes causal inference.

PMID 42668418
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PubMedEMBO molecular medicine2026-08-30

A cavity-reduced prefusion RSV F bivalent vaccine elicits durable and protective immunity.

Liu Lijie L, Yan Mengrong M, Liang Ruoxu R, Wu Qingxin Q et al.

Respiratory syncytial virus (RSV) remains a major cause of severe respiratory disease, and stabilization of the prefusion (preF) conformation of the F glycoprotein is central for vaccine development. Here, we report a structure-guided engineering strategy that enhances preF stability by reducing the hydrophobic cavity within the trimeric F protein. Targeted modifications at metastability-associated sites generated RVF-88, a disulfide-free stabilized preF immunogen that preserves key neutralizing epitopes, including antigenic site Ø, while exhibiting improved structural integrity and long-term storage stability. Formulated as an unadjuvanted bivalent vaccine, RVF-88 elicited potent neutralizing antibody responses and durable immune protection lasting up to 5 months in mice. Vaccination also protected both mice and cotton rats against RSV challenge. Structural analyses confirmed the intended cavity-reduction design, revealing a reduced apical hydrophobic cavity volume and surface area while maintaining the prefusion architecture. Together, these findings establish hydrophobic cavity reduction as a rational strategy for stabilizing prefusion RSV F and provide a promising next-generation vaccine candidate with improved stability and immunogenicity for further clinical development.

PMID 42668284
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PubMedACS applied materials & interfaces2026-08-30

Degradation Mechanisms of Fluorinated Disordered Rocksalt Cathodes: Effects of Electrolyte Chemistry and Discharge Voltage.

Ahmed Ridwan A RA, Lee Gi-Hyeok GH, Hershkovitz Eitan E, Li Tianyu T et al.

Cation-disordered rock-salt (DRX) oxides have emerged as a promising class of high energy density cathodes for next-generation lithium-ion batteries. Fluorination has been widely employed to tune the redox chemistry and structural stability of these materials, leading to enhanced electrochemical performance. However, the degradation mechanisms of fluorinated DRX (F-DRX) cathodes during electrochemical cycling remain poorly understood. Here, we investigate the degradation behavior of an F-DRX cathode cycled in a conventional carbonate-based electrolyte and a localized high-concentration electrolyte (LHCE). By correlating electrochemical performance with interfacial and bulk structural evolution, we elucidate the role of electrolyte chemistry and deep discharge voltage in governing structural transformation and degradation. The results reveal more pronounced surface and bulk structural changes in the conventional LiPF6-carbonate electrolyte relative to LiFSI-LHCE, indicating accelerated degradation in the former. Lowering the discharge cutoff voltage from 2.0 to 1.5 V further promotes interfacial degradation in both electrolyte systems. This work demonstrates that the LHCE offers superior compatibility with F-DRX cathodes, enabling stable cycling by mitigating surface and bulk structural degradation. These insights clarify the interplay between electrolyte chemistry and voltage window in F-DRX degradation and highlight the critical importance of advanced electrolyte designs for unlocking the full potential of DRX cathodes.

PMID 42669203
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PubMedEnvironmental epigenetics2026-08-30

Prenatal environmental determinants of aromatase brain-promoter methylation in cord blood: chemical, airborne, pharmacological, and nutritional factors.

Tanner Samuel S, Drummond Katherine K, Thomson Sarah S, Vacy Kristina K et al.

Aromatase, an enzyme encoded by the gene CYP19A1, plays central roles in neurodevelopment. In the brain, its function is to convert androgens into neuroestrogens, ensuring balanced hormonal signalling. Both animal experiments and human studies have shown that, in males, disruption of aromatase, either genetically or epigenetically, can increase symptoms of autism. Prenatal exposure to bisphenol A (BPA), a common plastic chemical, can increase levels of DNA methylation-a key epigenetic modification-at the brain-specific CYP19A1 promoter, P1.f, reducing CYP19A1 expression. However, the extent to which other neurodevelopmentally relevant environmental exposures influence P1.f methylation remains unclear. Here, in the Barwon Infant Study (BIS) birth cohort (N = 906), we analysed the association between 25 prenatal exposures (from five classes previously linked to neurodevelopmental outcomes: manufactured chemicals, air pollution, and pharmacological, nutrition and sunlight-related factors) and methylation of the CYP19A1 P1.f promoter using Weighted Quantile Sum (WQS) regression. We found that the WQS mixture index, a weighted combination of the prenatal exposures, was positively associated with higher P1.f methylation (Adjusted Mean Difference (AMD) = 0.71 (95% CI 0.11, 1.32), P = 0.021), indicating reduced brain aromatase activity. Prenatal exposures with the strongest contribution to the mixture effect included bisphenols (including BPA), reduced sunlight, household mould, phthalates, low folate intake, and air pollution. These findings highlight epigenetic modification of the aromatase gene as a biologically plausible, convergent mechanism through which multiple environmental risk factors for autism may exert effects.

PMID 42668842
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PubMedInternational journal of cardiology. Cardiovascular risk and prevention2026-08-30

Comment on "Tocotrienol-rich fraction of vitamin E in diabetes and cardiovascular disease: From molecular mechanisms to clinical application".

Mi Shiting S, Guo Xinru X, Chen Tielong T

PMID 42668495
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