Drug Database
ZI

zinc acetate dihydrate (Wilzin / Wilzin)

✓ Approved

Recordati S.p.A. · Small Molecule · Small Molecule

What is zinc acetate dihydrate?

zinc acetate dihydrate is a small molecule developed by Recordati S.p.A.. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesWilzin, Wilzin
CompanyRecordati S.p.A.
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Recordati S.p.A.

Therapeutic Indications

zinc acetate dihydrate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Congenital, familial and genetic disordersHepato-lenticular degeneration✓ Approved

Related Research Articles

PubMedFrontiers in nutrition2026-10-15

Correcting zinc deficiency in nursing home residents: a randomized trial comparing 30 and 60 mg/day elemental zinc supplementation.

Ortega Edwin F EF, Yao Jonathan H JH, Guo Weimin W, Boehm Sarah K SK et al.

Low serum zinc is associated with higher pneumonia incidence and illness duration compared to individuals with adequate serum zinc levels. However, the optimal and safe zinc supplementation dose to correct deficiency has not been established. This study aimed to determine the optimal and safe dose of elemental zinc supplementation to correct deficiency in older adults residing in nursing homes. Methods: We conducted a 12-month randomized, placebo-controlled, double-blind clinical trial in zinc-deficient nursing home residents, comparing supplementation of 30 and 60 mg/day elemental zinc versus placebo on zinc status and potential adverse effects (n = 26-35/group). Both the 30 and 60 mg/day groups significantly increased serum zinc levels compared to placebo (p < 0.001). All participants in the 60 mg/day group reached the target threshold (> 70 μg/dL), with 100% achieving zinc adequacy by month 8. In contrast, only 46.4% (13 of 28) of participants in the 30 mg/day group reached this threshold, with the proportion plateauing at month 8. No participant in the placebo group reached zinc adequacy. No impact on copper status was detected. Although not powered for clinical outcomes, exploratory analyses showed participants in the placebo group reported significantly more coughing episodes, fevers, and chills throughout the study compared to those in 30 and 60 mg/d supplemented groups. In zinc deficient older adults, 60 mg/day of elemental zinc effectively corrected deficiency with no adverse effects. These findings inform the dosing protocol for a fully powered randomized trial testing the effect of zinc supplementation on pneumonia incidence and outcomes in this population. https://clinicaltrials.gov/, identifier NCT05527899.

PMID 42876725
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PubMedFrontiers in cellular and infection microbiology2026-10-15

MerR-type regulator ZccR links zinc homeostasis to biofilm formation and interspecies competition in Streptococcus mutans.

Pan Yangyang Y, Xu Zhaonan Z, Wang Shuyu S, Xu Muxin M et al.

Zinc is widely present in the oral microenvironment and can influence the growth of oral bacteria. ZccR is a MerR-type transcriptional regulator that controls zinc efflux in Streptococcus mutans (S. mutans), but its role in biofilm virulence and interspecies competition with oral commensals remains unclear. This study aimed to investigate the role of ZccR in the formation of single-species biofilms of S. mutans and dual-species biofilms with oral commensal streptococci, and its underlying regulatory mechanisms. We constructed an in-frame zccR knockout mutant of S. mutans. The growth curve, crystal violet staining, anthrone method, scanning electron microscopy, fluorescence in situ hybridization, and deferred antagonism assay were used to assess growth, biofilm development, dual-species biofilm composition, and interspecies competitive capacity. RNA-seq was employed to identify genome-wide transcriptional alterations, and promoter-lacZ reporter strains were constructed to confirm the transcriptional regulation mode of ZccR on zccE and on itself. The deletion of zccR significantly suppressed biofilm formation and water-insoluble exopolysaccharide production of S. mutans at 150 μM Zn2+, a concentration that only modestly affected planktonic growth. In dual-species biofilms containing Streptococcus gordonii (S. gordonii), the mutant exhibited reduced oxidative stress tolerance and weaker inhibition of S. gordonii, despite upregulation of bacteriocin genes. RNA-sequencing identified 89 differentially expressed genes (67 upregulated and 22 downregulated), including downregulation of the mutanobactin cluster and FAD-dependent oxidoreductases, upregulation of iron-uptake genes, induction of HomR-tcy-linked cystine-uptake pathways, glutamine biosynthesis, and CRISPR-Cas genes, and a shift from sucrose import (scrA/msmX) toward lac-dependent lactose/galactose metabolism. Most of these shifts tracked intracellular zinc accumulation rather than direct ZccR control. Promoter-lacZ assays revealed that ZccR activates zccE and represses its own promoter, and zinc acts on these promoters through ZccR-dependent and ZccR-independent routes. ZccR links zinc homeostasis with biofilm formation and oral interspecies ecology of S. mutans, thus offering a future intervention point for cariogenic biofilm control.

PMID 42876498
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PubMedThe Egyptian journal of immunology2026-10-15

Immunometabolic dysregulation in gastric ulcer: Association of pro- and anti-inflammatory cytokines, trace elements, and atherogenic lipid profile.

Auda Furqan M FM, Ali Basim M BM, Al-Zubaidy Haider F S HFS

Gastric ulcer remains a prevalent gastrointestinal disorder characterized by disruption of the gastric mucosal barrier due to an imbalance between injurious and protective factors. Recent attention has focused on the role of inflammatory mediators, micronutrient status, and metabolic alterations in the progression of this condition. Cytokines are known to promote inflammatory cascades and mucosal damage and modulates immune responses during gastric injury. Also, trace elements including zinc and copper are essential for maintaining antioxidant defense, immune function, and tissue repair. This case control study included 60 patients diagnosed with gastric ulcer and 60 apparently healthy individuals as normal controls. All participants were recruited from the Gastroenterology and Hepatology Hospital in Al-Najaf. The two groups were matched in terms of age and body mass index to minimize potential confounding effects. Serum levels of IL-10, IL-1beta, zinc, copper, and lipid profile parameters were assessed using standard laboratory methods. Statistical analysis was carried out using SPSS version 26. Due to non-normal distribution of variables, median values were used for data representation. Spearman's rank correlation test was applied to evaluate associations among variables, and the receiver operating characteristic curve analysis was used to determine the diagnostic performance of the studied parameters. The findings revealed a significant elevation in both IL-1beta and IL-10 levels among gastric ulcer patients compared to controls, indicating activation of inflammatory and regulatory immune pathways. Zinc levels were significantly reduced in patients, suggesting a possible link between micronutrient depletion and impaired mucosal defense. The present study demonstrated a combined pattern of inflammatory activation, zinc deficiency, and lipid profile disturbance in gastric ulcer patients. These alterations may collectively contribute to disease pathogenesis and could serve as useful indicators for disease assessment and monitoring.

PMID 42875887
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PubMedChemical communications (Cambridge, England)2026-10-15

Facet-selective molecular regulation of Zn metal anodes for durable aqueous zinc-ion batteries.

Qin Lin L, Xiao Dengqiao D, Sun Qiuqi Q, Wang Zhenguo Z et al.

Aqueous zinc-ion batteries (AZIBs) are attractive for grid-scale energy storage, yet Zn anodes suffer from dendrites, side reactions and restricted current windows. Herein, capecitabine (CAP) is employed as a electrolyte additive for Zn-deposition regulation and interfacial stabilization. The N/O-containing groups in CAP partially reconstruct the Zn2+ solvation and water hydrogen-bond network, reducing water activity. Meanwhile, facet-selective adsorption of CAP on Zn(100), forms an adsorption-mediated interfacial layer that suppresses parasitic reactions and promotes compact Zn(100)-textured deposition. Consequently, Zn‖Zn symmetric cells operate stably for over 7000 h at 1 mA cm-2/1 mAh cm-2. Moreover, Zn‖ZVO full cells retain 82.45% capacity after 5500 cycles at 5 A g-1. CAP-mediated electrolyte-structure regulation and Zn(100)-selective interfacial modulation provide a molecular strategy for highly reversible Zn metal anodes.

PMID 42876255
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PubMedOrganic & biomolecular chemistry2026-10-15

Visible-light-promoted bismuth-catalysed synthesis of dihydroquinoline scaffolds from β-enaminones.

Khadanga Lambodar L, Roopan Selvaraj Mohana SM

Dihydroquinolines are established as important scaffolds in medicinal chemistry owing to their ubiquitous occurrence in bioactive molecules. Utilising water as a solvent in photochemical synthesis provides a synthetic route for chemical transformations under mild conditions. Herein, we report a step-economical and efficient heterogeneous N-doped Bi2WO6 catalysis to obtain a diverse array of dihydroquinolines by using ammonium acetate as a cheap nitrogen source. The protocol exhibits excellent functional group tolerance and is amenable to gram-scale synthesis. The post-synthetic transformations open a window to access structurally complex as well as molecularly diverse heterocyclic scaffolds.

PMID 42876403
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PubMedFood & function2026-10-15

Prebiotic potential and modulation of the fecal microbiota by konjac oligo-glucomannan prepared using Pediococcus acidilactici mannanase.

Yang Shuhan S, Chen Xi X, Li Zijing Z, Yang Ruoxi R et al.

In this study, konjac oligo-glucomannan (KOGM) was prepared from konjac glucomannan (KGM) by enzymatic hydrolysis using β-mannanase derived from Pediococcus acidilactici HDM2. The prepared KOGM had an average molecular weight of 13.4 kDa under optimized conditions (50 °C, pH 6.0, 80 U mL-1 and 180 min). The KOGM exhibited selective prebiotic potential by promoting probiotic growth, particularly Lacticaseibacillus paracasei HD1.7 and Lactiplantibacillus plantarum CICC 6076. In contrast, it inhibited the growth of potentially harmful bacteria, including Klebsiella pneumoniae and Enterobacter spp. Its prebiotic potential was further evaluated using an in vitro fecal fermentation model with six treatment groups: blank control, commercial mannan oligosaccharides (MOS), KGM, KOGM, KGM combined with HDM2 (KGM2), and KOGM combined with HDM2 (KOGM2). After 24 h of fermentation, the KOGM2 group exhibited the lowest pH (3.89 ± 0.03, P < 0.05) and increased production of short-chain fatty acids (SCFAs), particularly acetate (2062.72 μg mL-1), propionate (1356.81 μg mL-1), and valerate (16.89 μg mL-1). Notably, the KGM2 group produced the highest acetate level, while KGM yielded the greatest butyrate content (206.7 ± 15.0 μg mL-1). α and β diversity analyses revealed that KGM and KOGM treatments enhanced microbial diversity and accelerated community stabilization. Furthermore, KOGM enriched beneficial phyla such as Bacteroidetes and Actinobacteria, stimulated the growth of beneficial genera including Bifidobacterium, Prevotella, and Limosilactobacillus, and reduced potential pathogens including Escherichia-Shigella and Proteobacteria. These findings highlight the prebiotic potential of enzymatically prepared KOGM, which effectively modulates gut microbiota composition and promotes beneficial metabolic activity.

PMID 42876295
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