Drug Database
ZI

zinc acetate dihydrate (Wilzin / Wilzin)

✓ Approved

Recordati S.p.A. · Small Molecule · Small Molecule

What is zinc acetate dihydrate?

zinc acetate dihydrate is a small molecule developed by Recordati S.p.A.. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesWilzin, Wilzin
CompanyRecordati S.p.A.
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Recordati S.p.A.

Therapeutic Indications

zinc acetate dihydrate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Congenital, familial and genetic disordersHepato-lenticular degeneration✓ Approved

Related Research Articles

PubMedBioactive materials2026-08-30

Reversing zinc dyshomeostasis and oxidative stress: A metallothionein 1-activating MXene/Zn2+ triple-action nanotherapeutic strategy for chronic non-bacterial prostatitis.

Liu Kailai K, Zhang Yuchen Y, Gao Yanyao Y, Zheng Yunhe Y et al.

Chronic non-bacterial prostatitis (CNP), a prevalent and debilitating urological disorder affecting 8.4% of men aged 15-60 years, presents significant clinical challenges due to the paucity of targeted therapies and poor patient adherence. To address this unmet medical need, we developed an innovative multifunctional nanoplatform (QM (Zn) NPs) by integrating Ti3C2 MXene with a quercetin-zinc coordination complex (Que-Zn) for precision CNP therapy. This system leverages chondroitin sulfate (Chs)-mediated CD44 targeting to achieve selective accumulation in inflamed prostate tissue, thereby enhancing Zn2+ bioavailability while enabling co-delivery of MXene and Que-Zn therapeutic payloads. Upon localization, QM (Zn) NPs orchestrate a coordinated therapeutic cascade: MXene scavenges reactive oxygen species (ROS) via electron-deficient sites, while Que-Zn drives M1-to-M2 macrophage repolarization and facilitates Zn2+ cellular uptake. The accumulated intracellular Zn2+ critically upregulates metallothionein 1 (Mt1), activating the IKK/NF-κB/IκB axis to resolve inflammation and oxidative damage. Transcriptomic analysis unequivocally identified Mt1 as the pivotal mediator of Zn2+-driven microenvironment reprogramming. Notably, QM (Zn) NPs not only significantly alleviated pelvic pain by mitigating neuronal oxidative stress but also exhibited excellent biocompatibility. This work pioneers a targeted nano-theranostic strategy that synergistically restores zinc homeostasis, quenches ROS, and reprograms immune responses, thereby establishing a transformative paradigm for CNP management.

PMID 42668497
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PubMedBiochemistry. Biokhimiia2026-08-30

EF-Hand Calcium-Binding Motif: Novel Structural and Functional Insights.

Denessiouk Konstantin A KA, Permyakov Evgeny A EA, Denesyuk Alexander I AI, Permyakov Sergey E SE

The EF-hand motif is one of the most widespread calcium-binding protein motifs in nature, mediating calcium signaling across a variety of biological processes. While structural and functional properties of the individual proteins within the EF-hand superfamily are well studied, general principles governing organization and function of these proteins are only now being elucidated. This review examines some of these emerging patterns, including recently discovered structural elements of the EF-hand motif (EF-hand zone, one-residue and three-residue units, local "Clamp" units, and "black" and "gray" clusters). Additionally, we discuss the ability of certain EF-hand proteins to recognize a broad spectrum of protein targets, as well as their zinc-binding properties. New structural data on the EF-hand domain allow proposing a structural-functional classification for the proteins in this family. Furthermore, tendency of some EF-hand proteins toward promiscuity and zinc binding significantly expands their functional importance.

PMID 42669557
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PubMedInternational journal of biomaterials2026-08-30

A Comparative Effect of Nano-Zirconia and Nano-Zinc Oxide on Color Stability of Pigmented Maxillofacial Silicone Under Accelerated Aging.

Shakir Shahad Mohammed SM, Salih Zryan Jaza Hama ZJH, Bunyan Shahad Fadhil SF, Aljumaily Izzaldeen Yaseen IY et al.

This in vitro study was designed to assess and compare the color stability of pigmented maxillofacial silicone elastomers reinforced with nano-zirconia and nano-zinc oxide with silicone without nanoparticles following accelerated weathering at various time intervals. A total of 150 disc-shaped pigmented maxillofacial silicone specimens were prepared and classified into one control group of 50 silicone elastomers pigmented without nanoparticles and two experimental groups of 50 nano-zirconia (ZrO2) and 50 nano-zinc oxide (ZnO). The samples were then exposed to artificial weathering for 200, 400, and 600 h of accelerated weathering. All color measurements were performed at baseline and after aging using same specimens assigned to each interval with a spectrophotometer in the Commission Internationale de l'Eclairage (CIELAB) color space. Color differences (ΔE) were analyzed using two-way repeated measures ANOVA with Greenhouse-Geisser correction (p < 0.05). Color change values of both groups increased markedly with time aging, indicating that nanoparticle reinforcement significantly influenced the color change over time. At all aging intervals, the ZrO2 group demonstrated the lowest ΔE values, followed by ZnO, while the control group exhibited the highest discoloration. After 600 h of accelerated aging, mean ΔE values were 3.23 for the control group, 2.82 for ZnO, and 2.16 for ZrO2, exhibiting a superior color stability of zirconia-reinforced silicone. Nano-ZrO2 showed better color change stability than nano-ZnO at all aging periods, indicating that it may be used to increase the esthetic longevity of maxillofacial silicone prosthesis.

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PubMedChemical communications (Cambridge, England)2026-08-30

Magnesium-carbon laminates enable nickel-catalyzed synthesis of aryl C-glycosides in flow.

Endo Hirofumi H, Kodani Kazuki K, Sasaki Norihiko N, Nagaki Aiichiro A et al.

Nickel-catalyzed coupling reactions of glycosyl bromides and aryl halides were performed using metal-carbon laminates composed of zinc or magnesium metal plates and carbon fiber felts. The metal-carbon laminates act as reducing agents to generate a reactive nickel species and enable the flow synthesis of aryl C-glycosides using a flow reactor.

PMID 42669293
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PubMedChemistry, an Asian journal2026-08-30

Phosphine-Free NNN Bis-Iminopyridine Supported Zinc(II) Catalysts: A Sustainable Platform for C─C Bond Formation Reactions via Borrowing Hydrogen Approach of Primary Alcohols.

Saini Rahul R, Kukreti Prashant P, Pattnaik Tanya T, Chauhan Rahul R et al.

In this study, we present a methodology for direct C─C bond formation using renewable primary alcohols as alkylating agents, catalyzed by base metal-derived Zn(II) complexes. We utilized two well-defined phosphine-free NNN bis-iminopyridine pincer ligands (L1 and L2) for the synthesis of zinc(II) catalysts C1 and C2, which were thoroughly characterized using UV-vis, IR, HRMS, and single-crystal x-ray diffraction techniques. Both complexes C1 and C2 effectively promoted the selective mono-alkylation of a variety of carbo-nucleophile, including aromatic ketones, α-tetralone, fluorene, and oxindole, by employing both aromatic and aliphatic primary alcohols as alkyl sources. A wide range of substrates, encompassing 42 derivatives, were investigated, resulting in isolated yields as high as 92%. The developed method was successfully applied at the gram scale, demonstrating its practical applicability and potential for scalability. Additionally, control experiments were performed to elucidate the reaction mechanism, and HRMS analysis verified the presence of significant Zn(II) intermediates involved in the catalytic process.

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PubMedJournal of chromatography. A2026-08-30

Automated miniaturized LLE-GC-MS/MS for the analysis of EPA 8270 SVOCs and multi-class pesticides in water using ethyl acetate.

Feo Maria Luisa ML, Benedetti Paolo P, Zanaboni Moira M, Tofful Luca L et al.

The determination of trace-level semi-volatile organic compounds (SVOCs) following EPA Method 8270 traditionally relies on manual liquid-liquid extraction (LLE) using large volumes of dichloromethane (DCM). However, recent 2024 TSCA regulations restricting DCM due to human health risks necessitate sustainable analytical alternatives. This study presents a fully automated, miniaturized LLE (micro-LLE) method for 170 analytes including EPA 8270 targets and multi-class pesticides (organochlorine (OCPs), organophosphorus (OPPs) and organonitrogen (ONPs) pesticides and pyrethroids). The workflow utilizes a TriPlus RSH SMART autosampler to integrate standard preparation, surrogate spiking, and extraction with on-line GC-MS/MS injection. Ethyl acetate was validated as a "green" alternative to DCM, with a 1:1 NaCl:MgSO₄ salt mixture optimizing the salting-out effect. This procedure achieved a tenfold enrichment factor using only 1.5 mL of solvent for 10 mL of sample. Method validation showed excellent linearity (R2> 0.995 for 70% of analytes) and precision (RSD < 15%). Method limits of quantification (MLOQs) between 0.05 and 10 µg/L meet stringent regulatory requirements. The method's robustness was confirmed through real-world Saharan deposition samples, identifying high levels of Phenothrin (211 ppb) and Endosulfan ether (140 ppb). This robotic workflow provides a high-throughput, sustainable solution for modern environmental monitoring.

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