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doxycycline (Perio Product / Atridox / doxycycline, Atrix)

✓ Approved

Pharmascience, Inc. · Small Molecule · Small Molecule

What is doxycycline?

doxycycline is a small molecule developed by Pharmascience, Inc.. It is approved for therapeutic indications via oral (po) or topical.

Drug Profile

Brand NamesPerio Product, Atridox, doxycycline, Atrix
CompanyPharmascience, Inc.
Drug ClassSmall Molecule
RouteOral (PO), Topical
StatusApproved
Sources: ClinicalTrials.gov, Pharmascience, Inc.

Therapeutic Indications

doxycycline is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsPeriodontitis✓ Approved

Related Research Articles

PubMedJournal of oral biology and craniofacial research2026-08-30

Influence of matrix metalloproteinase inhibitors on resin-dentin bond strength and hybrid-layer characteristics of caries-affected dentin using a universal adhesive system.

Dhatavkar Prasanna P, Aggarwal Shalini S, Kesharani Pooja P, Borkar Anamika A

Matrix metalloproteinase-mediated collagen degradation compromises the durability of resin-dentin bonds, particularly in caries-affected dentin. Natural matrix metalloproteinase (MMP) inhibitors have gained attention as biocompatible alternatives to conventional synthetic agents for improving adhesive stability. To evaluate the effects of natural and synthetic MMP inhibitors on microtensile bond strength and failure patterns in caries-affected dentin bonded with a universal adhesive using etch-and-rinse and self-etch modes. A total of 240 extracted human permanent molars with artificially induced caries-affected dentin were allocated to 16 subgroups according to pretreatment agent and bonding mode. The pretreatment agents included grape seed extract, green tea extract, riboflavin, cranberry extract, chlorhexidine, doxycycline, sodium fluoride, and no inhibitor. A universal adhesive and nanohybrid composite resin were applied according to the assigned etch-and-rinse or self-etch protocol. Microtensile bond strength was measured using a universal testing machine. Data were analyzed using one-way analysis of variance, chi-square test, and Pearson correlation coefficient at a significance level of 0.05. Etch-and-rinse bonding produced significantly greater bond strength than self-etch bonding. Grape seed extract and green tea extract showed the highest bond-strength values, followed by riboflavin and cranberry extract. Chlorhexidine, doxycycline, and sodium fluoride showed limited improvement. Adhesive failure predominated the association with bond strength. Etch-and-rinse application of a universal adhesive combined with natural matrix metalloproteinase inhibitors, especially grape seed and green tea extracts, enhanced resin-dentin bond strength in caries-affected dentin.

PMID 42668588
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PubMedIDCases2026-08-30

Emergence of a novel NDM-4-producing Citrobacter freundii complex species in a complicated urinary tract infection treated with cefiderocol.

Boehm Cheyanne C, Dingle Tanis C TC, Croxen Matthew A MA, Lynch Tarah T et al.

Multidrug-resistant (MDR) Gram-negative infections represent a growing global health threat with increasingly limited therapeutic options. We report a case of complicated urinary tract infection in a 70-year-old woman with underlying renal cysts complicated by rupture and subsequent formation of left infrarenal and paracolic pelvic abscesses. The initial infection was caused by Escherichia coli; however, following initial prolonged broad-spectrum antimicrobial therapy, a novel New Delhi metallo-β-lactamase (NDM type carbapenemase)-producing Citrobacter species was subsequently isolated from urine cultures. Whole-genome sequencing confirmed identification as a novel Citrobacter species and identified the presence of a blaNDM-4 gene. Antimicrobial susceptibility testing demonstrated resistance to most tested agents, with susceptibility limited to nitrofurantoin, cefiderocol, aztreonam, doxycycline, and tigecycline. Repeat abscess drainage and treatment with cefiderocol resulted in clinical and microbiological resolution of infection. This case underscores the critical role of drainage and access to newer antibiotic agents in management of complex intra-abdominal infections. Genome sequencing aids the detection of novel reservoirs of antibiotic resistance genes in carbapenemase-producing Enterobacterales that may emerge during prolonged antimicrobial exposure.

PMID 42668689
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PubMedRespirology case reports2026-08-29

Long-Term Recurrence-Free Outcome After Doxycycline Pleurodesis With Pulmonary Rehabilitation and Nutritional Support in an Underweight Patient With COPD: A Case Report.

Notariza Kemas Rakhmat KR, Pradono Prasenohadi P, Widjanantie Siti Chandra SC, Rachmi Elfina E et al.

Secondary spontaneous pneumothorax (SSP), a complication of chronic obstructive pulmonary disease (COPD), recurs more frequently in underweight patients. This case report describes a 63-year-old malnourished man with COPD presenting with recurrent left-sided SSP shortly after hospital discharge for a previous episode. Following chest tube reinsertion and complete lung re-expansion, chemical pleurodesis was performed using 1000 mg doxycycline in saline. Transient pleuritic pain was controlled with intravenous ketorolac and intrapleural lidocaine. No other immediate or delayed adverse events occurred. In parallel, pulmonary rehabilitation, including breathing exercises, posture correction, moderate-intensity endurance and inspiratory muscle training, was initiated alongside nutritional repletion with a respiratory-specific oral nutritional supplement. Over a 22-month follow-up, the patient remained free of SSP recurrence, with improved functional capacity and weight gain. This report describes a long-term recurrence-free outcome after doxycycline pleurodesis combined with pulmonary rehabilitation and nutritional support in an underweight patient with COPD.

PMID 42666801
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PubMedFrontiers in medicine2026-08-29

Acupuncture for nummular eczema of the lower legs in an older adult: a case report.

Pan Jinyuan J, Yu Hongmin H, Ye Wenjia W, Liang Yiyun Y

Nummular eczema, also known as nummular dermatitis or discoid eczema, is a chronic inflammatory dermatosis characterized by coin-shaped or discoid eczematous plaques with pruritus, most commonly affecting the extremities, particularly the lower legs. Persistent itch, barrier dysfunction, and repeated scratching may impair sleep and quality of life. Direct evidence for acupuncture in the treatment of nummular eczema remains limited. A 68-year-old woman presented with symmetrical coin-shaped erythema, scaling, and infiltrated plaques, accompanied by severe pruritus on the lateral aspects of both lower legs for more than 1 month. Previous oral doxycycline, antihistamines, and potent topical corticosteroids had provided limited benefit. At presentation, the visual analog scale (VAS) score was 8; the retrospective assessment of the baseline clinical photographs yielded an Investigator's Global Assessment (IGA) score of 3. The clinical diagnosis was nummular eczema. She received manual acupuncture at bilateral Quchi (LI11), Xuehai (SP10), Zusanli (ST36), Yanglingquan (GB34), Zulinqi (GB41), and Xiangu (ST43), three times weekly for a total of six sessions. Pruritus and skin lesions improved progressively. VAS scores decreased from 8 at baseline to 3, 1, and 0 at the second, fourth, and sixth treatment visits, respectively; retrospective IGA scores based on the available clinical photographs decreased in parallel from 3 to 2, 1, and 0. By treatment completion, the bilateral lower-leg lesions had almost resolved, with only mild residual pigmentation. No clinically apparent adverse events occurred. At 4 and 12 weeks after treatment, the patient reported no obvious recurrence of pruritus or skin lesions. In this case, acupuncture was temporally associated with progressive relief of pruritus and near-complete resolution of nummular eczema lesions after a limited response to short-term conventional pharmacological treatment. Acupuncture may be considered as a potential adjunctive option for selected patients, but controlled studies are required to clarify its specific efficacy and safety.

PMID 42666184
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PubMedEmerging infectious diseases2026-08-28

Neoehrlichiosis Causing Hemolytic Anemia in Patients Treated with Rituximab, Norway, 2024-2025.

Paulson Martin M, Wennerås Christine C, Quarsten Hanne H, Berg Kristine K KK et al.

Neoehrlichiosis is caused by infection with the tickborne intracellular bacterium Neoehrlichia mikurensis. We describe 3 cases of direct antiglobulin test-negative hemolytic anemia in rituximab-treated patients infected with tickborne N. mikurensis bacteria in Norway during 2024-2025. All 3 patients had splenomegaly and night sweats. The hemolysis ranged from mild with compensated hemolysis to severe transfusion-dependent hemolysis that resulted in splenectomy in 1 case. All patients experienced complete resolution of hemolytic anemia and other symptoms of infection after eradication therapy with doxycycline for 21 days. Neoehrlichiosis should be considered as a curable cause of hemolytic anemia in N. mikurensis-endemic regions.

PMID 42660584
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PubMedArab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology2026-08-28

Antimicrobial resistance, bacterial density, and eradication outcomes of Helicobacter pylori infection in Egyptian patients: A prospective cohort study.

Zaky Saad S, Zaghloul Nariman N, Hetta Helal F HF, Badary Dalia M DM et al.

Helicobacter pylori is a widespread pathogen linked to gastritis, peptic ulcers, and gastric cancer. Increasing antimicrobial resistance is making eradication more difficult. The aim is tostudy how clinical symptoms, endoscopic and histopathological findings, bacterial density, and antimicrobial resistance patterns of H. pylori are related in Egyptian patients. In our study, 100 treatment-naïve patients with gastrointestinal symptoms suggestive of H. pylori infection and positive stool antigen tests underwent endoscopy, gastric biopsy, histopathology, and culture with antimicrobial susceptibility testing. All patients received 14-day levofloxacin-based triple therapy. Treatment response was assessed clinically and by stool antigen testing.. Epigastric pain was the most common symptom, reported by 83% of patients, followed by nausea and vomiting in 58%. Weight loss and pallor were less frequent, at 24% and 18%, respectively. Abnormal upper gastrointestinal endoscopy findings were present in 97% of patients, with 53% showing erosive or ulcerative lesions, indicating significant mucosal involvement. Higher H. pylori bacterial density was associated with gastric ulcers, erosions, mucosal atrophy, and duodenal lesions (p < 0.001). Higher bacterial density was significantly associated with severe mucosal lesions and increased the risk of ulcerative disease, resulting in more severe epigastric pain and gastrointestinal bleeding. Histopathology revealed chronic inflammation in 95% of patients and active inflammation in 80%, indicating ongoing mucosal activity. Treatment failed in 43% of cases and was closely associated with higher bacterial density, confirming the impact of bacterial load on treatment outcomes. Antimicrobial testing showed high resistance to common first-line drugs, including amoxicillin (53.5%), clarithromycin (46.5%), and amoxicillin-clavulanic acid (50.7%). In contrast, meropenem, doxycycline, and rifampicin showed no detected resistance, indicating potential utility against infections with resistance. Bacterial density is an important predictor of mucosal damage and treatment failure. The high rate of resistance to standard first-line antibiotics highlights the need for new treatment strategies and region-specific guidelines.

PMID 42665498
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