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folic acid + vitamin B6 + vitamin B12 + primorine (Folmor)

✓ Approved

Zylera · Small Molecule · Small Molecule

What is folic acid + vitamin B6 + vitamin B12 + primorine?

folic acid + vitamin B6 + vitamin B12 + primorine is a small molecule developed by Zylera. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesFolmor
CompanyZylera
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Zylera

Therapeutic Indications

folic acid + vitamin B6 + vitamin B12 + primorine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Metabolism and nutrition disordersHypercholesterolaemia✓ Approved

Related Research Articles

PubMedPhysiological research2026-07-17

Impact of Co-Supplementation of Gallic Acid With Vitamin C on Oxidant Stress, Inflammation, Hepatic and Renal Histology of Type 2 Diabetic Rats Induced With Fructose and Streptozotocin.

Yan S S, Xiang X X, Hua W W

This study assessed the impact of gallic acid plus vitamin C on systemic oxidant stress, inflammation, hepatic and renal histology of rats with type 2 diabetes mellitus. Twenty five albino male rats were allotted into five categories of five rats each and treated hereafter as: control and diabetic group (fed rat diets and water), vitamin C (diabetic treated rats administered vitamin C, 50 mg/kg), gallic acid (diabetic treated rats administered gallic acid at 20 mg/kg), gallic acid plus vitamin C (diabetic treated rats administered 20 mg/kg gallic acid and 50 mg/kg vitamin C). The study duration was forty two days. The diabetic group had significant raise (P<0.05) of fasting glucose, glycated hemoglobin, insulin resistance scores, oxidative stress and inflammatory markers (in the liver, kidney and serum), alteration of relative liver and kidney weights, liver and kidney function indices, significant decrease (P<0.05) in total hemoglobin, serum insulin, insulin sensitivity and pancreatic beta cell function scores, body weights and pathological changes in their liver and kidney histology. These changes were ameliorated following supplementation of the diabetic group with gallic acid, vitamin C and gallic acid plus vitamin C combined treatment. Intervention with vitamin C was more efficacious than gallic acid. However, combined treatment of gallic acid plus vitamin C was more efficacious than the single treatments in modulating systemic and local oxidative stress, inflammation and in restoring the altered liver and kidney histology of the diabetic rats. Key words Antioxidants " Type 2 diabetes mellitus " Diabetic liver disease " Diabetic kidney complication " Natural products.

PMID 42466700
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PubMedFrontiers in nutrition2026-07-17

Temporal changes in post-bariatric nutritional deficiency anemia: a propensity score-matched analysis of 2015-2017 versus 2022-2023 cohorts.

Chen I-Wen IW, Kao Chia-Li CL, Lai Yi-Chen YC, Chang Ying-Jen YJ et al.

Metabolic and bariatric surgery (MBS) is associated with postoperative nutritional deficiencies, yet whether temporal shifts in surgical practice and healthcare delivery have influenced the risk of nutritional anemia remains unclear. We compared the 2-year incidence of postoperative nutritional anemia between patients who underwent MBS between 2015 and 2017 and 2022-2023. Using the TriNetX Global Collaborative Network, we conducted a propensity score-matched cohort study of adult patients undergoing laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass. The primary outcome was the 2-year cumulative incidence of nutritional anemia, assessed from 90 to 730 days postoperatively. The secondary outcomes included iron deficiency anemia (IDA), vitamin B12 deficiency anemia, other anemia, all-cause hospitalization, and emergency department visits. After 1:1 propensity score matching, 13,010 patients were included in each cohort. Compared with the early cohort (2015-2017), the late cohort (2022-2023) had a significantly higher risk of nutritional anemia (6.61% vs. 5.30%; hazard ratio [HR] 1.34, 95% confidence interval [CI] 1.22-1.49; p < 0.001), including iron deficiency anemia (HR 1.36, p < 0.001) and vitamin B12 deficiency anemia (HR 1.32, p = 0.025). No significant difference was observed for other anemia (HR 1.05, p = 0.386). The risk of all-cause hospitalization was higher in the late cohort (HR 1.57, p < 0.001), whereas emergency department visits did not differ significantly. Sensitivity and subgroup analyses yielded consistent findings for the primary outcome and iron deficiency anemia, although the association with vitamin B12 deficiency anemia was not uniformly significant across all models. In this observational study, the 2022-2023 cohort had a higher risk of coded or clinically detected postoperative nutritional anemia than earlier cohorts. Given the modest absolute risk difference and a diagnosis-code-based outcome, this finding should be interpreted as a higher burden of recognized anemia diagnoses rather than definitive evidence of increased biological anemia incidence. These results support adherence to existing postoperative nutritional monitoring recommendations rather than a more intensive surveillance schedule.

PMID 42466138
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PubMedJournal of physiological anthropology2026-07-17

An exploratory study on the association between vitamin D intake or synthesis and sleep health in young adult women: an observational study.

Yoshizu Rika R, Sasaki Toru T, Nakajima Hideaki H, Eto Hiromi H et al.

Vitamin D deficiency, which is highly prevalent in modern society, is associated with health issues, including sleep-wake disorders and depression. This pilot study aimed to examine the relationship between dietary vitamin D intake or vitamin D synthesis from ultraviolet exposure and serum 25-hydroxyvitamin D (25[OH]D) levels as an indicator of vitamin D status, as well as their association with sleep health and depressive symptoms. Twenty-nine young adult women participated in two surveys conducted in spring and summer. Vitamin D intake was estimated based on responses to a dietary questionnaire. The amount of vitamin D synthesized in the skin through ultraviolet exposure was calculated by estimating ultraviolet exposure over a 2-week period. Serum 25(OH)D concentrations were measured using liquid chromatography-tandem mass spectrometry. Sleep habits were assessed using a 2-week sleep diary, and depression and insomnia symptoms were evaluated using questionnaires. The mean (SD) serum 25(OH)D concentrations in spring and summer were 8.9 (2.9) and 15.5 (4.8) ng/mL, respectively. The median (IQR) dietary vitamin D intake adjusted for energy expenditure based on dietary surveys was 8.5 (6.6, 9.2) μg/day in spring and 6.2 (4.3, 10.2) μg/day in summer (P = 0.40). The median (IQR) amount of vitamin D produced from ultraviolet exposure increased from 10.5 (4.6, 17.4) μg/day in spring to 17.0 (10.1, 34.5) μg/day in summer (P = 0.009). Among those with low serum 25(OH)D concentrations or low vitamin D intake in summer, the delayed midpoint of sleep was observed. No significant correlation was found between changes in serum 25(OH)D concentrations from spring to summer and changes in depression or insomnia symptoms. All participants exhibited vitamin D deficiency during the spring term. In contrast, during the summer term, serum 25(OH)D levels increased, primarily due to enhanced vitamin D synthesis resulting from ultraviolet exposure of the skin. However, the observed increase in serum 25(OH)D levels from spring to summer did not correlate with any improvement in depression or insomnia symptoms.

PMID 42464419
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PubMedThe Pan African medical journal2026-07-17

Association between vitamin D levels and depression among type 2 diabetes mellitus patients in the Southern Region of Malaysia.

Amsah Norizzati N, Isa Zaleha Md ZM, Ahmad Norfazilah N, Kassim Zaid Z et al.

depression is a significant public health concern among patients with type 2 diabetes mellitus (T2DM) worldwide. Vitamin D, essential for brain health, plays a role in neuroinflammation and neurotransmitter synthesis, processes linked to depression. However, few studies have explored the association between vitamin D levels and depression in T2DM patients. this cross-sectional study investigated the relationship between serum vitamin D levels and depression among 330 T2DM patients in Johor, Malaysia. Serum 25-hydroxyvitamin D levels were measured using ultra-performance liquid chromatography (UPLC) and categorized as deficient (<30 nmol/L), insufficient (30??50 nmol/L), or sufficient (>50 nmol/L). Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9). the prevalence of depression was 35.5%. Multiple logistic regression analysis revealed that depression was significantly associated with older age (>60 years) (adjusted OR 2.04, 95% CI: 1.23-3.38), vitamin D deficiency (adjusted OR 4.24, 95% CI: 1.99-8.03), vitamin D insufficiency (adjusted OR 1.62, 95% CI: 1.19-2.71), and the use of both oral and injection medications (adjusted OR 1.86, 95% CI: 1.05-3.31). ensuring adequate vitamin D levels, particularly in elderly T2DM patients, may reduce the risk of depression, emphasizing the importance of integrated and holistic management strategies. Keywords: Vitamin D, depression, diabetes, mental health, type 2 diabetes mellitus.

PMID 42465826
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PubMedAnnali italiani di chirurgia2026-07-17

Pre- and Postoperative Nutritional Deficiencies in Patients Undergoing Bariatric Surgery: A Retrospective Cohort Study.

Algethami Mohammed R MR, Jamal Wisam W

To assess the changes in biochemical indicators of nutritional deficiencies before and after bariatric surgery. This retrospective cohort study included 480 adult patients who underwent bariatric surgery between June 2016 and June 2019 at a tertiary care center in Saudi Arabia. Demographic data, comorbidities, and pre- and postoperative biochemical parameters, including hemoglobin, iron profile, Vitamin D, Vitamin B12, albumin, calcium, and parathyroid hormone levels, were extracted from the medical records. These biochemical parameters were used to assess micronutrient status and identify clinically relevant nutritional deficiencies based on established laboratory thresholds. Paired t- and McNemar tests were used to compare the pre- and postoperative values. Statistical significance was set at p < 0.05. We found a high prevalence of pre- and postoperative nutritional deficiencies among patients. The mean hemoglobin decreased from 13.09 to 12.34 g/dL (mean difference -0.75 g/dL; 95% CI -0.89 to -0.61; p < 0.001). We observed a significant association between ferritin and gender pre- and postoperatively, which was lower in women than in men preoperatively and decreased in both sexes postoperatively. The prevalence of 25-hydroxyvitamin D deficiency was 88.0% preoperatively and 72.7% postoperatively in patients with available laboratory data. A high prevalence of pre- and postoperative nutritional deficiencies was observed among patients undergoing bariatric surgery in Saudi Arabia. Although certain parameters improved after surgery, others remained prevalent or worsened postoperatively. These findings highlight the importance of structured nutritional assessments and regular biochemical monitoring before and after bariatric surgery.

PMID 42464830
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PubMedNutrition & metabolism2026-07-17

Low vitamin D status and cardiometabolic trait clustering in a primary-care adult cohort: association analysis and exploratory explainable machine-learning classification.

Mozaffar Boshra B, Alsanie Saleh A SA, Ashfaq Fauzia F, Madkhali Nahlah Jaber NJ et al.

Low serum 25-hydroxyvitamin D (25(OH)D) commonly co-exists with obesity and adverse cardiometabolic traits. However, its cross-sectional association with dyslipidaemia, body composition and glycaemic markers in primary-care adults remains incompletely characterised. This study examined these associations as the primary objective and, as a secondary exploratory objective, assessed whether routine clinical variables could classify concurrent vitamin D deficiency using interpretable machine-learning models. In this cross-sectional study, adults attending routine health check-up services underwent anthropometric and body-composition assessment (BMI, body fat mass, body fat percentage and lean mass), metabolic-profile screening and vitamin-status assessment. Vitamin D status was classified as deficient (< 20 ng/mL), insufficient (20-29.9 ng/mL) or sufficient (≥ 30 ng/mL). Group comparisons, correlation analyses and multivariable regression models were performed. In a secondary exploratory analysis, logistic-regression and random-forest models were used to classify vitamin D deficiency from routine clinical variables after internal cross-validation. In the overall analytic sample, the mean serum 25(OH)D level was 20.3 ± 8.0 ng/mL, and 50.3% of participants were obese. Vitamin D deficiency was associated with significantly higher BMI, body fat mass, body fat percentage, fasting blood glucose, HbA1c, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), triglycerides (TG) and TG-derived very-low-density lipoprotein cholesterol (VLDL-c) and with significantly lower high-density lipoprotein cholesterol (HDL-c) (all p < 0.05). Serum 25(OH)D was inversely correlated with adiposity indices and TG and positively correlated with HDL-c. In the secondary exploratory classification analysis, the dimension-reduced random-forest model showed higher internal discrimination than logistic regression for classifying vitamin D deficiency in this dataset. Primary-care cohort with a high obesity burden, lower vitamin D status was associated with greater adiposity, less favourable glycaemic indices and a more atherogenic lipid profile. The exploratory machine-learning analysis suggests that routine nutritional, body-composition and biochemical variables may help classify concurrent vitamin D deficiency. However, these findings require external validation and should not be interpreted as evidence of causality or immediate clinical utility.

PMID 42464303
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