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folic acid + vitamin B6 + vitamin B12 + primorine (Folmor)

✓ Approved

Zylera · Small Molecule · Small Molecule

What is folic acid + vitamin B6 + vitamin B12 + primorine?

folic acid + vitamin B6 + vitamin B12 + primorine is a small molecule developed by Zylera. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesFolmor
CompanyZylera
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Zylera

Therapeutic Indications

folic acid + vitamin B6 + vitamin B12 + primorine is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Metabolism and nutrition disordersHypercholesterolaemia✓ Approved

Related Research Articles

PubMedThe British journal of nutrition2026-10-15

Nutritional intakes and their association with symptom severity among women with Hyperemesis Gravidarum.

Sandberg Maja M, Kelly Laura L, Cunningham Alexandra A, Augustin Hanna H et al.

Hyperemesis Gravidarum (HG) is characterised by severe nausea and vomiting in pregnancy. Despite the critical role of nutrition during pregnancy and risk of malnutrition in this cohort, few studies have reported dietary intakes of women with HG. The aim was to assess the nutritional intakes of women with HG compared with dietary recommendations and to explore the association between nutritional intakes and symptom severity. In this cross-sectional study, women with a diagnosis of HG attending a day assessment unit in a large maternity hospital in Dublin, Ireland, were invited (March 2021-January 2022) to participate. Nutritional intake was assessed using 24-h food and fluid diaries. Median intakes were compared with requirements using Wilcoxon signed-rank tests. The median (interquartile range) energy and fluid intake of the thirty-six women included was 1050 (481-1461) kcal and 1196 (778-2081) mL compared with estimated requirements of 2057 (1978-2332) kcal and 2300 mL (p < 0·001 for both). The median intakes of studied nutrients and fluid were significantly below estimated requirements. Spearman's correlations between nutritional intakes and symptom severity (24-h Pregnancy-Unique Quantification of Emesis and Nausea score) were calculated for twenty-nine participants. Several nutrient intakes, including energy, macronutrients, Na, potassium, Ca, Fe, iodine, vitamin D, thiamine and vitamin B12, were significantly negatively correlated with nausea and/or vomiting scores. In conclusion, women with HG consume inadequate energy, fluid and essential nutrients, with poorer intake associated with more severe nausea and vomiting. These findings highlight the need for routine nutrition assessments and tailored interventions to improve nutritional status in women with HG.

PMID 42876064
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PubMedFrontiers in medicine2026-10-15

Hypercalcemia and acute kidney injury caused by occupational inhalation of vitamin D3: a case report.

Zhu Shan S, Chen Luping L, Ying Jun J, Ye Hongying H et al.

Vitamin D intoxication is a rare but potentially life-threatening condition that can lead to severe hypercalcemia and serious complications. Most reported cases are associated with long-term or high-dose oral vitamin D preparations, dietary supplement use, or inappropriate iatrogenic prescribing. In contrast, occupational inhalation exposure remains exceedingly uncommon. We report the case of a 25-year-old man who developed parathyroid hormone (PTH)-independent hypercalcemia and acute kidney injury (AKI) due to excessive exogenous vitamin D3 exposure in the workplace. Following prompt treatment, his clinical condition improved and he was discharged. This case underscores the importance of actively eliciting a history of occupational exposure in patients with PTH-independent hypercalcemia, particularly when there is no clear history of oral supplement use, to reduce missed diagnoses and facilitate prompt recognition and treatment.

PMID 42876639
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PubMedThe Egyptian journal of immunology2026-10-15

Assessment of serum levels of vitamin D and tumor necrosis factor alpha in ulcerative colitis patients at Egyptian Military Hospitals: Cross-sectional observational study.

Eldahan Wedad W, Hassan Mohamed Z H MZH, Asaad Ahmed M AM, Salaheldin Mohamed M et al.

Ulcerative colitis (UC) is a chronic inflammatory disorder confined to the colonic and rectal mucosa. The disease is marked by infiltration of immune cells, leading to excessive production of inflammatory mediators. A key pro-inflammatory cytokine that plays a vital role in the pathophysiology of ulcerative colitis is tumor necrosis factor alpha (TNF-alpha). Low levels of vitamin D have been associated with several autoimmune disorders. This study aimed to assess vitamin D serum levels in UC patients as regard TNF-alpha serum levels and the Severity of UC (UCDAI). This cross-sectional observational research was carried out at Military healthcare facilities in Cairo, Egypt, over six months, from 1 July 2025 to 31 December 2025. Utilizing a convenience sample of 50 adults aged 15 to 70 years with a confirmed diagnosis of ulcerative colitis, newly diagnosed. They were divided into two groups according to disease severity (UCDAI or Mayo score): 26 patients in the mild group & 24 patients in the moderate/severe group. Demographic data were collected from patients' interviews. Colonoscopy for ulcerative colitis disease activity index (UCDAI) score, CBC, ESR, CRP, and Fecal calprotectin (FC) were investigated at Egyptian Military hospitals. Serum levels of 25-hydroxyvitamin D (using CLIA) and TNF-alpha (using ELISA) were measured at central laboratories of the armed forces and blood bank. Correlation analysis showed Serum Vitamin D had a moderate negative correlation with UCDAI (r = -0.466, p-value= 0.001), and a strong negative correlation with serum TNF-alpha (r = -0.669, p-value <0.001). Serum TNF-alpha showed a moderate positive correlation with UCDAI (r = 0.472, p-value= 0.001). Fecal calprotectin had a strong positive correlation with UCDAI (r = 0.704, p-value <0.001) and a weak positive correlation with serum TNF-alpha (r = 0.388, p-value= 0.005). In conclusion, this study demonstrates that patients with moderate to severe ulcerative colitis had pronounced mucosal and systemic inflammation, reflected by markedly elevated fecal calprotectin and TNF-alpha levels, concomitant with significantly lower vitamin D concentrations compared with those in mild disease.

PMID 42875905
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PubMedDevelopmental medicine and child neurology2026-10-15

Vitamin D deficiency in early pregnancy and the risk of developing cerebral palsy: A case-control study.

Bergman Ebba E, Rylander Lars L, Lindh Christian C, Thacher Jesse D JD

To investigate whether maternal deficiency of vitamin D in early pregnancy increases the risk of cerebral palsy (CP) in offspring. This registry and biobank-based case-control study consisted of mother-child pairs from Scania, Sweden. Cases (n = 322) were identified from a nationwide CP-register born between 1995 and 2014. Random population controls (n = 343) and preterm controls (n = 258) were identified from a birth registry. Serum samples taken during pregnancy were obtained from a biobank and 25(OH)D3 concentrations were categorized into three groups: sufficient (≥ 75 nmol/L), insufficient (50-74.9 nmol/L), and deficient (< 50 nmol/L). Logistic regression was used to investigate associations between 25(OH)D3 concentrations and CP. Separate analyses were completed among children born preterm and at term, as well as for subtypes of CP. Deficiency of 25(OH)D3 was not associated with a significantly higher risk of CP compared with sufficient values in the studied groups of all children (odds ratio [OR]: 1.34; 95% confidence interval [CI]: 0.86-2.10), children born at term (OR: 1.48; 95% CI: 0.89-2.44), and children born preterm (OR: 0.74; 95% CI: 0.37-1.46). No apparent association between 25(OH)D3 and CP was observed; however, the relatively small sample size and reliance on a single vitamin D measurement may have limited the detection of modest effects.

PMID 42875866
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PubMedBMC plant biology2026-10-15

Combined application of bacterial biofertilizers, seaweed, and Thymbra spicata extract enhanced productivity, nutritional value, and postharvest shelf life of cucumber (Cucumis sativus L.).

Karami Bahareh B, Bagnazari Majid M, Mohammadi Meisam M, Azizi Afsaneh A

Environmentally friendly biostimulants and biofertilizers have emerged as promising alternatives to synthetic agricultural inputs for improving crop productivity, fruit quality, and postharvest longevity. This study investigated the effects of Thymbra spicata L. extract at 0% (E0), 10% (TE1), and 20% (TE2), applied individually or in combination with seaweed biofertilizer (1%) (SB) and bacterial biofertilizer (10%) (BB), on the growth, yield, physiological responses, and postharvest characteristics of cucumber (Cucumis sativus L. var. eureka) under field conditions. The experiment was conducted as a factorial arrangement in a randomized complete block design with three replications. The results showed that the combined application of TE1 + SB + BB was the most effective treatment with respect to yield, vitamin C content, antioxidant activity, and postharvest longevity. Compared with the untreated control, this treatment increased fruit number by 29.32%, total yield by 43.23%, fruit firmness by 22.34%, vitamin C content by 33.25%, antioxidant activity by 72.93%, and shelf life by 121.67%, while reducing fruit weight loss by 45.67%. Although several other treatments improved specific physiological and biochemical traits, TE1 + SB + BB provided the greatest benefits for the major yield- and postharvest-related attributes evaluated in this study. These findings indicated that integrating 10% T. spicata extract with seaweed and bacterial biofertilizers enhanced cucumber yield, antioxidant capacity, and postharvest longevity, and could represent an effective and sustainable approach for cucumber production.

PMID 42875743
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PubMedBasic & clinical pharmacology & toxicology2026-10-15

Evidence on Glutathione and Boosters for Prevention of Chemotherapy-Induced Neuropathy: A Systematic Review and Network Meta-Analysis.

Geum Min Jung MJ, Jeon Jinyoung J, Moon JinYoung J, Lee Hyun Woo HW et al.

Chemotherapy-induced peripheral neuropathy (CIPN) adversely affects treatment efficacy and quality of life. Despite studies on glutathione (GSH) or GSH boosters' antioxidative effects for prevention, optimal management remains uncertain. We conducted a systematic review and network meta-analysis of randomized controlled trials to consolidate and critically appraise the current evidence and to compare the efficacy of GSH and GSH boosters for the prevention of CIPN. The MEDLINE, Embase and CENTRAL databases were searched through March 2025. Twenty-five RCTs involving 1625 patients were included. No intervention significantly reduced all-grade CIPN compared with placebo. N-acetylcysteine (odds ratio [OR] 0.19, 95% credible intervals [CrI] 0.05-0.63), GSH (OR 0.34, 95% CrI 0.13-0.79) and vitamin E (OR 0.33, 95% CrI 0.11-0.91) were associated with a reduced incidence of grade 3/4 CIPN compared with placebo. N-acetylcysteine ranked highest for both all-grade and grade 3/4 CIPN prevention. These findings remained consistent in sensitivity analyses excluding patients with pre-existing neuropathy but were not retained in analyses restricted to double-blind studies. Overall, N-acetylcysteine, GSH, and vitamin E were associated with potential reductions in severe CIPN, with N-acetylcysteine consistently ranking highest, although these associations should be regarded as preliminary. Further rigorously conducted and adequately powered trials are warranted to confirm these findings and evaluate agents demonstrating potential benefits.

PMID 42876024
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