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abuse-deterrent extended release tablet technology

✓ Approved

Inspirion Delivery Technologies · therapeutic agent

What is abuse-deterrent extended release tablet technology?

abuse-deterrent extended release tablet technology is a therapeutic agent developed by Inspirion Delivery Technologies. It is approved for therapeutic indications via others.

Drug Profile

CompanyInspirion Delivery Technologies
RouteOthers
StatusApproved
Sources: ClinicalTrials.gov, Inspirion Delivery Technologies

Therapeutic Indications

abuse-deterrent extended release tablet technology is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresOral appliance application✓ Approved

Related Research Articles

PubMedDrug development and industrial pharmacy2026-08-30

Development of Extended-Release Oral Dosage Forms of Salbutamol Sulfate Using the Hot-Melt Extrusion Manufacturing Technique.

Ramadan Banan B, Al-Zoubi Nizar N, Migdadi Eman E, AlSuwais Alia Kh AK et al.

To fabricate and characterize extrudable polymeric matrices using a combination of ethyl cellulose (EC) and two different grades of hydroxypropyl cellulose (HPC) that can provide sustained drug release of the model drug salbutamol sulfate. Implementation of the Hot-Melt Extrusion (HME) technique in the fabrication of polymeric combinations that will provide ready-to-use matrices for sustained release dosage forms. Two formulation groups were developed; each with six formulations. The first group contained EC: HPC 370,000 ratios ranging from 55.52:13.8% to 6.9:62.46%, respectively. The second group contained EC: HPC 80,000 ranging from 59.4:10% to 9.4:60%, respectively. The release profiles were determined via in vitro studies to assess the ability of matrices to prolong salbutamol release. Solid-state characterization was also performed on the raw material and representative extrudates formulations using differential scanning calorimetry (DSC) and X-ray powder diffraction (XRPD) and polarized light microscopy (PLM). The first group formulations exhibited prolonged drug release profiles that accelerated progressively as the level of HPC 370,000 increased. In contrast, the second group formulations exhibited a noticeably faster release, demonstrating that HPC 80,000 can effectively accelerate drug release through enhanced matrix erosion and water penetration. DSC and XRPD revealed that the model drug remained in its stable crystalline state even after thermal processing via HME. PLM further confirmed drug crystallinity within the extrudates. EC-HPC matrices successfully demonstrated the feasibility of using HME to prepare sustained-release matrices for salbutamol sulfate with the ability to tune drug release by varying polymer grade and ratio.

PMID 42669207
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PubMedJournal of interpersonal violence2026-08-30

Childhood Emotional Abuse and Aggressive Behaviors in Delinquency: The Mediators of Emotional Dysregulation and Deviant Peer Affiliation.

Jiang Lina L, Ying Liuhua L, Wu Xinhui X

Childhood emotional abuse is a well-established risk factor for delinquent behavior. However, research examining the pathways from emotional abuse to aggression within an integrated theoretical model remains limited. The current study examines the serial mediation of emotional dysregulation and deviant peer affiliation in the relationship between childhood emotional abuse and aggressive behaviors among male juvenile delinquents. A total of 438 male adolescents (mean age = 19.03 years, SD = 2.82) were recruited from a juvenile correctional facility in China. Participants completed a battery of questionnaires, including the five-item emotional abuse subscale of the Childhood Trauma Questionnaire-Short Form, the Peers' Deviant Behaviors Scale, the Difficulties in Emotion Regulation Scale, and the Buss-Perry Aggression Questionnaire. A latent variable structural equation modeling analysis was conducted to test a hypothesized serial mediation model. The results revealed a significant direct effect of emotional abuse on aggressive behavior. The relationship was independently mediated by both emotional dysregulation and deviant peer affiliation, as well as sequentially through emotional dysregulation leading to increased deviant peer affiliation. These findings suggest that emotional dysregulation and affiliation with deviant peers are critical mechanisms through which childhood emotional abuse fosters aggressive behavior. This has important implications for designing targeted interventions for psychological service providers working with this population.

PMID 42668410
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PubMedJournal of interpersonal violence2026-08-30

"Love is Real. It Takes Many Shapes and Forms": The Concept of Love Among Children in Out-of-Home Placements.

Sherman Schuchalter Ayelet A, Klebanov Bella B

Child abuse studies have contributed significantly to the understanding of the multidimensional dynamic between parents and their children in the context of abuse. Recently, the concept of love in this unique context has received growing attention. The current study was designed to examine the perception of love by adults who experienced parental abuse in their childhood and lived in out-of-home placements. The study comprised interviews with 15 adults who were abused by their parents in childhood and removed to out-of-home placements in Israel. Data were collected through semi-structured in-depth interviews, and transcribed. Qualitative thematic analysis was carried out on all 15 interviews. Three main themes were identified. The first theme delves into the complex interplay of love and maltreatment from the parent. The subsequent theme illustrates the participants' perceptions of themselves as an "object" subjected to abuse during their early childhood by their mothers and once again when separated from their biological homes by child protection services. The third and final theme sheds light on the participants' encounters with love in out-of-home placements. The current study's findings illustrate how love can exist even where abuse occurs. The study highlights the crucial role of caregivers in out-of-home placements in acknowledging the multidimensional nature of child-parent dynamics. Moreover, the current study demonstrates how a healthy, loving relationship with caregivers in out-of-home placements affects participants' perceptions of love.

PMID 42668413
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PubMedNeurotoxicology2026-08-30

An Integrative Model of Ketamine-Induced Memory Dysfunction: From Synapse to Circuit in Clinical Context.

Mohammadi Mola M, Saeedi Amin A, Vakilabad Ali Asghar Kheirkhah AAK, Seyedi Fatemeh F et al.

Ketamine presents a modern pharmacological paradox, acting as both a rapid-acting antidepressant and a drug of abuse with significant cognitive consequences. While its therapeutic potential is revolutionary, chronic exposure is increasingly associated with persistent and specific deficits in episodic and working memory. This narrative review moves beyond descriptive lists of ketamine's effects to propose a novel integrative model that delineates the coherent pathophysiological cascade through which chronic ketamine exposure induces memory dysfunction. We synthesize evidence that the initiating event-NMDA receptor antagonism, particularly on GABAergic interneurons-triggers a glutamate surge and glutamatergic dysregulation. This initial insult activates a self-reinforcing and pathological amplifying loop of neuroinflammation (e.g., microglial activation, cytokine release) and oxidative stress (e.g., mitochondrial dysfunction, ROS/RNS generation). These converging insults subsequently suppress BDNF/TrkB neurotrophic signaling and cause synaptic disintegration, impairing the plasticity mechanisms that underlie learning and memory. The cascade structurally culminates in apoptotic neuronal deletion, which permanently degrades the cellular substrate within critical memory circuits. This molecular and cellular pathology ultimately manifests as systems-level dysfunction, specifically the functional disconnection of the hippocampus-prefrontal cortex axis, explaining the core clinical memory deficits. By bridging evidence from synapse to circuit, this integrative model provides a unified framework for understanding individual vulnerability, proposes biomarkers for personalized risk assessment, and identifies targeted neuroprotective strategies to mitigate cognitive harm while preserving ketamine's therapeutic benefits.

PMID 42669313
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PubMedInternational journal of pharmaceutics2026-08-30

Intranasal delivery of Semaglutide using a thermoresponsive PNPHO nanocarrier: formulation development, characterization and biological evaluation.

Sayka Khan Tanisha Tabassum TT, Jerry Wong Chun Yuen CY, Sheikh Zara Z, Fathi Ali A et al.

Semaglutide (SMG) is a glucagon-like peptide-1 receptor agonist with a promising efficacy and safety profile that is widely used for reducing obesity by targeting the appetite control centres in the brain and for type 2 diabetes management by enhancing insulin release and suppressing glucagon secretion. SMG is currently administered subcutaneously that is invasive with reduced patient compliance or orally leading to decreased efficacy owing to first-pass effects. In this study, a nanoparticle (NP) formulation of SMG was developed using a thermoresponsive and biocompatible synthetic polymer, PNPHO (poly(N-isopropylacrylamide-co-(N-acryloxysuccinimide)-co-(polylactide/-hydroxy methacrylate)-co-(oligo (ethylene glycol)), to investigate its potential to enhance nasal mucosal absorption and prolong residence time via the needle-free intranasal (IN) route. The NP formulation was characterized in vitro for physicochemical parameters, stability, mucoadhesion, regional nasal deposition, drug release profile, and cellular permeation, and in vivo for glucose sensitivity and biodistribution. Monodispersed NPs displayed an average size of 26.14 ± 0.19 nm, a negative surface charge with high SMG encapsulation (89%), improved stability against enzymatic degradation and increased permeation across nasal epithelial cells in vitro compared to SMG alone (p < 0.0001). In contrast, it reduced transport across hCMEC/D3 BBB cells. Nasal cast studies revealed greater NP deposition in the turbinates compared to the free drug. In vivo, the NP formulation demonstrated prolonged nasal retention of the formulation within the sinus region along with an improved glucose tolerance with a 24 h dosing regimen, showing an extended period of pharmacological activity that can be utilized for reducing dosing frequency. No detectable brain fluorescence was observed in vivo. Overall, these findings corroborate the potential of IN delivery of thermoresponsive SMG-PNPHO NP formulation with increased efficacy compared to current SMG delivery modes.

PMID 42669320
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PubMedPakistan journal of medical sciences2026-08-30

Multidrug resistant bacterial infection in liver transplant recipients: A Deterrent and obstacle.

Misbah Nazish N, Haider Jahanzaib J, Hassan Muhammad M, Fatima Mehreen M

To determine the microbiological spectrum of multi-drug resistant (MDR) bacterial infections within the first 30 days post-living donor liver transplantation (LDLT) and identify the associated risk factors contributing to their emergence. This retrospective cohort study reviewed the medical records of patients who underwent LDLT from January 2020 to December 2024 at the Liver Transplant and Hepatopancreatobiliary Surgery Unit of Dow University Hospital, Karachi. Patients were categorized into MDR and no-MDR groups based on culture-confirmed MDR bacterial infection with clinical features of sepsis. Types of MDR bacterial infections were noted. Baseline, pre-transplant, intraoperative, and post-transplant variables were recorded. Pearson Chi-square test, Mann-Whitney U test, and univariate and multivariate logistic regression analyses were performed for statistical inference. Of 151 LDLT recipients, 75 (49.7%) developed MDR bacterial infections within 30 days. Among these, gram negative MDR organisms were predominated, with carbapenem-resistant Enterobacteriaceae (21.2%) and carbapenem-resistant Acinetobacter baumannii (20.5%) most frequent, followed by vancomycin-resistant Enterococci (13.2%). On univariate analysis, MDR infection was associated with pre-transplant ICU admission, renal dysfunction, prolonged postoperative ICU stay, mechanical ventilation >48 h, hemodialysis and/or sustained low-efficiency dialysis (SLED), postoperative complications, longer invasive device duration, prolonged hospital stay, central line-associated blood stream infection (CLABSI), and intra-abdominal infections. On multivariate analysis, only CLABSI [Wald χ²=17.696 (OR 0.021; 95% CI: 0.003-0.127; p<0.001)] and intra-abdominal infections [Wald χ²=25.567 (OR 0.008; 95% CI: 0.001-0.050; p<0.001)] remained independently associated with MDR infection. Nearly half of LDLT recipients developed MDR infections, predominantly due to gram-negative organisms. CLABSI and intra-abdominal infections emerged as the key predictors of MDR bacterial infections.

PMID 42668754
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