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albumin (Zenalb)

✓ Approved

Kedrion · Cell-based Therapies · Cell-based Therapies

What is albumin?

albumin is a cell-based therapies developed by Kedrion. It is approved for therapeutic indications via injectable (others) or intravenous (iv).

Drug Profile

Brand NamesZenalb
CompanyKedrion
Drug ClassCell-based Therapies
RouteInjectable (Others), Intravenous (IV)
StatusApproved
Sources: ClinicalTrials.gov, Kedrion

Therapeutic Indications

albumin is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Vascular disordersThrombosis✓ Approved

Related Research Articles

PubMedThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians2026-07-17

Association of LDH-derived biochemical ratios with severe pre-eclampsia: a multicenter retrospective cohort study.

Geyik Bayman Melike M, Türen Demir Emine E, Kılıç Orhan O, Metin Ülfet Sena ÜS et al.

Pre-eclampsia (PE) is a major pregnancy-related hypertensive disorder associated with increased maternal and perinatal morbidity, particularly in severe cases. Early identification of patients at risk for severe disease remains clinically important, especially using simple and widely accessible laboratory markers. This study aimed to evaluate the association between Lactate dehydrogenase (LDH) derived biochemical ratios and severe pre-eclampsia in a multicenter obstetric cohort. This multicenter retrospective cohort study included 326 pregnant women diagnosed with pre-eclampsia between January 2020 and July 2024 at two tertiary referral centers in Türkiye. Patients were classified as having non-severe pre-eclampsia (n = 116) or severe pre-eclampsia (n = 210) according to established clinical criteria. LDH-derived biochemical ratios, including LDH/albumin, LDH/creatinine, LDH/uric acid, and uric acid/creatinine, were calculated using routinely obtained laboratory parameters. Receiver operating characteristic (ROC) curve analysis was performed to assess the predictive performance of these biomarkers for severe disease, while multivariate logistic regression analysis was used to determine independent predictors associated with severe pre-eclampsia. LDH/albumin, LDH/creatinine, and LDH/uric acid ratios were significantly higher in women with severe pre-eclampsia compared with those with non-severe disease (all p < 0.05). Among the evaluated biomarkers, the LDH/albumin ratio demonstrated the best predictive performance for severe pre-eclampsia, with an Area under the curve (AUC) of 0.639 (95% Confidence interval (CI) 0.579-0.702, p < 0.001). An LDH/albumin cutoff value of 11.38 yielded a sensitivity of 36.8% and a specificity of 86.2%. In multivariate logistic regression analysis, the LDH/albumin ratio remained independently associated with severe pre-eclampsia (Odds ratio (OR): 1.19, 95% CI: 1.08-1.31, p < 0.001). LDH-derived biochemical ratios, particularly the LDH/albumin ratio, may represent simple and readily available biomarkers for identifying patients at increased risk for severe pre-eclampsia. Because these parameters are inexpensive and routinely obtained in obstetric practice, they may provide additional support for early risk stratification and clinical assessment. Further prospective multicenter studies are needed to validate these findings.

PMID 42463416
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PubMedWater research2026-07-17

Overlooked properties difference of biogenic sulfur resulting in distinct performance in serving as an electron donor for microbial denitrification.

Zhang N N, Yi G G, Ren R R, Zhang G G et al.

Biogenic sulfur (bio-S0) is recognized as a more efficient electron donor compared to its chemical counterpart in microbial denitrification. However, the performance differences among various types of bio-S0 remain poorly understood, posing a challenge in identifying the optimal variant. In this study, we comparatively investigated three distinct bio-S0 samples-bio-S0-A1 and bio-S0-A2, both obtained from single-reactor bio-S0 production processes with varying organic coating thicknesses, and bio-S0-B, sourced from a dual-reactor bio-S0 production process-alongside chemical sulfur (chem-S0) in terms of property characterization, denitrification performance, and microbial composition. Our results showed that bio-S0-B exhibited an elevated denitrification rate compared to the chem-S0, but was less effective than bio-S0-A1 and bio-S0-A2. This discrepancy could be attributed to the differing sulfur-related properties, such as polysulfane content and crystallinity. Regarding the other two bio-S0 samples (bio-S0-A1 and bio-S0-A2), our findings indicated that the organic coating negatively impacted denitrification performance. Inspired by this, we further demonstrated that bio-S0 can be optimized by destroying the organic coating, leading to an increase of up to 3.2-fold in denitrification rate. Variations of microbial composition were noted among different bio-S0 samples, with the relative abundance of Moheibacter showing a positive correlation with the denitrification rate. This study offers a property-based guideline for optimizing the selection of bio-S0 and further refining raw bio-S0 to enhance its effectiveness as an electron donor for denitrification.

PMID 42462649
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PubMedFrontiers in microbiology2026-07-17

Engineered microbes to enable a circular economy for biodegradable plastics.

Madushanka Dushmantha D, Beard Cole C, Kolitha Bhagya S BS, Dissanayake Lakshika L et al.

Plastic pollution resulting from the continued dominance of fossil-derived polymers is a major global environmental challenge. Although biodegradable plastics, such as polylactic acid (PLA), polyhydroxyalkanoates (PHAs), polybutylene succinate (PBS), polybutylene adipate terephthalate (PBAT), and related materials, are increasingly being deployed as alternatives, their environmental performance is frequently constrained by infrastructure gaps, uncontrolled carbon loss, and incomplete degradation under realistic conditions. Therefore, biodegradability alone does not guarantee circularity of the material. To address this, intentional rerouting of plastics and their monomers into upcycling streams offers a widely applicable solution. This review advances the circular bioeconomy framework built on engineered depolymerization and metabolic bio-funneling of biodegradable and selected synthetic plastics. We present recent progress in enzyme-mediated polyester breakdown, emphasizing hydrolases and oxidoreductases, the kinetic and structural determinants of activity, and protein engineering strategies that broaden substrate scope and enhance operational stability. We then organize bio-upcycling strategies according to key metabolic entry nodes: pyruvate, acetyl-CoA/β-oxidation, and aromatic/dicarboxylate pathways, to demonstrate how plastic-derived monomers can be systematically redirected toward platform chemicals, fuels, specialty monomers, and next-generation biopolymers through pathway rewiring, flux control, and redox balance. In addition to biological conversion, we evaluate chemo-biological hybrid systems and integrated techno-economic and life cycle considerations, including process efficiency, enzyme cost, toxicity mitigation, and infrastructure compatibility. We further highlight emerging tools, such as systems biology, adaptive laboratory evolution, synthetic consortia design, and machine-learning-guided protein optimization, which accelerate the design-build-test-learn cycle for scalable microbial platforms for plastic upcycling. Collectively, this study reframes biodegradable plastics not as materials designed merely to disappear but as programmable carbon reservoirs that can be captured, upgraded, and reintegrated into biomanufacturing value chains. Actively closing the loop through engineered bio-upcycling, rather than relying on passive environmental degradation, offers a practical pathway to align plastic utility with environmental sustainability and achieve a truly circular bioeconomy.

PMID 42466128
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PubMedScientific reports2026-07-17

Evaluation of the properties of gel, film and paper coated with nanocellulose and nanochitin.

Dehghani Firouzabadi Mohammadreza M, Bousfield Douglas D, Tajvidi Mehdi M

Bio-based nano-materials have great potential as films and as paper coatings to produce materials that are suitable for food packaging. However, more needs to be understood about the characteristics of the starting materials and how they influence the final film properties. The objective of this study was to comparatively investigate the structural, thermal, mechanical, rheological, and functional properties of nanocellulose and nanochitin films or gels and their application as bio-coatings for paper. The thermal behavior of nanocellulose and nanochitin samples was similar. The tensile strength and strain of the nanocellulose films were significantly higher than those of the nanochitin films. The viscosity of both nanocellulose and nanochitin gels decreased uniformly with increasing shear rate. The coating process was carried out at a speed of 5 cm/s for single-layer and double-layer coatings. Bio-coating of the paper with nanochitin significantly improved the barrier properties (resistance to water, air, and oil penetration). At similar coat weights, the nanochitin-coated papers always consistently exhibited a lower thickness than the nanocellulose-coated papers. The brightness of nanocellulose-coated papers was higher than that of nanochitin-coated papers. This study demonstrates the potential of these bio-based nanomaterials for sustainable and effective paper bio-coatings.

PMID 42463733
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PubMedBioresource technology2026-07-17

Structural evolution and reaction pathways of hematite reduction by biomass-lignin derived bio-coke.

Wu Kefeng K, Ge Lichao L, Yao Lei L, Yang Chunxia C et al.

In this study, bio-cokes with different mass ratios were prepared by co-pyrolysis of pine sawdust and lignin, and their hematite reduction behavior, gas release characteristics, and carbon structural evolution at 600-1000 °C were systematically investigated. The results show that hematite reduction follows a stepwise pathway of Fe2O3 → Fe3O4 → FeO → Fe, with the FeO-to-Fe transition identified as the key rate-controlling step because it becomes thermodynamically favorable only above 800 °C. Increasing the lignin proportion improved the fixed carbon content of bio-coke, leading to higher reduction efficiency at all tested temperatures, with a maximum reduction rate of 96.8% at 1000 °C. TG-FTIR and kinetic analyses revealed that the P2-L1 sample released CO and CO2 more intensely and concentratively in the high-temperature region, thereby enhancing gas-phase reduction through the Boudouard reaction. Raman spectroscopy and microscopic observations further confirmed that higher lignin content promoted ordered carbon structural reorganization during high-temperature treatment, forming a more stable and graphitized carbon structure. This facilitated deeper deoxygenation and higher metallic iron yield. This work investigates the influence of lignin content variation in the blended feedstock on bio-coke structure and reduction performance, providing guidance for the development of biomass-derived reducing agents in low-carbon metallurgy.

PMID 42462832
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PubMedAnnali italiani di chirurgia2026-07-17

Pre- and Postoperative Nutritional Deficiencies in Patients Undergoing Bariatric Surgery: A Retrospective Cohort Study.

Algethami Mohammed R MR, Jamal Wisam W

To assess the changes in biochemical indicators of nutritional deficiencies before and after bariatric surgery. This retrospective cohort study included 480 adult patients who underwent bariatric surgery between June 2016 and June 2019 at a tertiary care center in Saudi Arabia. Demographic data, comorbidities, and pre- and postoperative biochemical parameters, including hemoglobin, iron profile, Vitamin D, Vitamin B12, albumin, calcium, and parathyroid hormone levels, were extracted from the medical records. These biochemical parameters were used to assess micronutrient status and identify clinically relevant nutritional deficiencies based on established laboratory thresholds. Paired t- and McNemar tests were used to compare the pre- and postoperative values. Statistical significance was set at p < 0.05. We found a high prevalence of pre- and postoperative nutritional deficiencies among patients. The mean hemoglobin decreased from 13.09 to 12.34 g/dL (mean difference -0.75 g/dL; 95% CI -0.89 to -0.61; p < 0.001). We observed a significant association between ferritin and gender pre- and postoperatively, which was lower in women than in men preoperatively and decreased in both sexes postoperatively. The prevalence of 25-hydroxyvitamin D deficiency was 88.0% preoperatively and 72.7% postoperatively in patients with available laboratory data. A high prevalence of pre- and postoperative nutritional deficiencies was observed among patients undergoing bariatric surgery in Saudi Arabia. Although certain parameters improved after surgery, others remained prevalent or worsened postoperatively. These findings highlight the importance of structured nutritional assessments and regular biochemical monitoring before and after bariatric surgery.

PMID 42464830
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