Drug Database
KH

KH-741 (KH 741 / KH741)

✓ Approved

Chengdu Kanghong Pharmaceutical · Small Molecule · Small Molecule

What is KH-741?

KH-741 is a small molecule developed by Chengdu Kanghong Pharmaceutical. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesKH 741, KH741
CompanyChengdu Kanghong Pharmaceutical
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Chengdu Kanghong Pharmaceutical

Therapeutic Indications

KH-741 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Psychiatric disordersBipolar I disorder✓ Approved

Related Research Articles

PubMedMolecular genetics and genomics : MGG2026-10-15

USP11 inhibits cuproptosis in non-small cell lung cancer by deubiquitinating IGF2BP2 to enhance the stability of m6A-modified ATOX1 mRNA.

Wang Lin L, Li Jiansheng J, Li Hongxia H

Inducing cuproptosis is considered a novel strategy to impede non-small cell lung cancer (NSCLC) progression. ATOX1 suppressed cuproptosis by chelating free copper ions. This study seeks to elucidate the pathways that regulate ATOX1 upstream and thereby pinpoint molecular targets for activating cuproptosis in NSCLC. Cuproptosis was induced with ES-Cu. Malignant phenotypes were assessed using CCK-8, clonogenic, and Transwell assays. RNA immunoprecipitation, RNA pull-down, and actinomycin D chase were used to examine IGF2BP2-ATOX1 mRNA interaction and mRNA stability. Protein-protein interactions and ubiquitination were examined by co-immunoprecipitation. The co-localization of USP11 and IGF2BP2 was visualized by immunofluorescence. IGF2BP2 protein stability was assessed following cycloheximide treatment. Copper content was quantified using a commercial kit. Gene and protein levels were evaluated by RT-qPCR and Western blot. RNA-binding domain mutant rescue experiments were conducted to determine the functional requirement of IGF2BP2 KH domains. A subcutaneous xenograft model was established to validate the regulatory axis in vivo. ATOX1 suppressed cuproptosis to support NSCLC proliferation. IGF2BP2 bound to the CDS of ATOX1 mRNA via the m6A site at position 261, thereby enhancing ATOX1 mRNA stability. The KH3-4 domains of IGF2BP2 were indispensable for this regulation. Upregulation of ATOX1 by IGF2BP2 inhibited cuproptosis and consequently drove NSCLC proliferation. USP11 maintained IGF2BP2 protein stability via deubiquitination, leading to suppression of cuproptosis and promotion of NSCLC progression through the IGF2BP2/ATOX1 axis in vitro. In vivo, the USP11-IGF2BP2-ATOX1 axis might promote NSCLC tumor growth by suppressing cuproptosis. USP11‑dependent deubiquitination stabilized IGF2BP2, which subsequently increased ATOX1 mRNA stability in an m6A‑dependent manner. Elevated ATOX1 expression inhibited cuproptosis and thereby accelerated NSCLC progression.

PMID 42875701
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PubMedAnalytical methods : advancing methods and applications2026-10-14

Development and performance evaluation of extraction and purification procedures for halogenated DBPs in soil and lettuce.

Dumas Mathieu M, Coulomb Bruno B, Demelas Carine C, Vassalo Laurent L et al.

Reuse of treated wastewater in agriculture exposes soils and edible crops to halogenated disinfection byproducts (DBPs), toxic compounds formed during chlorination. While DBPs are well characterized in water, analytical methods for soil and plant matrices remain scarce, limiting risk assessment for food safety and groundwater contamination. This gap hinders the implementation of EU Regulation 2020/741 on safe wastewater reuse. We developed and evaluated two solid-liquid extraction methods for 36 DBPs across 8 families (THMs, HANs, HNMs, HKs, HALs, HAcAms, HAs, and HAAs) in artificial/natural soils and lettuce, combined with pass-through SPE clean-up (ENVI-Carb for lettuce, Florisil for soils), to reduce matrix effects and enhance system stability and sensitivity. Extraction parameters (pH, ionic strength, and agitation/sonication time) were optimized using GC-ECD. HAAs were esterified prior to clean-up to avoid retention. Recovery rates ranged from 54.3-117.4% (29/36 analytes >80% for soil, 28/36 for lettuce), with method detection limits 14 times lower than prior work on lettuce (0.06-11.69 ng g-1 dry soil or fresh lettuce). The clean-up step was optimized using both GC-ECD (quantitative) and GC-MS (qualitative). Matrix effects were minimized, improving system robustness using the SPE approach. Stability tests revealed rapid degradation of HNMs, HALs, HANs and HKs in moist soils (<24 h) with halohydrins, HAcAms and HAAs identified as degradation products. This work provides sensitive, reliable tools for monitoring halogenated DBPs in agricultural soil/plant systems, supporting compliance with wastewater reuse regulations and addressing critical gaps in food safety risk assessment.

PMID 42872480
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PubMedChemico-biological interactions2026-10-13

Polylactic acid nanoplastics induce kidney injury by activating the TRPM2-mediated mitophagy pathway.

Yan Ziwen Z, Jia Tiantian T, Zhou Yuankun Y, Xu Hengyi H

Polylactic acid nanoparticles (PLA NPs) are widely used biodegradable plastics, but their potential health risks remain unclear. This study explores whether PLA NPs induce renal cell apoptosis through a mitochondrial pathway involving transient receptor potential melastatin 2 (TRPM2) and mitophagy. Adult male C57BL/6 mice were orally exposed to 0.1, 1, and 10 mg/kg/day PLA NPs for 28 consecutive days. PLA NPs caused dose-dependent kidney injury, with the high-dose group (group H, 10 mg/kg/day) showing the most severe renal apoptosis and functional impairment. In group H, renal calcium ion (Ca2+) levels, mitophagy, and TRPM2 expression were significantly elevated. To investigate the mechanism, TRPM2-KO mice (group KH) and mitophagy inhibitor Mdivi-1-treated mice (group Md) were orally administered 10 mg/kg/day PLA NPs daily. Compared with group H, both group KH and group Md showed reduced renal injury, as evidenced by decreased apoptosis and restored mitochondrial function. These results indicate that PLA NPs induce oxidative stress, activate the TRPM2 channel, cause calcium overload and excessive mitophagy, and ultimately trigger renal cell apoptosis. This study provides a theoretical basis for targeted treatment of kidney diseases caused by PLA NPs.

PMID 42863736
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PubMedBritish journal of pharmacology2026-10-13

Cholinergic inputs to motoneurons in the spinal cord augment focal muscle spasticity in rodents.

Meglić Patrik P, Šoštarić Petra P, Tsape Eirini E, Galani Melpomeni M et al.

Cholinergic premotor inputs to motoneurons support high levels of motor output when required. However, the possible role of these inputs in pathologically elevated muscle tone has not been characterised. To address this, we examined the modulatory effect of spinal acetylcholine (ACh) on experimental spastic paralysis. Rats were injected with tetanus neurotoxin (TeNT, 33-100 pg, im) into gastrocnemius to induce sustained rigid hind-paw extension and resistance to passive ankle flexion. The effects of spinal ACh on experimental hypertonia were probed by lumbar intrathecal application of the AChE inhibitor neostigmine (NEO) or a muscarinic M2 receptor antagonist (AQ-RA 741). Effects of NEO on extracellular ACh were measured in the facial nucleus after TeNT (33 pg) or botulinum toxin A (BoNT/A, 2 U) injection into the rat whisker pad. The intensity of TeNT-evoked hindlimb hypertonia (10 pg, im) was assessed in mice with genetic ablation of cholinergic C bouton source interneurons (V0C interneurons). NEO augmented the severity of TeNT-evoked hypertonia, whereas AQ-RA 741 attenuated it. Local perfusion of NEO caused a BoNT/A-sensitive increase in extracellular ACh concentration. The involvement of cholinergic C boutons was corroborated by reduced hypertonia following TeNT challenge (10 pg, im) in V0C-ablated mice. Our results suggest that spinal cholinergic transmission, associated with vesicular ACh release and M2 signalling at C boutons, exacerbates experimental spastic paralysis. We reveal a new role for endogenous spinal ACh, with implications for developing new therapeutic approaches to treat spasticity and hyperkinetic movement disorders.

PMID 42867165
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PubMedWorld journal of urology2026-10-13

BLAST-bladder lithiasis assessment of surgical treatment in real-world practice. A global prospective multicentre registry by EAU Endourology.

Gauhar Vineet V, Yuen Steffi Kar Kei SKK, Herrmann Thomas T, Kalathia Jaisukh J et al.

This registry aimed to establish a comprehensive global database to characterise contemporary real-world surgical approaches to bladder stones and to describe postoperative stone-free rate (SFR) and complications according to the surgical treatment route. The BLAST (Bladder Lithiasis Assessment of Surgical Treatment) registry prospectively enrolled 805 patients across 31 centres in 16 countries between May 2025 and February 2026. Patients underwent transurethral intervention (TI, n = 741), percutaneous suprapubic (PSI, n = 39), or open surgery (OI, n = 25). Postoperative SFR was graded using cross-sectional computer tomography, or ultrasonography, X-ray, or flexible cystoscopy, as Grade A (100% complete clearance), Grade B (single residual fragment), Grade C (multiple residual fragments). Perioperative complications were classified by the Clavien-Dindo criteria. The cohort was predominantly male across all groups. TI patients were older (median 66 vs 60 and 59 years; p = 0.023) and presented with smaller stones (median 2.1 vs 3.0 cm in both other groups; p < 0.001). A history of urinary tract reconstruction was markedly more prevalent in the PSI cohort (23.1% vs 3.5% and 4.0%; p < 0.001). Median hospital stay was significantly shorter following TI (2 vs 3 days; p < 0.001), accompanied by a shorter duration of catheterisation (p < 0.001). Early complications within 48 h were most frequent after OI (48.0% vs 18.6% and 17.9%; p = 0.001), although major complications (Clavien-Dindo ≥ 3) remained rare and comparable across all modalities. No mortality was recorded. Grade A SFR was achieved in 95.5% of TI, 84.6% of PSI, and 100% of OI (p = 0.001). Reintervention for residual fragments was required significantly more often following PSI (10.3% vs 1.3% and 0%; p < 0.001). Transurethral cystolithotripsy was the predominant approach in this real-world international cohort and was associated with high stone clearance and shorter postoperative recovery. Percutaneous and open approaches were selectively used in patients with larger stone burdens, complex anatomy, prior urinary tract reconstruction, or specific urethral limitations. These findings describe contemporary treatment patterns and observed outcomes rather than comparative treatment effectiveness.

PMID 42867550
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PubMedHealth science reports2026-10-11

Work-Related Stress Among Neglected Work Forces in Tertiary Hospitals, Eastern Ethiopia: A Cross-Sectional Study.

Tolera Sina Temesgen ST, Getaneh Dawit Kassaye DK, Tafesse Ararso A, Mohammed Fethia F et al.

Hospital cleaners are an often-neglected workforce routinely exposed to hazardous working conditions that increase their risk of work-related stress (WRS). However, evidence on WRS among hospital cleaners in low- and middle-income countries, including Ethiopia is limited. This study aimed to determine the prevalence of WRS and identify associated factors among hospital cleaners working in eight tertiary hospitals in eastern Ethiopia. A hospital-based cross-sectional study was conducted among 741 cleaners from May to August 2023. Work-related stress (WRS) was assessed using modified items from the Copenhagen Psychosocial Questionnaire II (COPSOQ-II) and the National Health Survey. Severe and low WRS were classified using the mean cut-off score derived from the summed components of physical indicators of WRS. Data quality was ensured through training, pretesting, expert evaluation of the assessment tools, and internal consistency testing using Cronbach's alpha. Data were entered into EpiData version 3.1 and analyzed using Stata 17MP. Descriptive statistics summarized participant characteristics. Binary and multivariable logistic regression analyses identified factors associated with WRS. Variables with p < 0.20 were included in the multivariable model, and AORs with 95% CIs were reported. Of 741 hospital cleaners, 679 participated (response rate: 91.63%). The prevalence of severe WRS was 29.16% (95% CI: 25.77%-32.74%). Multivariable analysis identified significant factors. Workload (AOR = 10.23, 95% CI: 6.16-16.98; p < 0.001), smoking (AOR = 6.64, 95% CI: 3.53-12.51; p < 0.001), khat chewing (AOR = 4.07, 95% CI: 2.34-7.09; p < 0.001), job dissatisfaction (AOR = 2.67, 95% CI: 1.24-5.76; p = 0.012), less-than-monthly supervision (AOR = 1.63, 95% CI: 1.01-3.06; p = 0.030), lack of social recognition (AOR = 3.11, 95% CI: 1.63-5.92; p < 0.001), sleeping difficulties (AOR = 2.18, 95% CI: 1.27-3.71; p = 0.004), and inadequate OHS services (AOR = 1.64, 95% CI: 1.16-2.83; p = 0.043) increased WRS. Experience > 6.72 years reduced stress (AOR = 0.44, 95% CI: 0.26-0.75; p = 0.003). The study concludes that almost one-third of cleaners in tertiary hospitals had severe WRS. Higher levels of stress were substantially associated with smoking, chewing khat, job dissatisfaction, infrequent supervision, lack of social recognition, trouble sleeping, and inadequate workplace health and safety services, with workload being the most significant predictor. Conversely, higher levels of education and more work experience were protective factors. These findings highlight the necessity of comprehensive workplace interventions that reduce excessive workloads, support occupational health and safety services, improve supervision and recognition, promote healthy lives, and support cleaners' professional growth.

PMID 42859737
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