Drug Database
KH

KH-741 (KH 741 / KH741)

✓ Approved

Chengdu Kanghong Pharmaceutical · Small Molecule · Small Molecule

What is KH-741?

KH-741 is a small molecule developed by Chengdu Kanghong Pharmaceutical. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesKH 741, KH741
CompanyChengdu Kanghong Pharmaceutical
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Chengdu Kanghong Pharmaceutical

Therapeutic Indications

KH-741 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Psychiatric disordersBipolar I disorder✓ Approved

Related Research Articles

PubMedZhonghua wai ke za zhi [Chinese journal of surgery]2026-08-30

[Analysis of the prevalence rate and risk factors of gallstone in the elderly in Xuhui District of Shanghai].

Su T M TM, Song Q Q, Shen L L, Li S S et al.

Objective: To investigate the prevalence and the risk factors of gallstone in Xuhui District of Shanghai,providing a scientific basis for developing targeted prevention and control measures. Methods: This is a cross-sectional study,which was conducted on permanent resident elderly individuals aged 65 and above who had established health records and completed annual health examinations between January and December 2024,across 13 community health centers in Xuhui District,Shanghai. A total of 48 844 elderly participants were included in the study, including 21 483 males and 27 361 females, aged (72.0±6.1) years (range: 65 to 106 years). The gender, age, height, weight, results of fasting venous blood and ultrasound results were collected.The absolute standardized mean difference (ASMD) was calculated to assess the balance of covariates between groups.Based on the presence of gallbladder stones detected by ultrasonography, the participants were divided into the study group and the control group. Rank-sum test and χ2 test were used for data analysis, and logistic regression analysis was performed to explore the risk factors for gallbladder stone formation. Results: The ASMD values of the total population and study sample were all≤0.2. The overall prevalence of gallstone in the study population was 14.44% (7 054/48 844), with a prevalence of 13.67% (3 741/27 361) in female and 15.42% (3 313/21 483) in males The prevalence of gallbladder polyps was 5.50%(2 682/48 844).The proportion of fatty liver was 45.50%(22 224/48 844). Additionally, a statistically significant difference in total cholesterol levels was observed between the gallstone group (range:4.34 to 5.77 mmol/L) and the non-gallstone groups (range: 4.39 to 5.82 mmol/L)(Z=-2.093, P<0.05). Multivariate Logistic regression analysis revealed that body mass index (BMI) ≥28 kg/m2 (OR=1.19, 95%CI: 1.17 to 1.20) and fatty liver disease (OR=1.22, 95%CI: 1.05 to 1.41) were independent influencing factors for gallstone formation (both P<0.05). Compared with the 65 to 69 years group, the risks of gallstones were significantly higher in the 70 to 74 years group (OR=1.25, 95%CI: 1.05 to 1.48) and the group aged 80 years and above (OR=1.28, 95%CI: 1.03 to 1.61). Conclusions: The prevalence of gallstone is relatively high among the elderly population in Xuhui District, Shanghai. BMI ≥28 kg/m2 and fatty liver disease are independent risk factors for gallstones. Compared with people aged 65 to 69 years, those aged 70 to 74 years and ≥80 years have an increased risk of developing gallstones.

PMID 42669448
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PubMedJournal of the mechanical behavior of biomedical materials2026-08-29

Synergistic modification with silanized MgO nanoparticles and MAP-POSS enhances mechanical performance and antibacterial activity of dental composite resins.

Sun Hao H, Bu Yanxin Y, Cao Wenxin W, Hu Yucui Y et al.

This study developed a dental composite resin incorporating KH-570-modified magnesium oxide nanoparticles (MgONPs) and methacryloxypropyl polyhedral oligomeric silsesquioxane (MAP-POSS), and evaluated its microstructure, physicochemical properties, antibacterial activity, and in vitro cytocompatibility. MgONPs were surface-modified with 3-(methacryloyloxy)propyltrimethoxysilane (KH-570), and composite resin specimens containing 2 wt% modified MgONPs with gradient additions of MAP-POSS were prepared, using a commercial composite resin as the control. Filler structure and modification were characterized by XRD and FTIR, and the composite resins were analyzed by SEM and FTIR. Depth of cure, Vickers hardness, water sorption, solubility, compressive strength, and flexural strength were measured. Antibacterial activity was evaluated against planktonic Streptococcus mutans (S. mutans) using the film contact method, and cytotoxicity was assessed using the CCK-8 assay with L-929 fibroblasts. Among the tested formulations, the specimen containing 4 wt% MAP-POSS and 2 wt% modified MgONPs exhibited the densest microstructure, the highest degree of conversion (83.03%), the greatest depth of cure and mechanical properties, a moderate reduction in viable planktonic S. mutans (R = 1.16), and no obvious cytotoxic response under the tested conditions. These results indicate that the combination of MAP-POSS and silane-modified MgONPs may be a feasible strategy for achieving balanced mechanical reinforcement and antibacterial functionality in dental composite resins.

PMID 42667729
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PubMedThe American journal of emergency medicine2026-08-28

Intentional substance exposures at school reported to United States poison centers, 2000-2024.

Bienfang Alyssa A, Hays Hannah L HL, Badeti Jaahnavi J, Rine Natalie I NI et al.

The objective of this study was to investigate the characteristics and trends of intentional substance exposures at school among children 6-18 years old reported to United States (US) poison centers. Using a retrospective cohort study design, National Poison Data System data from 2000 to 2024 were analyzed. National population estimates from the US Census Bureau were used to calculate population-based rates, including age- and sex-specific rates, of exposure per 100,000 US population. Analyses included descriptive statistics and calculation of risk ratios (RRs) with 95% confidence intervals (CIs). From 2000 to 2024, US poison centers received reports of 122,700 intentional exposures that occurred at school among children 6-18 years old. Exposures most commonly involved high school-aged children (45.9%), males (56.7%), or a single substance (91.3%). Although most intentional exposures did not receive treatment at a healthcare facility (64.2%), 23.2% were treated/evaluated and released, and 5.3% resulted in admission to a non-critical care or critical care unit. Almost half (48.2%) of intentional substance exposures were not followed (judged to be a non-toxic exposure or to have minimal clinical effects possible), while 21.8% were associated with a minor effect and 20.0% with no effect. However, 10.0% had a serious medical outcome, including 0.7% (n = 741) with a major effect; there were two deaths. More than half of the intentional exposures occurring at school were attributable to intentional misuse (62.2%), followed by abuse (23.6%) and suspected self-harm or suicidal intent (14.2%). Exposures among high school-aged children were more likely to be associated with a serious medical outcome (RR: 5.00, 95% CI: 4.78-5.22), abuse (RR: 2.99, 95% CI: 2.92-3.06), or suspected self-harm or suicidal intent (RR: 3.28, 95% CI: 3.17-3.39) than those among elementary school- and middle school-aged children. Abuse was more likely to be associated with a serious medical outcome (RR: 4.51, 95% CI: 4.35-4.68) than non-abuse-related intentional exposures. Likewise, suspected self-harm or suicidal intent-related exposures were more likely to be associated with a serious medical outcome (RR: 2.33, 95% CI: 2.24-2.43) than exposures not related to suspected self-harm or suicidal intent. The rate of intentional exposures at school per 100,000 US children 6-18 years old fluctuated over time and increased overall by 77.5% from 7.5 in 2000 to 13.3 in 2024, including a transient sharp decline in 2020 and 2021 coinciding with the COVID-19 pandemic. The rate increased by 287.4% from 3.1 in 2000 to 11.9 in 2024 among elementary school-aged children, 111.9% from 10.0 in 2000 to 21.3 in 2024 among middle school-aged children, but decreased by 4.2% from 10.1 in 2000 to 9.7 in 2024 among high school-aged children. The exposure rate of middle school-aged children surpassed that of high school-aged children in about 2015. The increasing rate of reported intentional substance exposures at school among elementary school- and middle school-aged children, combined with the greater severity observed among high school-aged children, underscores the need for targeted and coordinated prevention and early identification strategies that integrate substance use education and mental health screening and intervention.

PMID 42664740
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PubMedEndocrinology, diabetes & metabolism2026-08-27

Global Research Landscape on Leptin Resistance and Obesity-Related Metabolic Dysfunction: Trends, Networks and Visualisation Analysis (1995-2025).

Zyoud Sa'ed H SH

Leptin resistance is closely linked to obesity, insulin resistance, inflammation and cardiometabolic disorders. However, the global research output on leptin resistance and obesity-related metabolic dysfunction has not been mapped in detail. This study aimed to analyse global research trends in this field from 1995 to 2025. Publications were retrieved from the Scopus database. Bibliometric indicators included annual growth, document type, productive countries, institutions, journals, highly cited publications and international collaboration. VOSviewer version 1.6.21 was used to visualise country collaboration and title-abstract term co-occurrence. A total of 2162 publications were included. Publication output increased substantially across the study period but fluctuated, peaking in 2014 and remaining broadly stable thereafter. Articles were the most common document type (n = 1658; 76.69%), followed by reviews (n = 433; 20.03%). The United States ranked first (n = 741; 34.27%), followed by China (n = 255; 11.79%), Japan (n = 132; 6.11%), Spain (n = 131; 6.06%) and Germany (n = 124; 5.74%). Harvard Medical School was the most productive institution, and Endocrinology was the most active journal. Cowley et al. had the most cited publication, with 2052 citations. Term mapping revealed three main themes: 'clinical metabolic dysfunction and cardiometabolic risk,' 'hypothalamic leptin signalling and energy homeostasis,' and 'body weight regulation and developmental programming.' Research on leptin resistance and obesity-related metabolic dysfunction expanded substantially between 1995 and 2025, although annual output fluctuated and plateaued after its 2014 peak. The maps suggest a broadening of terminology from early leptin biology and experimental models towards inflammatory, cardiometabolic and mechanistic topics; this pattern should not be interpreted as proof of a causal or complete transition. Collaboration remained concentrated among high-output countries.

PMID 42659627
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PubMedDentistry journal2026-08-26

Microbial Biofilm Reduces the Strength Reliability of 3D-Printed Appliance Resins.

May Watt Sook WS, Zicong Ng N, Rosa Vinicius V, Foong Kelvin Weng Chiong KWC

Background/Objectives: Three-dimensionally (3D) printed resins are increasingly used for removable orthodontic appliances, but how their mechanical reliability changes in the oral environment is unclear. This study evaluated the effect of bio-ageing environment and material type on the biaxial flexural strength and Weibull reliability of one conventional acrylic resin (Orthocryl, OC) and two 3D-printed photopolymer resins (BioMed Clear, BMC; and KeySplint Hard, KH). The Weibull modulus (m) reflects how consistent, or predictable, the strength is among specimens, independent of its average value. Methods: Disc specimens (n = 32) were aged for 24 h at 37 °C in pooled human saliva, a Streptococcus mutans biofilm, or water, and the biaxial flexural strength was measured by the piston-on-three-balls method (1 mm/min). Data were analysed with two- and three-parameter Weibull statistics to estimate the Weibull modulus (m), characteristic strength (σ0), strength at 5% failure probability (σ5%), and threshold strength (σμ), with model selection guided by the Akaike Information Criterion. Results: Biofilm exposure lowered m while σ0 was preserved: m fell from 9.96 (saliva) and 7.98 (water) to 1.95 for OC, and from 17.61 and 13.01 to 2.62 for BMC, whereas σ0 stayed near 55 MPa (OC) and 64 MPa (BMC). Under biofilm the modulus of all three converged to low values (1.4-2.6), abolishing the differences among materials; OC and BMC required a three-parameter model only after biofilm (σu ≈ 41 MPa), whereas KH required it in every environment (σu = 28.9-38.7 MPa). Conclusions: Biofilm ageing mainly reduced strength predictability, while characteristic strength was largely preserved. This indicates that flexural strength alone may be insufficient to qualify resins for removable appliances, and that printed resins studied here are not inherently superior or inferior to conventional acrylic.

PMID 42645461
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PubMedOral and maxillofacial surgery2026-08-26

The role of elective neck dissection in parotid acinic cell carcinoma: a systematic review.

Pabbati Sai S, Cook Daniel D, Heaton James J, Freeman Samuel S et al.

Acinic cell carcinoma (AciCC) is a rare parotid malignancy treated by parotidectomy with or without a neck dissection depending on clinical or radiographic neck node involvement. The role of elective neck dissection (END) in the clinically node-negative neck, intended to address occult lymph node metastases (OLNM), remains contentious. This review was conducted per PRISMA 2020. Searches through PubMed, EMBASE, and CINAHL were conducted up to May 2025. Data extraction focused on survival, recurrence outcomes and OLNM. Risk of bias was assessed using the Newcastle-Ottawa Scale. From 741 screened articles, 13 retrospective cohort studies were included. Across 2,646 parotid AciCC cases, 788 underwent END, 77 demonstrating OLNM. Marked heterogeneity was observed among studies, with reported OLNM rates ranging from 0% to 37.5% and a weighted mean of 9.8%. High-grade transformation was associated with poorer survival; advanced T-stage showed a less consistent association, and grade-stratified nodal differences were generally based on small samples and not statistically significant. Routine END is not supported in low-grade, early-stage AciCC. High-grade transformation is an adverse prognostic factor; the independent value of advanced T-stage is less certain, resting largely on some single cohort studies. END has not been shown to improve survival, and comparisons are confounded by indication. Any role in higher-risk disease remains uncertain and should be individualised rather than routine. Multi-institutional registries with standardised reporting are needed to strengthen the evidence.

PMID 42642545
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