Drug Database
KH

KH-741 (KH 741 / KH741)

✓ Approved

Chengdu Kanghong Pharmaceutical · Small Molecule · Small Molecule

What is KH-741?

KH-741 is a small molecule developed by Chengdu Kanghong Pharmaceutical. It is approved for therapeutic indications via unknown.

Drug Profile

Brand NamesKH 741, KH741
CompanyChengdu Kanghong Pharmaceutical
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Chengdu Kanghong Pharmaceutical

Therapeutic Indications

KH-741 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Psychiatric disordersBipolar I disorder✓ Approved

Related Research Articles

PubMedDevelopment and psychopathology2026-07-17

Peer victimization and adjustment: Moderation by perceptions of same-race and other-race classmates' behavior.

Troop-Gordon Wendy W, Gordon Julia R JR, Christensen Karl K

Drawing on the "social misfit" hypothesis, this study tested whether peer victimization is more predictive of maladjustment when children have many same-race classmates who they view as low in aggression. Also accounted for were children's race, the racial composition of the classroom, and children's perceptions of other-race peers. Data were collected in the fall, winter, and spring of a school year from 1,424 4th and 5th grade children (Mage = 10.06; SDage = 0.67; Rangeage = 8.43-13.03; 683 girls; 741 boys; 39.61% Black; 60.39% White) in the Southeastern United States. Measures included children's ratings of the aggressiveness of their participating Black and White classmates; teacher-reports of depressive symptoms, anxiety, and social withdrawal; and peer-reports of peer victimization, aggression, and prosocial behavior. Consistent with the social misfit hypothesis, when children viewed same-race classmates as low in aggression, peer victimization was more strongly associated with internalizing problems in the fall for Black children (R2: 0.05-0.16) and with heightened anxiety in the spring for White children with many same-race classmates (R2 = 0.09). Although some protective effects of viewing other-race classmates as aggressive emerged, associations with heightened anxiety (R2: 0.06-0.09) underscored the need to promote positive interracial relationships to optimize children's mental health.

PMID 42466709
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PubMedSurgery2026-07-17

Global surgery in Australia and New Zealand universities (GANZ): A binational cross-sectional study of medical student education.

Lew Chen C, Robinson Samuel J A SJA, Goh Sarah S, Karim Md Nazmul MN et al.

Five billion individuals worldwide lack access to safe and affordable surgical care, a deficit disproportionately skewed toward low- and middle-income countries. Global surgery may be defined as "an area of study, research, practice, and advocacy" aiming to improve health outcomes for surgical patients. Universities play an important role in global surgical work in high-income countries. We aimed to determine the relevant knowledge, attitudes, and perspectives of medical students in Australia and Aotearoa New Zealand (ANZ). We surveyed senior medical students in ANZ medical schools (n = 24) from August to October 2022. Participants were recruited through university channels, social media, and snowball sampling. Participants completed questionnaires examining attitudes, exposures, and content knowledge relating to global surgery. A total of 851 eligible responses were analyzed. This included 189 of 851 (22.2%) participants with prior global surgery exposure, most commonly through student organizations (10.9%), and 686 of 851 (80.6%) participants believed global surgery to be relevant to medical students. Few participants (72 of 851; 8.5%) reported timetabled teaching of global surgery content, despite 494 of 741 (66.7%) supporting mandatory inclusion in medical school curricula. Preferred methods of global surgery exposure did not align with the methods received, and global surgery was infrequently reported in university curricula. Global surgery knowledge was limited and lower than that of students overseas. Despite this, participants indicated significant interest in global surgery teaching. ANZ medical students lack global surgery education and knowledge. Most global surgery education is delivered through nonacademic methods, including student societies and social media. Educators should consider these findings when planning medical school curricula.

PMID 42463262
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PubMedAnalytical methods : advancing methods and applications2026-07-17

Research on quality homogenization of preparations from multi-part botanical materials based on pseudotargeted metabolomics and machine learning: a case study of Cocculus orbiculatus (L.) DC.

Liu Annian A, Wang Xiaorui X, Tan Daopeng D, Qin Lin L et al.

The use of multiple medicinal parts from a single herbal source for disease treatment is a common practice in traditional Chinese medicine. However, variations in the ratio of these parts can lead to inconsistencies in product quality. Therefore, ensuring uniform quality by controlling the ratio of different plant parts is a key challenge for Traditional Chinese Medicine (TCM) products. In this study, UHPLC-Q-TOF-MS was employed to acquire MS data of Cocculus orbiculatus (L) DC. (C. orbiculatus) quality control samples under different collision energies. Ion pairs were screened using the MRM-Ion Pair Finder online platform, and a pseudo-targeted metabolomics method was established based on 741 ion pairs from C. orbiculatus roots and stems using UHPLC-Q-Trap-MS in MRM mode. Chemical profiles of different batches of Ningmitai capsule (NMTC) and mixtures of C. orbiculatus roots and stems in varying ratios were further acquired. Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were applied to identify both differential and non-differential metabolites. Subsequently, the established ratio range was validated using a root-to-stem ratio of 1 : 80. A total of 167 differential metabolites were identified based on VIP > 1, P < 0.05, and FC > 2 or FC < 0.5. Ten key compounds were further selected using the random forest (RF) algorithm as potential quality markers for NMTC. Moreover, machine learning models based on RF, k-nearest neighbors (KNN), and logistic regression were constructed using non-differential markers. Validation results demonstrated that even at an extreme root-to-stem ratio of 1 : 80 encountered in production, the determined mixing ratio range of 70 : 1 to 1 : 290 ensures uniform quality of NMTC. This study not only improves the utilization efficiency of C. orbiculatus but also offers a novel strategy for quality control of multi-part herbal medicines.

PMID 42464953
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PubMedInternational journal of molecular sciences2026-07-15

Effect of Anti-Müllerian Hormone on Oocytes In Vitro Maturation in Sheep.

Zhang Peipei P, Li Yupeng Y, Shi Xiaodi X, Guo Xiaofei X et al.

Improvement in the in vitro maturation (IVM) of oocyte quality is a gateway to enhancing the efficiency of in vitro embryo production. The anti-Müllerian hormone (AMH) is a crucial hormone secreted by granulosa cells that effectively suppresses primordial follicle recruitment and regulates follicular growth and development. This study was designed to investigate the role of AMH on the IVM of sheep oocytes. In this current study, oocytes in vitro were cultured in media supplemented with AMH. We comprehensively analyzed the impact of AMH on various developmental parameters of sheep oocytes, such as cellular activity, cortical granules (CGs) migration, cytoskeleton and mitochondrial function of oocytes. Furthermore, Smart-seq2 single-cell RNA sequencing (scRNA-seq) was employed to elucidate the oocytes' development. The results showed that treatment with 100 ng/mL improved the maturation rate of the oocytes, the normal distribution rate of cortical granules and mitochondrial function, while reducing the rate of spindle abnormalities in oocytes. A total of 741 differentially expressed genes (DEGs) were observed between the FSH_12 h and AMH_12 h groups, and 746 DEGs were observed between the FSH_24 h and A+F groups. KEGG pathway analysis revealed that the FSH_12 h and AMH_12 h groups significant enrichment in DEGs were associated with p53, MAPK, PI3K-Akt and TGF-beta signaling pathways, and the FSH_12 h and AMH_24 h groups significant enrichment in DEGs were associated with cAMP, AMPK, Hedgehog and estrogen signaling pathways. These findings suggest that AMH may regulates oocytes IVM via several candidate signaling pathways. Our results provide preliminary clues for exploring the regulatory mechanism of sheep oocyte maturation and optimizing relevant culture systems.

PMID 42449976
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PubMedScientific reports2026-07-12

Design of an intelligent security system for cyber-attack detection in petrochemical SCADA networks based on a hybrid artificial neural network and Krill-Herd algorithm.

Nozari Amir Mahdi AM, Dashtdar Masoud M, Chamkoori Alireza A

In the past few years, with the increasing severity of cyber-attacks, network security has become a burning topic in safety-critical industries such as petrochemicals. SCADA systems, as the central hub of industrial process control, are under constant attack by reconnaissance and intrusion attempts. To secure these environments, this study proposes a comprehensive two-tier intelligent security system. Initially, industrial network traffic was captured using Wireshark to distinguish reconnaissance attack patterns from normal operations. For the first tier, a monitoring script was developed to extract behavior-based scores, which are then analyzed by an Artificial Neural Network (ANN) optimized via the Krill-Herd (KH) algorithm to effectively detect early-stage attacks (ARP, Port, and ICMP scans). Furthermore, to address sophisticated application-layer threats, the system incorporates a second tier: a Bottleneck Deep Neural Network (BDNN) optimized by the KH algorithm. This module analyzes advanced statistical features to successfully detect stealthy manipulations within the Modbus protocol. The results confirm that the proposed two-tier system detects reconnaissance and stealthy Modbus attacks with high accuracy and very low inference latency. The Krill-Herd (KH) algorithm contributes automated hyperparameter selection and faster convergence rather than a statistically significant accuracy gain over a well-tuned Adam baseline. Ultimately, this framework can serve as a highly effective, intelligent tool in cyber defense against evolving threats in petrochemical industries.

PMID 42436316
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PubMedBritish journal of pharmacology2026-07-11

Dualsteric and dual-acting modulation of muscarinic receptors by antagonist KH-5.

Janoušková-Randáková Alena A, Dolejší Eva E, Chetverikov Nikolai N, Jakubík Jan J

Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH-5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors. Functional responses at human M1 and M2 receptors expressed in CHO cells were assessed using inositol phosphate accumulation and [35S]GTPγS binding, respectively. Radioligand binding studies employed orthosteric antagonists and agonists in combination with KH-5 and classical allosteric modulators. Data were analysed using competitive, allosteric and dualsteric binding and operational models. Molecular docking, molecular dynamics simulations, and site-directed mutagenesis were used to identify structural determinants of KH-5 binding. KH-5 antagonised responses to multiple agonists in a saturable and probe-dependent manner, but did not decrease maximal response to agonists, contradicting simple allosteric antagonism. At M2 receptors, antagonism was largely competitive. Binding studies revealed transient enhancement of agonist binding at M1 receptors at nanomolar concentrations of KH-5, best described by a dualsteric binding model involving independent orthosteric and ectopic site interactions. KH-5 did not bind to the classical muscarinic allosteric site at the second extracellular loop but interacted with an extracellular vestibule site. At M1 receptors, the most parsimonious model among those tested combines orthosteric competition with an ectopic/allosteric component. At M2 receptors, KH-5 behaves predominantly as an orthosteric antagonist under the present conditions, although a weak or probe-specific allosteric component cannot be excluded.

PMID 42432875
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