Drug Database
HF

HFA Modulite techn

✓ Approved

Chiesi Farmaceutici S.p.A. · therapeutic agent

What is HFA Modulite techn?

HFA Modulite techn is a therapeutic agent developed by Chiesi Farmaceutici S.p.A.. It is approved for therapeutic indications via inhaled.

Drug Profile

CompanyChiesi Farmaceutici S.p.A.
RouteInhaled
StatusApproved
Sources: ClinicalTrials.gov, Chiesi Farmaceutici S.p.A.

Therapeutic Indications

HFA Modulite techn is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresOral appliance application✓ Approved

Related Research Articles

PubMedFrontiers in neurology2026-10-14

Revaluation of the tongue function of the modified hypoglossal-to-facial transfer: a comparative cohort study.

Zhang Ying Y, Zhang Zhongding Z, Tang Yinda Y, Wang Baimiao B et al.

Traditional end-to-end hypoglossal-to-facial anastomosis (HFA) was a common surgical procedure for uncured severe facial palsy, however, was related to tongue dysfunction. We developed a modified hypoglossal-to-facial anastomosis (MHFA) procedure with the additional process of the anastomosis of the transected hypoglossal nerve and the ramus descendens hypoglossi, aiming to salvage the tongue function. We retrospectively collected 45 cases of MHFA in our center from January 2020 to December 2022. A comparative analysis was conducted from MHFA and 27 cases of HFA in the early stage at our center. The tongue disability index was used to evaluate the tongue function during the follow-up. Baseline characteristics were comparable between HFA (n = 27) and MHFA (n = 45) groups (all p > 0.05). MHFA demonstrated longer operative time (198.27 vs. 157.78 min, p < 0.001). Up to the last follow-up, MHFA showed superior outcomes: smaller tongue deviation angle (13.38° ± 9.56° vs. 23.86° ± 10.52°, mean difference 10.47°[95%CI 5.65-15.29], p < 0.001), lower incidence of severe deviation (>30°: 8.9% vs. 37.0%, p = 0.003), and reduced tongue-related complications (24.4% vs. 66.7%, p < 0.001). Specifically, MHFA had significantly fewer swallowing (11.1% vs. 37.0%, p = 0.009) and articulation defects (13.3% vs. 44.4%, p = 0.003). TDI scores were markedly lower in MHFA (1.63 ± 0.53 vs. 2.23 ± 0.50, mean difference 0.60 [0.34-0.85], p < 0.001), particularly in swallowing, articulation, and psychological subdomains (all p < 0.05). Strong correlation existed between tongue deviation and TDI scores (r = 0.890, p < 0.001). Facial nerve recovery showed no intergroup difference (HB score improvement: 2.40 ± 0.69 vs. 2.33 ± 0.73, p = 0.699). MHFA appears promising for reducing tongue morbidity, but its clinically relevant advantage over HFA requires prospective validation using standardized outcomes.

PMID 42871405
Read full article →
PubMedCancer treatment and research communications2026-10-05

Rethinking cardiovascular risk stratification in TKI-treated chronic myeloid leukemia.

Cordeanu Elena-Mihaela EM, Zheng Franck F, Ame Shanti S, Stephan Dominique D

Tyrosine kinase inhibitors (TKIs) targeting BCR::ABL1 have transformed chronic myeloid leukemia (CML) into a chronic condition with near-normal life expectancy, but peripheral artery disease (PAD) has emerged as a major source of morbidity, particularly with nilotinib and ponatinib. Current cardiovascular management relies on general population risk scores and ankle-brachial index (ABI) measurement, tools not designed to capture TKI-specific vascular biology or detect subclinical arterial damage. We appraise cardiovascular risk stratification tools and vascular imaging modalities in the context of TKI-treated CML, and propose an integrated algorithm combining dual risk scoring, ABI, and targeted femoral duplex ultrasound (DUS). Vascular outcome reporting in TKI trials is hampered by terminological inconsistency: Major Adverse Limb Events (MALE), the standard limb-specific endpoint in contemporary cardiovascular trials, has never been adopted in any TKI/CML publication. Existing risk scores (SCORE2, HFA-ICOS) neither capture TKI-accelerated atherosclerosis nor discriminate limb-specific risk. ABI detects only established stenosis and is further limited by TKI-induced medial arterial calcification. The femoral artery is both the earliest site of subclinical atherosclerosis and the preferential anatomical target of TKI-induced vascular damage; thus, femoral plaque detection may serve as a risk reclassification instrument. Because vascular risk differs by line of therapy and imaging resources are finite, screening should be targeted to patients in whom the result would change agent selection and preventive strategies. Integrating femoral DUS into cardiovascular risk stratification shifts the objective from diagnosing established disease to preventing it. Whether this translates into fewer events remains to be demonstrated.

PMID 42833183
Read full article →
PubMedAttention, perception & psychophysics2026-10-02

Response variability reveals hidden social-category effects in facial-expression categorization.

Tipples Jason J

The "happy-face advantage" (HFA)-faster categorization of happy versus fearful expressions-is typically established using mean reaction times (RTs), which obscure the structure of the RT distribution. The present research examined how facial expression and social-category cues influence emotion categorization using ex-Gaussian modelling, decomposing RTs into mean (μ), variability (σ), and slow-tail responding (τ). Ex-Gaussian modelling revealed that expression effects were distributed across distinct components of the RT distribution. Whereas mean RT (μ) replicated the happy-face advantage, σ indexed systematic differences in response consistency and τ captured selective increases in unusually slow responses. These findings demonstrate that social-category influences on emotion categorization are distributed across multiple components of the RT distribution that remain hidden in conventional analyses of mean RT.

PMID 42823593
Read full article →
PubMedSpectrochimica acta. Part A, Molecular and biomolecular spectroscopy2026-10-01

Tuning of emitting colors and mimicking advanced Boolean logic functions via stimuli-responsive luminescence behavior of bimetallic lanthanide complexes comprising a TADF-active ligand.

Ahmed Toushique T, Haque Sk Firoj SF

Syntheses, characterizations and detailed investigations on the photophysical behaviors of a new array of four homobimetallic LnIII-complexes of type {(Ln2(hfa)6 (phen-Hbzim-tpy)} are undertaken in this work, where Ln = LaIII (1), EuIII (2), SmIII (3) and TbIII (4); hfa = hexafluoroacetylacetonate and phen-Hbzim-tpy = 2-[4-(2,6-dipyridin-2-yl-pyridin-4-yl)phenyl]-1H-imidazole[4,5-f][1,10]phenanthroline. Substantial improvement in terms of absorption, emission and sensitization efficacy is achieved herein compared to our related monometallic as well as homobimetallic complexes based on 2-thenoyltrifluoroacetone (tta). Interestingly, all the complexes, including the La(III), are found to inherit the thermally assisted delayed fluorescence (TADF) property of the phen-Hbzim-tpy bridging ligand and display excellent luminescence thermometric properties. DFT calculations of a representative complex (LaIII) also support the occurrence of the TADF event. The Eu(III) and Tb(III) complexes exhibit remarkable thermochromic behavior. The luminescence spectral characteristics of the complexes are also modulated to a significant extent upon varying the excitation wavelengths, which, in turn, appears instrumental in terms of generating various emitting colors in Sm(III) and Tb(III) complexes. Additionally, these stimuli-responsive luminescence behaviors of the complexes are employed to mimic the operations of two combinational logic gates to complement their practical utility in the field of advanced optical security.

PMID 42822369
Read full article →
PubMedCardiorenal medicine2026-09-30

Right Ventricular Free Wall Strain Is Associated with Low-Grade Albuminuria in HFpEF: A Cross-Sectional Cohort Study.

Kind Andreas A, Zurkan Daniela D, Chitroceanu Alexandra Maria AM, Spinka Fabian F et al.

Introduction Heart failure with preserved ejection fraction (HFpEF) presents a major health burden worldwide. Up to 40% of HFpEF patients present with elevated urine-albumin-creatinine-ratio levels (UACR). In this subgroup, the risk for adverse cardiovascular (CV) outcomes is increased. Prior studies suggest a correlation between albuminuria and incident heart failure and adverse outcomes even at levels below current clinical thresholds and in the presence of preserved renal function and may mark early cardio-renal and endothelial dysfunction. Whether right ventricular (RV) systolic function, as measured by RV free wall strain (RVFWS), relates to albuminuria in heart failure with preserved ejection fraction (HFpEF) has not been characterized. Methods Patients with HFpEF (LVEF ≥50%, HFA-PEFF score ≥5 or invasively elevated filling pressures) and patients of a CKD comparator cohort (CKD ≥G3 or >A1 and ≥1 CV risk factor, without diagnosed HF) were pooled from two cross-sectional cohort studies for this analysis. All patients underwent comprehensive assessment including albuminuria and RVFWS measurement. Albuminuria was categorized by KDIGO stage (A1/A2/A3). RVD was defined by RVFWS ≥ -20%, RV FAC <35% or TAPSE <17 mm. We examined the association between RVFWS and albuminuria using a multivariate linear model with a cohort interaction term and cohort-specific models. Model robustness was assessed by elastic-net regression, bootstrap internal validation, E-value and by adding NT-proBNP, neutrophile count, pulmonary artery systolic pressure and urinary α1-microglobulin individually in separate sensitivity models. Inter- and intra-observer reproducibility of RVFWS was quantified. Results In total, 119 HFpEF and 133 CKD patients were identified. In HFpEF, RVFWS was more impaired (-22.5% vs. -25.7%, p < 0.001) and RVD more prevalent (30% vs. 16%). Median UACR lay within the KDIGO A1 range in both cohorts. More impaired RVFWS was associated with higher UACR in HFpEF (adjusted UACR ratio 1.55 per 5% less-negative strain, 95% CI 1.17-2.04, p=0.002) but not in the CKD cohort (p=0.380), with a significant cohort interaction (p=0.002). The association persisted after adjustment in sensitivity models, and RVFWS was retained by penalized regression. Inter- and intra-observer agreement of RVFWS was moderate-to-good (ICC 0.71 and ICC 0.69, respectively). Discussion In ambulatory HFpEF patients with predominantly low-grade albuminuria, RVFWS is associated with UACR independently of clinical confounders, an association not observed in a CKD cohort with CV risk factors and not attenuated after adjustment for estimated PASP.

PMID 42814665
Read full article →
PubMedIndian journal of ophthalmology2026-09-29

The TsiogkaSpaeth grid in Indian patients with primary open-angle glaucoma: A cross-sectional diagnostic accuracy study.

Talavar Hema H, Droulia Athina A, Pradeep B V BV, Spaeth George L GL et al.

To evaluate the diagnostic accuracy of an innovative visual field grid tool, the TsiogkaSpaeth (TS) Grid, in detecting visual field defects in patients with primary open-angle glaucoma (POAG) and to compare its performance with standard automated perimetry. This hospital-based cross-sectional study included 51 participants (73 eyes) with POAG and age-matched controls. All participants underwent comprehensive ophthalmic evaluation, TS Grid testing, and Humphrey Visual Field Analyzer (HFA) 24-2 SITA Standard testing as the reference standard. Diagnostic accuracy parameters including sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and receiver operating characteristic (ROC) curve analysis were calculated. Correlations between TS Grid scores and standard automated perimetry indices (mean deviation [MD], pattern standard deviation [PSD], visual field index [VFI]) were analyzed. The TS Grid demonstrated a sensitivity of 91.7%, a specificity of 89.2%, PPV of 89.2%, and NPV of 91.7%. The area under the ROC curve was 0.904, indicating excellent diagnostic accuracy. TS Grid scores showed strong positive correlation with MD and VFI and a negative correlation with PSD ( P < 0.001). The TS Grid is a reliable, low-cost, and portable tool for visual field assessment in POAG. Its high diagnostic accuracy and ease of use make it a valuable adjunct for screening and functional evaluation, particularly in resource-limited settings.

PMID 42809254
Read full article →

+3436 more articles available with a free account

Sign up free to view all articles →

Ask about HFA Modulite techn