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ethyl icosapentate (MND2119 / MND 2119 / icosapent, Mochida)

✓ Approved

Sumitomo Pharma Co., Ltd. · Small Molecule · Small Molecule

What is ethyl icosapentate?

ethyl icosapentate is a small molecule developed by Sumitomo Pharma Co., Ltd.. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesMND2119, MND 2119, icosapent, Mochida
CompanySumitomo Pharma Co., Ltd.
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Sumitomo Pharma Co., Ltd.

Therapeutic Indications

ethyl icosapentate is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Metabolism and nutrition disordersHyperlipidaemia✓ Approved
Metabolism and nutrition disordersHypertriglyceridaemiaPhase III

Related Research Articles

PubMedFrontiers in pharmacology2026-10-07

Structure-based virtual screening identifies ethyl rosmarinate as a SLC1A6-targeted therapeutic candidate for bladder cancer.

Wang Hao H, Liu Hongquan H, Ma Xin X, Wang Wenyu W et al.

SLC1A6 remains poorly characterized in bladder cancer. This study investigated its expression pattern, clinical relevance, cellular localization, functional implications, and potential pharmacological modulation. Bulk transcriptomic cohorts, clinical data, single-cell RNA-seq data, and spatial transcriptomic data were analyzed to characterize SLC1A6 in bladder cancer. We evaluated SLC1A6 expression, prognosis, clinicopathological associations, immune microenvironment features, metabolic programs, and predicted drug sensitivity. Single-cell and spatial analyses were used to identify the main cellular source and tissue localization of SLC1A6. Virtual knockout analysis was used to estimate pathway changes after SLC1A6 depletion. SLC1A6 expression was validated using Human Protein Atlas immunohistochemistry images, paired clinical tissue Western blotting, and qPCR/Western blotting in bladder cancer cell lines. Structure-based virtual screening and molecular docking were performed, followed by functional testing of ethyl rosmarinate in T24 and UM-UC-3 bladder cancer cells. SLC1A6 was upregulated in bladder cancer tissues and cell lines and was associated with poor survival, advanced clinicopathological features, immunosuppressive characteristics, metabolic remodeling, and poorer survival outcomes in immunotherapy-treated cohorts. Single-cell and spatial analyses showed that SLC1A6 was mainly enriched in epithelial tumor cells and epithelial-dominant tumor regions. SLC1A6-high epithelial cells showed enhanced lipid- and glycan-related metabolic activity. Virtual knockout analysis predicted broad pathway alterations after SLC1A6 depletion. Virtual screening prioritized ethyl rosmarinate as a candidate SLC1A6-interacting compound, and CETSA further supported its cellular target engagement with SLC1A6. In T24 cells, ethyl rosmarinate reduced SLC1A6 protein expression and suppressed migration, colony formation, and invasion. Consistent phenotypic effects on migration, clonogenic growth, and invasion were further observed in UM-UC-3 cells. SLC1A6 is an epithelial-enriched, clinically relevant molecule associated with malignant progression, immune suppression, and metabolic remodeling in bladder cancer. Ethyl rosmarinate may represent a candidate compound for further investigation in SLC1A6-related bladder cancer models.

PMID 42840239
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PubMedFrontiers in nutrition2026-10-07

Identifying dietary and daily product-use patterns explaining joint variation in multiple urinary phthalate metabolites via sparse reduced-rank regression.

Park Hyun-Wook HW, Lee Donghwan D, Park Bomi B

Phthalates are synthetic plasticizers widely used in consumer and industrial products, resulting in widespread human exposure and potential adverse reproductive, neurodevelopmental, and metabolic effects. However, the relative contributions of diverse lifestyle-related sources to the overall phthalate burden remain unclear. In this study, we aimed to identify dietary and daily product use factors most prominently associated with joint variations in urinary phthalate metabolite mixtures in a nationally representative sample of Korean adults. We analyzed data from 3,760 adults from the Korean National Environmental Health Survey Cycle 4 (2018-2020). Information on dietary consumption, food-contact material use, and consumer product use was collected through questionnaires, and urinary concentrations of eight phthalate metabolites [mono-methyl phthalate, mono-ethyl phthalate, mono-n-butyl phthalate, mono-benzyl phthalate, mono-(2-ethyl-5-hydroxyhexyl) phthalate, mono-(2-ethyl-5-oxohexyl) phthalate, mono-(2-ethyl-5-carboxypentyl) phthalate, and mono-(3-carboxypropyl) phthalate] were measured. Sparse reduced-rank regression was used to identify latent patterns of dietary consumption, food-contact material use, and consumer product use jointly associated with the eight metabolite levels after covariates adjustment, and analyses were repeated by sex. A single latent pattern was identified, in which all phthalate metabolites showed positive loadings (+0.10 to +0.46). Mineral spring water (+0.08), grains (+0.08), tap water (+0.06), and beverages in plastic pouches (+0.08) exhibited the largest loadings in the same direction as the phthalate metabolites. In sex-stratified analyses, drinking water and grain consumption among men and the use of beverages in plastic pouches and makeup products among women showed prominent loadings in the same direction as the eight metabolites. Consumption of mineral spring water, tap water, grains, and beverages in plastic pouches were major dietary and daily product use factors associated with higher urinary phthalate metabolite mixtures in Korean adults. Given that current Korean regulations cover a limited subset of phthalates at levels less stringent than international standards, expanding regulatory frameworks for drinking water and food-contact materials and adopting precautionary lifestyle measures are warranted, along with prospective studies to clarify source-specific causal pathways.

PMID 42839968
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PubMedRSC advances2026-10-07

Opening the black box: study of the multi-target anticancer mechanisms of Ecballium elaterium cucurbitacins via in vitro, network pharmacology, and molecular docking analyses.

Saka Enver E, Mahmoud Orchid A OA, Eldahshan Omayma A OA, Singab Abdel Nasser B ANB et al.

Ecballium elaterium is a perennial plant species that belongs to the Cucurbitaceae family. In this study, we examined the biological activities and analyzed the chemical profiles of ethyl acetate, acetone, aqueous acetone, and water extracts from different parts (aerial parts, fruit peels, and seeds) of E. elaterium. We performed chemical characterization using UPLC-ESI-MS/MS. To investigate the biological activities of the extracts, antioxidant capacity, enzyme inhibition, and cytotoxicity assays were conducted. Thirty-eight compounds were detected in the extracts, and cucurbitacins and their glycosides were the major components in the aerial parts and fruit peels. The aqueous acetone extract of the seeds exhibited the highest ABTS radical scavenging activity (155.82 mg TE per g), whereas the acetone extract of the aerial parts showed the greatest reducing power. The ethyl acetate extract of the aerial parts exhibited the highest inhibitory activity against AChE and BChE. Overall, the seed extracts showed glucosidase-inhibitory activity. The ethyl acetate extract of the aerial parts exhibited notable cytotoxic activity against the HCT-116 cell line (IC50 of 90.44 µg mL-1). Network pharmacology analysis linked the cucurbitacin-rich constituents to a converging set of cancer-related protein targets, and molecular docking predicted favorable binding affinities toward key hub proteins such as EGFR and STAT3, offering a preliminary computational rationale for the observed antitumor effects. As a result, the different E. elaterium extracts may serve as potential sources of bioactive compounds for further study and development in health-promoting applications.

PMID 42840479
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PubMedJournal of the science of food and agriculture2026-10-07

Phytochemical profiling and bioactivity of Rhaponticoides mykalea: α-glucosidase inhibition, apoptosis-associated cytotoxicity, and in silico molecular insights.

Paşayeva Leyla L, Ersoy Miray M, Fatullayev Hanifa H, Arslan Ayşe Kübra Karaboğa AKK et al.

Rhaponticoides mykalea is an endemic species with limited data on its phytochemistry and biological activity. The aqueous ethanol extract (700 mL L-1, v/v) of the aerial parts and its n-hexane, ethyl acetate (RPEtAc), n-butanol, and water fractions were evaluated for enzyme inhibition, antioxidant activity, cytotoxicity, and apoptosis-related effects, together with LC-HRMS profiling and molecular docking/MM-GBSA analysis. Among the samples, RPEtAc showed the highest total phenolic (273.49 ± 3.80 mg GAE g-1) and flavonoid (175.45 ± 2.53 mg CE g-1) contents and the strongest DPPH, FRAP, and CUPRAC activities. It was the most active α-glucosidase inhibitor (IC50 = 128.78 ± 2.57 μg mL-1), exceeding acarbose (209.21 ± 1.32 μg mL-1) under the assay conditions, and the most cytotoxic fraction toward RL95-2 endometrial cancer cells (IC50 = 15.35 ± 0.68 μg mL-1, 48 h), increasing caspase-3 and caspase-9 activities and the Bax/Bcl-2 ratio. LC-HRMS identified phenolic acids (chlorogenic, vanillic, ferulic, and 3-(4-hydroxyphenyl)propionic acids) and flavonoid derivatives. In silico, flavonoid glycosides detected in RPEtAc (quercetin 3-rutinoside 7-glucoside, narcissin, isoquercitrin) showed favorable predicted MM-GBSA binding at the BCL-2 BH3 groove, and quercetin, narcissin, and rutin at the α-glucosidase site. The ethyl acetate fraction of R. mykalea aerial parts is a phenolic-rich fraction with antioxidant, α-glucosidase inhibitory, and apoptosis-associated cytotoxic activity demonstrated at the fraction level. The docking results provide computational support only and require experimental validation with isolated compounds. © 2026 Society of Chemical Industry.

PMID 42839359
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PubMedBMC complementary medicine and therapies2026-10-07

Green extraction routes for conversion of Nerium oleander L. biomass into bioactive agents: phytochemical insights and antimicrobial promise.

Selim Mohamed T MT, Mahmoud Nashaat N NN

Nerium oleander L. (N. oleander) is a species of shrub or small tree in the Apocynaceae family that has high levels of digitalin linear activity and cardiac glycosides, especially nerine and oleander. The study was researched to assess the in vitro proximate compositions, phytochemical analysis, and antimicrobial activity of the dried stems, leaves, and flowers of N. oleander extracted using various solvents. Petroleum ether, ethyl acetate, acetone, methanol, and water extracts of the various solvents were tested for total phenol, flavonoid, and tannin contents using various phytochemical assays, while the antimicrobial activity was evaluated using the agar well diffusion method against six bacterial and fungal strains. The flowers had a higher moisture content (9.40%), whereas the stems had a higher ash content (18.58%) than the leaves and flowers. The flowers also had higher lipid, carbohydrate, and crude protein contents (4.33, 66.16, and 15.29%, respectively). The leaves of the N. oleander produced a maximum yield followed by flowers and stems, respectively. The highest percentage extractive yield was demonstrated by water extracts, which were followed by methanol, acetone, ethyl acetate petroleum ether extracts. The findings of the study showed that alkaloids, flavonoids, tannins, glycosides, steroids, coumarins, quinones, phenols, cardiac glycosides, and terpenoids were found by phytochemical analysis of N. oleander in different parts, while saponins and anthraquinones were completely absent in all parts. On the other hand, anthocyanins are present only in flowers and completely absent in stems and leaves. The greatest levels of phenol content, flavonoids and tannins were found in acetone extract of the flowers (157.12 ± 17.62 mg GAE/g, 187.43 ± 15.91 mg QE/g, and 89.93 ± 18.77 mg TAE/g, respectively), while the petroleum ether extract of stems had the lowest amount (5.45 ± 2.65 mg GAE/g, 6.43 ± 0.29 mg QE/g and 3.45 ± 2.05 mg TAE/g, respectively). Antimicrobial tests revealed the extract's ability to inhibit several Gram-positive bacteria (Staphylococcus aureus ATCC 6538 and Bacillus subtilis ATCC 6633), Gram-negative bacteria (Pseudomonas aeruginosa ATCC 9027, Salmonella Typhimurium ATCC 14028 and Escherichia coli ATCC 11229), and eukaryotic strains such as unicellular fungi (Candida albicans ATCC 10231). These results highlight the potential of N. oleander extracts as natural antimicrobials.

PMID 42839274
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PubMedActa chimica Slovenica2026-10-07

Revisiting ruthenium scorpionate chemistry: Reactivity of bis(3,5-dimethylpyrazol-1-yl)acetic acid toward organoruthenium(II) precursors.

Rebernik Gracej Mihaela M, Kitanovski Nives N, Kljun Jakob J

The reactivity of the scorpionate ligand bis(3,5-dimethylpyrazol-1-yl)acetic acid (L1H) toward organoruthenium(II) precursors was investigated. Reactions of chlorido and bromido p-cymene ruthenium dimers afforded the corresponding complexes in which L1H acts as a neutral κ2-N,N' donor. In the presence of acetonitrile and base, ligand deprotonation was accompanied by displacement of the p-cymene ligand, yielding a tris(acetonitrile)ruthenium(II) complex containing a κ3-N,N',O-coordinated scorpionate ligand.  Under ethanol-containing reaction conditions, in situ esterification of the coordinated carboxylic acid group was observed, yielding crystals of a new ruthenium complex 4 containing the ethyl ester derivative of the ligand. The compounds 1-3 were characterized by NMR, IR, HRMS, while the crystal structures of compounds 1·H2O, 3·MeOH, and 4 were determined by single-crystal X-ray diffraction. The results demonstrate the influence of reaction conditions on the coordination mode and transformation of bis(pyrazolyl)acetate ligands in ruthenium chemistry.

PMID 42839571
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