Sumitomo Pharma Co., Ltd. · Small Molecule · Small Molecule
ethyl icosapentate is a small molecule developed by Sumitomo Pharma Co., Ltd.. It is approved for therapeutic indications via oral (po).
| Brand Names | MND2119, MND 2119, icosapent, Mochida |
| Company | Sumitomo Pharma Co., Ltd. |
| Drug Class | Small Molecule |
| Route | Oral (PO) |
| Status | Approved |
ethyl icosapentate is developed for 2 unique indications across 1 therapeutic area.
| Therapeutic Area | Condition | Phase |
|---|---|---|
| Metabolism and nutrition disorders | Hyperlipidaemia | ✓ Approved |
| Metabolism and nutrition disorders | Hypertriglyceridaemia | Phase III |
Api A M AM, Bartlett A A, Belsito D D, Botelho D D et al.
Swami Kanchan K, Nagargade Mona M, Dadhich Ankita A, Kumar Prem P et al.
Urea is susceptible to leaching and volatilization, which reduces the nitrogen use efficiency and causes environmental damage by greenhouse gas addition and groundwater pollution. Here, to overcome this in circular economy fashion, a biodegradable controlled-release urea coating has been developed by directly utilizing recalcitrant coir pith with castor oil as plasticizer and ethyl cellulose as sealer. To form a stable and uniform coating, the coir pith has been engineered to nanoscale by a green phosphate-assisted wet milling process using dipotassium hydrogen phosphate. The lower hydration energy of potassium facilitates penetration and increases turgor pressure to fragment without using toxic strong oxidizers. The phosphate tethers simultaneously and provides charge-based repulsion. The esterification between the carbonyl groups in castor oil and the hydroxyl groups of ethyl cellulose resulted in hydrophobicity (water contact angle: ~125°), alongside ~80% biodegradation under soil burial conditions after 60 days. The coated urea reduced the nitrogen losses, showing a ~ 9% increase in wheat grain yield compared with bare urea. Finally, the life cycle analysis demonstrated the environmental sustainability of the proposed green manufacturing strategy.
Tang Shaocong S, Li Jiabao J, Wang Jiaxuan J, Yuan Quan Q et al.
Aqueous zinc (Zn) metal batteries (AZMBs) are promising for sustainable energy storage, yet their development is severely compromised by the interfacial instability arising from a water-rich and disordered electric double layer (EDL). Herein, we establish a rational screening strategy that combines density functional theory with molecular dynamics simulations to identify cationic regulators (both organic and inorganic) capable of reshaping the EDL structure through optimized interfacial affinity and transport kinetics. The results reveal that 1-ethyl-3-methylimidazolium exhibits strong interfacial affinity, which enables the formation of a hydrophobic shielding layer that suppresses parasitic reactions, demonstrating a "static passivation" effect. In contrast, sodium ion, as electric field-responsive species, provides "dynamic regulation" by homogenizing Zn2+ flux and lowering the desolvation energy barrier. Consequently, this dual-cation strategy constructs a water-poor and ordered EDL, enabling Zn anodes to operate stably for over 5000 h with a high Coulombic efficiency of 99.73%. Ultimately, guided by these mechanistic insights, a machine learning framework is further developed to enable predictive and scalable additive screening.
Lathan Uthaya U, Kaya Beyzanur B, Matubbar Farzina F, Chami Mohamed M et al.
Biological systems integrate multiple feedback processes to regulate their adaptation to evolving stimuli with high specificity. Inspired by wavelength-selective feedback processes in visual signaling, we present a synthetic nanoreactor system capable of producing orthogonal, wavelength-dependent positive and negative feedback loops. Polymersomes functionalized with a broad-spectrum pyrazolone-based Donor-Acceptor Stenhouse Adduct (DASA) encapsulate an esterase enzyme and undergo light-gated permeability switching. Upon irradiation, the nanoreactors operate out-of-equilibrium, hydrolyzing ethyl acetate to generate acetic acid in a wavelength-programmed manner. Under yellow light (590 nm), positive feedback is mediated by spectral unmasking: acid-induced protonation of a solubilized dye decreases competition for yellow light, enhancing membrane permeability and enzyme activity, yielding a positive feedback loop. In contrast, blue light (405 nm) irradiation leads to the accumulation of the same dye that spectrally competes with the photoswitch, progressively suppressing membrane permeability by formation of a negative feedback loop. These stimulus-specific feedback dynamics enable reversible and tunable control over enzymatic reaction kinetics. Importantly, this platform introduces a paradigm shift for light-programmed, autonomous regulation in synthetic cell mimics and could open a pathway to dynamic modulation of microscale environments and biointerfaces without genetic intervention.
Derayea Sayed M SM, Badry Sara I SI, Nagi Dalia M DM, Oraby Mohamed M
A sensitive spectrofluorimetric technique exhibiting acceptable selectivity was established for the quantification of formoterol (FMT) via the von Pechmann condensation reaction, leading to the formation of intensely fluorescent coumarin derivatives. In this reaction, FMT interacts with ethyl acetoacetate in the presence of concentrated sulfuric acid, producing a fluorescent product. The emitted fluorescence was recorded at 445 nm following excitation at 361 nm. Experimental parameters influencing the reaction were carefully optimized to achieve maximum fluorescence response and method stability. The proposed method exhibited excellent linearity across the concentration range of 20-500 ng mL-1, with a correlation coefficient (r) of 0.9998. The limits of detection (LOD) and quantification (LOQ) were found to be 4 ng mL-1 and 12 ng mL-1, respectively. Acceptable selectivity was demonstrated under the studied formulation conditions, as no significant interference was observed from commonly used pharmaceutical excipients, including lactose monohydrate, magnesium stearate, gelatin, titanium dioxide and placebo. A reaction pathway based on the reported von Pechmann condensation was proposed, and the method was validated in accordance with ICH guidelines. The applicability of the method was successfully demonstrated for the determination of FMT in pharmaceutical dosage forms, including content uniformity testing, showing satisfactory recovery results. Finally, the environmental impact of the method was assessed using various greenness evaluation tools, indicating a favorable greenness profile and practical applicability.
Rabbani Imran I, Rafiq Muhammad M, Shah Suliman S, Ahmad Tariq T et al.
Antagonistic microorganisms from extreme environments have gained great attention from scientists due to increasing threat of global antimicrobial resistance. In this context, previously isolated cold-adapted isolate from Passu glacier Alcaligenes pakistanensis LTP10 was used to extract their antimicrobial metabolites with organic solvents. MIC and MBC assays of the extract were performed. The synergistic effect of LTP10 ethyl acetate extract was studied with known antibiotics against Staphylococcus aureus and Escherichia coli. The extract was analyzed by FTIR, GC-MS, and in silico studies. Ethyl acetate extract of LTP10 has shown a maximum activity of 20 ± 1.0 and 19.3 ± 1.2 mm against Staphylococcus epidermidis and S. aureus, respectively. MIC of the extract was 0.4 and 1.6 mg/mL against S. aureus and E. coli, respectively. FTIR analysis revealed the presesnce of functional groups belonging to alcohols, aliphatic hydrocarbons, and nitrogen containing organic compouns. GC-MS analysis confirmed the presence of important antimicrobial compounds Dodecanoic acid, 3-hydroxy-, 7,9-Di-tert-butyl-1-oxaspiro(4,5)deca-6,9-diene-2,8-dione, and Pyrimidine-2,4(1H,3H)-dione in ethyl acetate extract of LTP10. A molecular docking study of these compounds has shown that 7,9-Di-tert-butyl-1-oxaspiro(4,5)deca-6,9-diene-2,8-dione has strong binding affinity of -7.8 kcal/mol against dihydrofolate reductase. Moreover, an ADMET study of the compounds has predicted their good intestinal absorption and non-toxic nature. In this work, we uniquely identify and characterize antimicrobial metabolites of glacier-derived Alcaligenes, combining GC-MS profiling with in-silico analysis. It was concluded that Alcaligenes pakistanensis LTP10 could be considered a good source for antimicrobial compound production, which should be further characterized by analytical techniques.
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