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ethyl icosapentate (MND2119 / MND 2119 / icosapent, Mochida)

✓ Approved

Sumitomo Pharma Co., Ltd. · Small Molecule · Small Molecule

What is ethyl icosapentate?

ethyl icosapentate is a small molecule developed by Sumitomo Pharma Co., Ltd.. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesMND2119, MND 2119, icosapent, Mochida
CompanySumitomo Pharma Co., Ltd.
Drug ClassSmall Molecule
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, Sumitomo Pharma Co., Ltd.

Therapeutic Indications

ethyl icosapentate is developed for 2 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Metabolism and nutrition disordersHyperlipidaemia✓ Approved
Metabolism and nutrition disordersHypertriglyceridaemiaPhase III

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PubMedFrontiers in medicine2026-10-15

Pathological mechanisms of long non-coding RNA FOXD2-AS1 promoting osteosarcoma mediated by the COI-1/OCN/Runx-2 signaling pathway.

Ren Zhipeng Z, Deng Liandong L, Sun Jie J, Kang Yuxiang Y et al.

Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents. Despite three decades of research efforts, no significant improvement in patient survival rates has been achieved, highlighting the urgent need for in-depth investigation into its pathogenesis to develop novel therapeutic strategies and more effective drugs. FOXD2-AS1, a long non-coding RNA, has been implicated in the prognosis and survival of various cancers, but its role in OS remains underexplored. This study therefore aimed to investigate the functional involvement of FOXD2-AS1 in OS progression and to evaluate a biocompatible delivery system for its in vitro and in vivo application. We synthesized mPEG-PDPA hydrogel via free radical polymerization of 2-(diisopropylamino)ethyl methacrylate (PDA) and polyethylene glycol monomethyl ether acrylate (mPEG-AC), and employed this hydrogel as a delivery vehicle for FOXD2-AS1. The biocompatibility and safety of the empty hydrogel were first validated through both in vitro cell assays and in vivo animal experiments. To explore the mechanistic actions of FOXD2-AS1, we performed real-time quantitative PCR and Western blot analyses, and conducted transcriptome profiling to identify downstream pathways and associated genes. Our results demonstrated that the mPEG-PDPA hydrogel itself was non-toxic and reliable as a delivery vehicle. Functionally, FOXD2-AS1 promoted alkaline phosphatase (ALP) release and exacerbated the inflammatory response, thereby accelerating the development and deterioration of OS. Mechanistically, FOXD2-AS1 activated the F-box protein Coronatine Insensitive 1 homolog (COI-1)/OCN/Runx-2 signaling pathway, as confirmed by qPCR and Western blot. Transcriptome analysis further revealed that this process involved changes in cell migration, apoptosis, and cell cycle regulation, with CPS1-IT1, ANKRD10-IT1, TBC1D3P1-DHX40P1, and RGS5 identified as key associated genes. Collectively, our findings provide new insights into the pathological mechanisms of OS and offer valuable data support for future therapeutic strategy development.

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PubMedFood chemistry2026-10-14

Ester markers of sweet fruit aroma prediction in Xiangning Cabernet Sauvignon dry red wines.

Li Na N, Li Guanyu G, Miao Chengpeng C, Cheng Yang Y et al.

Sweet fruit aroma is characteristic of Cabernet Sauvignon dry red wines from the Xiangning appellation, China Loess Plateau. To identify its volatile markers, 13 consecutive vintages of Xiangning Cabernet Sauvignon were analyzed using sensomics and chemometric approaches. Results indicated that sweet fruit aroma fluctuated inconsistently yet maintained consistently high levels across vintages, with vintage exerting a significant influence (P < 0.05). Moreover, fruity ester content increased and then slightly decreased during storage, among which ethyl acetate, isoamyl acetate, ethyl isobutyrate, ethyl butyrate, ethyl octanoate were identified as sweet fruit aroma markers through omission tests and PLSR. Sweet fruit aroma was attributed to ester marker content and ethyl acetate/ethyl isobutyrate proportion, with sweet fruit flavor intensity prediction model developed using natural logarithm concentrations of markers. This study identifies ester markers that confirm the aging potential of sweet fruit aroma in Xiangning Cabernet Sauvignon, providing data for the optimization of winemaking technology.

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PubMedFood chemistry2026-10-14

Characterization of key odor-active compounds in aged Chinese grain whisky by sensory-directed flavor analysis and simulation.

Ma Xiaoduo X, Feng Ranran R, Zhang Zhibin Z, Li Ting T et al.

Chinese grain whisky possesses distinctive flavor owing to the unique raw materials and barrel aging process, yet its aroma chemistry has not yet been fully studied. All the odor compounds of aged whisky were initially determined by two-dimensional gas chromatography-mass spectrometry (GC × GC-MS) with solid-phase microextraction (SPME) and liquid-liquid extraction (LLE). A total of 43 odor-active compounds were identified by aroma extract dilution analysis (AEDA) with gas chromatography-olfactometry-mass spectrometry (GC-O-MS), with 31 compounds (OAV ≥ 1) confirmed. Moreover, the aroma recombination successfully replicated the original sensory profile (fruit, coconut, flower, acid, and vanilla), while the omission experiments demonstrated ethyl 2-methylbutanoate, ethyl octanoate, vanillin, whisky lactone, β-damascenone, 2-phenylethanol and 3-methylbutanoic acid were indispensable. Finally, OR1A1 exhibited the strong binding energy to β-damascenone, vanillin, whisky lactone and 2-phenylethanol through the hydrogen bonding and hydrophobic interactions. Therefore, comparing pre- and post-aging profiles confirmed critical odorants, providing a foundation for aroma control and quality standardization.

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PubMedNatural product research2026-10-14

Synthesis of genipin derivatives and study of their anti-inflammatory activity.

He Yifan Y, Xu Jie J, Tang Xin X, Meng Xin X et al.

This study aimed to evaluate the anti‑inflammatory properties of genipin derivatives. Based on preliminary findings, a series of genipin derivatives were synthesised using either BF3·Et2O:H2O = 1:50 (v:v) or p‑toluenesulfonic acid as catalysts, and their structures were characterised by 1H‑NMR,1³C‑NMR, and HRMS. The BV2 microglial cell line was used as the experimental model; cytotoxicity and nitric oxide (NO) levels were assessed via CCK‑8 and Griess assays, respectively, and the therapeutic index (IC50/EC50) was calculated for preliminary screening. All eighteen synthesised derivatives significantly inhibited NO release. Based on the therapeutic index, derivative 1b (1 R‑O‑ethyl genipin) was identified as having superior anti‑inflammatory activity. Further examination in cellular inflammation models using qRT‑PCR, ELISA, and Western blotting revealed that both genipin and derivative 1b dose‑dependently reduced the expression of pro‑inflammatory mediators (TNF‑α, IL‑6, and iNOS) while upregulating anti‑inflammatory markers (IL‑10 and Arg‑1) compared with the model group. Collectively, 1 R‑O‑ethyl genipin exhibits favourable anti‑inflammatory activity, offering new possibilities for the treatment of neuroinflammation and related disorders.

PMID 42872531
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PubMedThe Journal of pharmacology and experimental therapeutics2026-10-14

Locomotor stimulant and methamphetamine-like interoceptive effects of putative impurity N-ethyl-methamphetamine in rodents: Role of Phase I metabolism.

Gannon Brenda M BM, Pressley Justin M JM, Fomin Andriy A, Rowe Sierra S et al.

Over the past 20 years, N-ethyl-methamphetamine (NEM) has been identified in seized methamphetamine (METH) samples. Often considered a byproduct or impurity of illicit METH synthesis, its structural similarity to METH suggests that it may have pharmacological actions of its own or be metabolically converted to METH or amphetamine (AMPH) in vivo. These studies assessed the potency and effectiveness of NEM as a locomotor stimulant compared to METH in NIH Swiss mice, and probed the role of cytochrome P450 (CYP) vs non-CYP metabolism in these locomotor effects using pretreatments with the broad spectrum CYP inhibitor 1-aminobenzotriazole (1-ABT) or the selective CYP2D6 inhibitor quinidine. Blood samples taken from mice treated with NEM, with and without pretreatments of 1-ABT or quinidine, were quantitively analyzed for NEM, METH, and AMPH using Quadrupole Time-of-Flight. Additionally, the discriminative stimulus effects of NEM were assayed in Sprague-Dawley rats trained to discriminate METH from saline. NEM produced dose-dependent locomotor stimulant and METH-like interoceptive effects, but with a slower onset and less potently than METH. Locomotor stimulant effects of NEM were abolished by pretreatment with 1-ABT or quinidine, and both pretreatments also decreased conversion of NEM to METH and AMPH in mouse blood. These data demonstrate METH-like biological effects of NEM and suggest that the likely mechanism for these effects is metabolic conversion of NEM to METH and AMPH via CYP2D6. NEM thus functions as a prodrug for METH and AMPH, and would be expected to have METH-like abuse liability in humans. SIGNIFICANCE STATEMENT: N-ethyl-methamphetamine (NEM) has been identified in seized methamphetamine (METH) samples, and is typically considered a byproduct or impurity of illicit METH synthesis. These studies demonstrate METH-like biological effects of NEM and suggest that the likely mechanism for these effects is metabolic conversion of NEM to METH and AMPH via CYP2D6. NEM thus functions as a prodrug for METH and AMPH, and would be expected to have METH-like abuse liability in humans.

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PubMedChemistry & biodiversity2026-10-14

Bioactive Compounds and Antidiabetic Properties of Launaea mucronata Hydroethanolic Extract: Phytochemical and Pharmacological Insights.

Mohamed Amira A, El Amir Dalia D, Abdel-Fattah Maha M MM, Zaki Mohamed A MA et al.

Launaea mucronata has been traditionally used in folk medicine worldwide for managing various diseases. This study investigated the phytochemical composition and biological activities of the hydroethanolic extract of L. mucronata aerial parts. Total phenolic and flavonoid contents were 63.77 ± 0.21 mg GAE/g and 20.91 ± 1.56 mg QE/g, respectively. Phytochemical investigation yielded lupeol (1) and β-sitosterol (2) from the n-hexane fraction; ethyl caffeate (3) and apigenin (4) from the dichloromethane fraction; apigenin (4), luteolin (5), and apigenin-7-O-glucuronide (6) from the ethyl acetate fraction. Antioxidant capacity, assessed via 2,2‑diphenyl‑1‑picrylhydrazyl (DPPH, 109.30 ± 0.75 mg AAE/g) and phosphomolybdenum (119.18 ± 0.93 mg AAE/g) assays, was notable. The extract also showed significant antidiabetic potential, inhibiting α-glucosidase (IC50 = 0.14 ± 0.005 mg/mL) and α-amylase (IC50 = 0.23 ± 0.007 mg/mL), with activity comparable to acarbose (IC50 = 0.07 ± 0.002 mg/mL and 0.09 ± 0.003 mg/mL, respectively). In vivo, alloxan-induced diabetic rats given oral doses (200 and 400 mg/kg, 21 days) exhibited significant hypoglycemic effects, moderate insulinotropic activity, antioxidant actions, and histological improvements in key metabolic organs. These findings suggest L. mucronata as a promising natural candidate for further development as an adjunct therapy for diabetes mellitus (DM).

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