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INJEX system

✓ Approved

Equidyne · therapeutic agent

What is INJEX system?

INJEX system is a therapeutic agent developed by Equidyne. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection or subcutaneous injection.

Drug Profile

CompanyEquidyne
RouteInjectable (Others), Intramuscular (IM) Injection, Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, Equidyne

Therapeutic Indications

INJEX system is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresOral appliance application✓ Approved

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Li Jiage J, Liu Yansong Y, Zhang Jin J, Zhang Yanan Y et al.

Penicillin intermediate wastewater contains recalcitrant organics and residual antibiotics that favor the enrichment of antibiotic-resistant bacteria and the dissemination of antibiotic resistance genes (ARGs). In this study, a pilot-scale simultaneous coupling ozonation and biodegradation (SCOB) system was applied to treat the secondary biochemical effluent of penicillin intermediate wastewater. The reactor achieved stable operation under selected conditions of a 6 h hydraulic retention time, a 2 h ozone supply period, and an ozone dosage of 5 mg/(L·h). Compared with the standalone biodegradation system, the SCOB system enhanced chemical oxygen demand removal by 25.90%, UV254 removal by 31.34%, and a 34.93-fold increase in chroma removal. The SCOB system attenuated both chronic and acute toxicity in the effluent. Microbial analyses revealed that, despite lower biomass, microbial activity increased by 21.04% in the SCOB system, accompanied by distinct community succession, with Proteobacteria, Actinobacteria, and Chloroflexi as the dominant phyla and Hyphomicrobium as the dominant genus. The SCOB system also reduced intracellular reactive oxygen species levels and suppressed ARGs abundance and dissemination. The total abundance of ARGs decreased by 10.34%, while multidrug resistance plasmids were reduced by 25.40%. This study provides engineering guidance for developing pilot-scale SCOB as an advanced treatment strategy for simultaneously achieving pollutant removal and ARGs risk mitigation in antibiotic-containing wastewater.

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PubMedAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026-08-30

A Novel Sparse Cellular Labeling System with Tunable Gradients and Long-Term Stability.

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The dense packing of cells within tissues poses challenges for studying cellular properties. Sparse labeling, genetically targeting a small subset of densely distributed cells, provides a powerful approach to investigate cellular morphology, connectivity, dynamics, and functions, especially in neuroscience. However, current sparse labeling methods are generally restricted to fixed labeling densities and often exhibit a decline in sparsity over time. In this study, by maximizing the utility of commonly used recombinases and the relational recognition sites, we constructed a versatile sparse labeling system, termed Tri-M (Multi-recombinase, Multi-recognition site, and Multi-nested), built upon competitive recombination. The Tri-M system, which integrates transgenic mice with viral injection, enables tunable and graded sparse labeling of specific cell types within specific brain regions with long-term stability. This system significantly enhances the ability to track, analyze, and manipulate cells within tissues characterized by dense cellular packing, from single cells to populations.

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Endoscopic combined intrarenal surgery for staghorn calculus in a horseshoe kidney with double collecting system: A case report.

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Horseshoe kidney (HSK) with a duplicated collecting system and a bifid ureter is a unique surgical challenge. We report the case of a 43-year-old male patient with a left HSK, duplicated collecting system, bifid ureter, staghorn calculus in the lower moiety, and proximal ureteral stone. The procedure of mini-endoscopic combined intrarenal surgery (mECIRS) with mini-percutaneous nephrolithotomy (mini-PCNL) was successfully performed, resulting in minimal blood loss and no intraoperative complications. This case exemplifies the feasibility of employing mECIRS with a single-tract, tubeless mini-PCNL, combined with flexible ureteroscopy, to achieve complete stone clearance in a rare and challenging anatomical context.

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Ligand-mediated electron transfer in pH-tolerant Mn(II)/Fe(VI) bimetallic system: High-valent iron-oxo generation for efficient antibiotic removal.

Ou-Yang Jia-Xuan JX, Chen Xin-Jia XJ, Huang Yu-Kun YK, Guo Jia-He JH et al.

Ferrate-based advanced oxidation processes (Fe(VI)-AOPs) show promise for antibiotic abatement in water, but their practical application is typically limited by pH sensitivity, unstable active species, and insufficient electron transfer in real water matrices. To address these issues, we developed a novel ethylenediaminetetraacetic acid (EDTA)-bridged Mn(II)/Fe(VI) bimetallic synergistic system. Such a unique system could achieve 96.26% degradation of target antibiotics within 2 min via a non-radical direct electron transfer pathway, with stable performance across a wide pH range (5.0-9.0) relevant to natural and engineered water systems. Comprehensive characterization confirmed that EDTA functioned as a ligand to stabilize Mn(II) by complexation, suppressed the disproportionation of Mn(III) intermediates, key processes that enhanced pollutant removal. Moreover, the EDTA-Mn complex acted as an electron mediator, facilitating the conversion of Fe(VI) to highly reactive high-valent iron-oxo species (Fe(IV)=O and Fe(V)=O) and establishing a synergistic reaction pathway of ligand regulation-metal cycling-electron transfer-high-valent iron generation. Notably, computational toxicology combined with multi-level biological assays (microbial inhibition, phytotoxicity, and animal developmental toxicity) demonstrated that the system could effectively degrade antibiotics and also substantially reduce their acute and chronic ecotoxicity, addressing a critical gap in conventional AOPs that often overlook post-degradation ecological risks. This study systematically clarified the molecular mechanisms, catalytic oxidation performance, and environmental safety of the ligand-bridged bimetallic system, providing a robust basis for developing green, stable, and scalable water treatment technologies suitable for real-world antibiotic remediation.

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Validation of SARS-CoV-2 neutralization assay using VSV-based pseudovirus system.

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The gold standard for SARS-CoV-2 neutralization assays involves wild-type virus, which requires Biosafety Level 3 (BSL-3) containment. To improve safety and accessibility, pseudovirus-based neutralization assays utilizing non-replicating particles like Vesicular Stomatitis Virus (VSV) expressing the SARS-CoV-2 spike protein can be conducted under BSL-2 conditions. This study aimed to perform the analytical validation of a VSV-based pseudovirus system for SARS-CoV-2 using recombinant monoclonal antibody. Pseudo-VSV carrying SARS-CoV-2 Spike proteins were produced using LentiX-293T cells. The assay system was optimized for Multiplicity of Infection (MOI) and assessed for specificity, limit of quantification (LOQ), linearity, accuracy, and precision using the neutralizing mAb BD-604. The system was optimized at an MOI of 0.25. The assay proved highly specific, as mAb BD-604 showed clear neutralizing activity while mAb 1A9 did not. The limit of quantification (LOQ) was determined to be 125 ng of mAb BD-604, with a linear range of 125 - 1000 ng. The relative accuracy remained within the 80-120% range, and the precision (%CV) ranged from 1.92% to 13.57%. Additionally, the system successfully characterized variant-specific neutralization, revealing that BD-604 was effective against the Wuhan, Delta, and Omicron BA.1/BA.2 strains but lacked activity against the Omicron XBB.1.5 variant. This validated pseudo-VSV based SARS-CoV-2 neutralization assay is a valuable bioassay for evaluating neutralizing antibody potency against various SARS-CoV-2 strains in a BSL-2 environment, thus making it useful for vaccine and therapeutic development.

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Methods for producing a National Infection Prevention and Control Manual in Scotland: 2025 update with a new considered judgement form.

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The National Infection Prevention and Control Manual (NIPCM) is an online evidence-based resource developed by Antimicrobial Resistance and Healthcare Associated Infection (ARHAI) Scotland (NHS Scotland). Following a 2022 evaluation and informed by lessons from the COVID-19 pandemic, the NIPCM guidance development process was reviewed to improve transparency and support auditable decision-making. The guidance development methodology, inclusive of the recommendation grading system, was assessed as part of an annual review process. Extant infection prevention and control (IPC) or public health guidance development frameworks of relevance were identified and appraised for potential integration into a new considered judgement form (CJF), which was piloted in practice with working groups. Elements from the SIGN 50 and HICPAC methodologies were incorporated into ARHAI Scotland's new CJF with notable addition of a dedicated 'Expert opinion' section. The recommendation grading system was altered from a lettered system (A-C) to use of the terms 'recommendation' and 'good practice point'. By clearly documenting decision making, context and expert opinion, the new CJF improves transparency and supports guidance users with interpretation and implementation. The new grading system more adequately conveys the strength of supportive evidence and practical intent of recommendations.

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