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INJEX system

✓ Approved

Equidyne · therapeutic agent

What is INJEX system?

INJEX system is a therapeutic agent developed by Equidyne. It is approved for therapeutic indications via injectable (others) or intramuscular (im) injection or subcutaneous injection.

Drug Profile

CompanyEquidyne
RouteInjectable (Others), Intramuscular (IM) Injection, Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, Equidyne

Therapeutic Indications

INJEX system is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresOral appliance application✓ Approved

Related Research Articles

PubMedACS sensors2026-10-15

Cleavage Activity Adjustment of the CRISPR/Cas System for Enhanced Diagnostics.

Zhao Yining Y, Qiao Panpan P, Yang Min M, Chen Ling L et al.

The CRISPR/Cas system, known for its high precision and efficiency in genome editing, has garnered significant interest and demonstrated potential in diagnostics, owing to advantages such as sensitivity and cost-effectiveness. However, the application of the CRISPR/Cas system in diagnostics is constrained by two inherent challenges. On one hand, the sensitivity of the CRISPR/Cas system for the direct detection of low-abundance targets remains to be further improved for the demands of practical detection. On the other hand, the integration of nucleic acid amplification with the CRISPR/Cas system in one-pot assays presents difficulty of balance between target amplification and cleavage of Cas proteins. To overcome these constraints, researchers have encouragingly developed diverse strategies for precisely adjusting the cleavage activity of the CRISPR/Cas system. This review systematically summarizes advancements across six major strategies, including protein engineering, crRNA engineering, activator engineering, reporter engineering, the influence of metal ions and small molecules, and aggregation-mediated enhancement. These approaches either enhance cleavage efficiency for amplification-free, ultrasensitive detection, or temporarily suppress the cleavage activity to coordinate kinetics in integrated one-pot systems. Furthermore, future perspectives are discussed, which will contribute to the development of cleavage activity adjustment of the CRISPR/Cas system, providing insights for next-generation diagnostic technologies.

PMID 42876087
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PubMedJournal of Alzheimer's disease reports2026-10-15

Development and prospect of treating Alzheimer's disease using the glymphatic system.

Gu Jiajie J, Liu Zekai Z, Gu Jiaxiang J

Alzheimer's disease (AD) is a common neurodegenerative disorder with progressive cognitive decline and typical amyloid-β (Aβ) and tau pathologies, whose pathogenesis remains unclear. The glymphatic system, a core cerebral waste clearance pathway, has become a critical target for AD pathogenic research and novel therapy development. This review explores the glymphatic system's structure and function, illustrates its correlation with AD pathogenesis, summarizes targeted therapies, and highlights research limitations and future directions to facilitate AD translational research. Relevant literatures published from 2012 to 2025 were retrieved from PubMed and Web of Science databases with the combined keywords of "Alzheimer's disease", "glymphatic system", "meningeal lymphatic vessels", "Aβ clearance" and "lymphatic therapy for AD". The included literatures were systematically sorted, and the basic mechanism, therapeutic strategy and research limitations were analyzed and summarized. The glymphatic system clears 30%-50% of cerebral Aβ in rodent models via meningeal lymphatic and parenchymal pathways, yet human evidence is lacking. Glymphatic dysfunction, APOE4 genotype, and immune imbalance promote Aβ and tau accumulation and AD progression. Several glymphatic-targeted strategies have demonstrated preclinical efficacy, with intranasal agents and photostimulation progressing into early-phase clinical trials. The glymphatic system is a promising therapeutic target for AD by improving brain waste clearance. Existing limitations include species discrepancies, unclear causal relationships and insufficient clinical data. Future research will focus on human-specific mechanisms, staged intervention strategies, and rigorous safety evaluation of targeted treatments.

PMID 42876912
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PubMedFrontiers in public health2026-10-15

Survey of public health education combined with intelligent prescription intervention system on antibiotic use in the county-level hospitals.

Xie Xiaoyan X, Yang Lei L, Yue Xiaohui X, Ding Ailing A et al.

This study evaluated the combined effectiveness of an antibiotic health literacy intervention and a prescription pre-audit intelligent decision system on antibiotic utilization. Thereby providing a reference basis for conducting antibiotic health literacy intervention activities and promoting rational drug use in similar hospitals. Evidence-based popular science materials, including handbooks, videos, and lectures, were developed as part of a combined intervention that integrated antibiotic education with a prescription pre-audit intelligent decision system. Variations in irrational antibiotic administration, antibiotic use density, and drug cost ratio were compared between the pre-intervention and post-intervention stages. A retrospective analysis was also conducted to summarize the classification and severity of respiratory ward medication events and the compliance of prescriptions recorded in the system from October to December 2025. Multiple forms of health literacy intervention materials concerning rational antimicrobial administration were designed in this research, covering printed leaflets, WeChat posts, promotional videos and face-to-face training sessions. Educational interventions combining online and offline modes were associated with reductions in departmental antibiotic use density and the proportion of antibiotic expenditure relative to total medication costs. Integrated with the prescription pre-audit intelligent decision system, prescription-related risks derived from irrational medication orders were stratified into distinct severity grades in light of clinical realities of the ward. From October to December 2025, the counts of prescriptions with defects in treatment indications, dosing schedules, delivery routes and contraindication violations all declined relative to the baseline period of October to December 2024. This study observed that the multifaceted intervention, including interactive antimicrobial stewardship training for frontline clinicians and nurses, real-time patient-centered health education, and the prescription pre-audit intelligent decision system, has considerable potential to cut antimicrobial consumption. Upgrading health literacy intervention by integrating big data, artificial intelligence and other technologies and extending such comprehensive strategies to the entire hospital represents a promising approach for future implementation.

PMID 42876734
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PubMedJournal of neuroendocrinology2026-10-15

Opioids and the oxytocin system: Mechanistic interactions altering maternal neuroplasticity.

Richardson Lauren M LM, Veenema Alexa H AH, Brummelte Susanne S

Due to the ongoing opioid epidemic, there has been a rise in the use of medications for opioid use disorder (MOUD) during pregnancy. This paper examines how buprenorphine (BUP), the new golden standard for MOUD, may disrupt maternal care through dysregulation of the oxytocin (OXT) system. OXT is central to parturition, lactation, caregiving, and coordinating activity across the maternal brain network (MBN), including the paraventricular (PVN) and supraoptic nucleus, medial preoptic area, and nucleus accumbens. The endogenous opioid system normally regulates OXT release, with μ-opioid receptor (μOR) and κ-opioid receptor (κOR) signaling influencing OXT neurons. BUP has a unique mechanism of action as it is a partial μOR agonist and a κOR antagonist, which may lead to complex interactions with endogenous opioids and subsequently the OXT system during pregnancy. In line with this, recent preclinical research suggests that BUP exposure during gestation results in reduced maternal motivation and inconsistent pup-directed care in rodent models. Therefore, this paper will explore the possible underlying mechanisms of how BUP exposure may dysregulate the OXT system and thus play a role in the observed maternal care deficits. In particular, we propose that chronic BUP exposure dampens PVN OXT output, disrupts synchrony across the MBN, and constrains OXT-driven neuroplasticity. Further, we will discuss the potential of postpartum OXT administration to restore maternal behaviors by re-engaging OXT signaling and network activity in both clinical and preclinical models. By integrating receptor, network, and behavioral evidence, this review provides a framework for understanding BUP's impact on maternal care through oxytocinergic disruptions and for potential translational interventions.

PMID 42876328
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PubMedPlant cell reports2026-10-15

Development of a genetic transformation system in Echinochloa phyllopogon by particle bombardment.

Gondo Takahiro T, Sugahara Manami M, Ng Hwan May HM, Yasuda Kentaro K et al.

A stable particle bombardment-mediated transformation system was developed for Echinochloa phyllopogon, providing a platform for functional analysis of genes involved in herbicide metabolic detoxification. Echinochloa phyllopogon is a major C4 grass weed that causes serious yield losses in paddy fields and has evolved resistance to multiple herbicides. Understanding the molecular mechanisms underlying this resistance requires functional analysis of candidate genes involved in herbicide metabolic detoxification. However, the lack of a stable transformation system has limited such approaches. In this study, we established a particle bombardment-mediated transformation system for E. phyllopogon using embryogenic calli and plasmid pAHC25 carrying the GUS reporter gene and the bialaphos resistance gene (bar) selectable marker. Three morphologically distinct callus types were identified, among which Type 1 (compact) and Type 2 (friable) embryogenic calli exhibited significantly higher regeneration ability and transient GUS expression than Type 3 calli (wet and viscous). This finding indicates that callus quality is a critical determinant of transformation efficiency. In addition, callus culture duration significantly affected transformation outcomes. Calli cultured for 90 days produced the highest transformation efficiency (5.0%) and retained full regeneration capacity, whereas prolonged culture (300 and 630 days) resulted in reduced regeneration and transformation efficiency. Stable transgene integration and expression were confirmed by Southern blot analysis and histochemical GUS staining. Furthermore, transgenic plants exhibited strong resistance to Basta in the T1 generation, indicating that the herbicide-resistant phenotype was transmitted to the next generation. These results demonstrate that both callus type and culture duration are key factors for efficient transformation. The transformation system established in this study provides a valuable platform for functional analysis of genes involved in herbicide metabolic detoxification in E. phyllopogon.

PMID 42875630
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PubMedZhonghua er ke za zhi = Chinese journal of pediatrics2026-10-15

[Application of the percutaneous ventricular assist system in 2 children with heart failure].

Wu X H XH, Zhao Z Z, Liu Y Y YY, Wang Z Z et al.

PMID 42876105
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