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sumatriptan (Alsuma autoinjector / sumatriptan, King / Alsuma)

✓ Approved

US WorldMeds, LLC · HTR1D · Small Molecule

What is sumatriptan?

sumatriptan is a small molecule developed by US WorldMeds, LLC. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesAlsuma autoinjector, sumatriptan, King, Alsuma
CompanyUS WorldMeds, LLC
Drug ClassSmall Molecule
Molecular TargetHTR1D
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, US WorldMeds, LLC

Mechanism of Action

Molecular Targets

sumatriptan acts on 1 molecular target:

HTR1D5-hydroxytryptamine receptor 1D (HTR1DA, HT1DA)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

sumatriptan is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Nervous system disordersMigraine✓ Approved

Related Research Articles

PubMedCase reports in dentistry2026-07-17

Case Report: Simple Triple of the Median Maxillary Labial Frenum.

Almahdi Hatim Mohammed HM, Alghafli Hussain Adel HA, Alasafirah Abdullah Othman AO, AlSaleem Mousa Haney MH et al.

The median maxillary labial frenum (MMLF) is an anatomical structure composed of mucous membrane and connective tissue within the oral cavity. It serves as a key component of the septo-premaxillary traction system, extending from the nasal septum to the mucosal aspect of the lip and from the midline of the lip anteriorly to the median interincisal suture. The frenum exhibits dynamic and variable morphology, with its shape, size, and position changing throughout various stages of growth and development. A 20-year-old Saudi male presented to the King Faisal University Dental Complex Clinics. The patient's medical, dental, and family histories were unremarkable, with no syndromic conditions reported among family members. Both extraoral and intraoral examinations were within normal limits, except for the presence of a simple triple labial frenum. Direct visual inspection was performed to evaluate the frenum's form, size, and point of attachment. Blanching or tension was assessed by gently drawing the upper lip outward and upward. The simple triple frenum type of MMLF is a rare anatomical variation, with a reported prevalence ranging from 1.0% to 1.57%. The frenum is classified as pathogenic when associated with midline diastema, gingival recession, loss of papilla, interdental bone loss, reduced lip mobility, difficulty with oral hygiene, and malalignment of teeth. Pathogenic frena may also present with a flattened papilla closely attached to the gingival margin, insufficiently attached gingiva, and a shallow vestibule. Emphasizing frenum assessment during oral examinations is essential to prevent misdiagnosis of normal anatomical variations as pathological findings. Accurate identification supports appropriate intervention and effective treatment planning.

PMID 42465582
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PubMedRisk analysis : an official publication of the Society for Risk Analysis2026-07-17

The Wells-Riley Model Revisited II: Parameter Uncertainty and Population Heterogeneity.

Marshall Marcus M, Edwards Alexander J AJ, Pinnell Dominique D, King Marco-Felipe MF et al.

In this work, we revisit the Wells-Riley model, which has been widely used to estimate airborne infection risk in indoor settings. In particular, we consider a probabilistic (i.e., "stochastic") framework of the Wells-Riley model which allows one to quantify infection risk in terms of the per-capita probability of infection for each susceptible individual, as well as the probability distribution of the number of infections (here referred to as "exposures") during the indoor interaction. Directly extending the work by Edwards, King, Noakes et al. (2024), we consider here the situation where the main parameters in the Wells-Riley model (namely, the quanta generation rate q $q$ , the ventilation rate Q $Q$ , the number of infectors I $I$ , or the duration of the indoor interaction T $T$ ) may be random or uncertain. We show how, in this case, the per-capita infection risk P i n f e c t i o n $P_{infection}$ becomes a random variable between 0 and 1, and compute its density function under some parametric assumptions. This allows for a comprehensive analytical quantification of uncertainty when dealing with heterogeneous populations, uncertain environmental conditions, or stochastic human behavior. Our results reveal that infection risk can vary significantly depending on the distribution and variability of model parameters. In particular, using mean parameter values in the classical Wells-Riley model can lead to systematic inaccuracies: Uncertainty in q $q$ , T $T$ , or b $b$ leads to infection risk overestimation, while environmental stochasticity (i.e., uncertainty in ventilation or removal rates) can lead to infection risk underestimation. We also investigate which parameter mainly drives the uncertainty in infection risk when two model parameters are simultaneously random.

PMID 42464558
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PubMedEuropean journal of clinical pharmacology2026-07-16

Unveiling the sumatriptan dose-relief relationship.

Rigaut Clément C, Haut Benoit B, Lambert Pierre P, Goole Jonathan J

This article aims to correlate the pharmacokinetic parameters of sumatriptan to the percentage of patients experiencing relief after two hours. Using data from the literature, a two-compartment pharmacokinetic model is developed to compute the concentration of sumatriptan in the brain across various routes of administration and doses. This concentration is then correlated to its clinical effect. The maximum concentration of sumatriptan in the brain correlates linearly with the percentage of patients experiencing pain relief after two hours. Based on the evolution over time of the brain concentration, the action time can also be predicted for different route-dose combinations. The present correlation provides a relationship between the dose of sumatriptan and its effect for multiple routes of administration. The approach developed in this work could be adapted to other molecules to explore their dose-response relationships.

PMID 42458128
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PubMedPloS one2026-07-16

Exploring the relationship between supervisory support, self-efficacy, and satisfaction among nursing students in Saudi Arabia.

Eid Thurayya T, Alshaibany Faihan F FF, Alodhailah Abdulaziz M AM, Alshehri Waleed M WM

Supervisory support during clinical placements is central to nursing students' professional development. Professional self-efficacy, students' confidence in performing clinical tasks, is increasingly recognised as a key outcome associated with transition to practice and workforce retention. In Saudi Arabia, Vision 2030 healthcare reforms have intensified demand for qualified nurses, making the quality of clinical supervision a strategic priority. This study examined the relationships among supervisory support, professional self-efficacy, and nursing student satisfaction at King Saud University-affiliated hospitals. This descriptive cross-sectional study was conducted among 145 nursing students (second-, third-, and fourth-year bachelor's degree students) at three King Saud University-affiliated teaching hospitals in Riyadh, Saudi Arabia. Participants were selected using stratified random sampling based on year of study. Data were collected using four validated instruments: a sociodemographic questionnaire, the Supervisory Support Scale (9 items; Cronbach's α = 0.90), the Nursing Student Satisfaction Scale (6 items; α = 0.88), and an adapted Professional Self-Efficacy Scale (12 items; α = 0.90). Descriptive statistics summarised the three key study variables (supervisory support, professional self-efficacy, and student satisfaction) alongside sociodemographic characteristics. Pearson correlation coefficients assessed the strength and direction of linear associations among continuous study variables. Formal mediation analysis was conducted using the PROCESS macro (Model 4) with 5,000 bias-corrected bootstrap resampling iterations. Of 175 students approached and meeting eligibility criteria, 145 returned valid questionnaires (response rate = 82.9%). The sample was predominantly female (60.7%) and in the age range of 20-22 years (66.9%). Students reported high levels of supervisory support (mean = 4.10 ± 0.53 out of 5), satisfaction with clinical placements (mean = 4.11 ± 0.52), and professional self-efficacy (mean = 4.06 ± 0.56). Supervisory support was strongly correlated with satisfaction (r = 0.68, p < 0.001) and professional self-efficacy (r = 0.57, p < 0.001); professional self-efficacy was positively correlated with satisfaction (r = 0.49, p < 0.001Statistical mediation analysis revealed that professional self-efficacy partially mediated the supervisory support-satisfaction relationship: the indirect association (ab = 0.13, 95% CI [0.07, 0.19]) was statistically significant and accounted for approximately 19% of the total association. In regression analysis, supervisory support remained significantly associated with satisfaction (β = 0.43, p < 0.001) even after accounting for professional self-efficacy, consistent with partial statistical mediation. Supervisory support was significantly and positively associated with nursing students' satisfaction and professional self-efficacy. These findings, grounded in social cognitive theory, suggest that high-quality supervision may enhance clinical learning outcomes both directly and through strengthening students' professional confidence. Standardising supervisory practices, investing in supervisor training, and creating structured feedback mechanisms are priorities for improving nursing education in Saudi Arabia and advancing national nursing workforce goals under Vision 2030.

PMID 42461836
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PubMedScientific reports2026-07-16

Sleep duration among medical students and its association with bronchial asthma, anxiety, and depression.

Almeneessier Aljohara Saud AS, Alobaid Shaden A SA, Albakr Farah F FF, Alajlan Alhanoof A AA et al.

Guidelines recommend 7-9 h of sleep per night for an optimal sleep duration. We aimed to estimate sleep duration and the proportion of participants reporting bronchial asthma and screened positive for anxiety and depressive symptoms among medical students. This cross-sectional study included all medical students at the College of Medicine, King Saud University. Data were collected through an online Google Form questionnaire that included students' demographics, sleep duration, asthma, screening for anxiety and depression, using validated screening tools (Generalized Anxiety Disorder scale-2, and Whooley's Case-finding Instrument for depression). The study recorded 1097 responses (response rate: 75.7%). The students' mean sleep duration was 6.76 ± 1.5 h, with 46.5% reported a short sleep duration of < 7 h per night. 14% reported bronchial asthma, 31.4% screened positive for anxiety symptoms, and 62.7% screened positive for depressive symptoms. The asthma* anxiety* depression interaction as a predictor for sleep duration was not statistically significant, p=.866. On the other hand, we examined sleep duration as a predictor for anxiety and depression; sleep duration (p = .016) and sex (p < .001) were significantly associated with anxiety. It is important to integrate mental health promotion and sleep health education within medical training programs to support student well-being and optimize academic performance. Longitudinal studies are needed to clarify the factors that influence short sleep duration among medical students.

PMID 42457931
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PubMedJournal of clinical neurophysiology : official publication of the American Electroencephalographic Society2026-07-16

Peripheral Nerve Cross-Sectional Area in Healthy Thai Children: Reference Values for Clinical Neuromuscular Ultrasound.

Paprad Tanitnun T, Amornvit Jakkrit J, Stonsaovapak Chernkhuan C, Naothaworn Kamin K et al.

Ultrasonography of the nerve cross-sectional area (CSA) is increasingly used to support the diagnosis of peripheral neuropathies. However, normative CSA reference values in children, particularly in Southeast Asian populations, are limited. Ultrasonographic nerve CSA measurements were conducted in 164 healthy Thai children aged 1 to 18 years at King Chulalongkorn Memorial Hospital, Thailand. Participants were classified into six age groups. CSA was measured in 10 peripheral nerves at 34 anatomical sites and bilateral cervical roots (C5-C7), and the median CSAs were calculated. Correlations between CSA and body weight, height, and age were calculated using Spearman and Pearson correlation coefficients. Intraobserver and interobserver reliability were evaluated in a subset of participants using intraclass correlation coefficients. Normative CSA values were established for all examined nerves and sites. Most nerves demonstrated proximal-to-distal tapering in CSA, with the median nerve exhibiting a unique pattern of larger CSA at the wrist and mid-upper arm. C7 root was the largest cervical root measured (median CSA up to 7.0 mm2 in older adolescents). CSA demonstrated moderate-to-strong correlations with anthropometric variables, including weight, height, and age (r = 0.36-0.78). The tibial, sciatic, and median nerves showed the strongest correlations (all P < 0.001). Intraobserver and interobserver reliability were good-to-excellent across the selected nerves. Nerve CSA is influenced by age, weight, height, and location in this Southeast Asian population. These normative reference values may serve as a reference for distinguishing normal from pathological findings and aid clinical decision making in pediatric neurophysiological practice.

PMID 42461751
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