Drug Database
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beclometasone dipropionate (Aerobec / Junik / Ventolair)

✓ Approved

Teva Pharmaceutical Industries Ltd. · NR3C1 · Small Molecule

What is beclometasone dipropionate?

beclometasone dipropionate is a small molecule developed by Teva Pharmaceutical Industries Ltd.. It is approved for therapeutic indications via inhaled.

Drug Profile

Brand NamesAerobec, Junik, Ventolair
CompanyTeva Pharmaceutical Industries Ltd.
Drug ClassSmall Molecule
Molecular TargetNR3C1
RouteInhaled
StatusApproved
Sources: ClinicalTrials.gov, Teva Pharmaceutical Industries Ltd.

Mechanism of Action

Molecular Targets

beclometasone dipropionate acts on 1 molecular target:

NR3C1nuclear receptor subfamily 3 group C member 1 (GR, GCCR)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

beclometasone dipropionate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersAsthma✓ Approved

Related Research Articles

PubMedJournal of aerosol medicine and pulmonary drug delivery2026-07-16

Toward Next-Generation Propellants: Assessing Lung Deposition of Beclometasone Dipropionate, Formoterol, and Glycopyrrolate Formulated with HFA-152a Using Functional Respiratory Imaging.

Matturro Angelo A, Monshi Tousi Navid N, Sadafi Hosein H, Cuoghi Erika E et al.

Pressurized metered-dose inhalers (pMDIs) rely on hydrofluoroalkane (HFA) propellants that have a high global warming potential (GWP). Reformulation with next-generation, low-GWP propellants, such as HFA-152a, offers a strategy to reduce climate impact; however, changes in propellant composition can affect aerosol characteristics and potentially alter lung deposition, requiring robust demonstration of therapeutic equivalence. Functional respiratory imaging, combining high-resolution computed tomography and computational fluid dynamics, was used to compare the lung deposition of a fixed triple combination of beclometasone dipropionate, formoterol fumarate, and glycopyrronium bromide (BDP/FF/GB) delivered via a pMDI formulated with either HFA-134a (Reference) or HFA-152a (Test). Ten patients with chronic obstructive pulmonary disease (GOLD stages 2-4) were retrospectively selected. Patient-specific airway geometries, a standardized inhalation profile, and formulation-specific particle size distributions and plume characteristics were applied. Deposition was quantified in the intrathoracic, central + distal, and peripheral lung regions, and the (central + distal)/peripheral ([C + D]/P) deposition ratio was evaluated. Mean intrathoracic deposition was comparable between the Reference and Test formulations, ranging from 45.95% to 46.88% of the delivered dose (DD). Deposition in the central + distal airways accounted for 12% of DD for both formulations, whereas peripheral deposition predominated, with 33.7% of DD for the Test formulation and 34.5% of DD for the Reference formulation. The (C + D)/P ratios were similar across all active components (0.35-0.37), indicating consistent preferential deposition in the peripheral/small airways. Although inter-patient variability was observed, intra-subject comparisons showed close agreement between propellants. Reformulation of the BDP/FF/GB pMDI with the low-GWP propellant HFA-152a preserved total and regional lung deposition characteristics relative to the current HFA-134a formulation. These findings support the maintenance of deposition performance while enabling a substantial reduction in environmental impact, reinforcing the potential of HFA-152a as a next-generation propellant for carbon minimal pMDI therapies.

PMID 42461266
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PubMedLasers in medical science2026-07-16

Combined compound betamethasone and 595 nm pulsed dye laser improves hypertrophic scar and is associated with enhanced autophagy in myofibroblasts.

Sui Shijia S, Bian Shijun S, Xia Zhikuan Z, Wu Jiamin J et al.

Compound betamethasone combined with 595 nm pulsed dye laser (PDL) is widely used in the clinical management of hypertrophic scars. However, the mechanisms underlying this enhanced effect remain poorly understood. This study evaluated its therapeutic efficacy and investigated whether induction of autophagy in myofibroblasts is associated with scar improvement. A rabbit ear hypertrophic scar model was established and divided into control, compound betamethasone injection (BI), PDL, and combined (BI + PDL) groups. Scar morphology and histological changes were assessed. Autophagy was evaluated using transmission electron microscopy (TEM) and immunohistochemical detection of LC3B and p62. In vitro, hypertrophic scar-derived myofibroblasts were treated with betamethasone dipropionate (BD), PDL, or their combination (BD + PDL). Cell viability, collagen expression, and autophagic activity were analyzed using CCK-8 assays, Western blotting, MDC staining, immunofluorescence, and TEM. Chloroquine was used to assess autophagic flux. The combined BI + PDL treatment produced the most pronounced improvement in scar architecture, with reduced collagen deposition, decreased microvessel density, and increased number of apoptotic cells. Autophagy levels were significantly elevated in the combination group both in vivo and in vitro. In cultured myofibroblasts, BD + PDL markedly inhibited cell viability and reduced type I and type III collagen expression. This effect was accompanied by increased autophagosome formation, an elevated LC3II/LC3I ratio, and decreased p62 expression. Importantly, inhibition of autophagic flux with chloroquine attenuated the collagen-suppressive effect of the combined treatment. Compound betamethasone combined with 595 nm PDL significantly improves hypertrophic scars, an effect associated with enhanced autophagic activity in myofibroblasts which may partly mediate collagen degradation.

PMID 42461415
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PubMedTopics in companion animal medicine2026-07-15

Concurrent Babesia gibsoni infection as a negative prognostics indicator of survival in dogs diagnosed with immune-mediated hemolytic anemia: A prospective cohort study.

Bandaranayaka Nishadi N, Dissanayake Anuruddhika A, Jinadasa Rasika R, Govinna Mihidum M et al.

Immune-mediated haemolytic anaemia (IMHA) is a common autoimmune disorder in dogs. Haemoparasites, particularly intracellular organisms, are well-recognized causes of secondary IMHA and are associated with poorer clinical outcomes. However, the prognostic impact of concurrent Babesia gibsoni infection in dogs with IMHA remains incompletely characterized. This study aimed to compare survival outcomes between dogs with primary IMHA and those with IMHA associated with B. gibsoni infection. Fifty-five dogs (34 purebred, 21 crossbred; age 7 months-9 years) diagnosed with IMHA, according to ACVIM guidelines, were included. Twenty-six dogs had primary IMHA (11 males, 15 females), and 29 dogs had IMHA with natural B. gibsoni infection (12 males, 17 females), confirmed by PCR. All dogs received immunosuppressive therapy consisting of prednisolone (1 mg/kg q12h PO) or dexamethasone sodium phosphate (0.2 mg/kg q24h IV). Dogs with B. gibsoni infection additionally received antibabesial treatment that included initial imidocarb dipropionate (6.6 mg/kg IM) in two weeks interval, and doxycycline up to three weeks (10 mg/kg q12h PO). Cases were followed for 60 days. Survival analysis was performed using Cox proportional hazards regression. During follow-up, 40 dogs died of IMHA and 2 from unrelated causes. In multivariable analysis, male sex (HR=2.1; 95% CI: 1.1-4.2; p=0.034), marked spherocytosis (HR=2.1; 95% CI: 1.1-4.3; p=0.032), and concurrent B. gibsoni infection (HR=2.6; 95% CI: 1.2-2.9; p=0.024) were independently associated with increased hazard of death. In conclusion, male sex, marked spherocytosis, and B. gibsoni co-infection are key independent predictors of a poor prognosis in dogs with IMHA.

PMID 42448039
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PubMedInternational journal of chronic obstructive pulmonary disease2026-07-13

Real-World Effectiveness and Safety of Extrafine Triple Therapy in COPD Patients with Comorbid and Cardiovascular Conditions.

Rogliani Paola P, Bakakos Petros P, Stolz Daiana D, Piraino Alessio A et al.

This study evaluated the real-world effectiveness and safety of extrafine single-inhaler triple therapy (SITT) with beclometasone dipropionate/formoterol fumarate/glycopyrronium bromide (BDP/FF/GB) in chronic obstructive pulmonary disease (COPD) patients with diverse comorbidity burdens, cardiovascular (CV) history, or CV risk. A pooled analysis of six observational studies assessed outcomes in subgroups with 1-2 or ≥3 comorbidities, CV history, or CV risk. Endpoints included COPD Assessment Test (CAT) scores, exacerbation, lung function (FEV1), adherence (TAI-10), and cardiopulmonary events, evaluated at 3, 6, and 12 months. Comparisons were made with reference populations (0 comorbidities, no CV history, and no CV risk). Among 5356 patients, 2431 had 1-2 comorbidities, 1087 had ≥3, 312 had a CV history, and 117 met CV-risk criteria. CAT scores decreased significantly in all subgroups following SITT initiation. Patients with comorbidities showed smaller CAT improvements vs those without, while CV history/risk groups showed greater CAT improvements than their reference groups up to month 6. Regardless of comorbidity burden or CV history, most patients remained exacerbation-free and FEV1 improved, with no long-term differences between groups. Adherence improved as well, with patients with ≥3 comorbidities potentially showing higher adherence over the long term. Cardiopulmonary events were more frequent in higher-comorbidity groups early on but became similar over time. Patients with a CV history consistently reported more cardiopulmonary events than those without, while those with CV risk achieved similar results compared to no-risk group at any time point. This analysis provides real-world evidence supporting extrafine BDP/FF/GB SITT as an effective and safe option for COPD patients with comorbidities, including CV history or risk. These findings help address an evidence gap in vulnerable populations and support timely initiation of SITT in high-risk patients in clinical practice.

PMID 42438692
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PubMedCurrent research in parasitology & vector-borne diseases2026-07-11

Retrospective analysis of anamnesis, clinical signs, therapy, and outcome in 342 dogs with acute Babesia canis infections.

Eisenecker Clara M CM, Moritz Andreas A, von Hohnhorst Imke M IM, Strube Christina C et al.

Babesia canis is a protozoan vector-borne pathogen causing infections in dogs. Acute B. canis infections are emerging in central and eastern Europe. Clinicopathological abnormalities include fever, thrombocytopenia, and pigmenturia. This retrospective study aimed to analyse anamnesis, stays abroad, clinicopathological abnormalities, therapy, and outcome in dogs with acute B. canis infections in Germany. Three hundred and forty-two dogs with positive piroplasmid-PCR results (B. canis identified after sequencing) and negative Anaplasma phagocytophilum-PCR results between January 2018 and December 2024 were included if data on hematocrit, platelets, and leukocytes were available. Information about anamnesis, clinical findings, therapy, and outcome was collected through questionnaires. Acute B. canis infections occurred mainly in autumn (218/342; 63.7%), followed by spring (67/342; 19.6%), winter (34/342; 9.9%), and summer (23/342; 6.7%). Most dogs tested positive in northern federal states (259/342; 75.7%), with Berlin/Brandenburg, Saxony, Saxony-Anhalt, the Saarland, the Rhine-Main area and the Ruhr area classified as high-risk areas. Lethargy (147/220; 66.8%) and fever (127/228; 55.7%) were most frequently reported. Pigmenturia was detected in 53/204 dogs (26.0%). All 164 dogs with available information on treatment received imidocarb dipropionate (median dosage 3.3 mg/kg; 1.7-6.8 mg/kg body weight). An uncomplicated course of disease was reported in most dogs (169/193, 87.6%). The mortality rate was 6.7%. Acute B. canis infections are most often uncomplicated if prompt treatment is initiated and represent a differential diagnosis in case of thrombocytopenia throughout the year, even when presented without fever and pigmenturia, especially in high-risk areas.

PMID 42433610
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PubMedBMC veterinary research2026-07-03

Molecular prevalence and clinical profiles of canine babesiosis in northern India.

Kumari Ansu A, Agnihotri Divya D, Nehra Anil Kumar AK, Moudgil Aman Dev AD

Canine babesiosis is a significant and emerging tick-borne disease caused by Babesia spp. This study investigated the molecular prevalence, hematobiochemical profiles, and risk factors for B. vogeli and B. gibsoni infections in dogs in northern India, addressing the molecular research on babesiosis prevalence in this region. An overall prevalence of canine babesiosis by microscopy and PCR was 12.5% (27/216) and 27.78% (60/216), respectively. The prevalence rates for B. vogeli by microscopy and conventional PCR were 10.64% and 22.22%, respectively, whereas the corresponding rates for B. gibsoni were 1.85% and 5.55%, respectively. Results revealed that B. vogeli was the predominant species. Non-descript dogs were significantly more susceptible to B. vogeli infection (OR: 27.491; 95% CI: 1.092-692.018; P < 0.05). Additionally, dogs with enlarged lymph nodes were three times more likely to be B. vogeli-positive (OR = 3.338; 95% CI: 1.345-8.287; P < 0.05). Dogs under one year had higher odds of B. vogeli infection, but this was not statistically significant (OR = 1.765; 95% CI: 0.663-4.703). Similarly, B. gibsoni infection was associated with dogs over four years old (P < 0.001) and males (P < 0.05). Vital parameters (temperature, pulse rate, and respiration rate) showed no significant association with B. vogeli and B. gibsoni infections. Hematological parameters, viz., hemoglobin (Hb), total erythrocyte count (TEC), packed cell volume (PCV), and platelet count, were significantly decreased in both B. vogeli and B. gibsoni affected dogs (P < 0.05). Babesia gibsoni-infected dogs had significantly lower TEC, PCV, and platelet count than B. vogeli-infected dogs. Biochemical parameters, viz., alanine aminotransferase (ALT), total bilirubin (TB), direct bilirubin (DB), indirect bilirubin (IDB), and blood urea nitrogen (BUN), were significantly increased, with decreased albumin levels (P < 0.05). Babesia gibsoni-infected dogs had significantly higher BUN, TB, and IDB levels than B. vogeli-infected dogs. Treatment was based on the Babesia species, with imidocarb dipropionate for B. vogeli and a combination therapy (diminazene aceturate, imidocarb dipropionate, and clindamycin) for B. gibsoni, which showed promising efficacy. The study highlighted the importance of accurate diagnosis and species-specific treatment for canine babesiosis, with B. vogeli being more prevalent (22.22%) than B. gibsoni (5.55%), and distinct risk factors and clinical implications for each Babesia species in northern India. These findings contribute to the understanding of Babesia epidemiology in the region and highlight the need for further studies to inform the development of targeted control strategies.

PMID 42393672
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