Drug Database
TE

teriparatide (Xinfutai)

✓ Approved

Shenzhen Salubris Pharmaceuticals Co., Ltd. · PTH1R · Recombinant Proteins

What is teriparatide?

teriparatide is a recombinant proteins developed by Shenzhen Salubris Pharmaceuticals Co., Ltd.. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesXinfutai
CompanyShenzhen Salubris Pharmaceuticals Co., Ltd.
Drug ClassRecombinant Proteins
Molecular TargetPTH1R
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, Shenzhen Salubris Pharmaceuticals Co., Ltd.

Mechanism of Action

Molecular Targets

teriparatide acts on 1 molecular target:

PTH1Rparathyroid hormone 1 receptor (PTHR, EKNS)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

teriparatide is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Musculoskeletal and connective tissue disordersOsteoporosis✓ Approved

Related Research Articles

PubMedFrontiers in public health2026-07-17

Factors associated with the severity of nutritional anemia during pregnancy in Shenzhen (2021-2023): a cross-sectional analysis.

Lian Yonghong Y, Zhang Mi M, Lin Kaiwu K, Xu Lingyu L et al.

Nutritional anemia during pregnancy is a major public health concern and a leading contributor to adverse maternal and neonatal outcomes. The determinants of anemia severity remain insufficiently characterized in rapidly urbanizing regions. This study aimed to identify factors associated with the severity of nutritional anemia among pregnant women in Pingshan District, Shenzhen. A retrospective cross-sectional study was conducted using data from the Shenzhen Maternal and Child Health Management Information System. A total of 4,025 pregnant women diagnosed with nutritional anemia between 2021 and 2023 with complete records were included. Anemia severity was classified based on the lowest hemoglobin concentration during pregnancy as mild or moderate-to-severe. Univariate and multivariable logistic regression analyses were performed to identify independent risk factors. Among the 4,025 pregnant women included, 1,176 (29.2%) had moderate-to-severe nutritional anemia. In the fully adjusted model, migrant population status was independently associated with an increased risk of moderate-to-severe anemia compared with permanent residents (OR = 1.6, 95% CI: 1.3-1.9). Higher parity was also independently associated with greater anemia severity, with women having two or more prior deliveries exhibiting a 1.4-fold increased risk (OR = 1.4, 95% CI: 1.2-1.8). In addition, after excluding cases in which prenatal risk stratification was elevated solely due to anemia, a high prenatal risk status at the initial antenatal visit remained significantly associated with moderate-to-severe anemia (OR = 1.6, 95% CI: 1.2-2.1). Conversely, a pre-pregnancy BMI ≥ 25 kg/m2 was inversely associated with anemia severity (OR = 0.7, 95% CI: 0.5-1.0), while maternal age was not independently associated with anemia severity. In this urbanized district of Shenzhen, migrant status, higher parity, and elevated prenatal risk were independent factors associated with moderate-to-severe nutritional anemia among women diagnosed with nutritional anemia. Early anemia screening and targeted nutritional interventions for these high-risk subgroups may help reduce anemia severity and improve maternal and neonatal outcomes.

PMID 42465642
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PubMedInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2026-07-17

Pregnancy- and lactation-associated osteoporosis: A position statement of the IAPM, IOF, ECTS, ESCEO, IMS, and EMAS.

Hadji Peyman P, Athanasiadis Apostolos A, Brandi Maria-Luisa ML, Chakhtoura Marlene M et al.

Pregnancy- and lactation-associated osteoporosis (PLO) is a syndrome characterized by fragility fractures (most commonly vertebral, often multiple) occurring in late pregnancy or the early postpartum period. This position statement summarizes the current knowledge of PLO, and the recommended procedure for assessment, diagnosis and treatment based on a review of published evidence. As PLO is a rare condition, controlled, comparative clinical studies are limited. Individual studies were reviewed, focusing on design, size, follow-up, evaluation of safety, and factors that impact PLO outcomes. Diagnosis of PLO should include a detailed clinical examination, a review of medical and treatment history, and laboratory tests to rule out secondary osteoporosis. Imaging techniques can be used to inform the appropriate treatment pathway, which will depend on whether the patient is antepartum or postpartum. Management of PLO and fractures includes calcium/vitamin D intake/supplementation, considering stopping breastfeeding, and analgesia, if necessary. Treatment with bone-specific agents should be evaluated on an individual basis to reduce subsequent fracture risk, noting that their use in PLO patients is off label. If pharmacological treatments are used, they must be given alongside effective contraceptive measures. Bisphosphonates can pass the placental barrier and are detectable in bone for years, so adverse effects on future pregnancies, although not yet reported, cannot be excluded. Preferred treatment options are teriparatide/abaloparatide or romosozumab. Second-choice treatments are denosumab followed by bisphosphonates or bisphosphonates alone. This position statement includes a pragmatic approach for identifying women with PLO and suggests developing an individualized treatment plan that might include pharmaceutical intervention.

PMID 42464584
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PubMedJournal of the mechanical behavior of biomedical materials2026-07-17

Effect of reusing cobalt-chromium alloy powders in direct metal laser sintering on powder characteristics and metal-ceramic bond strength.

Berk Taha Yasin TY, Çelik Öge Selin S, Uçar Yurdanur Y, Ekren Orhun O

The purpose of this in vitro study was to evaluate the effect of reusing Co-Cr alloy powders without addition of new powder on powder characteristics, ion release, and metal-ceramic bond strength. Co-Cr alloy powders consisting of virgin powder (G1) and powders reused through the 4th (G4), 7th (G7), 10th (G10), and 13th (G13) manufacturing cycles of a DMLS system were analyzed by scanning electron microscopy (SEM), laser particle size distribution (LPSD), and X-ray diffraction (XRD). Bar-shaped Co-Cr specimens (0.5 × 3 × 25 mm) were fabricated with DMLS from the corresponding powder groups (n = 15), veneered with porcelain according to ISO 9693-1, and tested for metal-ceramic bond strength using 3-point bending. Ion release was measured with inductively coupled plasma mass spectrometry (ICP-MS). Bond strength data was analyzed with 1-way analysis of variance and Dunnett T3 tests (α = .05), and Weibull analysis was performed for reliability assessment. No significant differences were found in metal-ceramic bond strength among the groups (P > .05). Mean bond strength values ranged from 56.8 ± 8.2 MPa (G7) to 78.2 ± 39.5 MPa (G13). SEM analyses revealed progressive powder deformation with increasing reuse cycles, whereas LPSD analysis demonstrated only slight changes in particle size distribution (d50: 23.4-23.7 μm). XRD analysis demonstrated similar cubic-phase characteristics among all groups. ICP-MS analysis demonstrated increased Co, Mo, and W ion release with increasing powder reuse, whereas Cr remained undetectable in all groups. Repeated reuse of Co-Cr alloy powders without virgin powder adding did not adversely affect metal-ceramic bond strength but resulted in progressive morphological deformation and increased ion release with increasing reuse cycles.

PMID 42462486
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PubMedMicrobiome2026-07-17

Invertebrates gut viromes mediate microbial adaptation to pharmaceutical diversity under warming.

Wang Ya-Ning YN, Zheng Jin-Ting JT, Chen Xue-Peng XP, Shen Luo-Qin LQ et al.

Pharmaceutical pollution is an emerging environmental concern that can disrupt microbial communities and ecological processes, while climate warming adds further stress with broad ecological consequences. Soil invertebrates such as collembolans harbor gut microbiomes essential for host health and ecosystem stability, yet the responses of these communities-particularly viral communities-to combined pharmaceutical and warming pressures remain unclear. Here, we used controlled microcosm experiments with Folsomia candida to investigate how pharmaceutical diversity and fluctuating warming jointly shape gut microbiomes through bacteria-virus interactions. Pharmaceutical diversity significantly reduced the alpha diversity of gut viral communities in F. candida, an effect not observed in surrounding soils. Diurnal warming increased the proportion of lysogenic phages and enhanced auxiliary metabolic genes (AMGs) such as ACADM and nrdA. Functional validation in Escherichia coli BL21 confirmed that these genes mitigate oxidative stress and improve host thermal tolerance. In contrast, diverse pharmaceuticals increased the proportion of lytic phages, likely driving nutrient turnover through a "kill-the-winner" dynamic that stimulated bacterial taxa involved in pharmaceutical degradation. Moreover, warming amplified the disruption of gut bacterial communities caused by pharmaceutical diversity and strengthened bacteria-virus co-occurrence networks. Our findings reveal that gut viruses act as pivotal regulators of microbial adaptation under concurrent chemical and climate stressors. By mediating host resilience and microbial dynamics, the gut virome provides mechanistic insights into ecosystem stability, and may also serve as an early indicator of combined pharmaceutical and warming stress in soil invertebrate systems, underscoring the need to integrate viral-microbial interactions into One Health framework for environmental risk assessment. Video Abstract.

PMID 42464372
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PubMedGlobal public health2026-07-17

Local governance and health equity: Practical reflections from Chinese crisis governance.

Zhang Ting T, Xu Ran R

This study examines mass testing in three Chinese cities since 2020 as a 'stress test' for local governance. It analyses the governance performance of Shenzhen, Nanjing and Wuxi in terms of efficiency, equity and community resilience. Using Melbourne's pandemic lockdown as a reference case, it discusses the underlying mechanisms linking different governance approaches to health equity outcomes. The study adopts a nested governance framework to examine how governance capacities and policy logics operate across different local contexts. The results indicate that Chinese cities can efficiently complete mass testing within a few days, but face pressures related to health equity and community resilience. Melbourne's lockdown governance emphasised participation and institutional transparency, but advanced policies at a relatively slower pace. This study recommends building a dynamic governance mechanism that better balances efficiency and equity.

PMID 42467188
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PubMedScientific reports2026-07-17

Compaction characteristics and lump crushing behavior of homologous gangue powder grouted uncemented backfill.

Zhang Zilong Z, He Xiang X, Feng Xiaowu X, Wei Longqiang L et al.

The homologous material system is a green backfill technology that utilizes mine-derived associated solid wastes to prepare filling materials in situ, with minimal or no introduction of exogenous components, thereby achieving a closed-loop "mining-beneficiation-backfill" paradigm. Backfill systems using gangue powder as the primary material can provide effective support for underground caving zones while offering significant advantages in cost and sustainable mining. In this study, an integrated mold for filling, curing, and loading was independently designed, and confined compression and acoustic emission (AE) tests were conducted on gangue powder slurries with varying particle sizes and concentrations. The stress-strain responses under confined compression, AE ring-down counts and spatial localization, and fractal dimensions of crushed gangue were systematically analyzed, and the cause of the qualitative transformation in slurries around 100 mesh was discussed. The results show that: (1) At 6 MPa, the backfill specimens reach 83%-88% of their maximum strain, which can be regarded as the structural yield critical point of this material. (2) The maximum strain depends solely on the post-filling porosity and is inversely proportional to both the slurry concentration and the mesh size (i.e., finer particles lead to lower strain). (3) The backfill strength is influenced by multiple interacting factors; generally, finer particle sizes and higher concentrations yield higher strength. However, when the concentration exceeds 50%, slurries with particle sizes larger than 100 mesh suffer from reduced fluidity, resulting in decreased backfill strength. (4) The 100 mesh threshold represents the point of qualitative change in gangue powder slurries. The underlying mechanism is the competition between force fields: as particle size decreases, the gravitational force on particles diminishes following a power-law, while short-range repulsive forces increase exponentially. Research on homologous material systems is an essential step toward addressing increasingly complex backfill environments and provides valuable guidance for backfill scheme selection and strength prediction.

PMID 42463752
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