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Purethal Mites (Purethal Mites)

✓ Approved

HAL Allergy Group · therapeutic agent

What is Purethal Mites?

Purethal Mites is a therapeutic agent developed by HAL Allergy Group. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesPurethal Mites
CompanyHAL Allergy Group
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, HAL Allergy Group

Therapeutic Indications

Purethal Mites is developed for 3 unique indications across 3 therapeutic areas.

Therapeutic AreaConditionPhase
Respiratory, thoracic and mediastinal disordersRhinitis allergic✓ Approved
Immune system disordersAllergy to animal✓ Approved
Eye disordersConjunctivitis allergic✓ Approved

Related Research Articles

PubMedZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2026-07-16

[Clinical characteristics and influencing factors of routine pulmonary ventilation function in children with allergic rhinitis induced by house dust mites].

Zhuang Shi-Jie SJ, Fan Ting-Ting TT, Lai Rong-Li RL, Ruan Xin-Yu XY et al.

To study the clinical characteristics and influencing factors of routine pulmonary ventilation function in children with allergic rhinitis induced by house dust mites. A retrospective cross-sectional study was conducted on 361 children with allergic rhinitis scheduled for house dust mite-specific immunotherapy at Shenzhen Children's Hospital from November 2019 to December 2025. Routine pulmonary ventilation function test results and influencing factors were analyzed. Among the 361 children, 159(44.0%) showed abnormal pulmonary ventilation function, of which 107(67.3%) involved small airway dysfunction. Multiple linear regression analysis showed that age was negatively correlated with forced vital capacity (FVC) (β=-1.83, P0.05) and forced expiratory volume in the first second (FEV1) (β=-1.97, P0.05). Body mass index was positively correlated with FVC (β=1.08, P0.05) and FEV1 (β=0.75, P0.05), and negatively correlated with FEV1/FVC ratio (β=-0.31, P0.05). Children with allergic rhinitis induced by house dust mites may present with early abnormalities in pulmonary ventilation function. Age and body mass index are influencing factors on routine pulmonary ventilation function parameters. Early and regular monitoring of lung function is recommended, especially for children at different ages and those with obesity.

PMID 42457330
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PubMedExperimental & applied acarology2026-07-15

Population fluctuation of Acalitus essigi and Acalitus orthomerus (Acari: Eriophyidae) associated with inhibited ripening of blackberry (Rubus spp.).

Díaz-Martínez Santos S, Otero-Colina Gabriel G, Rodríguez-Bautista Geremías G, Ochoa-Martínez Daniel L DL et al.

The objective of this research was to confirm the identity of the mites associated with the disease known as inhibited ripening of blackberries, also known as redberry, in all phenological stages of three commercial varieties of blackberry (Rubus spp.). The association of the mites with redberry is reported through an exhaustive analysis that includes the study of their fluctuation in the different morphological structures of the plant throughout its phenology, as well as taxonomic determination by optical and scanning electron microscopy. Acalitus essigi and Acalitus orthomerus were found in nine morphological structures of the plants, showing preferences for vegetative buds, reproductive buds, and polydrupes, where both species were frequently found in coexistence. Redberry occurred in the late stages of polydrupe harvest in Tupy and X001 varieties, while the SP-Erandy variety did not show symptoms of this disease. In addition, two additional species of the Eriophyoidea superfamily associated with Rubus spp. were identified, Diptacus rubuscolum and Aculus schlechtendali; they infested the surface of leaves, being determined as vagrants.

PMID 42455199
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PubMedInternational journal of environmental health research2026-07-15

Distribution and abundance of rodents, shrews, and their ectoparasites of zoonotic importance in different ecosystems of the Karaikal region of Puducherry (Union Territory), India.

Kaliyaperumal Rajaraman R, Thiruvengadam Kannan K, Rahi Manju M, Daniel Reegan Appadurai A

Rodents are the most diversified mammals in the world and also serve as reservoirs of many pathogens of public health importance. The objective of this study is to examine the distribution and abundance of rodents and shrews and their ectoparasites in different ecological settings viz. rural, urban, coastal, and agricultural areas in the Karaikal region of Puducherry Union Territory, India. Standard methodology was used to capture the rodents and shrews and to collect the ectoparasites. The study revealed that the highest number of rodents and shrews were encountered in the urban ecosystem (36.7%). Among the rodents and shrews, Suncus murinus (Asian house shrew) captured from different ecosystems was the highest in number (42.2%) than rodents. Among the different ectoparasites collected, the percentage of trombiculid mites was high (83.2%). Plague vectors Xenopsylla cheopis and X. astia (12.6%), ticks, and lice (below 5%) were also recorded. The highest prevalence of trombiculid mites and plague fleas in the Karaikal region of Puducherry Union Territory warrants continuous surveillance to prevent ectoparasite-borne diseases.

PMID 42452785
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PubMedVeterinary medicine and science2026-07-15

Mitochondrial COI and cytb Characterisation of K-Lineage Varroa destructor Isolates From Kastamonu, Türkiye.

Atelge Mübeccel M, Ercan Nuri N, İnci Abdullah A, Yıldırım Alparslan A

Varroa destructor is the most important ectoparasitic mite of the western honeybee (Apis mellifera) and remains a major threat to apiculture worldwide. Molecular characterisation of local mite populations is essential for understanding lineage composition and for establishing sequence-based epidemiological baseline data. This study aimed to determine the haplotypes and phylogenetic relationships of representative V. destructor isolates collected from Kastamonu Province in the Western Black Sea region of Türkiye using mitochondrial COI and cytb markers. A total of 100 adult female mites were collected from 10 locations, and one representative high-quality isolate from each locality (n = 10 per locus) was selected for bidirectional sequencing. Partial mitochondrial COI and cytb regions were amplified by PCR and sequenced. Consensus sequences were compared with GenBank records using BLASTn, and separate comparative datasets were constructed for each marker. Multiple-sequence alignments were generated with MAFFT, substitution models were selected with ModelFinder, and phylogenetic relationships were inferred using Maximum-likelihood and Bayesian approaches. All sequenced Kastamonu representatives were completely identical within each marker, indicating mitochondrial homogeneity among the analysed isolates. In both the COI and cytb datasets, the study isolates clustered within the invasive K (Korean) lineage of V. destructor. In the COI analysis, the Kastamonu sequence grouped clearly with K-lineage references and separately from J-lineage sequences. The cytb analysis supported the same lineage assignment and likewise revealed no local mitochondrial subdivision within the sequenced representative subset. Comparative diversity analyses showed that, although the broader global datasets retained regional variation, the Kastamonu isolates analysed in this study were represented by a single mitochondrial background at both loci. The representative V. destructor isolates analysed from Kastamonu were identical at both mitochondrial markers analysed and belonged exclusively to the invasive K-lineage. These findings provide sequence-based confirmation of the maternal lineage detected among the sequenced mites and establish a regional molecular baseline for future surveillance of V. destructor populations in Türkiye. However, these findings should be interpreted within the limits of the representative sequencing design and should not be considered a definitive estimate of population-wide genetic diversity.

PMID 42455587
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PubMedScientific reports2026-07-15

Digital phenotyping accelerates soil biodiversity discovery.

Filgueiras Camila C CC, Kim Yongwoon Y, Gluesenkamp Daniel D, Willett Denis S DS

Soils are among the most biodiverse ecosystems on the planet, home to staggering amounts of small organisms. Many of these organisms are not known to science. This biodiversity 'dark matter' remains largely unexplored because identifying small soil organisms requires either specialized taxonomic expertise or expensive molecular methods, creating a throughput bottleneck that restricts ecosystem-scale monitoring. To explore this dark matter, we developed a high-throughput digital phenotyping approach using multispectral flow cytometry to create digital 'fingerprints' of soil organisms. Analyzing 2318 organisms spanning nematodes, collembola, mites, and tardigrades, we show that these digital fingerprints distinguish taxonomic groups with high accuracy and capture phylogenetic signal that explains 91% of variance in DNA barcode relationships. Machine learning alignment enables us to assess genetic similarity based solely on digital fingerprints, allowing prediction of relationships without sequencing. Smart sampling strategies guided by these projections achieve 6-fold improvements in species discovery efficiency compared to traditional approaches, with advantages that compound as sampling increases. Our smart sampling approach has applications across domains and provides a scalable pathway for rapid biodiversity assessment with immediate applications in agriculture, conservation, and ecosystem monitoring.

PMID 42448786
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PubMedBiology2026-07-15

Biocontrol Potential of Androlaelaps casalis Against Two Key Phytoparasitic Nematodes: Tylenchulus semipenetrans and Meloidogyne incognita.

Al-Azzazy Mahmoud M MM, Al-Rehiayani Suloiman M SM

Plant-parasitic nematodes are a significant agricultural challenge, causing extensive damage to most essential crops globally. Predatory soil mites play a significant role as biocontrol agents against plant-parasitic nematodes and other pests in the soil ecosystem. A laboratory trial was conducted to evaluate the potential of the soil-dwelling predatory mite, Androlaelaps casalis (Berlese), to suppress the citrus nematode, Tylenchulus semipenetrans Cobb, and the root-knot nematode, Meloidogyne incognita (Kofoid and White). Our findings show that the predatory mite, A. casalis, completed development, oviposition, and survival when fed on second-stage juveniles of both T. semipenetrans (Ts-J2) and M. incognita (Mi-J2) and egg mass of M. incognita (Mi-EM) as prey in the lab in closed arenas at 30 °C, 55% RH. Survivorship was lower on (Mi-EM) than on (Ts-J2) and (Mi-J2). Individuals of A. casalis reared on (Ts-J2) and (Mi-J2) prey demonstrated enhanced performance as compared to (Mi-EM) prey. In addition, females laid a total of 48.72, 46.50, and 12.45 eggs on the three types of prey, respectively. Life table parameters showed that feeding of A. casalis on (Ts-J2) and (Mi-J2) led to the greatest intrinsic rate of increase per day (rm = 0.286 and 0.279 females/female/day), while preying on (Mi-EM) offered the lowest reproduction rate (rm = 0.092). In conclusion, this study provides novel insights into the biology and predatory performance of A. casalis under controlled laboratory conditions, providing foundational evidence that may inform the development of future sustainable nematode management strategies.

PMID 42450561
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