Drug Database
SC

SC-001 (SP009 / SC001)

✓ Approved

Declion Pharmaceuticals · · Polypeptide

What is SC-001?

SC-001 is a polypeptide developed by Declion Pharmaceuticals. It is approved for therapeutic indications via injectable (others) or intradermal injection.

Drug Profile

Brand NamesSP009, SC001
CompanyDeclion Pharmaceuticals
Drug ClassPolypeptide
RouteInjectable (Others), Intradermal Injection
StatusApproved
Sources: ClinicalTrials.gov, Declion Pharmaceuticals

Mechanism of Action

Molecular Targets

SC-001 acts on 1 molecular target:

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Therapeutic Indications

SC-001 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresBotulinum toxin injection✓ Approved

Related Research Articles

PubMedDiabetes research and clinical practice2026-08-30

Glycemic and safety outcomes of the insulin-only bionic pancreas in older adults and individuals with impaired awareness of Hypoglycemia: a post hoc analysis of a randomized pivotal trial.

Oktavian Puguh P, Kencono Wungu Citrawati Dyah CD, Amin Indah Mohd IM, Mudjanarko Sony Wibisono SW

Evaluate the efficacy and safety of iLet Bionic Pancreas (BP) in older adults and individuals with impaired awareness of hypoglycemia (IAH). This post hoc analysis used individual participant-level data from the Insulin-Only Bionic Pancreas Pivotal Trial (n = 440; NCT04200313). Eligible participants (n = 96) with type 1 diabetes, aged ≥ 60 years and/or had IAH (Clarke score ≥ 4), were randomized to BP with aspart/lispro (BP-Asp/Lis; n = 45), BP with fast-acting aspart configuration (BP-Fiasp; n = 31), or standard care (SC; n = 20) for 13 weeks. Compared with SC, time-in-range (70-180 mg/dL) significantly increased by 7.49 % (95 % CI: 2.61 to 12.38; ∼1.8 h/day) with BP-Asp/Lis and by 8.28 % (95 % CI: 3.15 to 13.41; ∼2.0 h/day) with BP-Fiasp, driven by reduced hyperglycemia. No significant differences were observed in hypoglycemia exposure. Severe hypoglycemia occurred in four participants (four events) on BP-Asp/Lis and one participant (two events) on SC. One diabetic ketoacidosis event occurred on BP-Fiasp due to an infusion set failure. In high-risk, clinically vulnerable populations, the BP system significantly improved glycemic control while maintaining safety parity with respect to hypoglycemia risk, providing a resilient therapeutic alternative for vulnerable cohorts.

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PubMedJournal of pediatric and adolescent gynecology2026-08-30

Structured Patterns of Multi-Material Menstrual Product Use Among Junior High School Girls in Ghana: A Cluster Analysis.

Asamoah Edward E, Affizie Godwin G, Antwi Vera Nyarkoa VN, Obeng Akua Ampofowaa Adu AAA et al.

Menstrual hygiene management among adolescent schoolgirls in low-income settings is shaped by unequal access to menstrual materials and inadequate school sanitation infrastructure. Existing research has focused primarily on the prevalence and predictors of individual menstrual products, with limited attention to whether multi-material use constitutes a structured behavioral phenomenon. We examined patterns of multi-material menstrual product use among junior high school girls in the Ashanti Region of Ghana and assessed whether these patterns varied across economic, institutional, and infrastructural conditions. We employed a quantitative cross-sectional survey design involving 416 menstruating girls purposively selected from five junior high schools in the Ashanti Region. We collected data using structured questionnaires and analyzed them using frequencies, crosstabulations, Pearson chi-square tests, K-means cluster analysis, and one-way analysis of variance. We found statistically significant associations between tissue and toilet roll use (χ² = 48.424, p < .001), cloth and toilet roll use (χ² = 45.779, p < .001), and tampon and cotton use (χ² = 201.393, p < .001), indicating structured patterns of co-use. Our cluster analysis identified three distinct behavioral profiles: Minimal Multi-Material Users (72.4%), High Multi-Material Users (19.5%), and Selective Multi-Material Users (8.2%). Access to private toilet facilities differed significantly across clusters (χ² = 7.317, p = .026), whereas access to personal financial resources and school support showed limited variation. Menstrual health interventions should prioritize improvements in private sanitation infrastructure alongside material provision to support safer menstrual management experiences for adolescent girls.

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PubMedClinical lung cancer2026-08-30

Consolidative Hypofractionated Radiotherapy for Oligometastatic Non-Small-Cell Lung Cancer.

Park Jongmoo J, Kang Min Kyu MK, Lee Shin Yup SY, Yoo Seung Soo SS et al.

Local consolidative therapy (LCT) has emerged as a widely recognized treatment strategy for patients with oligometastatic non-small-cell lung cancer (NSCLC), but clinical trial populations often do not reflect real-world complexities. This study evaluated the efficacy and safety of consolidative hypofractionated radiotherapy in a routine clinical cohort. We retrospectively reviewed 216 patients with oligometastatic NSCLC treated with consolidative hypofractionated radiotherapy (biologically effective dose [BED] ≥ 50 Gy, < 10 fractions) between 2013 and 2024. Outcomes included local control (LC), progression-free survival (PFS), overall survival (OS), and toxicity. Patients were classified as having "genuine" or "induced" oligometastatic disease (OMD) according to ESTRO/EORTC criteria. The median patient age was 73 years. At a median follow-up of 1.8 years, the 1-year LC, PFS, and OS rates were 88.7%, 51.2%, and 79.7%, respectively. Median PFS was 1.0 year and median OS was 2.6 years. In multivariable analysis, "induced" OMD was an independent predictor of worse LC (hazard ratio [HR], 2.546, P = .001) and PFS (HR, 1.863, P < .001) compared to "genuine" OMD. Radiotherapy parameters, including gross tumor volume and BED, were not significantly associated with survival outcomes. Grade 3 radiation pneumonitis occurred in 1.8% of patients; no grade 4-5 toxicities were observed. Consolidative hypofractionated radiotherapy is safe and effective for patients with oligometastatic NSCLC, including elderly patients. The OMD classification system provides superior prognostic value over technical radiotherapy parameters, suggesting that treatment strategies should be tailored to the biological trajectory of the disease.

PMID 42669250
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PubMedArthroplasty today2026-08-30

Hospital Bed Capacity Influences Patient Charges in Outpatient Robotic Total Knee Arthroplasty: A Propensity-Matched Study.

Misch Monica M, Katanbaf Reza R, Smitterberg Chase W CW, Mont Michael A MA et al.

The rise of robotic-assisted total knee arthroplasty (RA-TKA) surgeries has correlated with increased outpatient procedures aimed at improving efficiency and outcomes. However, patient charges vary widely due to differences in reimbursement structures, resource utilization, and the higher supply costs associated with robotics. Little is known about the impact of institutional characteristics, specifically hospital bed capacity, limiting understanding of charge variability and cost-control strategies. This study aims to examine whether hospital size affects patient charges for RA-TKA, focusing on (1) total charges and (2) operating room (OR) charges. Outpatient RA-TKA cases from January 1, 2017, to December 31, 2021, were identified from a national database. Hospitals were categorized by bed capacity: <300 beds and ≥ 300 beds. A 1:1 propensity score match controlled for demographics, clinical characteristics, and insurance status, resulting in 464 patients per group. Outcomes included total patient charges and OR (anesthesia, OR block time, and postanesthesia care) charges. Statistical analyses included Chi-square tests and independent t-test, with P < .05 considered significant. Hospitals with ≥300 beds showed significantly higher mean total charges ($65,315.6) compared to hospitals with <300 beds ($53,427.5) (P < .001). Mean OR charges were also elevated in larger hospitals ($30,367.2) vs smaller hospitals ($26,000.0) (P < .001). Larger hospitals were associated with significantly higher total and OR patient charges for robotic RA-THA, even after matching for clinical and insurance-related factors. These findings suggest that hospital size may be associated with variation in charge profiles beyond patient and payer characteristics.

PMID 42668622
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PubMedArthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association2026-08-30

Meniscal Repairs Performed With Posterior Cruciate Ligament Reconstruction Are Associated With Lower Failure Rates Than Isolated Repairs.

Varady Nathan H NH, Parise Suhas S, Ranawat Anil S AS, Williams Riley J RJ

To assess the incidence of meniscal repair (MR) failure after posterior cruciate ligament reconstruction (PCLR) + MR compared with MR alone. Patients undergoing isolated PCLR + MR or MR alone were identified from a large insurance database (PearlDiver). A cohort of isolated ACLR + MR was also developed to provide reference data. Demographic, surgical, and comorbidity data were collected and controlled for. The primary outcome was ipsilateral repair failure defined as revision meniscal surgery at 2 years. Secondary outcomes included ipsilateral revision or conversion arthroplasty (RoA). Time-to-event analyses were used to compare outcomes between groups. There were 21,358 patients (0.9% PCLR + MR, 99.1% MR alone) with a mean follow-up of 3.1 ± 2.1 years. Compared with patients who underwent MR alone, patients who underwent PCLR + MR had significantly lower meniscal failure (unadjusted: 4.1% vs 8.4%, P = .04; adjusted hazard ratio [HR]: 0.41 [0.20-0.82], P = .01) and RoA (unadjusted: 4.1% vs 8.7%, P = .03; adjusted HR: 0.40 [0.20-0.80], P = .01) rates at 2 years. For reference, compared with MR alone, a similar improvement in failure rates was seen with concomitant ACLR + MR (unadjusted: 5.6% vs 8.4%, P < .001; adjusted HR: 0.61 [0.57-0.66], P < .001), whereas there was no difference between PCLR + MR and ACLR + MR (unadjusted: 4.1% vs 5.6%, P = .40; adjusted HR: 0.64 [0.32-1.29], P = .21). MRs performed concomitantly with PCLR were associated with significantly lower failure rates compared with isolated MRs, with an effect size comparable to that of ACLR + MR. Level III, retrospective comparative cohort study.

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PubMedJournal of interpersonal violence2026-08-30

Social Relationships and the Moderating Role of Prior Bullying Experiences in Bystander Behaviors Among Later Adolescents.

Park Soowon S

Bullying is deeply embedded in adolescents' social ecologies and has enduring developmental consequences. Accordingly, the quality of social relationships, together with adolescents' prior bullying experiences, may play a critical role in shaping bystander behaviors. This study examined how peer, parent-child, and teacher-student relationships were associated with adolescents' bystander behaviors (i.e., defending, pro-bullying, passive bystanding), and whether these associations are moderated by prior experiences of bullying perpetration and victimization. Using nationally representative data from the Korean Children and Youth Panel Survey (12th grade, N = 2,224), multilevel modeling was employed to examine the main and interactive effects of social relationships and bullying experiences on bystander behaviors, accounting for the clustering of adolescents within schools. Peer relationship quality was uniquely associated with defending (β = .08, p = .026), whereas all types of higher-quality social relationships were associated with lower pro-bullying (peer: β = -.17, p < .001; parent-child: β = -.29, p < .001; teacher-student: β = -.07, p = .020). In contrast, higher-quality peer relationships were related to greater passive bystanding only among adolescents with bullying perpetration experience (β = .16, p = .006), and stronger parent-child relationships were associated with greater passive bystanding among those without bullying victimization experience (β = .15, p = .003). These findings reveal that the prosocial potential of social relationships is not unconditional: while peer, parent-child, and teacher-student relationships were consistently associated with lower pro-bullying and peer relationships were associated with greater defending, their associations with passive bystanding were contingent upon adolescents' prior bullying histories. Effective prevention therefore requires simultaneous assessment of relationship quality and bullying history, as these two dimensions appear to jointly shape whether relational resources are associated with passive bystanding or pro-bullying reinforcement.

PMID 42668417
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