Drug Database
SC

SC-001 (SP009 / SC001)

✓ Approved

Declion Pharmaceuticals · · Polypeptide

What is SC-001?

SC-001 is a polypeptide developed by Declion Pharmaceuticals. It is approved for therapeutic indications via injectable (others) or intradermal injection.

Drug Profile

Brand NamesSP009, SC001
CompanyDeclion Pharmaceuticals
Drug ClassPolypeptide
RouteInjectable (Others), Intradermal Injection
StatusApproved
Sources: ClinicalTrials.gov, Declion Pharmaceuticals

Mechanism of Action

Molecular Targets

SC-001 acts on 1 molecular target:

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Therapeutic Indications

SC-001 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresBotulinum toxin injection✓ Approved

Related Research Articles

PubMedMaterials (Basel, Switzerland)2026-10-16

Selective Adsorption Separation of Sc(III) and Zr(IV) from Acidic Solutions via Zr-SBA-15 with Rich Oxygen-Vacancy Defective.

Zhang Chuanxin C, Shi Lei L, Zhang Zhonghao Z, Li Xinsheng X

Aiming at the challenging selective separation of zirconium (Zr) and scandium (Sc) in hydrochloric acid systems, this study designed a Zr-SBA-15-30 adsorbent featuring abundant surface oxygen vacancy defects. The as-synthesized material possesses an ordered mesoporous structure, a high specific surface area of 477.606 m2/g, and a high density of surface oxygen vacancies. In a strongly acidic binary HCl solution containing both Zr and Sc, Zr-SBA-15-30 exhibited exceptional separation performance, achieving an adsorption capacity of 128 mg/g for Zr and an outstanding separation factor (SFSc/Zr) as high as 3480. Fitting results from adsorption isotherms and kinetic models revealed that the adsorption process is predominantly governed by chemisorption and proceeds mainly via monolayer adsorption. The higher ionic character of the Zr-O bond relative to the Si-O bond, Zr doping induces a redistribution of the local electron cloud density on the framework surface, thereby forming electron-rich centers with higher polarizability and stronger coordination activity. Meanwhile, the oxygen vacancy defects introduced by plasma treatment create defect energy levels within the band gap. This synergistic effect of Zr doping and oxygen vacancies can significantly enhance the separation of Zr/Sc. This work provides a viable material design strategy for the efficient separation of Zr and Sc under strongly acidic conditions.

PMID 42882608
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PubMedMolecules (Basel, Switzerland)2026-10-16

Interfacial Molecular Behavior and Organization of Low-Fluorine Surfactants at the sc-CO2/Water Interface.

Xue Chunlong C, Feng Sihan S, Gao Shan S, Zhao Chenkang C et al.

Understanding the molecular organization of surfactants at the sc-CO2/water interface is essential for the rational design of CO2-philic interfacial formulations with reduced fluorine content. In this work, three low-fluorinated anionic surfactants (LF1-LF3) with different hydrophobic-tail architectures were investigated together with a fluorine-free branched co-surfactant (ZBJ) using density functional theory (DFT) calculations and molecular dynamics (MD) simulations. DFT calculations revealed a clear amphiphilic segregation of solvent affinity: the fluorinated tails preferentially interacted with CO2, whereas the sulfonate headgroups exhibited stronger affinity for water. MD simulations showed that the surfactants, initially positioned at the sc-CO2/water interface, underwent interfacial reorganization and orientational ordering, with their fluorinated tails extending into the sc-CO2 phase and their hydrophilic headgroups oriented toward the aqueous phase. Tail branching strongly affected interfacial packing and structural stability; the three-tailed, claw-like LF3 formed the thickest and most thermodynamically stable monolayer, with an interfacial formation energy of -330.30 kJ/mol. In the LF3/ZBJ mixed system, ZBJ occupied packing voids between LF3 molecules, further stabilizing the mixed monolayer and yielding an interfacial formation energy of -342.07 kJ/mol. These results clarify how tail architecture, CO2-philic/hydrophilic partitioning, counterion coordination, and steric complementarity govern the interfacial organization and stabilization of low-fluorine surfactants, providing molecular-level guidance for the rational design of low-fluorine surfactant formulations for sc-CO2/water systems.

PMID 42883339
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PubMedMaterials (Basel, Switzerland)2026-10-16

Local Microstructural Environments Govern Evolution of Precipitate-Dislocation Interactions in an Al-Sc Alloy: Plasticity Regulation and Crack-Path Selection.

Gao Bo B, Li Tuo T, Ma Guoqiang G, Chu Zhibing Z

Nanoscale Al3Sc precipitates strongly influence dislocation transport and heterogeneous plastic deformation in Al-Sc alloys. Here, the environment-dependent evolution of precipitate-dislocation interactions in an Al-0.3 wt.% Sc alloy was investigated by in-situ TEM tensile testing, assisted by EBSD, TEM, EDS, and atomic-resolution HAADF-STEM. The ordered Al3Sc precipitates exhibit an average equivalent diameter of 27.0 ± 6.3 nm, an areal number density of ~27.5 μm-2, and an average center-to-center spacing of ~102 nm, corresponding to an effective obstacle spacing of ~75 nm. The modified Orowan model gives a critical shear-stress increment of ~67 MPa and a macroscopic strengthening contribution of ~205 MPa. During intragranular deformation, dislocations undergo repeated bowing, pinning, depinning, and renewed glide. Near grain boundaries, precipitate arrangements promote directional dislocation transport and heterogeneous strain accommodation. At the crack tip, selective pinning redistributes plastic flow, promotes crack-tip blunting, and activates alternative slip paths, contributing to crack-path deflection. These observations establish a continuous mechanistic link between nanoscale precipitate characteristics, dislocation transport, heterogeneous plasticity, and crack propagation in Al-Sc alloys.

PMID 42882709
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PubMedExperimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation2026-10-16

Etiologies and Independent Risk Architecture of 7-Day Graft Loss in Adult Liver Transplantation: A National Registry Analysis.

Khan Sohail S, Vugelman Melanie M, Borsellino Louis L, Zhorayev Olzhas O et al.

Seven -day graft loss (first postoperative week graft failure or recipient death ) has not been systematically characterized at a national scale in adult liver transplantation. We identified etiologies and independent predictors of 7 -day graft loss, primary nonfunction, and 7 -day posttransplant death in adult deceased donor liver transplant recipients. We retrospectively analyzed 54 646 adult deceased donor liver transplant recipients (Organ Procurement and Transplantation Network, 2015 -2024 )and evaluated etiologies and independent predictors of 7 -day graft loss, primary nonfunction, and 7 -day posttransplant death using multivariable logistic regression. Among 1442 events of 7 -day graft loss (2.6 % ), primary nonfunction predominated (43.6 % ), followed by graft thrombosis (10.3 % ) and infection (3.8 % ). Cardiovascular failure (42.6 % ) was the leading cause of 7 -day death. Retransplant (odds ratio 3.72; P < .001 ), Status 1 (odds ratio 2.24; P < .001 ), donation after circulatory death (odds ratio 1.82; P < .001 ), dialysis dependence (odds ratio 1.79; P <.001 ), and Black recipient race (odds ratio 1.74; P < .001 ) independently predicted 7 -day graft loss. Male recipient sex was protective (odds ratio 0.86; P = .01 ). Each additional hour of cold ischemia time increased 7 -day graft loss odds by 10 % (odds ratio 1.10; P < .001 ). The primary nonfunction model identified Hispanic (odds ratio 1.27; P = .03 ) and Asian (odds ratio 1.60; P = .02 ) recipient race as additional predictors, with 34 % lower odds from 2020 onward (odds ratio 0.66; P < .001 ), coincident with acuity circle allocation and expanded machine perfusion adoption. The 7 -day death model added recipient age ≥60 years (odds ratio 1.58; P < .001 ) and elevated Model for End -Stage Liver Disease score (odds ratio 1.01; P = .003 ) as independent contributors. Every predictor is ascertainable before transplant, supporting risk stratification during organ offers, informed donor -recipient matching, and perioperative optimization to reduce early graft loss.

PMID 42885706
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PubMedAnimals : an open access journal from MDPI2026-10-16

Establishment of Sertoli Cell Lines from Giant Pandas (Ailuropoda melanoleuca).

Shi Lin L, Liu Yuliang Y, Hou Rong R, Zheng Yi Y et al.

Giant pandas (Ailuropoda melanoleuca) are a critically protected endangered species in China, but current understanding of their testicular physiology and regulatory mechanisms for spermatogenesis remains limited. Sertoli cells (SCs), the sole somatic cell type within seminiferous tubules, play essential roles in nutritional support, blood-testis barrier (BTB) formation, and hormonal regulation, indispensable for germ cell development in testes. However, primary cultured SCs are prone to undergo replicative senescence, which severely impedes their in-depth studies in vitro. In this study, we introduced the SV40 large T antigen into giant panda primary testicular somatic cells via lentiviral transduction and then performed monoclonal isolation, eventually successfully establishing two immortalized cell lines (PD-SCs-1 and PD-SCs-2). These two cell lines exhibited long-term proliferative capacity and have been cultured for more than eight months and passaged over 70 times. They also stably expressed typical SC markers and retained intercellular junction-like structures and molecular responses to hormonal stimulation, supporting the preservation of several important SC characteristics. Yet, immortalization was accompanied by alterations in cellular properties, including reduced androgen receptor expression and chromosomal abnormalities. Together, the established PD-SCs-1 and PD-SCs-2 cell lines provide a valuable in vitro platform for in-depth investigation of the testicular niche, the mechanisms for spermatogenesis, and the pathology of reproductive disorders in giant pandas, and also lay the experimental groundwork for development of novel breeding technology and conservation of this endangered species.

PMID 42883101
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PubMedExperimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation2026-10-16

Sequential Kidney-First Retrieval and Early Graft Outcomes in Deceased Donor Kidney Transplantation: A Paired-Donor Comparative Cohort Study.

Kolte Sanjay S, Kashiv Pranjal P, Kriplani Akshay A, Munjewar Chandrakant C et al.

Prolonged cold ischemia is a principal modifiable determinant of delayed graft function after deceased donor kidney transplant. In conventional multiorgan procurement, kidneys are removed last, prolonging ischemic exposure, a problem magnified in resource-constrained programs. We assessed whether retrieving 1 kidney first, from a heart -beating donor before aortic cross -clamping, improves early graft outcomes. This retrospective paired-donor cohort study included 88 adult recipients of kidneys from 44 brain dead donors at collaborating centers in central India between January 2018 and December 2024. Group 1 (n = 44 ) received kidney retrieved first, before aortic clamping; group 2 (n = 44 ) received kidney retrieved last, after procurement of thoracic and remaining abdominal organs. Primary outcomes analyzed were cold ischemia time, delayed graft function, retrieval injury, and posttransplant hemodialysis. Secondary outcomes were first -hour urine output, day 8 serum creatinine, complications, graft loss, and mortality. We used multivariable logistic regression analyses to identify predictors of graft dysfunction. Cold ischemia time was shorter in group 1 than in group 2 (78.4 ± 48.37 vs 299.4 ± 108.65 min; P <.001 ). Group 1 recipients had higher first -hour urine output (374.2 ± 208.62 vs 186.1 ± 124.92 mL;P < .001 ), lower day 8 serum creatinine (1.3 ± 0.8 vs 3.1 ± 2.83 mg /dL; P < .001 ), lesser delayed graft function requiring hemodialysis (9.1 %vs 36.4 %; P = .002 ), and fewer retrieval injuries and posttransplant complications (6.8% vs 38.6 %; P < .001 ). Comparable advantages were observed among recipients of kidneys from expanded criteria donors. Retrieval of the kidney last independently predicted delayed graft function (adjusted odds ratio 3.92; 95 % CI, 1.41-10.87; P = .008 ). Kidney -first retrieval markedly shortened cold ischemia time and improved early graft function and retrieval safety without compromising procurement of other organs and proved to be a pragmatic ischemia -minimization strategy.

PMID 42885705
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