ibuprofen + arginine (Spedifen / Zafen / Espedifen)

Thermal Transformation of Selected Non-Steroidal Anti-Inflammatory Drugs Trapped in Silica Beads via Amine-Functionalised Silica Gel.

Sternik Dariusz D, Sienkiewicz Andrzej A, Gorgol Marek M, Lupa Joanna J et al.

This study presents solid dispersions of naproxen and sodium ibuprofen in porous SiO2 pellets (manufactured via the hard template method) before and after additional phase manufacture from amine-functionalised silica gel. Nanoscopic pore evolution of the investigated materials was examined at all stages of synthesis using positron annihilation lifetime spectroscopy (PALS). The TG-DSC-FTIR/MS in He and synthetic air provided information on the systems' thermal transformations. PALS showed that both drugs preferentially occupied smaller mesopores in SiO2 pellets. Thermal analysis revealed distinct atmosphere- and drug-dependent behaviour. Silica confinement delayed naproxen's thermal degradation but decreased sodium ibuprofen stability. Interestingly, thermal decomposition of sodium ibuprofen most likely also occurred through the evolution of volatile ibuprofen, as signals assigned to it were detected in both atmospheres, although less extensively in air. Encapsulation of naproxen in the investigated systems made it more resistant to high temperature, whereas for sodium ibuprofen the opposite tendency was observed. The amine-functionalized silica phase increased the overall thermal stability of both dispersions in helium, whereas oxidation in synthetic air seemed to be governed mainly by the NH2-SiO2 phase degradation.

Can painkillers quiet the bladder? Acetaminophen/ibuprofen and catheter-related bladder discomfort.

Jung Ki Tae KT

Accuracy of Caregiver Dosing of Acetaminophen and Ibuprofen for Febrile Children Presenting to a Saudi Arabian Tertiary Hospital Emergency Department.

Alqahtani Youssef A YA, Shati Ayed A AA, Al-Qahtani Saleh M SM, Mahmood Syed Esam SE et al.

Background: Fever and its related symptoms are common reasons for pediatric emergency department (ED) visits. Parents are often concerned about fever in children, and a frequent reason for ED visits is the persistence of fever despite the administration of antipyretics at home. It is hypothesized that caregivers often administer incorrect doses of acetaminophen and ibuprofen. Objective: To assess caregivers' dosing practices in children with fever by evaluating the accuracy of acetaminophen and ibuprofen dosing and to identify factors associated with inaccurate dosing in Saudi Arabia. Methodology: A cross-sectional survey was conducted over a six-month period from 1 January 2022 to 30 June 2022 in the emergency department. We included caregivers of children under 14 who received a quantifiable dose of acetaminophen or ibuprofen for fever. Data were collected using a structured questionnaire. Multivariable regression analysis was utilized to identify factors associated with inaccurate dosing. Results: A total of 330 caregivers of children were included in the study. The caregivers' ages ranged from 18 to 60 years, with a mean age of 32.3 ± 6.4. Of these, 148 (44.8%) had university-level education or higher, while 33 (10%) had education below high school level. Only 81 caregivers (24.5%) administered the correct dose of medication. In contrast, 118 (35.8%) gave subtherapeutic doses, 40 (12.1%) administered higher-than-recommended doses, and 91 (27.6%) were unsure about the correct dose. Multivariable regression indicated that caregivers with education below high school (aOR = 2.65; 95% CI: 1.30-5.40 for low dose) and those making self-directed dosing decisions (aOR = 2.10; 95% CI: 1.15-3.85 for low dose) were significantly associated with incorrect dosing. Conclusions: The study indicates that approximately three-quarters of caregivers either administered incorrect doses of acetaminophen or ibuprofen or were unsure of the correct dose. Given that 93% of caregivers were unaware of medication concentrations, targeted educational interventions are required to improve dosing accuracy.

Biocomposite Microparticles Incorporating Ibuprofen and ZnO Nanoparticles for Controlled Drug Delivery and Antimicrobial Therapy.

Rata Delia Mihaela DM, Trifas Gisela G, Somoghi Raluca R, Cadinoiu Anca Niculina AN et al.

Preparation of complex biomaterials capable of providing both controlled drug delivery and an increased antimicrobial effect without affecting healthy cells remains a major challenge in pharmaceutical and biomedical applications. This study reports the successful preparation of biocomposite microparticles based on carboxymethyl chitosan and poly (vinyl alcohol), co-loaded with zinc oxide nanoparticles with antimicrobial effect and Ibuprofen with anti-inflammatory, antipyretic, and analgesic effect. An environmentally friendly water-in-oil emulsion method using DL-limonene as a biocompatible oil phase was used to obtain these microparticles. FTIR analysis confirmed the formation of intermolecular ester and amide bonds and the successful incorporation of zinc oxide nanoparticles into the polymeric matrix. The obtained microparticles exhibited diameters ranging from 533 to 1054 nm and provided a biphasic Ibuprofen release profile, characterized by an initial burst release within the first 3 h followed by sustained diffusion-controlled release, achieving cumulative drug release of 84-100%. Biocomposite microparticles presented excellent hemocompatibility, with hemolysis values between 0.41% and 2.47%. Moreover, after 24 h of exposure to microparticles, human dermal fibroblasts exhibited a cellular viability ranging from 82.24% to 94.22% whereas prolonged treatment for 48 h resulted in a slight decrease of cell viability until 74.88%. Biocomposite microparticles exhibited notable antimicrobial activity against Streptococcus pneumoniae strain. These findings demonstrate that the combination of green fabrication, controlled Ibuprofen release, good biocompatibility, and antimicrobial efficacy highlights the potential of these biocomposite microparticles as innovative hybrid nanostructures that can significantly improve therapeutic outcomes.