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alternaria allergen SLIT

✓ Approved

HAL Allergy Group · therapeutic agent

What is alternaria allergen SLIT?

alternaria allergen SLIT is a therapeutic agent developed by HAL Allergy Group. It is approved for therapeutic indications via oral (po) or sublingual (sl)/oral transmucosal.

Drug Profile

CompanyHAL Allergy Group
RouteOral (PO), Sublingual (SL)/Oral Transmucosal
StatusApproved
Sources: ClinicalTrials.gov, HAL Allergy Group

Therapeutic Indications

alternaria allergen SLIT is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Immune system disordersHypersensitivity✓ Approved

Related Research Articles

PubMedCurrent medical research and opinion2026-08-30

Antidepressant initiation after sublingual immunotherapy in Japanese cedar pollinosis: a real-world propensity score-matched cohort study.

Matsushita Rie R, Tanaka-Mizuno Sachiko S, Kawakami Koji K

To evaluate whether sublingual immunotherapy (SLIT) for Japanese cedar pollinosis is associated with subsequent initiation of antidepressants, and to assess its clinical implications for mental health management in real-world clinical practice. We conducted a retrospective real-world cohort study using a large nationwide administrative claims database in Japan from 2014 to 2021. Adult patients diagnosed with Japanese cedar pollinosis were identified and classified as SLIT users or non-users using a new-user design. Propensity score matching was performed to balance patients' baseline characteristics, including age, sex, insurance type, and medical history. The primary outcome was initiation of antidepressant prescriptions. Hazard ratios were estimated using matched cohorts. A total of 4,126 SLIT users and 88,455 non-users were identified, with 3,991 propensity-matched patients in each group. Before matching, mental disorders were more prevalent among SLIT users than among non-users, whereas allergic rhinitis severity was similar between groups. Crude initiation rates of antidepressants were 5.0 and 2.9 per 1,000 person-years among SLIT users and non-users, respectively. After matching, no statistically significant association was observed between SLIT use and antidepressant initiation (hazard ratio = 1.11, 95% confidence interval = 0.73-1.69). Kaplan-Meier analysis also showed no significant between-group differences. No statistically significant association was observed between SLIT for Japanese cedar pollinosis and antidepressant initiation. These findings suggest that mental health outcomes should continue to be monitored independently of immunotherapy use in routine clinical practice. Further adequately powered studies with longer follow-up periods are warranted to better characterize depressive outcomes in this population.

PMID 42669179
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PubMedJournal of structural biology: X2026-08-29

Characterization of energy filtering slit widths for MicroED data collection.

Clabbers Max T B MTB, Hattne Johan J, Martynowycz Michael W MW, Gonen Tamir T

A favorable signal-to-noise ratio is essential for obtaining high-quality diffraction data in macromolecular electron crystallography. Inelastic scattering contributes significantly to the noise, reducing contrast between diffraction peaks and background, which complicates peak detection and compromises the accuracy of intensity integration. Energy filtering mitigates these challenges and enhances diffraction data quality by removing inelastically scattered electrons, leading to reduced background noise and sharper Bragg peaks. Previously, we reported a substantial improvement in MicroED data quality and resolution with energy filtering. Here, we systematically evaluate the impact of different energy filter slit widths for optimal MicroED data collection. Data from proteinase K lamellae were collected using 5, 10, and 20 eV energy filter slits. Our results show that the optimized energy filtering reduces background counts and improves the signal-to-noise ratio, enhancing the precision of intensity measurements and resulting in improved structural models. These findings provide insight into the optimization of energy filter slit settings that, when paired with direct electron detection, enhance data collection strategies by improving the signal-to-noise ratio, supporting higher quality data, and ultimately enabling more precise structure determination.

PMID 42667085
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PubMedCureus2026-08-29

Pigmented Contact Dermatitis to Cosmetics: A Prospective Observational Study From a Tertiary Care Hospital.

Khan Sania S, Chander Ram R, Pant Amrit A, Garg Vijay K VK et al.

Background Pigmented contact dermatitis (PCD) is a pigmentary variant of contact dermatitis characterized by gradually developing facial hyperpigmentation with minimal or absent overt dermatitis. Owing to its close resemblance to other causes of facial melanosis, PCD is frequently underdiagnosed. Patch testing plays a crucial role in identifying causative allergens and guiding avoidance-based management. Objectives To evaluate the clinical profile, dermoscopic features, and patch test allergen spectrum in patients with PCD attending a tertiary care hospital. Methods This prospective observational study was conducted over a period of 1.5 years in the Department of Dermatology, Santosh Medical College and Hospital, Ghaziabad. A total of 55 patients clinically diagnosed with PCD and fulfilling inclusion criteria were enrolled after informed consent. Detailed demographic and clinical data were recorded using a structured proforma. Dermatoscopic examination was performed using a DermLite DL5 dermoscope (DermLite LLC, Aliso Viejo, CA). Patch testing was carried out using the Indian Standard Battery and Indian Cosmetic Series, with readings taken at 48 hours, 96 hours, and on day 7, interpreted according to ICDRG criteria. Statistical analysis was performed using IBM SPSS version 27.0. Results The majority of patients were women (n=41; 74.5%), with the commonest age group being 31-40 years (n=23; 41.8%). Brownish-black pigmentation was the predominant clinical presentation. Dermatoscopy most frequently revealed brownish-gray background pigmentation, brown and gray globules, and follicular plugs with perifollicular white halos. Patch test positivity to at least one allergen was observed in 43 (78.2%) patients. Paraphenylenediamine (n=16; 27.1%) was the most common allergen, followed by cetrimide (n=9; 15.3%) and lavender absolute (n=7; 11.9%). Hair dye was the most frequent exposure source associated with allergen positivity. Conclusion: PCD predominantly affects young to middle-aged females and is strongly associated with cosmetic and hair dye exposure. Patch testing is an essential diagnostic tool for identifying relevant allergens and enabling effective prevention through targeted avoidance.

PMID 42666269
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PubMedSleep & breathing = Schlaf & Atmung2026-08-29

A hidden risk factor for residual mouth breathing in children after adenotonsillectomy: airborne allergen sensitization.

Zeng Zhilong Z, Gao Ru R, Chen Yu Y, Huang Shasha S et al.

Mouth breathing (MB), a common manifestation of sleep-disordered breathing in children may induce craniofacial developmental abnormalities leading to adenoid facies. Although adenoidectomy and/or tonsillectomy (A&T) represents the primary therapeutic intervention, a substantial proportion of pediatric patients exhibit residual mouth breathing postoperatively. Why a substantial subset of children exhibit residual MB remains a critical clinical question. Among the overlooked explanations for this incomplete recovery may be sensitization to airborne allergens-a hidden determinant of postoperative outcomes. This study sought to define the role of this under-investigated risk factor in the failure to resolve MB following A&T. A retrospective analysis was conducted on a cohort of children who underwent A&T at our hospital from June 2023 to June 2024. Incomplete lip seal during sleep was used as the diagnostic criterion for mouth breathing. Allergic rhinitis and rhinosinusitis symptoms were quantified using the Total Nasal Symptom Score (TNSS). Preoperative serum allergen screening was performed in all cases. Multivariate analyses were employed to assess associations between postoperative mouth breathing resolution and age, gender, BMI, allergen sensitization and TNSS. The study included 502 children. Residual mouth breathing was observed in 39.44% of cases. Atopy to airborne allergens was significantly correlated with surgical outcomes (P = 0.028), with house dust mites (HDM) sensitization exerting particularly strong effects (P = 0.002). Elevated TNSS scores for both allergic rhinitis (correlation coefficient R = 0.249) and rhinosinusitis (correlation coefficient R = 0.290) predicted diminished therapeutic response. Sensitization to airborne allergens, particularly HDM, is significantly associated with adverse mouth breathing resolution following A&T, suggesting it as a hidden associated factor for residual mouth breathing.

PMID 42667328
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PubMedInternational ophthalmology2026-08-29

Asia's eye health challenge: unravelling the spread and solutions for conjunctivitis.

Ahmed Syed Shahmeer SS, Zubair Shakeeba S, Mehmood Nadia N, Raza Ahmed Asad AA

Conjunctivitis remains one of the most common ocular conditions affecting paediatric and adult populations globally. South and Southeast Asia have experienced unprecedented seasonal surges in conjunctivitis cases, with tens of thousands of cases occurring over short periods, particularly during monsoon and pre-monsoon seasons. Conjunctivitis is classified into infectious causes (viral, bacterial, and chlamydial) and non-infectious causes (allergic, toxic, cicatricial, and immune-mediated). Viral conjunctivitis accounts for the majority of cases. Adenovirus's ability to survive on fomites for weeks, combined with pre-symptomatic shedding and low infectious dose, facilitates rapid community spread in overcrowded, poorly sanitized environments. Diagnosis requires aetiology-guided differentiation based on discharge patterns, associated symptoms, and lymph-node findings. Most viral cases are self-limiting and managed supportively. Antibiotic stewardship is critical for bacterial infections, while allergic conjunctivitis requires allergen avoidance and targeted pharmacotherapy. Contact-lens wearers demand careful evaluation for corneal involvement. Effective outbreak control requires multifaceted interventions: rigorous hand hygiene, school-based screening,coordinated community awareness campaigns, and systematic surveillance. Preventing unnecessary antibiotic and corticosteroid use reduces complications and antimicrobial resistance. Structured, evidence-based prevention coupled with judicious clinical management offer the most effective means of reducing transmission and complications across vulnerable populations.

PMID 42667473
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PubMedClinical reviews in allergy & immunology2026-08-29

From Barrier Disruption and Immune Dysregulation to Targeted Therapies in Atopic Dermatitis.

Luo Xin X, Li Yichuan Y, Feng Yinyi Y, Wang Ying Y et al.

Atopic dermatitis (AD) is a heterogeneous inflammatory skin disorder characterized by recurrent eczematous lesions and persistent pruritus. Its pathogenesis involves epidermal barrier dysfunction, immune dysregulation, microbial dysbiosis, and altered neuroimmune signaling. Genetic defects in structural proteins, particularly filaggrin, and altered epidermal lipids increase allergen and microbial penetration, perpetuating itch, scratching, tissue injury, and inflammation. Molecular evidence further reveals AD endotypes beyond conventional clinical phenotypes, with heterogeneity in immune polarization, barrier dysfunction, microbial colonization, and pruritic pathways. This heterogeneity may underlie differences in clinical presentation and treatment response. Conventional treatments, including skin hydration, antihistamines, and topical anti-inflammatory agents, often provide incomplete or transient control. Mechanism-based therapies targeting IL-4/IL-13, OX40/OX40L, JAK, and PDE4, together with AhR agonists, have broadened treatment options. However, efficacy must be balanced against treatment-specific risks. Biologics require monitoring for ocular and injection-site reactions, whereas systemic JAK inhibitors require monitoring for infections and laboratory abnormalities and carry regulatory class warnings regarding major adverse cardiovascular events, venous thromboembolism, and malignancy; however, these warnings are largely extrapolated from studies in older patients with rheumatoid arthritis, and the magnitude of these risks in patients with AD remains uncertain. Long-term safety and real-world evidence remain limited for several emerging therapies. This review synthesizes current knowledge of barrier dysfunction, immune heterogeneity, molecular endotypes, microbiome imbalance, neuroimmune signaling, and mechanism-based therapies. Integrating clinical phenotypes with molecular endotypes, predictive biomarkers, efficacy, and individualized safety assessment may enable more precise treatment selection and durable disease control.

PMID 42667317
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