Drug Database
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Gensci-004 (PEG rhGH / Gensci 004 / PEG Somatropin)

✓ Approved

GeneScience Pharmaceuticals Co., Ltd. · GHR · Small Molecule

What is Gensci-004?

Gensci-004 is a small molecule developed by GeneScience Pharmaceuticals Co., Ltd.. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesPEG rhGH, Gensci 004, PEG Somatropin
CompanyGeneScience Pharmaceuticals Co., Ltd.
Drug ClassSmall Molecule, Recombinant Proteins
Molecular TargetGHR,
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, GeneScience Pharmaceuticals Co., Ltd.

Mechanism of Action

Molecular Targets

Gensci-004 acts on 2 molecular targets:

GHRgrowth hormone receptor (GHBP, GHIP)
(TERG_01127)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

Gensci-004 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Endocrine disordersGrowth hormone deficiency✓ Approved

Related Research Articles

PubMedScientific reports2026-07-17

Influence of personality traits and clinical role models on changes in medical students' attitudes toward psychiatry: a prospective moderation analysis.

Fajwani Hajir H, Al-Mahrouqi Tamadhir T, Al-Harthi Ali A, Al-Alawi Mohammed M

Oman faces a critical shortage of psychiatrists, highlighting the need to better understand determinants of medical students' career attitudes toward psychiatry. Utilizing Social Learning Theory and Situational Strength Theory, this study examined how attitudes toward psychiatry evolve during clinical training through the interaction between individual characteristics (personality traits) and contextual influences (clinical learning environment and role models). The study aimed to determine whether personality traits and exposure to clinical role models moderate changes in students' attitudes during the psychiatry clerkship. A prospective single-group quasi-experimental pre-post study was conducted among 180 undergraduate medical students at Sultan Qaboos University during an eight-week psychiatry clerkship. Attitudes toward psychiatry and personality traits were assessed using the Attitudes Toward Psychiatry-30 (ATP-30) and Big Five Inventory-44 (BFI-44) scales. Moderation analyses were performed using Hayes' PROCESS macro to evaluate interaction effects between baseline attitudes, personality traits, and perceived role-model influence. Attitudes toward psychiatry improved significantly following clerkship exposure (mean ATP-30 score increased from 105.66 to 110.38; p < .001). Personality traits did not significantly moderate attitude change. However, perceived resident role-model quality demonstrated a significant interaction with baseline attitudes (b = - 0.953, p = .004), with the greatest improvement observed among students with initially less favorable attitudes toward psychiatry. Prior personal contact with mental health services was independently associated with lower post-clerkship attitude scores (b = - 4.553, p = .047). Psychiatry clerkships were associated with improved student attitudes, with role-model mentorship appearing more consequential than stable personality characteristics. As improved attitudes do not consistently translate into specialty recruitment, workforce strategies should move beyond passive clinical exposure toward structured mentorship, targeted career engagement, and culturally responsive psychiatric training models.

PMID 42463776
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PubMedInternational journal of radiation oncology, biology, physics2026-07-17

A Phase 1 Trial of Dose-Escalated Hypofractionated Adaptive Radiation Therapy With Atezolizumab for Advanced Head and Neck Cancers.

Awan Musaddiq M, Tarima Sergey S, Zenga Joseph J, Memon Abdullah A et al.

To determine the maximum-tolerated dose (MTD) of dose-escalated hypofractionated adaptive radiation therapy with atezolizumab in patients with head and neck squamous cell carcinomas (HNSCCs) in a phase 1 trial. Dose-escalated hypofractionated adaptive radiation therapy was a single-center phase 1 trial. Eligible patients were aged ≥18 years with de novo metastatic HNSCC or localized American Joint Committee on Cancer 8th edition T3-T4 N0-N3, T0-T4 N1-N3 HNSCC meeting one of the following criteria: (1) not candidates for concurrent cisplatin mirroring eligibility for NRG HN-004; (2) refused concurrent cisplatin-based chemoradiation; (3) had unresectable oral cavity cancer; or (4) had recurrent disease after definitive surgical resection alone. Patients received 15 fractions of radiation to escalating total doses of 50, 55, or 60 Gy to gross disease based on a time-to-event continual reassessment methodology. Atezolizumab (1680 mg) was delivered every 4 weeks for up to 1 year after treatment. The primary endpoint of the study was to determine the MTD of radiation. Eighteen patients were enrolled (11 men and 7 women, median age of 74 years [range, 52-89 years]). Five patients were enrolled in radiation dose level 1 (50 Gy in 15 fractions) and received atezolizumab on the first day of radiation. Three of these patients developed Herpes Simplex Virus Type 1 reactivation with excess toxicity. As such, the study was amended to remove the concurrent atezolizumab dose. Thirteen additional patients enrolled and began receiving atezolizumab after radiation. No dose-limiting toxicities were seen after the amendment, and the MTD of radiation was 60 Gy. No loco-regional failures were seen among 7 patients treated to 60 Gy with a 1-year progression-free survival of 71.4%. Radiation dose may be safely escalated to 60 Gy in 15 fractions with adjuvant atezolizumab with no new safety signals. However, concurrent atezolizumab with hypofractionated radiation promoted Herpes Simplex Virus Type 1 reactivation in a previously unreported manner, resulting in excess dose-limiting toxicities.

PMID 42467032
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PubMedmedRxiv : the preprint server for health sciences2026-07-17

Coffee Intake is Associated with Improved Insulin Sensitivity and Lower Visceral Adiposity: Evidence from Biomarker and Genetic Analysis.

Sevilla-González Magdalena M, Wang Xingyan X, Yun Huan H, Mei Zhendong Z et al.

Higher coffee intake has been associated with lower risk of type 2 diabetes (T2D), but the underlying biological pathways remain incompletely understood. To examine associations of coffee intake with insulin sensitivity, adiposity, and T2D risk, and assess whether coffee intake modifies associations between pathway-specific genetic susceptibility and incident T2D. Cross-sectional analyses among 806 participants without T2D in the VITamin D and OmegA-3 TriaL (VITAL) clinical sub-cohort, who underwent repeated dietary assessment, clinical phenotyping, and dual-energy X-ray absorptiometry imaging at baseline and year-2. Prospective analyses among 333,053 UK Biobank participants without T2D at baseline who had dietary and genetic data and were followed for a median of 13.3 years. Coffee intake assessed by food frequency questionnaires. In UK Biobank, 12 pathway-specific polygenic scores (pPS) representing distinct T2D pathophysiological mechanisms were evaluated. The primary outcomes, in VITAL, were HbA1c, oral glucose tolerance test-derived measures of glucose response and insulin sensitivity, β-cell function, and overall, truncal, and visceral adiposity; in UK Biobank, was incident T2D. In VITAL, higher coffee intake was associated with higher insulin sensitivity (standardized β per cup/day, 0.046; P = .004) and lower visceral adipose tissue mass (β, -0.047; P = .006), after adjusting for demographic, lifestyle, and clinical factors, including body mass index. In UK Biobank, higher coffee intake was associated with lower T2D incidence (hazard ratio per cup/day, 0.96; 95% CI, 0.95-0.97), lower triglyceride-to-HDL cholesterol ratio (β,-0.01; P = 2.51 × 10^-19), and lower visceral adipose tissue mass (β, -0.01; P = 4.28 × 10^-9). Associations of 3 pPS related to insulin resistance and fat distribution with incident T2D were attenuated among participants consuming higher amount of coffee than among non-consumers (P for interaction < .0043). Higher coffee intake was associated with greater insulin sensitivity, lower visceral adiposity, and lower risk of T2D. Together with the attenuation of associations between pathway-specific genetic susceptibility and T2D risk among higher coffee consumers, these findings suggest that insulin resistance and visceral adiposity-related pathways may contribute to the association between coffee intake and T2D risk. Question: Is coffee intake associated with specific insulin sensitivity and adiposity markers, and type 2 diabetes risk, and does it modify associations between pathway-specific genetic susceptibility and type 2 diabetes?Findings: In analyses repeated dietary, clinical, and imaging phenotyping in 806 VITAL participants and prospective data from 333,053 UK Biobank participants, higher coffee intake was associated with greater insulin sensitivity, lower visceral adiposity, and lower type 2 diabetes risk. Higher coffee intake also attenuated associations of three pathway-specific polygenic scores related to insulin resistance and fat distribution with type 2 diabetes risk.Meaning: These findings suggest that pathways related to insulin sensitivity and visceral adiposity may contribute to the associations between coffee intake and lower type 2 diabetes risk.

PMID 42465876
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PubMedJMIR cancer2026-07-16

AI-Enhanced Predictive Analytics to Optimize Tele-Oncology Implementation in Rural Settings: Scoping Review.

Husain Laiba L, Mullins Megan M, Etingen Bella B, Zafar Raaed Mohammed RM et al.

Tele-oncology addresses geographic barriers to cancer care, but implementation challenges persist in rural settings. AI-enhanced predictive analytics offer opportunities for optimizing deployment through personalized, data-driven strategies; however, evidence in rural tele-oncology contexts remains limited, and critical equity considerations remain underexamined. This scoping review aimed to map evidence on AI-enhanced predictive analytics in tele-oncology implementation, with particular attention to rural and underserved populations, to identify research gaps and inform implementation science priorities. We searched 5 databases (PubMed, Embase, CINAHL, Web of Science, and IEEE Xplore) using 4 concept domains (tele-oncology, rural implementation barriers, AI or predictive analytics, implementation science) from January 2015 through November 2025. Two independent reviewers screened 330 unique records (title or abstract; Cohen κ=0.78), with the principal investigator resolving conflicts. Of 138 full-text reviews (κ=0.82), 4 studies met inclusion criteria. Data extraction captured study characteristics, AI applications, implementation factors, and outcomes. We used narrative thematic analysis to map findings into three themes: (1) the current tele-oncology implementation landscape in rural and underserved settings, (2) potential AI applications addressing implementation challenges, and (3) implementation considerations for AI systems themselves. Four included studies (1 pilot feasibility study, 1 proof-of-concept validation study, 1 cross-sectional predictive study, and 1 platform development study; published 2019-2025) demonstrated limited evidence at the intersection of AI, tele-oncology, and rural health equity. Patient characteristics predicted telehealth modality preferences with 86.2% accuracy, revealing that male patients exhibited 66% increased odds of video selection versus female patients (P=.004), and urban residents showed 101% increased odds compared to rural counterparts (P<.001). Liu et al demonstrated that disadvantaged populations engaged with AI-generated health literacy content 2.52-fold more frequently than nondisadvantaged counterparts. However, all 4 studies documented substantial implementation barriers (patient, provider, organizational, and system levels) persisting despite technological sophistication. Organizational threshold effects, where remote monitoring interventions succeeded with adequate provider capacity but failed under resource constraints-suggest that algorithmic innovations cannot overcome structural limitations in rural facilities. No studies explicitly examined algorithmic bias, cross-population validation, or potential harms in rural contexts. Geographic concentration in high-resource countries (United States n=2, Greece n=1, and Singapore n=1) and limited oncology-specific focus underscore structural gaps in knowledge generation for underserved populations. Current evidence remains insufficient to support definitive practice recommendations. The observed evidence gap may reflect broader structural inequities in knowledge generation: populations with the greatest implementation challenges appear to remain substantially underrepresented in AI and digital health literature. Future research should prioritize comparative effectiveness studies in authentic rural contexts with implementation science outcomes, equity-centered cross-population validation, specification of translation mechanisms linking AI predictions to implementation strategies, health economic analyses, and mechanistic research on sociotechnical integration factors, ensuring technological innovation reduces rather than perpetuates disparities in cancer care.

PMID 42461982
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PubMedCancers2026-07-15

Immunogenetic and Transcriptomic Evidence Implicating the NKG2D-MICA/MICB Axis in CALR-Mutated Myeloproliferative Neoplasms.

Shivarov Velizar V, Tsvetkova Gergana G, Micheva Ilina I, Hadjiev Evgueniy E et al.

Background/Objectives: Immune surveillance is increasingly recognized as a modifier of myeloproliferative neoplasm (MPN) initiation and evolution, yet the contribution of the NKG2D receptor and its ligands MICA/MICB to CALR-mutated disease remains unclear. Methods: We performed high-resolution next-generation sequencing genotyping of MICA and MICB in 43 patients with CALR-mutated MPN (WHO 2022 criteria) and compared the allele and haplotype distributions with those of 156 healthy Bulgarian controls and 85 patients with JAK2 V617F-positive MPN. Associations were tested using age- and sex-adjusted additive generalized linear models; bi-locus haplotypes were evaluated using haplotype score methods. In a genotyped subgroup (35 CALR-mutated MPN patients and 105 controls), functional KLRK1 (NKG2D) polymorphisms were analyzed for haplotype-level associations. We also performed 700 ns molecular dynamics simulations of selected MICA variants in complex with NKG2D and reanalyzed publicly available single-cell RNA-sequencing data (GSE117826) and RNA-sequencing data from CRISPR/Cas9-edited CALR-mutant iPSC-derived megakaryocytes to evaluate MICA/MICB expression. Results: MICA*004:001 was significantly associated with CALR-mutated MPN versus controls (p = 0.004; Bonferroni-adjusted p = 0.047), while MICB*008:001 showed only nominal association. Exploratory haplotype analyses identified a MICA*009:01-MICB*004:001 haplotype associated with CALR-mutated status (p = 0.008) and a KLRK1 G-A-G-T haplotype (rs1049174-rs2617160-rs2246809-rs2617170) associated with increased CALR-mutated MPN risk (OR = 3.61; p = 0.029). Transcriptomic reanalysis indicated a higher fraction of CALR-mutant stem and progenitor cells expressing detectable MICA/MICB transcripts, and heterozygous CALR-mutant megakaryocytes exhibited higher MICA expression than the wild type. Conclusions: Together, these data support an exploratory immunogenetic and transcriptomic link between the NKG2D-MICA/MICB axis and CALR-mutated MPN, but direct protein-level and functional studies are required before mechanistic or therapeutic conclusions can be drawn.

PMID 42449598
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PubMedJournal of transcultural nursing : official journal of the Transcultural Nursing Society2026-07-15

A Brief Advance Care Planning Education Intervention for Socioeconomically Disadvantaged Dementia Caregivers: A Single-Group Pretest-Posttest Study.

Cho KyungAh K, Lee Jung-Ah JA, Baek Sang Yi SY, Yang Jisun J et al.

Introduction: Family caregivers of people with dementia play an essential role in advance care planning (ACP), yet engagement remains low among socioeconomically disadvantaged caregivers. This study evaluated a brief video- and leaflet-based ACP intervention. Methods: A single-group pretest-posttest study was conducted with 47 dementia caregivers recruited from public health centers providing home-visiting services. Participants received a 30-minute ACP intervention. Outcomes included decisional conflict, ACP engagement, and ACP-related perspectives, assessed at baseline and 1-month post-intervention using paired t-tests. Results: Participants demonstrated significant improvements in ACP-related knowledge (d = 0.37, p = .014), decisional conflict (d = 0.44, p = .004), and ACP engagement (d = 0.64, p < .001) at 1-month follow-up. No significant changes were found in ACP-related attitudes, perceived benefits, or perceived barriers. Discussion: Brief ACP education reduced decisional conflict and improved engagement, indicating its potential value. Further controlled studies are needed to assess long-term psychosocial effects.

PMID 42454473
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