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Gensci-004 (PEG rhGH / Gensci 004 / PEG Somatropin)

✓ Approved

GeneScience Pharmaceuticals Co., Ltd. · GHR · Small Molecule

What is Gensci-004?

Gensci-004 is a small molecule developed by GeneScience Pharmaceuticals Co., Ltd.. It is approved for therapeutic indications via injectable (others) or subcutaneous injection.

Drug Profile

Brand NamesPEG rhGH, Gensci 004, PEG Somatropin
CompanyGeneScience Pharmaceuticals Co., Ltd.
Drug ClassSmall Molecule, Recombinant Proteins
Molecular TargetGHR,
RouteInjectable (Others), Subcutaneous Injection
StatusApproved
Sources: ClinicalTrials.gov, GeneScience Pharmaceuticals Co., Ltd.

Mechanism of Action

Molecular Targets

Gensci-004 acts on 2 molecular targets:

GHRgrowth hormone receptor (GHBP, GHIP)
(TERG_01127)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

Gensci-004 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Endocrine disordersGrowth hormone deficiency✓ Approved

Related Research Articles

PubMedJournal of clinical and experimental neuropsychology2026-10-15

Self-reported memory strategy use following acquired brain injury.

Grevers Edo E, Frankenmolen Nikita L NL, Jansen Michelle G MG, Oosterman Joukje M JM et al.

Neuropsychological rehabilitation following acquired brain injury (ABI) often involves interventions teaching individuals with ABI strategies to compensate for memory impairment. However, little is known about spontaneous memory strategy use (i.e. without treatment) and its determinants. The primary aim was to compare spontaneous memory strategy use in daily life and during a memory task between participants with ABI and cognitively unimpaired controls. Other aims were to investigate the relationships between strategy use, demographic and clinical characteristics, and memory performance. Sixty adults (aged 27-71) with ABI (≥3 months post-injury) were included at the start of their rehabilitation program. The control group consisted of 187 cognitively unimpaired volunteers (aged 18-79). Spontaneous memory strategy use in daily life was measured using the strategy scale of the Metamemory in Adulthood Questionnaire (MIA). Memory complaints were assessed with the Everyday Memory Questionnaire-Revised (EMQ-R) and memory performance with the subtest Verbal Paired Associates of the Wechsler Memory Scale-Fourth Edition (WMS-IV VPA). Additionally, memory strategy use during the VPA was assessed. ABI participants reported less spontaneous strategy use in daily life than controls (t (242) = 2.93, p = .004, Hedges' g = .44), but not during a memory task (t (241) = 0.90, p = .367). Within both groups, more memory complaints and female sex were related to using more strategies in daily life. Task-related strategies were unrelated to memory performance in the ABI group but positively related in controls. ABI participants report using fewer memory strategies in daily life than controls, despite performing worse on a memory task and experiencing more memory complaints. Since efficiently employed compensation strategies are the most effective way to compensate for memory impairment, our results emphasize the importance of training memory strategies after ABI and provide valuable insights for creating individual treatment plans.

PMID 42876267
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PubMedInternational journal for quality in health care : journal of the International Society for Quality in Health Care2026-10-15

When Teamwork Is Not Enough: How Organizational Learning and Continuous Improvement Strengthen the Teamwork-Handoff Relationship in Hospitals.

Kim Seung-Hwan SH

Hospital handoffs, including shift changes and transfers across units, are vulnerable points in care delivery where communication failures may lead to information loss and preventable adverse events. Although teamwork is a well‑established driver of handoffs, prior research suggests that its effectiveness varies across organizational contexts. Organizational Learning and Continuous Improvement (OL-CI)-defined by routine review of work processes, testing of changes, and prevention of recurring problems-may strengthen the degree to which teamwork translates into more reliable handoff processes. This study examines whether OL-CI moderates the relationship between teamwork and handoffs in a hospital. A cross‑sectional dataset of 394 hospital‑unit observations was analyzed using validated composites from the Hospital Survey on Patient Safety Culture Version 2.0 (HSOPS 2.0). Handoffs and Information Exchange served as the dependent variable, Teamwork as the independent variable, and OL-CI as the moderator. All focal variables were mean‑centered and entered into a moderation model using the PROCESS macro (Model 1). Conditional effects were evaluated at low, median, and high levels of OL-CI. The model accounted for 50.7% of the variance in handoff quality. Teamwork demonstrated a significant positive association with handoffs (b = 0.416, p < .001), and OL-CI independently predicted better handoffs (b = 0.458, p < .001). The Teamwork × OL-CI interaction was significant (b = 0.223, p = .004), indicating that OL-CI strengthened the effect of teamwork on the quality of handoffs. Simple‑slope analyses showed a progressively stronger relationship between teamwork and handoffs at low (b = 0.372), median (b = 0.423), and high (b = 0.458) OL-CI levels, demonstrating that teamwork yields greater gains in units with stronger OL-CI practices. The findings indicate that teamwork contributes to higher-quality handoffs, with greater benefits in organizations that support continuous learning and improvement. To promote reliable handoffs, hospitals should combine teamwork development and structured handoff tools with established practices for process review, recurring feedback, and the prevention of repeated communication failures. Longitudinal research is recommended to clarify these relationships and determine which organizational practices are most effective in sustaining high-quality handoffs over time.

PMID 42876038
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PubMedPsychological medicine2026-10-14

Cortisol and cognition in psychotic disorders: A systematic review and multi-level meta-analysis.

Chen Haytham Zhichao HZ, Yong Jia Xin Michelle JXM, Haussler Senta M SM, Murray Robin M RM et al.

Emerging evidence suggests that dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, particularly cortisol, may contribute to the cognitive deficits commonly observed in psychotic disorders. We conducted the first combined systematic review and quantitative synthesis of associations between cortisol and cognition in psychosis. Twelve studies met inclusion criteria (940 participants; 74.68% cases; 39.57% female; mean age = 31.83 years). Of these, nine studies (822 participants; 71.04% cases; 35.96% female; mean age = 32.72 years) contributed data to three-level meta-analyses examining associations between basal cortisol and composite cognition, attention, working memory and processing speed (AWP), executive functioning (EF), and verbal learning and memory (VM). Cortisol sampling time significantly moderated the relationship between cortisol and EF (F = 10.98, p = .004), with a significant negative association emerging between afternoon/evening cortisol and EF (r = -0.27, 95% CI [-0.42, -0.12], p = .01). No other robust cortisol-cognition associations were observed. However, sensitivity analyses revealed a negative association between morning cortisol and AWP following exclusion of an influential study. These findings do not support a general association between basal cortisol and cognitive functioning in psychosis. Instead, they suggest that cortisol-cognition relationships may be both domain- and sampling-time-specific, with the strongest evidence linking elevated afternoon/evening cortisol to poorer executive functioning. Further research using more precise assessments of cortisol dynamics is needed to clarify the role of HPA-axis dysregulation in cognitive impairment across psychotic disorders.

PMID 42872395
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PubMedJournal of vascular and interventional radiology : JVIR2026-10-14

Intra-Articular Injection Use and Total Knee Arthroplasty After Genicular Artery Embolization for Knee Osteoarthritis: A Matched National Claims Analysis.

Singh Aryaman A, Shah Manav M, Vij Rohan R, Fountain Chandler C et al.

To characterize intra-articular injection use before and after genicular artery embolization (GAE) for knee osteoarthritis (OA) and to compare progression to total knee arthroplasty (TKA) with matched knee OA patients. This retrospective cohort study used the Merative MarketScan Commercial and Medicare Supplemental databases, 2014-2024. Patients undergoing GAE for knee OA were identified by CPT code 37242 with a knee OA diagnosis within 7 days, excluding non-OA indications. Annualized steroid and any intra-articular injection use was compared for the 12 months before and 6 months after GAE. Progression to TKA at 6 and 12 months was analyzed against non-GAE knee OA patients matched 10:1 on age, sex, region, index year, and baseline injection frequency. Of 436 patients with GAE for knee OA, 126 met enrollment criteria for the injection analysis (mean age, 64.2 years; 57.9% female). Mean annualized steroid injection use decreased from 0.96 to 0.48 per patient-year (-50.4%; P = .004) and any intra-articular injection from 2.88 to 1.60 (-44.4%; P < .001). Among 52 baseline steroid injection users, 36 (69.2%) stopped and 46 (88.5%) had fewer injections. TKA did not differ from matched comparators at 6 months (5.8% vs 6.8%; P = .858) or 12 months (13.1% vs 12.8%; P = 1.000). Steroid injection use decreased after GAE, while early progression to TKA did not differ from matched comparators. Prospective studies with longer follow-up and clinical outcomes are needed to determine whether GAE reduces the need for injections or affects long-term TKA rates.

PMID 42874703
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PubMedNursing ethics2026-10-14

Nurses' support for medical assistance in dying: A systematic review and meta-analysis.

Zhu Zhengjun Z, Liu Changying C, Jiang Meifang M, Liu Yuyu Y et al.

BackgroundMedical assistance in dying (MAID) raises complex ethical and professional questions for nurses, whose attitudes may vary across legal, sociocultural, and clinical contexts. Although nurses' experiences and attitudes toward assisted dying have been extensively examined, the prevalence and contextual variation of nurses' support for MAID across the international evidence remain unclear.Research aimTo estimate the prevalence of nurses' support for MAID and examine whether support varies across geographic, legal, clinical, and country-income contexts.Research designA systematic review and meta-analysis of studies reporting quantitative data on nurses' support for MAID or related assisted-dying practices.Search and quality appraisal10 electronic databases were searched from inception to 10 May 2025. Methodological quality was appraised using the Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data. Random-effects models were used to pool prevalence estimates, with subgroup analyses and univariable meta-regression used to examine contextual variation.Results26 studies involving 12,529 nurses from 19 countries were included. The pooled prevalence of support for MAID was 42.5% (95% confidence interval 34.6%-50.4%), with very high between-study heterogeneity (I2 = 99.6%). Support varied by geographic region (p = .004), with pooled estimates of 51.0% in Europe, North America, and Oceania, 30.1% in Asia, and 23.1% in Africa. Support was also higher where an eligible form of assisted dying was legally authorized than where it was not (58.4% vs 37.6%; p = .038). Neither clinical setting nor country income level was significantly associated with support.ConclusionsNurses' support for MAID varies substantially across the available international evidence and should not be interpreted as a uniform global professional position. Geographic region and legal status were associated with this variation, supporting the need for context-sensitive ethical preparedness, role clarity, and organizational support rather than assumptions of professional consensus.

PMID 42870391
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PubMedSleep advances : a journal of the Sleep Research Society2026-10-14

Napping during major depressive episodes identifies a distinct hypersomnolence phenotype.

Geoffroy Pierre Alexis PA, Heiligenstein Célia C, Mauries Sibylle S, Ulm Justin J et al.

Prior studies have linked depression with napping, though findings remain inconsistent. Given that major depressive episodes (MDE) commonly involve sleep-wake and circadian disturbances, we hypothesized that daytime Napping during MDE reflects more pronounced sleep/circadian disruptions and a distinct clinical profile. We compared MDE patients with and without napping (MDE-NAP vs MDE), as well as unipolar and bipolar subgroups, using subjective and objective biomarkers, including actigraphy. The MDE-NAP group had more frequently hypersomnia (30.6% vs 8.2% p < .001), daytime sleepiness (73.1% vs 41.8%, p < .001), daytime fatigue (97.1% vs 88.5%, p = .042), family history of depression (68.2% vs 52.2%, p = .044), weight gain (42.2% vs 21.6%, p = .006), and feelings of guilt (75.0% vs 57.8%, p = .027). The unipolar napping group had greater weight gain (48.8% vs 21.4%, p = .004) and more hypersomnia (26.1% vs 3.4%, p < .001). The bipolar napping group were more frequently women (76.9% vs 52%, p = .046), with more suicidal ideation (65.4% vs 37.8%, p = .031), sad mood (73.1% vs 43.1%, p = .019), hypersomnia (38.5% vs 15.8%, p = .04), and guilt (61.9 vs 35.1, p = .049). Regarding sleep scales, MDE-NAP had more hypersomnolence symptoms (HSI total score, p < .001), with higher frequencies of sleep inertia, daytime sleep, sleepiness, daytime dysfunction, and sleep attacks; and showed longer sleep duration (PSQI sleep duration, p = .025), and higher sleep efficiency (PSQI sleep efficiency, p = .015). Actigraphy did not reveal significant between-group differences in the subsample with usable recordings (N = 90). Daytime napping during MDE appears to identify a distinct hypersomnolence phenotype with sleep-vegetative burden, supporting the systematic assessment of napping to guide personalized sleep- and circadian-based therapeutic strategies. This paper is part of the Sleep and Circadian Mechanisms in Mental Health Collection.

PMID 42871667
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