Drug Database
PT

PT-003

✓ Approved

Pediatrix Therapeutics · Unknown · Unknown

What is PT-003?

PT-003 is a unknown developed by Pediatrix Therapeutics. It is approved for therapeutic indications via unknown.

Drug Profile

CompanyPediatrix Therapeutics
Drug ClassUnknown
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Pediatrix Therapeutics

Therapeutic Indications

PT-003 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Immune system disordersHypersensitivity✓ Approved

Related Research Articles

PubMedJournal of cardiovascular electrophysiology2026-08-30

Sub-Acute Re-Elevated Pacing Thresholds After Atrial Leadless Pacemaker Implantation.

Wu Dongyan D, He Le L, Lu Fengmin F, Shao Ying Y et al.

The safety and efficacy of the atrial leadless pacemaker (A-LP) with helix fixation have been demonstrated. Usually, elevated acute thresholds decrease gradually and normalize within 24 h. Here, we report a case of subacute re-elevation of pacing thresholds after hospital discharge. An 80-year-old female with a history of bradycardia underwent A-LP implantation. At the time of the procedure, the final pacing threshold (PT) was measured at 4.0 V/0.4 ms. On post-procedural Day 1, the PT at 0.4 ms pulse width decreased to 1.0 V. On Day 4, the PT was 1.0 V/0.4 ms prior to the patient's discharge. However, on Day 5, she was readmitted to the hospital due to the loss of atrial capture at the maximum output available after an intravenous administration of 150 mg amiodarone for atrial flutter. Over 3 days of monitoring, atrial PT was higher than 6 V/1.5 ms. A traditional DDD pacemaker was implanted due to recurrent sinus asystole associated with dizziness. At the 1-month follow-up, the PT of atrial A-LP was 0.5 V/0.4 ms. Two months later, an ambulatory Holter confirmed the stable and normal atrial capture of the A-LP after lowering the base rate of the DDD pacemaker. At the 3-month follow-up, PT of the A-LP remained 0.5 V/0.4 ms. Sub-acute re-elevated PT of the A-LP during the perioperative period may persist for more than 1 week and then normalize within 1 month. If PT re-elevation is suspected to be related to peri-electrode inflammation, a conservative approach with continued monitoring of threshold changes may be considered.

PMID 42669180
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PubMediScience2026-08-30

Comparative effectiveness of multiple interventions for Alzheimer's disease on ABC syndromes and QoL: A Bayesian network meta-analysis.

Gao Fujia F, Luo Guangxin G, Liu Bokuan B, Qiu Xu X et al.

Evidence comparing directly pharmacological and non-pharmacological treatments for Alzheimer's disease (AD) is scarce. The ABC symptoms-activities of daily living (ADLs) (A), behavioral and psychological symptoms (BPSs) (B), cognitive function (C), and quality of life (QoL)-are critical for diagnosing and assessing treatment effects in AD. This study aims to evaluate five interventions for AD: pharmacological therapy (PT), photobiomodulation (PBM), cognitive therapy (CT), exercise therapy (ET), and repetitive transcranial magnetic stimulation (rTMS) using a Bayesian network meta-analysis approach. Among 6,450 records screened, 91 randomized controlled trials (RCTs) involving 12,242 participants met the inclusion criteria. PBM and rTMS showed significant benefits for cognitive function in AD patients. PT and CT showed notable effectiveness in enhancing activities of daily living. For QoL, CT and ET were identified as more favorable outcomes. Collectively, each intervention exerts unique merits targeting ABC symptoms and QoL, implying combined pharmacological and non-pharmacological regimens could optimize therapeutic gains for AD management.

PMID 42668611
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PubMedJournal of colloid and interface science2026-08-30

Metal-organic framework-coupled ZnIn2S4 for boosting photocatalytic hydrogen evolution.

Yu Tingting T, Ran Yiqing Y, Gong Picheng P, Ye Hui H et al.

Metal-organic frameworks (MOFs) have attracted tremendous interest in the photocatalytic hydrogen evolution reaction (HER). Nevertheless, their practical catalytic performance is limited by the rapid recombination of photogenerated charge carriers and sluggish interfacial reaction kinetics. Herein, a hierarchically structured UiO-66-NH2(Hf) / ZnIn2S4 (denoted UN-66/ZIS) heterostructure was rationally fabricated via a solvothermal strategy to simultaneously regulate charge separation efficiency and optimize interfacial catalytic kinetics. Benefiting from the intimate heterointerface and built-in electric field, the optimized UN-66/ZIS sample exhibits remarkably improved visible-light absorption capability and charge transport efficiency, achieving a photocatalytic hydrogen production of 6052 ± 206 μmol·g-1, which greatly outperforms pristine UN-66 and ZIS. More importantly, in-situ X-ray photoelectron spectroscopy combined with density functional theory calculations directly unveils the mechanism of interfacial charge redistribution and directional electron transfer responsible for the enhanced carrier separation efficiency, offering mechanistic insights into the improved catalytic activity. Furthermore, loading of Pt cocatalyst effectively accelerates the surface hydrogen evolution kinetics. The corresponding hydrogen evolution rate increases to 14,403 ± 287 μmol·g-1·h-1, approximately seven times that of the Pt-free heterostructure. This work proposes a synergistic strategy integrating heterojunction engineering and cocatalyst modulation to simultaneously optimize light harvesting, charge separation and surface reaction kinetics, which provides new guidelines for the rational design of high-performance MOF/sulfide photocatalysts toward solar hydrogen production.

PMID 42669254
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PubMediScience2026-08-30

Integrating neural decoding, memristive materials, and adaptive control frameworks for next-generation hippocampal memory prosthetics.

Mo Fan F, Zhao Xiaoyu X, Xu Yuanhong Y, Tang Chengxuan C et al.

Memory prosthetics, closed-loop brain-computer interfaces that decode hippocampal activity and deliver adaptive stimulation, are transitioning from animal proof-of-concept to first-in-human trials. Realizing chronically implantable systems requires co-design of three materials-mediated subsystems whose structure-property-processing (SPP) relationships have been treated in isolation: biocompatible electrode interfaces, on-chip neuromorphic computation, and closed-loop control hardware. This review presents an integrated framework. We map neuroscientific findings (theta-phase tracking, theta-gamma coupling, sharp-wave ripple detection) onto engineering specifications for latency, sampling, and charge injection, and onto materials requirements for impedance, switching endurance, and chronic stability. We develop an SPP taxonomy of two dominant materials families: chronic electrode coatings (Pt-Ir, IrOx, PEDOT:PSS, carbon-based, MXene) and oxide memristive synapses (Al2O3/TiO2-x, SrTiO3, HfO2). We further distinguish established findings from emerging directions and flag where small-cohort clinical results have been over-generalized. This synthesis provides materials-design targets for next-generation memory-prosthetic hardware.

PMID 42668603
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PubMed[Rinsho ketsueki] The Japanese journal of clinical hematology2026-08-30

[Utility of global coagulation assays for hemostasis management in hyperclearance-type autoimmune acquired coagulation factor V deficiency].

Nakazawa Haru H, Togitani Kazuto K, Kitaoka Mayuko M, Okada Mitsuo M et al.

We report the case of an 80-year-old woman in which marked prolongation of prothrombin time (PT) and activated partial thromboplastin time (APTT) noted upon diagnosis of autoimmune hemolytic anemia revealed severe factor V (FV) deficiency. A mixing study showed a downward-convex pattern and the Bethesda assay for inhibitors was negative, which initially suggested congenital FV deficiency. Although the patient had concomitant early-stage esophageal cancer, infusions of fresh frozen plasma (FFP) failed to correct the coagulopathy, necessitating postponement of endoscopic therapy. Subsequently, a comprehensive evaluation by the Standardization Committee of the Japanese Ministry of Health, Labour and Welfare detected anti- FV IgG, establishing the diagnosis of hyperclearance-type autoimmune FV deficiency (AiFVD). Despite corticosteroid therapy, conventional coagulation screening test results remained markedly abnormal, complicating periprocedural management. In contrast, viscoelastic testing (VET) and thrombin generation testing (TGT), including ex vivo supplementation assays, indicated that adequate hemostasis could be achieved, allowing the endoscopic treatment to proceed safely. This case underscores that, even in FV deficiency with a negative inhibitor screen, testing for anti-FV IgG is essential for identifying hyperclearance-type AiFVD. Furthermore, ex vivo VET and TGT provided actionable assessments of hemostatic capacity and proved useful for guiding management in AiFVD.

PMID 42669503
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PubMedJournal of interpersonal violence2026-08-30

Social Relationships and the Moderating Role of Prior Bullying Experiences in Bystander Behaviors Among Later Adolescents.

Park Soowon S

Bullying is deeply embedded in adolescents' social ecologies and has enduring developmental consequences. Accordingly, the quality of social relationships, together with adolescents' prior bullying experiences, may play a critical role in shaping bystander behaviors. This study examined how peer, parent-child, and teacher-student relationships were associated with adolescents' bystander behaviors (i.e., defending, pro-bullying, passive bystanding), and whether these associations are moderated by prior experiences of bullying perpetration and victimization. Using nationally representative data from the Korean Children and Youth Panel Survey (12th grade, N = 2,224), multilevel modeling was employed to examine the main and interactive effects of social relationships and bullying experiences on bystander behaviors, accounting for the clustering of adolescents within schools. Peer relationship quality was uniquely associated with defending (β = .08, p = .026), whereas all types of higher-quality social relationships were associated with lower pro-bullying (peer: β = -.17, p < .001; parent-child: β = -.29, p < .001; teacher-student: β = -.07, p = .020). In contrast, higher-quality peer relationships were related to greater passive bystanding only among adolescents with bullying perpetration experience (β = .16, p = .006), and stronger parent-child relationships were associated with greater passive bystanding among those without bullying victimization experience (β = .15, p = .003). These findings reveal that the prosocial potential of social relationships is not unconditional: while peer, parent-child, and teacher-student relationships were consistently associated with lower pro-bullying and peer relationships were associated with greater defending, their associations with passive bystanding were contingent upon adolescents' prior bullying histories. Effective prevention therefore requires simultaneous assessment of relationship quality and bullying history, as these two dimensions appear to jointly shape whether relational resources are associated with passive bystanding or pro-bullying reinforcement.

PMID 42668417
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