Drug Database
PT

PT-003

✓ Approved

Pediatrix Therapeutics · Unknown · Unknown

What is PT-003?

PT-003 is a unknown developed by Pediatrix Therapeutics. It is approved for therapeutic indications via unknown.

Drug Profile

CompanyPediatrix Therapeutics
Drug ClassUnknown
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Pediatrix Therapeutics

Therapeutic Indications

PT-003 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Immune system disordersHypersensitivity✓ Approved

Related Research Articles

PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-10-15

Structure-Dependent Interfacial Electrostatic Regulation Enables Platinum-Efficient Hydrogen Evolution in Pt-Ag Bimetallic Nanowires.

Chong Carice C, Boong Siew Kheng SK, Raja Mogan Tharishinny T, Zhang Jiajia J et al.

The electrocatalytic hydrogen evolution reaction (HER) is central to sustainable hydrogen production. Platinum (Pt) is widely regarded as the benchmark HER catalyst due to its near-optimal catalytic properties. However, its scarcity and high cost severely constrain scalable deployment. Here, we demonstrate that structure-induced interfacial electrostatic regulation enables platinum-efficient HER while minimizing Pt loading. A one-dimensional nanoensemble composed of Ag nanowires decorated with Pt nanoparticles integrates electronic hybridization, facet-dependent charge accumulation, and directional charge transport to boost HER. The solid PtAgNW (S-PtAgNW) nanoarchitecture containing only 15 wt.% Pt achieves the lowest overpotential of 290 mV at an ECSA-normalized current density of 500 mA cm-2 with a Tafel slope of 42 mV dec-1. It delivers a Pt-normalized hydrogen production rate of ∼50 mol gPt -1 h-1 at ∼93% Faradaic efficiency, representing a >6-fold enhancement over its hollow counterpart despite the latter possessing higher Pt loading and similar interfacial chemistry. Mechanistic analysis reveals that Ag-to-Pt electronic coupling and facet redistribution toward Ag(111) enhance electron accumulation under bias, strengthening the interfacial electrostatic environment that governs proton-electron coupling. These findings establish interfacial electrostatic regulation, rather than Pt loading or intrinsic catalyst chemistry alone, as an important determinant of efficient HER.

PMID 42876226
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PubMedAnalytical methods : advancing methods and applications2026-10-15

Combined LA-ICP-MS with empirical coefficient correction and Bi fire assay for the determination of ultra-trace Pt, Pd, and Au in geochemical samples using a 194Pt isotope spike as the internal standard.

Guo Xiaorui X, Liu Yan Y, Ni Wenshan W, Wang Tiantian T et al.

In this work, a novel and environmentally friendly method based on bismuth fire assay (Bi-FA) combined with laser ablation ICP-MS (LA-ICP-MS) was established for the determination of ultra-trace Pt, Pd, and Au in geochemical samples, using a Pt isotope spike (194Pt) as the internal standard. Due to the low toxicity and low, stable blank values of the Bi2O3 collector, Bi-FA could be directly employed for the pre-concentration of Pt, Pd, and Au prior to analysis. The Ag slices prepared by annealing and tableting were analyzed at multiple points by LA-ICP-MS. This approach offered advantages including rapid analysis, good measurement stability, and the elimination of polyatomic ion interference and dilution effects associated with solution-based analysis. As the internal standard, the Pt isotope spike was thoroughly mixed with the target elements (Pt, Pd, and Au in the sample) in each Ag prill, and its distribution was consistent with that of the target elements. This method resolved the issue of uneven distributions of Pt, Pd, and Au in the Ag slices, thereby enabling internal standard correction for LA-ICP-MS by calculating the intensity of 194Pt from the Pt isotope spike. In addition, optimization experiments were conducted for key parameters, including laser frequency, energy density, ablation spot diameter, and ICP-MS dwell time. The Ag slices prepared from certified reference materials (CRMs) were used as the calibration standards. The standard samples had the same matrix as the real samples, which reduced laser ablation fractionation effects, minimized analytical errors, and improved accuracy. The standard curves were plotted by the empirical coefficient method and showed excellent linearity with correlation coefficients (R2) of 0.9999 (Pt), 0.9998 (Pd), and 0.9995 (Au). The limits of detection (LODs) of the method were 0.066 (Pt), 0.052 (Pd), and 0.090 (Au) ng g-1. The proposed method was validated by determining the Pt, Pd, and Au in CRMs, showing excellent agreement with certified values. When applied to geochemical samples, the results were consistent with those obtained by lead fire assay combined with graphite furnace atomic absorption spectrometry (Pb-FA-GF-AAS). The recoveries were 2.5-107.8% (Pt), 91.4-108.0% (Pd), and 91.0-109.2% (Au), demonstrating the good accuracy of the proposed method.

PMID 42876253
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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-10-15

Unleashing Platinum-Sulfur Synergy in Ultranano-Structured Conjugated Porous Polymers Based on Thiazole for Efficient Hydrogen Generation.

Palenzuela-Rebella Sandra S, Lorenzon Alessandro A, Gomez-Mendoza Miguel M, García-Tecedor Miguel M et al.

The molecular design of conjugated porous polymers (CPPs) offers a powerful strategy to control their optoelectronic properties and interactions with semiconductor and metallic cocatalyst interfaces. Here, we develop an ultrananostructured thiazolo[5,4-d]thiazole (TzTz)-based CPP (UN_IEP-48), whose sulfur-containing units provide favourable sites for interaction with Pt. High-performance microfluidic processing enables its intimate integration with TiO2, yielding an optimized UN_IEP-48@T3 hybrid containing only 3 wt.% polymer. Photoluminescence and transient absorption spectroscopy reveal efficient charge separation consistent with a direct Z-scheme mechanism, directing the reduction pathway toward the CPP. Remarkably, photodeposition of only 0.5 wt.% Pt increases the H2 evolution rate from 3.0 to 94.3 mmol g-1 h-1, corresponding to a 30-fold enhancement and a photonic efficiency of 34.91%. Increasing Pt loading to 1 wt.% provides essentially no further improvement, highlighting efficient noble-metal utilization. Microscopy reveals preferential Pt localization on polymer-rich regions, while FTIR, XPS, and electrochemical impedance measurements support strong Pt-TzTz interactions and facilitated electron transfer. These results demonstrate how molecular engineering of CPPs can couple nanoscale heterojunction formation with cocatalyst interfacial chemistry, maximizing photocatalytic H2 production while minimizing noble-metal loading.

PMID 42876257
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PubMedClinics in orthopedic surgery2026-10-15

The Sacro-Femoral-Pubic Angle May Estimate Pelvic Tilt in Patients with Severe Developmental Dysplasia of the Hip and Leg Length Discrepancy Undergoing Total Hip Arthroplasty.

Avci Özgür Ö, Öztürk Alpaslan A, Akalın Yavuz Y, Çevik Nazan N et al.

Spinopelvic movement disorders are associated with instability after total hip arthroplasty (THA). In patients with Crowe type 3-4 developmental dysplasia of the hip (DDH) and leg length discrepancy (LLD), sagittal radiographs may not allow accurate assessment of spinopelvic motion. This study aimed to evaluate the sacro-femoral-pubic (SFP) angle, a coronal plane parameter, as a predictor of calculated pelvic tilt (PT). Thirty-two patients with neglected unilateral Crowe type 3-4 DDH who underwent THA were retrospectively analyzed. Preoperative SFP angle and sacral slope (SS) were measured, and preoperative PT was calculated using postoperative pelvic incidence and preoperative SS values. The SFP angle showed a strong negative correlation with calculated PT (r = -0.77, p < 0.001). Linear regression analysis demonstrated that the SFP angle was a significant predictor of PT (β = -1.02, 95% CI, -1.32 to -0.72; adjusted R 2 = 0.58). The regression model demonstrated a root mean square error of 5.46°. The SFP angle may serve as an indirect surrogate for calculated PT in patients with Crowe type 3-4 DDH and LLD when preoperative sagittal spinopelvic assessment is not feasible prior to THA or spinal deformity surgery.

PMID 42876874
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PubMedFrontiers in bioengineering and biotechnology2026-10-15

Effect of low-intensity blood flow restriction combined with high-intensity resistance training on lower limb strength and stroke effect of table tennis players.

Li Han H, Zhao Rui R, Xiao Yi Y

This study aimed to investigate the effects of different strength training protocols on lower limb strength and stroke effect in table tennis players. A single-blind randomized controlled trial (RCT) design was employed. A total of 30 table tennis players were recruited and randomly assigned into three groups: the low-intensity blood flow restriction training (LI-BFRT) group, high-intensity resistance training (HI-RT) group, and combined training (CB-RT) group. All participants completed an 8-week strength training intervention with three sessions per week. Key indicators including knee peak torque, squat jump (SJ) height, countermovement jump (CMJ) height, peak rate of force development (PRFD), and stroke effect were measured before and after the intervention. No significant differences in all baseline indicators were observed among the three groups (p > 0.05). After the intervention, the CB-RT group exhibited extremely significant improvements in knee flexion and extension peak torques, SJ and CMJ heights, PRFD, and stroke effect (p < 0.01). In the LI-BFRT group, left knee extension PT was extremely significantly improved (p < 0.01); Meanwhile SJ height, PRFD, and forehand topspin loop effect were all significantly enhanced (p < 0.05). In the HI-RT group, left knee extension PT was extremely significantly increased (p < 0.01); Meanwhile, left knee flexion PT, right knee flexion and extension peak torques, CMJ height, PRFD, and forehand backspin loop effect were all significantly improved (p < 0.05). The results indicate that compared with single LI-BFRT or HI-RT, CB-RT exhibited a greater improvement trend in lower limb strength and stroke effect among table tennis players.

PMID 42876602
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PubMedThoracic cancer2026-10-15

Efficacy and Safety of Immune Checkpoint Inhibitors for Lung Cancer Complicated by Interstitial Pneumonia: The CS-Lung 003 Study, Branch Number 28.

Hamai Kosuke K, Kanaji Nobuhiro N, Watanabe Naoki N, Ishikawa Nobuhisa N et al.

Immune checkpoint inhibitors (ICIs) improve the prognosis of patients with previously treated non-small cell lung cancer (NSCLC). However, the efficacy and safety of ICIs for patients with NSCLC complicated with interstitial pneumonia (IP) remain unknown. This study aimed to analyze patients with NSCLC and IP treated with ICIs and to investigate the efficacy and exacerbation frequency of ICI therapy. We prospectively enrolled patients with NSCLC and IP at multiple centers and examined progression-free survival (PFS) and overall survival (OS) using the Kaplan-Meier method. The median PFS was 5.8 months, and the median OS was 9.7 months. ICI-related lung injury was observed in seven of the 19 patients (36.8%). Pneumonitis was observed in one of five patients with a usual interstitial pneumonia (UIP) pattern and in six of 14 patients with a non-UIP pattern; however, there was no significant difference in onset frequency. Furthermore, we observed no significant difference in PFS between patients with and without ICI-related pneumonitis (6.8 vs. 3.3 months, respectively; p = 0.826). OS tended to be shorter in patients with ICI-related pneumonitis, but the difference was not significant (8.0 vs. 16.7 months, respectively; p = 0.172). The use of ICIs in patients with NSCLC and IP produces long-term responses in some cases; however, there is a high possibility of ICI-related pneumonitis. In cases where the condition worsens, post-treatment may be difficult, and the prognosis may be poor.

PMID 42876359
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