Drug Database
PT

PT-003

✓ Approved

Pediatrix Therapeutics · Unknown · Unknown

What is PT-003?

PT-003 is a unknown developed by Pediatrix Therapeutics. It is approved for therapeutic indications via unknown.

Drug Profile

CompanyPediatrix Therapeutics
Drug ClassUnknown
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Pediatrix Therapeutics

Therapeutic Indications

PT-003 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Immune system disordersHypersensitivity✓ Approved

Related Research Articles

PubMedInorganic chemistry2026-07-17

Bulkiness Makes the Difference: Modulating Solid-State Emission of Anticoronavirus Active Pt(tpy)C(O)NHCH2R Complexes Featuring Adamantyl vs Propargyl R Groups.

Klarek Mateusz M, Wysocka Daria D, Füllborn-Ott Judith J, Trzybiński Damian D et al.

Solid-state photoluminescence (PL) of Pt(II) terpyridine-type (tpy) complexes relies on intermolecular Pt···Pt metallophilic interactions, and it can be tuned through bulky substituents disturbing them. We took advantage of this property by designing the Pt(II) 2,2':6'2"-tpy complexes [L1PtCl]PF6 and [L2PtCl]PF6 bearing either propargyl or 1-adamantyl connected to the tpy ligand. At 293 K, PL spectra of both complexes are characterized by broadband featureless orange-red emission (λPL ≈ 650 nm) characteristic of 3MMLCT excited states. This is an indication of short Pt···Pt contacts between individual molecules in powder. The PL spectra of [L1PtCl]PF6 and [L2PtCl]PF6 are significantly different from each other at 77 K. The former complex emits at 688 nm while the latter at 665 nm. This can be rationalized by the less sterically bulky ligand L1 promoting the formation of larger aggregates, while the more bulky L2 hinders this behavior. Unlike [L2PtCl]PF6, the monohydrate [L2PtCl]PF6·H2O shows a vibronically resolved 3MMLCT+ 3LC emission in powder form at λPL = 567 nm at 293 K and 560 nm at 77 K. Such behavior indicates relaxation of the Pt···Pt contacts caused by trapped water molecules. [L2PtCl]PF6 shows superior activity to [L1PtCl]PF6 against the HCoV-OC43 and influenza A viruses.

PMID 42466999
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PubMedJournal of the American Chemical Society2026-07-17

Rational Design of the Composite Perfluoro-Sulfonic Ionomer for High-Performance Proton Exchange Membrane Fuel Cells.

Mao Tingting T, Fan Haiyang H, Liu Youxing Y, Li Qinqin Q et al.

Scaling proton exchange membrane fuel cells (PEMFCs) is constrained by high cathodic overpotential and platinum usage for the oxygen reduction reaction, challenges exacerbated by catalyst poisoning from perfluorosulfonic acid (PFSA) ionomers. Though compositing PFSA with additives can mitigate this poisoning, progress has remained largely empirical due to the lack of quantitative assessment tools. Here, we introduce an electrochemical probe leveraging ionomer-coated single-crystal Pt(111) to quantify the coverage and strength of PFSA adsorption, elucidating how cationic additives suppress Pt poisoning. We identify an inverse correlation between cation hydration energy and PFSA adsorption, guiding the rational design of a poorly hydrated tetramethylammonium-anchored covalent organic framework (TMA+-COFs) as an ionomer additive. Electrochemical and spectroscopic analyses reveal that the composite TMA+-COFs/PFSA layer significantly inhibits sulfonate adsorption and poisoning onto Pt(111) through robust electrostatic interactions, which translates to a 1.7- and 4-fold activity enhancement for industrial Pt/C in rotating-disk and gas-diffusion electrodes, respectively. We also demonstrated a high mass activity of 1.08 A mgPt-1 in a PEMFC cathode with TMA+-COFs. Our work provides an alternative avenue to conventional catalyst engineering through the rational design of advanced composite ionomers for high-performance, low-Pt PEMFCs.

PMID 42463981
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PubMedNature communications2026-07-17

Intermetallic Pt3In concave tetrahedra for oxygen reduction electrocatalysis in proton exchange membrane fuel cells.

Yu Wenhe W, Li Menggang M, Li Lu L, Wu Xiaowen X et al.

Scaling proton exchange membrane fuel cells (PEMFCs) demands efficient and durable electrocatalysts for the cathodic oxygen reduction reaction (ORR). Concave surfaces and intermetallic phases have been proven to promote the activity and stability of Pt-based catalysts, yet integrating these two structural features in one catalyst remains challenging. Herein, we achieve this in a class of intermetallic, concave tetrahedral Pt3In (i-ct-Pt3In), through a sequential Pt(111)-selective wet-chemical etching and indium-enabled morphology-preservable annealing. The i-ct-Pt3In/C catalyst delivers a mass activity of 2.49 A mgPt-1 in acidic media, preserving 97.8% of its activity after 30,000 cycles. In phosphate-containing electrolytes, it achieves a mass activity of 0.3 A mgPt-1, representing a 7.5-fold improvement over commercial Pt/C and translating to a peak power density of 1.0 W cm-2 in a high-temperature PEMFC at 160 °C. Theoretical calculations verify weakened adsorption of oxygenates and phosphate anions on concave Pt3In(111) relative to flat Pt(111), accounting for enhanced ORR kinetics and phosphate tolerance. This work highlights the potential of ordering morphological nanocrystals for energy electrocatalysis.

PMID 42463711
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PubMedNational science review2026-07-17

Toluene oxidation with triple-module cooperativity in an atomically precise Cu4Pt2(C≡CCyOH)8 catalyst.

Tang Shisi S, Shen Chenyang C, Zhai Qingxi Q, Tian Yiqi Y et al.

The dismantling and reassembly of C(sp 3)-H bonds in hydrocarbons over both heterogeneous and homogeneous catalysts remain a fundamental challenge. Here, we report the toluene oxidation using an atomically precise Cu4Pt2(C≡CCyOH)8 cluster (HC≡CCyOH = 1-ethynyl-1-cyclohexanol) as the electrocatalyst with an exclusive selectivity for benzaldehyde accompanied by >99% Faradaic efficiency. Results reveal the systematic cooperativity of three functional modules combined into one cluster catalyst for six temporally subsequent events: the hydroxyl ligand of this cluster can capture water and then release it to the Cu sites, and water is sequentially activated on the Cu sites to form OH radicals; Pt sites engage in the abstraction of a hydrogen atom from the methyl group of toluene; the OH radicals then flip over to the Pt sites and react with dehydro-toluene to produce benzaldehyde, which is finally disentangled from the active sites with the help of the ligand. Meanwhile, the cluster is also used to catalyze the hydrogen evolution reaction at the cathode and exhibits much higher activity for hydrogen production than a typical Pt/C catalyst. Our study presents a molecular approach for designing highly active and selective catalysts for efficient inert molecule-involved reactions.

PMID 42465565
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PubMedAngewandte Chemie (International ed. in English)2026-07-17

Probe the Electron Spin Polarization of the Otherwise Unobservable 3MLCT Triplet State Through Polarization Transfer Accompanying the Intramolecular Triplet-Triplet Energy Transfer in Pt(II)-Salen Schiff Base Complexes.

Wu Yanran Y, Sukhanov Andrey A AA, Iagatti Alessandro A, Zhao Jianzhang J et al.

The non-Boltzmann population of the triplet sublevels in Pt(II)-Schiff base complexes, and other phosphorescent transition metal complexes, exhibits large zero-field splitting (ZFS, ∼25 cm-1), preventing a time-resolved electron paramagnetic resonance (TREPR) study. To investigate the intersystem crossing (ISC) electron spin selectivity of the Pt(II) complexes, we attached a perylene unit as a triplet energy acceptor. Our method relies on the conservation of spin angular momentum during the ultrafast intramolecular triplet-triplet energy transfer (TTET) from the metal-to-ligand charge transfer (3MLCT) state to the 3Pery state of the appended perylene unit, which has a small ZFS (0.05 cm-1) and can be studied with an X-band TREPR spectrometer. TTET occurs within ∼1 ps. TREPR spectra detected no signal from the native complex, while the modified complex showed the 3Pery state spectrum with an electron spin polarization (ESP) pattern (e, a, e, a, e, a), distinct from the spin-orbit coupling (SOC)-generated 3Pery state (e, e, e, a, a, a). Based on the orientation of the two units, the population ratios of the 3MLCT sublevels were deduced as Px:Py:Pz = 0.58:0.22:0.20 (in acceptor's coordinates). Our approach offers a novel way to deduce the ISC spin selectivity in phosphorescent transition metal complexes.

PMID 42464471
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PubMedChemical communications (Cambridge, England)2026-07-17

Platinum chalcogenides (S, Se, Te) for efficient electrochemical hydrogen evolution: structure-activity relationships, optimization strategies, and future perspectives.

Tang Qianqian Q, Yu Qinbo Q, Zhang Jian J, Li Jin J

Platinum chalcogenides (PtX, X = S, Se, Te) integrate the high intrinsic activity of platinum with the structural tunability of layered materials, making them promising candidates for electrocatalyzing the hydrogen evolution reaction (HER). This review establishes structure-activity relationships linking the crystal phase, layer thickness, and chalcogen identity to electronic properties such as conductivity, d-band center, and density of states. Key optimization strategies, including nanostructuring, heterostructure engineering, and disorder/activation engineering, enable ultralow Pt loadings while achieving HER activity comparable to commercial Pt/C. Despite progress, major challenges remain, including poor performance in neutral electrolytes, an incomplete understanding of catalytic dynamics, and inadequate long-term durability under industrial conditions. Future directions emphasize multicomponent heterostructures, surface engineering for complex media, multimodal operando techniques integrated with theoretical modeling, and AI-accelerated catalyst discovery. This review provides a framework for advancing PtX toward practical, cost-effective hydrogen production.

PMID 42466948
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