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Microspheres

✓ Approved

TTY Biopharm · therapeutic agent

What is Microspheres?

Microspheres is a therapeutic agent developed by TTY Biopharm. It is approved for therapeutic indications via unknown.

Drug Profile

CompanyTTY Biopharm
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, TTY Biopharm

Therapeutic Indications

Microspheres is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Surgical and medical proceduresOral appliance application✓ Approved

Related Research Articles

PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-10-15

Density Modulated (Co-W)@Ag Core-Shell Microspheres as Magnetic Fillers of Liquid Metal E-GaIn for Soft Intelligent Systems.

Xia Puyue P, Wang Zhaomeng Z, Fan Sining S, Zhang Wenhao W et al.

Through innovative composition and structural design, this study develops core-shell microspheres featuring Co-W alloy cores and Ag shells. Their formation relies on the synergistic effect of solid-liquid interface dewetting, principle of energy minimization, and marangoni effect. These microspheres serve as functional fillers within liquid metal (LM) matrix to create magnetic liquid metal (MLM) with magnetism and enhanced conductivity. We focus on the physical mechanism of density matching, achieved by using high-density W to align the density of Co-W cores with that of liquid Ag. This strategy effectively suppresses the upward buoyancy of cores during spheroidization. Furthermore, finite element simulations elucidate the critical role of the marangoni effect in promoting the formation of this core-shell structure. Experimental results verify that density matching significantly improves the encapsulation quality of Ag shells, thereby endowing the fillers with exceptional resistance against LM corrosion. Finally, the versatility of this MLM is validated across the magnetically actuated liquid-metal soft robot, refreshable liquid-metal blackboard, self-healing circuits, and magnetic liquid-metal strain sensor. These diverse applications underscore the immense potential of MLM as the robust candidate for modern soft intelligent systems.

PMID 42876304
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PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-10-14

Confined-Space Self-Assembly of Nano-HNS Into Hierarchical Micro-Nano Structured Microspheres for Selective Stimuli Sensitization and Passivation.

Liang Wenxuan W, He Guoqiang G, Shi Handong H, Dong Wenshuai W et al.

To address the balance between reactivity and safety in nano-HNS, this study presents a green composite molding strategy that facilitates the self-assembly of nano-HNS into micro-nano-structured microspheres within confined spaces. This approach utilizes confined spaces to precisely control the morphology and size of the resultant microspheres. The effects of process parameters on the morphology and size of microspheres were systematically investigated, and the underlying formation mechanisms were elucidated. Comprehensive characterizations encompassing morphology, crystal structure, mechanical sensitivity, thermal behavior, and impact properties were conducted. The results demonstrate that the synthesized HNS microspheres possess high sphericity, an average particle size of 224.2 µm, and exhibit favorable fluidity and bulk density. This approach effectively reduces the mechanical sensitivity of the material while preserving the crystal structure and thermal stability of HNS-IV (impact sensitivity: 12 J vs. 20 J; friction sensitivity: 216 N vs. 240 N). Furthermore, it enhances the initial sensitivity to short duration shock, as evidenced by reductions in the 50% and 99.9% initiation voltages by 18 and 48 V, respectively. This approach facilitates the synergistic stimulation of selective sensitization and passivation. This methodology is straightforward and applicable, providing a versatile and eco-friendly approach for the multi-structural modification of nano-HNS.

PMID 42872843
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PubMedSmall methods2026-10-14

Magnetic-Dielectric Heterojunctions Regulation in Ni-MnO/C Microspheres With Tunable Electromagnetic Wave Absorption.

Yan Zhikai Z, Zhang Tingjia T, Huang Mengqiu M, Rao Longjun L et al.

Heterojunctions engineering is crucial for optimizing dielectric polarization and electromagnetic (EM) wave absorption, yet precise spatial control over semiconductor components in magnetic-dielectric microspheres remains challenging. Herein, super-dispersed MnO protrusions and Ni particles were confined within a carbon matrix, constructing unique Ni-MnO/C microspheres via a pyrolysis-controlled strategy. Leveraging differences in oxygen affinity, MnO protrusions and Ni particles with tunable dispersity, size, and content were systematically achieved, enabling precise regulation of dielectric behaviors and EM wave absorption. The optimized Ni-MnO/C composite achieved an outstanding minimum reflection loss of -51.49 dB and a maximum effective absorption bandwidth (EAB) of 5.20 GHz. Significantly, by further integrating the composite into metamaterial designs and heat-transfer flexible films, the EAB was dramatically broadened to 12.28 GHz, and thermal insulation was realized. This work introduces a morphological-engineering strategy that not only overcomes the dispersion-control bottleneck in heterojunctions design but also bridges the gap between microstructural tailoring and practical device applications, offering a new idea for high-performance EM wave absorption materials.

PMID 42872574
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PubMedCritical reviews in therapeutic drug carrier systems2026-10-14

Tumor Specific Drug Delivery: Conventional to Advanced Technologies.

Sharma Adarsh A, Thakur Aditya Pratap Singh APS, Ojha Arya A, Rathee Sunny S et al.

The treatment of tumors continues to pose significant challenges in modern medicine, necessitating innovative solutions to enhance therapeutic outcomes while reducing side effects. This review focuses on advancements in tumor management, emphasizing the role of novel drug delivery systems (NDDS) in overcoming the limitations of conventional therapies. Traditional approaches are discussed alongside the development of NDDS, including nanoparticle-based systems such as liposomes, polymeric nanoparticles, dendrimers, and solid lipid nanoparticles (SLNs), as well as microparticle-based systems like microspheres and microcapsules. Emerging technologies, including cubosomes, exosomes, carbon nanotubes, and quantum dots, are explored for their potential in targeted drug delivery and improved efficacy. Mechanisms of drug release and site-specific targeting are examined, with a particular emphasis on recent innovations and patents in the field. The review provides a forward-looking perspective on the integration of these advancements into clinical practice, aiming to transform the landscape of tumor therapy.

PMID 42870625
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PubMedACS pharmacology & translational science2026-10-14

Microsphere System Coloading Type I Collagen and Dexamethasone Sodium Phosphate for Osteoarthritis Therapy.

Chen Xianlan X, Zhang Lu L, Zheng Yan Y, Chi Haiyang H et al.

Knee osteoarthritis (KOA) has no effective nonsurgical treatment. Intra-articular therapy constitutes an effective localized intervention; however, persistent lymphatic drainage and synovial vascular exchange lead to rapid drug elimination. Encapsulating bioactive agents into microsphere delivery platforms enables localized intra-articular administration, with their scaffold-based spherical architecture serving as pharmaceutical and cellular carriers or tissue engineering scaffolds, representing a highly promising therapeutic avenue for KOA. Herein, PLGA was employed to prepare microspheres and a sustained-release microsphere formulation (MPs PLGA DSP@COLI) was prepared for KOA therapeutics, co-encapsulating type I collagen (COLI) and dexamethasone sodium phosphate (DSP). Characterization revealed uniform particle size distribution, favorable dispersibility, and extended-release kinetics. Functional assessments demonstrated robust anti-inflammatory efficacy and enhanced chondrocyte-mediated extracellular matrix deposition. Histopathological and immunohistochemical analyses demonstrated preserved cartilage matrix integrity, augmented COLII synthesis, diminished inflammatory cellular infiltration, and maintained homeostasis of cartilage matrix components, concomitant with reduced OARSI and synovitis scores. These effects collectively suppressed synovial hyperplasia and inflammation and suggested potential improvement in joint conditions. Overall, MPs PLGA DSP@COLI combines the pharmacological anti-inflammatory properties of DSP with the extracellular matrix-related biological functions of COLI, establishing an innovative "drug-device combination" therapeutic paradigm, which represents a promising therapeutic strategy for KOA.

PMID 42871791
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PubMedFrontiers in bioengineering and biotechnology2026-10-14

pH-responsive Zn2+-coordinated gellan gum/γ-polyglutamic acid hydrogel microspheres as functional biomaterials for intra-articular delivery: physicochemical design, smart release, and chondroprotective performance in osteoarthritis.

Zhang Kaiming K, Xue Haonan H, Li Xiangwei X, Zou Fuzheng F et al.

Osteoarthritis (OA) is a degenerative joint disease characterized by progressive degradation of the articular cartilage matrix, pain-related functional impairment, and a paucity of effective disease-modifying therapies. Curculigoside (Cur), a bioactive compound isolated from Curculigo orchioides, possesses anti-inflammatory and tissue-protective properties; however, its direct intra-articular application is hampered by insufficient local retention and limited sustained action. We developed a Zn2+-coordinated pH-responsive hydrogel microsphere delivery system (PGG-Zn@Cur) based on gellan gum (GG) and γ-polyglutamic acid (γ-PGA) to enable localized intra-articular delivery of Cur. Its cytocompatibility and chondroprotective effects were evaluated in IL-1β-stimulated chondrocytes. Transcriptomic analysis was further performed to investigate the potential molecular mechanisms underlying its therapeutic effects. PGG-Zn@Cur exhibited excellent cytocompatibility and restored cartilage matrix metabolic homeostasis in IL-1β-stimulated chondrocytes, as evidenced by increased COL2A1 and ACAN expression and reduced MMP13, ADAMTS5, and iNOS levels. Transcriptomic analysis implicated PI3K-AKT signaling and apoptosis-related pathways in the chondroprotective effects mediated by PGG-Zn@Cur. Mechanistically, PGG-Zn@Cur suppressed PI3K-AKT pathway hyperactivation, downregulated Cleaved Caspase-3 and Bax expression, attenuated chondrocyte apoptosis, and alleviated cartilage degeneration. These findings establish PGG-Zn@Cur as a microenvironment-responsive intra-articular platform that maintains cartilage matrix homeostasis and alleviates PI3K-AKT-associated apoptosis-related responses, offering a promising strategy for disease-modifying OA therapy.

PMID 42871198
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