Drug Database
NI

NIK-127

✓ Approved

Kowa · Small Molecule · Small Molecule

What is NIK-127?

NIK-127 is a small molecule developed by Kowa. It is approved for therapeutic indications via unknown.

Drug Profile

CompanyKowa
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Kowa

Therapeutic Indications

NIK-127 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Gastrointestinal disordersDiarrhoea✓ Approved

Related Research Articles

PubMedJournal of foot and ankle research2026-10-15

Research Capacity and Culture of Podiatrists in Canada (Quebec) and France: A Parallel Cross-Sectional Study.

Libier Solène S, Ghio Sergio Cortez SC, Perrier Antoine A, Brousseau-Foley Magali M et al.

Research capacity and culture (RCC) are essential for high-quality care. However, RCC remains poorly documented among French-speaking podiatrists. This study aimed to assess RCC among podiatrists in Quebec, Canada, and France at the individual, team, and organizational levels, and to compare RCC scores between both groups. A parallel, cross-sectional study was conducted targeting all licensed podiatrists practicing in Quebec, Canada (n = 304) and France (n = 14,208) in 2023. The data collection was carried online using a validated French version of the RCC tool items at the individual, team, and organizational levels using an 11-point scale ranging from 0 (no ability) to 10 (perfect ability). Mean RCC item scores (±SEM) were compared between Quebec and France respondents, with exploratory item-level analyses. Regression analyses were also used to determine associations between sociodemographic characteristics and overall RCC scores. A total of 2272 podiatrists initiated the survey (127 from Quebec and 2145 from France). Overall, mean individual RCC scores were low, but significantly higher in respondents from Quebec than those from France (3.32 vs. 2.75; p < 0.05). Team scores (2.29 vs. 1.82; p < 0.05) and organizational scores were also low overall, but significantly higher in respondents from Quebec than those from France (2.31 vs. 1.84; p < 0.05). Higher overall RCC scores were significantly associated with more dedicated research time, active research involvement, and research training; among Quebec podiatrists, practice outside private practice was also associated with higher RCC scores (all, p < 0.05). This is the first analysis of RCC among French-speaking podiatrists, and overall RCC levels were low. Higher RCC scores were associated with active research involvement, dedicated research time, research training, and, among Quebec podiatrists, practice outside private practice. These findings highlight potential targets for capacity-building initiatives to strengthen evidence-based podiatry in French-speaking contexts.

PMID 42876005
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PubMedFrontiers in plant science2026-10-15

Partitioning photoperiod- and chilling-driven cold hardiness in a Vitis riparia × V. vinifera F1 population.

Delavar Hava H, Kaya Ozkan O, Riaz Summaira S, Hatterman-Valenti Harlene H

Grapevine cold hardiness governs cultivar distribution and winter survival, and is a key constraint on viticulture in cold regions. We evaluated bud cold hardiness in a Vitis riparia × Vitis vinifera F1 population by differential thermal analysis across three environments (a California vineyard, an NDSU field, and an NDSU greenhouse), sampled nine times through the 2023-2024 dormant season. Mean low-temperature exotherms (LTEs) differed significantly among sampling times, and hierarchical clustering separated the genotypes into five hardiness classes defined by mean LTE, from very hardy (≤ -21.4 °C) to very susceptible (≥ -13.4 °C). Field vines reached a midwinter maximum of -22.7 °C, whereas greenhouse vines were most susceptible (-14.6 °C), and nine genotypes were hardier than the tender parent. Genotype accounted for only 7% of the phenotypic variance, giving a low single-observation heritability (H²i = 0.07) but a moderate entry-mean heritability (H²c = 0.49), which are distinct statistics reported separately. The seasonal trajectory was well described by logistic and response-surface models (R² = 0.99) and, on an accumulated-chilling axis, by a Weibull model (half-hardening at 184 chilling degree-days). A state-space model estimated the chilling contribution at ≈6.7 °C and identified three genotypes (536-078, 539-127, 536-142) that attained most of their hardiness under the short-day, moderate-cooling greenhouse regime without sub-zero exposure; because that regime combined shortening photoperiod with a 4 °C decline, these are described as short-day/low-temperature responsive rather than photoperiod-responsive. Mean hardiness and plasticity were uncorrelated, providing no evidence of a hardiness-stability trade-off. The December field and greenhouse samplings exposed the greatest among-genotype variance and are the most informative conditions for future QTL mapping; the nine genotypes hardier than the tender parent, and a hardy, stable subset, are identified as parents for cold-hardiness introgression.

PMID 42876794
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PubMedJournal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses2026-10-14

Postoperative Delirium in Pediatric Surgery Patients: Prevalence, Risk Factors, and Parental Anxiety.

Durmayüksel Esra E, İbrahimoğlu Özlem Ö, Saray Kılıç Hülya H, Akdeniz Kudubeş Aslı A et al.

This study aims to determine the prevalence and risk factors of postoperative delirium in pediatric surgical patients and its relationship with parental anxiety and the time the parent is taken to the child's care. This is a descriptive and cross-sectional study. This study was conducted with 127 pediatric patients and their parents in Turkey between August 2023 and August 2024. Data were collected using the Parent Information Form, the short form of the State-Trait Anxiety Inventory for parents, and the Ramsay Sedation Scale and Cornell Pediatric Delirium Rating Scale-Revised for children. The prevalence of postoperative delirium in children was 69.3%. Among parents, 79.5% experienced state anxiety and 21.3% experienced trait anxiety. Parents were reunited with their children an average of 13.42 ± 8.73 minutes after surgery, and a significant association was found between the timing of this reunion and the presence of delirium. Children whose parents were reunited later exhibited higher delirium rates. Postoperative delirium is highly prevalent among pediatric surgical patients and is influenced not only by biological factors but also by psychosocial and familial dynamics. Earlier parent-child reunification was associated with a lower prevalence of postoperative delirium in this study, highlighting the potential relevance of family-centered care in the early postoperative period. Strengthening family-centered nursing care and developing evidence-based interventions targeting early parental involvement are crucial for improving postoperative outcomes in children. Surgical nurses should strengthen their systematic observation skills and integrate family-centered care principles into practice to ensure early recognition of postoperative delirium and support holistic recovery in pediatric patients.

PMID 42873172
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PubMedJTCVS structural and endovascular2026-10-14

Early-term and midterm outcomes of endovascular completion of high-risk subacute and early chronic residual dissection after type A repair.

Ferraresi Marco M, Katsarou Maria M, Luigi Molinari Alessandro Carlo AC, Jovanovic Janko J et al.

Late mortality, progressive aneurysmal degeneration, and major reinterventions remain frequent after repair of type A aortic dissection. This study aimed to evaluate early- and midterm outcomes of endovascular completion in patients with high-risk residual dissection treated during the subacute or early chronic phase. This study was a single-center retrospective analysis of a prospectively maintained institutional database. All consecutive patients undergoing endovascular completion for high-risk residual aortic dissection after type A dissection repair between January 2017 and September 2025 were included. Completion was performed using thoracic endovascular aortic repair alone or combined with the stented-assisted balloon-induced intimal disruption and relamination technique when distal extension exceeded Ishimaru zone 5. Primary outcomes were 30-day mortality and morbidity, as well as 3- and 5-year survival and reintervention rates. Among 127 patients surviving initial type A repair, 48 (37.8%) underwent endovascular completion (subacute n = 33; early chronic n = 15). No 30-day deaths occurred, and technical success was achieved in all cases. Major adverse events occurred in 6.2%, with no spinal cord ischemia. Five patients (10.4%) required early reintervention. Median clinical follow-up was 54 months. Estimated survival was 97.9% at 3 years and 90.3% at 5 years. Freedom from major reintervention was 93.5% at 3 years and 89.1% at 5 years. False lumen thrombosis was achieved in 89.6% of thoracic and 81.4% of visceral segments. Endovascular completion of high-risk residual dissection after type A repair is safe and effective, providing excellent midterm survival, low major reintervention rates, and high rates of aortic remodeling.

PMID 42872173
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PubMedEuropean child & adolescent psychiatry2026-10-14

Impaired visual-motor integration function in children with attention-deficit/hyperactivity disorder: potential neural correlates from resting-state fNIRS.

Wang Wenchen W, Qian Hong H, Dong Min M, Pan Meirong M et al.

Visual-motor integration (VMI) impairment is common in Attention-Deficit/Hyperactivity Disorder (ADHD), yet its underlying neurobiological basis remains unclear. This study aimed to explore the characteristics of VMI in children with ADHD and its statistical role in the association between functional connectivity (FC) and core symptoms. A total of 332 children with ADHD and 103 healthy controls (HC) completed the Beery-Buktenica Developmental Test of Visual-Motor Integration (Beery VMI). Group comparisons and dimensional correlation analyses were performed to explore the VMI characteristics of children with ADHD. Subsequently, 127 children with ADHD and 91 HC children underwent resting-state functional near-infrared spectroscopy. Mediation analyses were performed to investigate the role of VMI in the relationship between atypical FC and core symptoms of ADHD. Children with ADHD exhibited deficits in VMI performance, with 28.92% showing abnormal VMI. VMI was negatively correlated with core ADHD symptoms. At the network level, VMI showed significant statistical indirect associations in the relationship between FC of DMN-DMN, DMN-DAN, and DMN-VAN networks and inattention symptoms, and between FC of the DMN-DAN networks and hyperactivity/impulsivity symptoms. At the channel level, VMI was also indirectly associated with FC of the left superior frontal gyrus (SFG)-right middle occipital gyrus (MOG) and ADHD core symptoms. Children with ADHD have deficits in VMI, and poorer VMI performance is associated with greater severity of core ADHD symptoms. Altered intra- and inter- network FC of the DMN may represent a potential neural correlate of VMI impairment in ADHD.

PMID 42873252
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PubMedJournal of pediatric endocrinology & metabolism : JPEM2026-10-14

Iodine exposure and thyroid function after prophylactic intragastric iodinated contrast administration for meconium obstruction of prematurity in extremely low birth weight infants.

Shimokaze Tomoyuki T, Toyoshima Katsuaki K, Hawaka Hideyuki H, Noguchi Takahiro T et al.

Maternal hypertensive disorders of pregnancy (HDP) increase the risk of meconium obstruction of prematurity in small-for-gestational-age (SGA) extremely low birth weight (ELBW) infants. While prophylactic intragastric amidotrizoate (Gastrografin®) promotes meconium excretion, concerns persist regarding iodine load and thyroid dysfunction. We retrospectively analyzed infants (<30 weeks, <700 g) born 2016-2024. The treated group (n=20) comprised SGA infants of mothers with HDP receiving prophylactic 5-fold diluted Gastrografin (iodine: 148-222 mg/kg) after stabilization. Controls included nontreated SGA infants (n=17), mostly lacking maternal HDP (thus not meeting prophylaxis criteria), and an appropriate-for-gestational-age (AGA) reference cohort (n=48). A 2018-2022 unexposed subcohort (n=21) provided baseline urinary iodine concentration (UIC) data. Treatment failure, necessitating therapeutic enema, occurred in 1/20 treated infants (5 %). Baseline UIC was 32 (IQR 25-127) vs. 25 (IQR 25-35) µg/L in combined controls (p=0.23). Day 1 postadministration, UIC surged to 326,000 (IQR 201,500-455,350) µg/L; by 2 weeks, it normalized to 348 vs. 267 μg/L (p=0.51). At 2 weeks, thyroid function was comparable between treated and nontreated SGA groups for TSH (5.8 vs. 5.1 μIU/mL; p=0.94), free T3 (1.56 vs. 1.55 pg/mL; p=0.68), and free T4 (0.98 vs. 0.78 ng/dL; p=0.31), though baseline HDP differences necessitate careful interpretation. Levothyroxine supplementation rates were 26 % vs. 13 %, respectively (p=0.42). Early postnatal iodine levels in preterm infants are low. Prophylactic intragastric Gastrografin facilitated meconium evacuation in high-risk SGA ELBW infants. The associated iodine elevation is transient. A nonsignificant numerical increase in levothyroxine supplementation within our small cohort necessitates further large-scale studies.

PMID 42872568
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