Drug Database
NI

NIK-127

✓ Approved

Kowa · Small Molecule · Small Molecule

What is NIK-127?

NIK-127 is a small molecule developed by Kowa. It is approved for therapeutic indications via unknown.

Drug Profile

CompanyKowa
Drug ClassSmall Molecule
RouteUnknown
StatusApproved
Sources: ClinicalTrials.gov, Kowa

Therapeutic Indications

NIK-127 is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Gastrointestinal disordersDiarrhoea✓ Approved

Related Research Articles

PubMedInternational journal of general medicine2026-08-30

Diagnostic Performance of Platelet-to-Lymphocyte Ratio and CA19-9 Added to EUS-FNA for Solid Pancreatic Lesions: A Single-Center Retrospective Study.

Liu Shasha S, Hu Chen C, Fan Yujing Y, Liu Lina L et al.

To evaluate the incremental diagnostic value of the platelet-to-lymphocyte ratio (PLR) and carbohydrate antigen 19-9 (CA19-9) when combined with endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in patients with solid pancreatic lesions. This retrospective single-center study included 127 consecutive patients who underwent EUS-FNA for solid pancreatic lesions between December 29, 2020, and October 23, 2023. Final diagnoses were established using a reference standard independent of the index EUS-FNA. Malignancy was confirmed by surgical pathology, independent cytologic or histologic evidence, or unequivocal radiologic progression or metastasis. Non-malignancy was established by independent benign pathology or lesion stability or regression without anticancer therapy during at least 24 months of clinical and imaging follow-up. Among 127 patients, 80 had malignant lesions and 47 had non-malignant lesions. EUS-FNA achieved an accuracy of 91.3%, sensitivity of 93.8%, specificity of 87.2%, positive predictive value of 92.6%, and negative predictive value of 89.1%. CA19-9 levels were significantly higher in malignant than in non-malignant lesions (median [IQR], 197.21 [9.51-928.36] vs 14.30 [3.97-211.02] U/mL; P=0.001), with an AUC of 0.692. The PLR plus CA19-9 model yielded an apparent AUC of 0.734 and an optimism-corrected AUC of 0.717. The EUS-FNA plus PLR plus CA19-9 model showed the highest discrimination, with an apparent AUC of 0.986 (bootstrap 95% CI, 0.962-1.000) and an optimism-corrected AUC of 0.981; the corresponding Brier scores were 0.033 and 0.041. EUS-FNA demonstrated high diagnostic accuracy for solid pancreatic lesions. PLR and CA19-9 provided complementary diagnostic value, and the three-variable model showed high diagnostic performance after internal validation.

PMID 42668854
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PubMedJournal of nutritional science and vitaminology2026-08-30

High Adherence to a Food Guide May Be Associated with Lower Serum C-Peptide Concentrations.

Mita Ayuka A, Takachi Ribeka R, Yamaji Taiki T, Yamagishi Marina M et al.

A balanced diet has been associated with a lower risk of total and cardiovascular mortality. One intermediate function linking a balanced diet and lower mortality may be optimal insulin secretion. We examined the association between adherence to the Japanese Food Guide Spinning Top (JFGST) and serum C-peptide concentration, an indicator of basal insulin secretion, in a cross-sectional study in a Japanese population, in whom rice (refined grains) is the staple food. A blood sample was collected in November 2012 and a 12-d weighed food record was collected over the subsequent year. A total of 210 healthy residents aged 35-80 y (83 men, 127 women) were included in the analysis. Multiple regression analysis was performed with log-transformed serum C-peptide concentration as dependent variable and total JFGST score or each score by category of dish as independent variable, with adjustment for age and BMI. In both men and women, total JFGST score was inversely associated with serum C-peptide concentration. Slope in the percentage of differences for every 1-point score addition based the regression coefficients was -2.3% (p<0.001) in men and -1.6% (p<0.001) in women. For specified categories of dishes, scores for grain dishes, snacks and alcoholic beverages, and total energy were inversely associated with serum C-peptide concentrations among men. Among women, in contrast, scores for milk and for fruit were inversely associated with serum C-peptide concentrations. A balanced diet consistent with the JFGST was inversely associated with serum C-peptide concentration among middle-aged Japanese.

PMID 42669528
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PubMedBiomaterial investigations in dentistry2026-08-30

Marginal adaptation and fracture resistance of CAD/CAM-fabricated PMMA, PEEK, and PEKK three-unit provisional fixed dental prostheses: an in vitro comparative study.

Harfi Mustafa Mohammad MM, Abo El-Farag Shaimaa Ahmed SA, Shams Ahmed A

Although polymethyl methacrylate (PMMA) is widely used for computer-aided design and computer-aided manufacturing (CAD/CAM) provisional restorations, high-performance polymers such as polyetheretherketone (PEEK) and polyetherketoneketone (PEKK) have been proposed as alternatives. However, limited data are available comparing these materials in multi-unit provisional fixed dental prostheses (FDPs). This in vitro study aimed to evaluate and compare the marginal adaptation and fracture resistance of CAD/CAM-fabricated three-unit provisional FDPs constructed from PMMA, PEEK, and PEKK. A total of 48 sound human maxillary teeth (24 second premolars and 24 second molars) were prepared to receive 24 CAD/CAM-fabricated three-unit provisional FDPs. Specimens were randomly assigned into three groups (n = 8) according to material: PMMA, PEEK, and PEKK. Marginal adaptation was initially measured before cementation using a stereomicroscope. Following cementation, all specimens underwent standardized thermomechanical aging (10,000 thermal cycles and 240,000 mechanical loading cycles), after which marginal adaptation was reevaluated. Fracture resistance was then assessed using a universal testing machine, followed by analysis with scanning electron microscopy. Data were statistically analyzed using two-way repeated-measures analysis of variance (ANOVA), one-way ANOVA, Tukey's post hoc test, and Fisher's exact test (P ≤ 0.05). Following cementation and aging, PMMA showed significantly lower marginal discrepancy than PEEK and PEKK (P < 0.001). PEEK exhibited a significant improvement in marginal adaptation after thermomechanical aging (P = 0.002), whereas PMMA and PEKK showed no significant changes. Fracture resistance differed significantly among groups (P < 0.001), with PEKK recording the highest mean fracture load (2,669 ± 204 N), followed by PEEK (1,849 ± 183 N), while PMMA showed the lowest mean value (1,072 ± 127 N). Under the tested experimental conditions, material type significantly affected both marginal adaptation and fracture resistance. Among the tested materials, PMMA demonstrated the lowest marginal discrepancy, and PEKK exhibited the highest fracture resistance, whereas PEEK provided a balanced performance.

PMID 42668713
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PubMedHLA2026-08-29

Characterisation of the Novel HLA-DRB3*01:127 Allele by Next-Generation Sequencing.

Pi Wenwen W, Dong Lina L, Li Qi Q, Zhang Wei W et al.

HLA-DRB3*01:127 differs from the HLA-DRB3*01:01:02:01 allele by one nucleotide substitution in the exon 3.

PMID 42666097
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PubMedLegal medicine (Tokyo, Japan)2026-08-29

Vitreous humour glucose and lactate kinetics in a hospital forensic cohort.

Montanari Eva E, Sabbatinelli Jacopo J, Dervišević Emina E, Kalfoglu Ersi E et al.

The inverse relationship between vitreous humour (VH) glucose and lactate, classically used in the Traub formula, is widely applied in post-mortem biochemistry. We analysed 127 VH samples from external examinations and forensic autopsies performed in a hospital forensic setting (PMI 4-187 h; 58 septic and 69 non-septic deaths). Glucose was available in 78 cases, lactic acid in all 127. Cases were stratified by PMI window, septic status and storage condition. Spearman correlations and non-parametric comparisons were applied. Within the first 24 h post-mortem, glucose and lactic acid showed significant opposite correlations with PMI. Glucose reached a low-value floor of approximately 2 mg/dl by 25-48 h, after which no meaningful PMI-related decrease was observed. Lactic acid showed a different trajectory: septic and non-septic cases had similar baseline levels at ≤10 h, but diverged thereafter, with continued increase in septic cases through 25-48 h. This divergence emerged after glucose depletion, suggesting glucose-independent lactate accumulation. Glucose-lactate coupling was absent in septic cases and weak in non-septic cases. VH glucose and lactic acid showed limited evidence of direct stoichiometric coupling in this hospital cohort. Glucose reflected PMI mainly within the first 24 h, whereas its interpretative value declined after reaching a post-mortem floor. Lactic acid showed a sepsis-associated post-mortem amplification not explained by glucose availability alone, possibly reflecting autolytic processes. These findings do not invalidate the Traub formula in its original diagnostic context, but caution against its uncritical application in heterogeneous forensic cohorts.

PMID 42667861
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PubMedHeart rhythm O22026-08-29

Atrial fibrillation ablation in patients with hypertrophic cardiomyopathy: Findings and outcomes of repeat ablation procedures.

de Melo Junior Jose F JF, Haas Daniella D, Swain William H WH, Karim Shahid S et al.

Patients with atrial fibrillation (AF) and hypertrophic cardiomyopathy (HCM) commonly require repeat catheter ablation procedures for AF management. The mechanisms underlying the increased AF recurrence rates are poorly defined. We aimed to explore mapping findings and ablation outcomes among patients with HCM undergoing repeat AF ablation. In this single-center study, 45 patients with HCM underwent repeat AF ablation procedures (2015-2023). Patients were age- and sex-matched 1:1 to control patients without HCM undergoing repeat AF ablation. Details from comprehensive electroanatomic mapping were compared. Univariate and multivariate Cox regression analyses were used to evaluate prognostic factors for recurrent AF in HCM. The mean age in the HCM group was 57.5 ± 13.2 and 71% were male. The most common finding at repeat ablation was pulmonary vein (PV) reconnection (86.7% in the HCM group vs 75.5% in the control group, P = .34). Patients were followed for a median of 456 days (interquartile range 127-1148). 26 patients (57.8%) in the HCM group experienced recurrent AF during the follow-up period, compared with 23 patients (51.1%) in the control group (P = .52). No significant difference in AF recurrence was found between the 2 groups (log-rank P = .33). Left atrial volume index and early AF recurrence during the blanking period were both associated with AF recurrence in univariate analyses; however, these were not significant in multivariate analysis. PV reconnection is commonly observed in patients with HCM undergoing repeat AF ablation. Repeat AF ablation outcomes in patients with HCM were comparable to those in patients without HCM.

PMID 42666602
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