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UR

urea (Emolienta / urea, Vinas)

✓ Approved

Vinas · Small Molecule · Small Molecule

What is urea?

urea is a small molecule developed by Vinas. It is approved for therapeutic indications via topical.

Drug Profile

Brand NamesEmolienta, urea, Vinas
CompanyVinas
Drug ClassSmall Molecule
RouteTopical
StatusApproved

Therapeutic Indications

urea is developed for 4 unique indications across 1 therapeutic area.

Therapeutic AreaConditionPhase
Skin and subcutaneous tissue disordersDermatitis allergic✓ Approved
Skin and subcutaneous tissue disordersDermatitis atopic✓ Approved
Skin and subcutaneous tissue disordersDermatitis contact✓ Approved
Skin and subcutaneous tissue disordersPsoriasis✓ Approved

Related Research Articles

PubMedInternational journal of biological macromolecules2026-07-17

Green-manufacturing nano-coir-pith: a lingo-cellulose waste for fertilizer coating and crop production.

Swami Kanchan K, Nagargade Mona M, Dadhich Ankita A, Kumar Prem P et al.

Urea is susceptible to leaching and volatilization, which reduces the nitrogen use efficiency and causes environmental damage by greenhouse gas addition and groundwater pollution. Here, to overcome this in circular economy fashion, a biodegradable controlled-release urea coating has been developed by directly utilizing recalcitrant coir pith with castor oil as plasticizer and ethyl cellulose as sealer. To form a stable and uniform coating, the coir pith has been engineered to nanoscale by a green phosphate-assisted wet milling process using dipotassium hydrogen phosphate. The lower hydration energy of potassium facilitates penetration and increases turgor pressure to fragment without using toxic strong oxidizers. The phosphate tethers simultaneously and provides charge-based repulsion. The esterification between the carbonyl groups in castor oil and the hydroxyl groups of ethyl cellulose resulted in hydrophobicity (water contact angle: ~125°), alongside ~80% biodegradation under soil burial conditions after 60 days. The coated urea reduced the nitrogen losses, showing a ~ 9% increase in wheat grain yield compared with bare urea. Finally, the life cycle analysis demonstrated the environmental sustainability of the proposed green manufacturing strategy.

PubMedSmall (Weinheim an der Bergstrasse, Germany)2026-07-17

Tuning the Length of Filomicelles Prepared Via Templated Polymerization-Induced Self-Assembly.

Hochreiner Eleonora G EG, Pioruńska Wiktoria W, Mellot Gaëlle G, Fehér Bence B et al.

High-aspect-ratio polymeric micelles (filomicelles, FMs) are attractive anisotropic nanoparticles for a wide range of applications, however, their formation is typically confined to narrow hydrophilic/hydrophobic polymer block ratios, limiting systematic structure-property investigations. Consequently, independent control over micelle width, length, and stiffness remains challenging. A supramolecular polymerization-induced self-assembly (PISA) strategy using a bis-urea core template was recently shown to robustly yield wormlike micelles across a wide range of core block lengths; however, the resulting FM lengths remained highly polydisperse. Herein, we investigate two strategies to tune the contour length: (i) Blending in polymer without the bis-urea sticker and (ii) post-micellization sonication. Unexpectedly, incorporating non-sticker polymer can increase the contour length. Transmission electron microscopy (TEM), fluorescence cross-correlation spectroscopy (FCCS), and high-resolution atomic force microscopy (AFM) were used to elucidate the key factors contributing to this peculiar self-assembly mechanism. Sonication-induced cleavage led to shortening of the particles and narrower polydispersity in length. Combined, the two strategies provide access to a wide range of anisotropic micelles with accessible aspect ratios ranging from 1 to >150. Considering their long-term (colloidal) stability, the presented system is an ideal model to study the effect of micellar anisotropy, for example, in drug delivery relevant scenarios.

PubMedCurrent medical science2026-07-17

Predictive Value of Admission Renal Injury-Related Indicators for Fatal Outcomes in Patients with Severe Fever with Thrombocytopenia Syndrome.

Chen Xing X, Yan Li L, Xiang Xu X

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease with high mortality rates. While previous studies have focused primarily on the epidemiological and clinical aspects of SFTS, indicators of renal injury at admission have received limited attention. We retrospectively analyzed 260 patients with SFTS admitted to the study hospital between April 1, 2023, and July 18, 2024, who were classified into the survival group (n = 163) and death group (n = 97) on the basis of 28-day prognosis. Renal-related data were collected upon admission. Univariate and multivariate Cox regression analyses were used to identify independent predictors, and a nomogram was constructed. Receiver operating characteristic (ROC) curves and calibration curves were used to assess the discrimination and calibration of the model. Kaplan-Meier curves were used to assess the cumulative survival rate of patients with these risk factors. External validation was conducted in 40 patients with SFTS who were admitted to an affiliated branch hospital during the same period. The 28-day mortality rate was 37.3% (97/260). Multivariate analysis revealed age (HR = 1.053; 95% CI 1.027-1.079; P < 0.001), viral load (HR = 2.006; 95% CI 1.684-2.390; P < 0.001), and UREA (HR = 1.059; 95% CI 1.027-1.093; P < 0.001) as independent risk factors. The area under the curve (AUC) of the nomogram was 0.900 (95% CI 0.861-0.937), with 82.5% sensitivity and 84.0% specificity at the optimal cutoff (0.292). The calibration curve showed close agreement between the predicted and observed probability lines, indicating good model calibration. External validation yielded an AUC of 0.863 (95% CI 0.723-0.954), confirming favorable performance. Renal injury-related indicators at admission were strongly associated with fatal outcomes in patients with SFTS. Nomograms based on age, viral load, and UREA provide accurate and easily applicable tools for early risk stratification and may support individualized clinical management.

PubMedbioRxiv : the preprint server for biology2026-07-17

Structural Mechanism of Filamentation Induced Dampening of GTP Inhibition of Glutamate Dehydrogenase.

Shan Zelin Z, Darwish Noura I NI, Rivero-Gamez Andres A, Strutzenberg Timothy S TS et al.

Glutamate dehydrogenase (GDH) is a highly regulated key enzyme that catalyzes the reversible oxidative deamination of glutamate to α-ketoglutarate, positioning it at a critical hub linking amino acid catabolism to energy production while supplying ammonia for urea synthesis and other nitrogen pathways. Early investigations have shown that bovine GDH (bGDH), which shares 98% sequence identity with its human homolog, assembles into polymeric filaments with altered allosteric responses. Filamentation has only relatively recently been appreciated as a widespread mechanism of enzyme regulation, prompting a reevaluation of these early observations in GDH. Here, we use high-resolution cryogenic electron microscopy (cryo-EM) to show that bGDH hexamers assemble via reciprocal "antenna" interactions that oppose the conformational changes associated with GTP inhibition, revealing how filamentation reshapes GDH allostery and with implications for the treatment of human disease.

PubMedAngewandte Chemie (International ed. in English)2026-07-17

A Chemically Fueled Logic Gate With Temporally Programmable Output Delays by Harnessing Transient States of One Molecule in Two Independent Reaction Pathways.

Dong Junjie J, Pan Chunyu C, Duan Yixiong Y, Liu Donghao D et al.

Temporal output delays in logic gates are ubiquitous in biological systems, especially in the nervous system, which sustains the signal transmission with enhanced computational complexity and transmission accuracy. However, temporally programmable output delays in chemically fueled logic gates (CFLGs) have not been achieved in an artificial system. Here, we report a bioinspired CFLG with programmable time delays of the output signal by harnessing transient states of the same molecule in two independent reaction networks. The CFLGs show programmable transient states by regulating reaction networks of urea-urease and adenosine triphosphate and potato apyrase, respectively. Notably, a transient state with delayed output emerges, mimicking the signal processing in the synaptic delay of biological systems. A self-destructive information encryption with enhanced coding capacity and safety is achieved in the arrays of CFLGs with spatiotemporally programmable output states. The findings in this work expand the range of non-equilibrium soft materials and will accelerate the development of innovative materials that can execute exquisite logic functions with enhanced coding capacity and biomimetic time delays.

PubMedEcotoxicology and environmental safety2026-07-17

Associations of neonicotinoid exposure with renal function: A cross-sectional study with long-term toxicological validation.

Fu Jiaming J, Wang Hao H, Li Honghui H, Qiao Guojie G et al.

Neonicotinoids (NEOs) continuously exert chronic effects on human health, yet their impacts on renal function remain understudied. This study investigates the association between NEOs and renal function utilizing an integrated epidemiological and toxicological approach. Urinary NEOs and their characteristic metabolites were quantified using ultra-performance liquid chromatography-tandem mass spectrometry in 847 individuals from a Yinchuan community-dwelling elderly cohort. Multiple epidemiological models were employed to systematically evaluate both single and mixed exposure associations with renal parameters. Concurrently, a long-term imidacloprid (IMI) exposure mouse model (based on human equivalent exposure, 103 μg/kg/day) was established to validate the epidemiological findings. The population study revealed significant positive associations between all measured NEOs and serum uric acid (UA) levels (P < 0.05). In mixture analyses, IMI-olefin was identified as the predominant contributor to elevated UA and the primary driver of decreased estimated glomerular filtration rate among all NEOs. In animal models, environmentally relevant IMI exposure functionally validated these findings by significantly elevating UA and blood urea nitrogen levels (P < 0.05). Collectively, low-dose NEOs exposure is positively associated with renal dysfunction in elderly adults, a risk corroborated by murine models at population-relevant exposure levels.

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