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OX

Oxalyt-C

✓ Approved

Rottapharm Madaus · Small Molecule · Small Molecule

What is Oxalyt-C?

Oxalyt-C is a small molecule developed by Rottapharm Madaus. It is approved for therapeutic indications.

Drug Profile

CompanyRottapharm Madaus
Drug ClassSmall Molecule
StatusApproved
Sources: ClinicalTrials.gov, Rottapharm Madaus

Therapeutic Indications

Oxalyt-C is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Renal and urinary disordersCalculus urinary✓ Approved

Related Research Articles

PubMedAndrology2026-07-17

Comparative Analysis of In Vitro Aging in Liquid-Preserved Boar and Bull Semen Stored at 5°C and 16°C.

Khan Muhammad Umair MU, Neubert Marie Luis ML, Henneberg Sophie S, Jung Markus M et al.

Although the prolonged liquid preservation of porcine and bovine semen is an attractive alternative to cryopreservation, the quality of the semen deteriorates over time due to in vitro aging. To investigate the in vitro aging of porcine and bovine sperm after prolonged liquid preservation at 5°C and 16°C. Semen was collected from 10 Piétrain boars and 10 Holstein Friesian bulls. After dilution (boar: Androstar Premium; bull: Caprogen), semen samples (boar: 20 × 106/mL; bull: 40 × 106/mL sperm) were divided into two portions, which were stored at 5°C and 16°C for 6 days. Basic sperm quality parameters, such as progressive motility, thermo-resistance after 30 (TRT30) and 120 (TRT120) min at 38°C, and sperm morphology, as well as advanced multicolor assays, were examined on Days 1, 3, and 6 to evaluate viability, acrosome integrity, plasma membrane fluidity, intracellular calcium levels, and mitochondrial membrane potential. The data analysis was done using a general linear model (GLM) with repeated measures. Compared to 5°C, boar semen showed significantly higher values for TRT120, viable and acrosome-intact sperm with low membrane fluidity and intracellular calcium (VAI-LMLC), and VAI with high mitochondrial membrane potential (VAI-HMMP) at 16°C. Bull semen demonstrated superior quality when stored at 5°C. The GLM revealed significantly higher values for TRT30, TRT120, morphology and VAI on Day 3 at 5°C compared to 16°C. Over the course of all storage days, the mean values of VAI-LMLC and VAI-HMMP were significantly higher at 5°C. Although basic semen quality could be maintained for 6 days in liquid-preserved boar and bull semen, advanced semen quality parameters revealed differences in the in vitro aging of boar and bull sperm that were specific to species and storage temperature.

PMID 42466730
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PubMedHLA2026-07-17

The Novel HLA-C*01:02:01:78 Allele Identified in a Greek Haematopoietic Stem Cell Donor.

Kouniaki Diamanto D, Kitsiou Vasiliki V, Tsirogianni Alexandra A

The HLA-C*01:02:01:78 allele differs from HLA-C*01:02:01:01 by a single nucleotide substitution in 3' UTR.

PMID 42463456
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PubMedPhysiological research2026-07-17

Impact of Co-Supplementation of Gallic Acid With Vitamin C on Oxidant Stress, Inflammation, Hepatic and Renal Histology of Type 2 Diabetic Rats Induced With Fructose and Streptozotocin.

Yan S S, Xiang X X, Hua W W

This study assessed the impact of gallic acid plus vitamin C on systemic oxidant stress, inflammation, hepatic and renal histology of rats with type 2 diabetes mellitus. Twenty five albino male rats were allotted into five categories of five rats each and treated hereafter as: control and diabetic group (fed rat diets and water), vitamin C (diabetic treated rats administered vitamin C, 50 mg/kg), gallic acid (diabetic treated rats administered gallic acid at 20 mg/kg), gallic acid plus vitamin C (diabetic treated rats administered 20 mg/kg gallic acid and 50 mg/kg vitamin C). The study duration was forty two days. The diabetic group had significant raise (P<0.05) of fasting glucose, glycated hemoglobin, insulin resistance scores, oxidative stress and inflammatory markers (in the liver, kidney and serum), alteration of relative liver and kidney weights, liver and kidney function indices, significant decrease (P<0.05) in total hemoglobin, serum insulin, insulin sensitivity and pancreatic beta cell function scores, body weights and pathological changes in their liver and kidney histology. These changes were ameliorated following supplementation of the diabetic group with gallic acid, vitamin C and gallic acid plus vitamin C combined treatment. Intervention with vitamin C was more efficacious than gallic acid. However, combined treatment of gallic acid plus vitamin C was more efficacious than the single treatments in modulating systemic and local oxidative stress, inflammation and in restoring the altered liver and kidney histology of the diabetic rats. Key words Antioxidants " Type 2 diabetes mellitus " Diabetic liver disease " Diabetic kidney complication " Natural products.

PMID 42466700
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PubMedEuropean journal of psychotraumatology2026-07-17

Clinicians' experiences in diagnosing and treating complex post-traumatic stress disorder in adults: a reflexive thematic analysis.

Ahern John J, Fortune Donal G DG

Background: Complex post-traumatic stress disorder (C-PTSD) has been included in the International Classification of Diseases, 11th revision (ICD-11) to recognize the impact of significant trauma(s) on an affected individual. C-PTSD has the core symptoms of post-traumatic stress disorder (PTSD) with additional symptoms of disturbances of self-organization. While the ICD-11 has been in use globally since 2022, research is limited on how clinicians working in routine adult mental health (AMH) services adapt to diagnosing and treating C-PTSD.Objective: To investigate the experiences of clinicians in applying and treating C-PTSD with adults in a public AMH setting.Method: A reflexive thematic analysis approach was used to code and analyse results from semi-structured interviews conducted with 20 psychologists and psychiatrists.Results: Three key themes were identified from clinicians' experiences: (1) 'C-PTSD is beyond a simple diagnosis', reflecting challenges regarding understanding trauma history and differential diagnosis; (2) 'Balancing treatment on a tightrope', highlighting trust as a foundation required in the therapeutic relationship before attempting trauma processing through various treatment modalities; and (3) 'Resourcing for C-PTSD treatment success', emphasizing how adequate resources, regular supervision, training, and attuned trauma services are needed to overcome barriers to treatment of C-PTSD in public AMH settings.Conclusions: Clinicians reported key challenges in working with C-PTSD diagnosis in AMH settings. While clinicians are aware of the diagnostic criteria, building a therapeutic relationship with C-PTSD clients remains a challenge before engaging in effective interventions. The need for adequate access to resources, such as evidence-based treatment pathways, further training on C-PTSD across multidisciplinary teams, regular supervision, and trauma-informed services that are attuned to individuals' needs, is a key issue for clinicians that requires addressing in public AMH services.

PMID 42464788
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PubMedFrontiers in pharmacology2026-07-17

Intraperitoneal administertion: compatibility and stability of common antibiotics in amino acid-based peritoneal dialysate.

Zhang Bohua B, Zhong Lichao L, Zhou Xueli X, Zhong Hui H et al.

The preferred method of antibiotic administration for peritoneal dialysis-related peritonitis is intraperitoneal. However, there are few studies on the compatibility of antibiotics in amino acid-based peritoneal dialysate. Our study employed High Performance Liquid Chromatography (HPLC) and amino acid analyzer to evaluate the stability of different antibiotics in amino acid-based peritoneal dialysate. We also used the two-dose method to detect the antimicrobial potency of gentamicin. Gentamicin, ciprofloxacin, heparin Sodium and fluconazole showed excellent stability under different conditions (14 days at 4 °C: ≤3.57%, 14 days at 25 °C: ≤3.77%). β-Lactam antibiotics including meropenem, ceftazidime, cefotaxime, and aztreonam showed significant degradation, especially at high temperature (37 °C)(14 days at 4 °C: ≤59.98%, 14 days at 25 °C: 19.06%-84.97%, except for aztreonam demonstrating degradation at 48 h at 37 °C (18.51%-41.88%). Among them, meropenem was the least stable (14 days at 4 °C: 59.98%, 14 days at 25 °C: 84.97%). Low concentration vancomycin is relatively stable, while medium and high concentration vancomycin has poor stability (14 days at 4 °C 500 mg/L: 45.8%, 1 g/L 27.7%). Most amino acids remained basically stable under different antibiotic environments. We counted the degradation rate of all amino acids under different conditions. The maximum degradation rate appeared on glycine, but it was only 8.21%. Finally, we also found that the antibacterial efficacy of gentamicin in acid-based peritoneal dialysate was enhanced. Most antibiotics are stable in amino acid-based peritoneal dialysate. However, β-lactams (especially meropenem, ceftazidime, and cefotaxime) and medium-to-high dose vancomycin showed significant degradation and require prompt administration. The nutritional amino acid profile in dialysate remains largely unaffected. Gentamicin demonstrates enhanced antibacterial activity in the amino acid-based peritoneal dialysate.

PMID 42465997
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PubMedCellular and molecular life sciences : CMLS2026-07-17

Upregulation of PTPRO by WT1 alleviates podocyte injury in diabetic nephropathy through inhibiting the c-Abl/p53 pathway.

Guo Hengjiang H, Wang Li L, Tong Yiru Y, Jiang Yan Y et al.

Podocyte injury plays a central role in the pathogenesis of diabetic nephropathy (DN). Protein tyrosine phosphatase receptor type O (PTPRO) has been implicated in glomerular disease, yet its specific role and regulatory mechanism in DN remain poorly understood. Here, we demonstrated that PTPRO expression was significantly downregulated in the glomeruli of DN mice and patients with DN, as well as in cultured podocytes exposed to diabetic stressors. Functional studies revealed that Ptpro knockdown induced podocyte injury, characterized by reduced Nephrin and Podocin expression, increased apoptosis, actin cytoskeleton disruption, enhanced migration, and reduced adhesion. Conversely, PTPRO overexpression ameliorated high glucose (HG)-induced podocyte damage. Mechanistically, PTPRO interacted with and dephosphorylated c-Abl, thereby suppressing the c-Abl/p53 signaling pathway. Pharmacological activation of c-Abl abolished the protective effects of PTPRO. Furthermore, we identified PTPRO as a direct transcriptional target of WT1, a podocyte master transcription factor downregulated in DN. WT1 overexpression restored PTPRO expression, suppressed c-Abl/p53 signaling, and ameliorated HG-induced podocyte injury in vitro. In vivo, podocyte-specific overexpression of WT1 via adeno-associated virus delivery in db/db mice attenuated proteinuria, glomerulosclerosis, and podocyte foot process effacement, accompanied by restored PTPRO expression and inhibition of the c-Abl/p53 pathway. Collectively, these findings establish that PTPRO functions downstream of WT1 to protect podocytes in DN by suppressing c-Abl/p53 signaling. Targeting the WT1-PTPRO-c-Abl-p53 axis may represent a novel therapeutic strategy for DN.

PMID 42463527
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