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OX

Oxalyt-C

✓ Approved

Rottapharm Madaus · Small Molecule · Small Molecule

What is Oxalyt-C?

Oxalyt-C is a small molecule developed by Rottapharm Madaus. It is approved for therapeutic indications.

Drug Profile

CompanyRottapharm Madaus
Drug ClassSmall Molecule
StatusApproved
Sources: ClinicalTrials.gov, Rottapharm Madaus

Therapeutic Indications

Oxalyt-C is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Renal and urinary disordersCalculus urinary✓ Approved

Related Research Articles

PubMedAtherosclerosis plus2026-10-15

Lipoprotein(a) and early LDL-cholesterol target attainment after a first acute coronary syndrome: a real-world cohort study.

Riera-Molist Núria N, Puigoriol Juvanteny Emma E, Swedzky Federico F, Goutan-Roura Ester E et al.

Despite intensive lipid-lowering therapy, early attainment of the guideline-recommended LDL-cholesterol (LDL-C) target after acute coronary syndrome (ACS) remains suboptimal. Baseline factors associated with early LDL-C target attainment remain incompletely characterized, particularly the role of lipoprotein(a) [Lp(a)]. We aimed to assess early LDL-C target attainment after a first ACS and identify baseline factors associated with target attainment, with a particular focus on Lp(a). We conducted a retrospective cohort study of consecutive hospitalized adults with a first ACS undergoing percutaneous coronary intervention between January 2025 and April 2026. The primary endpoint was attainment of the guideline-recommended LDL-C target at early follow-up, defined as LDL-C < 55 mg/dL and a ≥ 50% reduction from baseline. Associations between clinical variables and LDL-C target attainment were assessed using multivariable logistic regression. Eighty-two patients were included; 70.7% were male and 37.2% had elevated Lp(a) levels. At a median follow-up of 5 weeks (IQR, 4-6), 31.7% attained the LDL-C target despite prescription of high-intensity statin therapy at discharge. In the multivariable model, low Lp(a) (OR 8.72; 95% CI 2.04-37.33), current smoking (OR 5.29; 95% CI 1.42-19.69), and ezetimibe use in addition to high-intensity statin therapy at discharge (OR 5.28; 95% CI 1.31-21.32) were associated with LDL-C target attainment. Early LDL-C target attainment after a first ACS remained limited despite routine prescription of high-intensity statin therapy. Elevated Lp(a) was associated with a lower likelihood of attaining the LDL-C target. Prospective studies are needed to confirm these findings.

PMID 42876442
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PubMedAdvanced materials (Deerfield Beach, Fla.)2026-10-15

Solvation-Equilibrium Locking Enables Ultrawide-Temperature Operation of High-Voltage Lithium-Metal Batteries.

Dong Qingyu Q, Chen Nan N, Li Yang Y, Li Li L et al.

High-energy lithium metal batteries are promising for space, polar, deep-sea, and other extreme environments, but their operation is constrained by temperature-sensitive ion transport, Li+ solvation, and interfacial chemistry. A solvation-equilibrium-locked electrolyte (SELE) is reported by combining dimethyl sulfite (DMS), a low-freezing weakly solvating solvent, with Pyr13DFOB (1-methyl-1-propylpyrrolidinium difluoro(oxalato)borate) as an ionic-liquid co-solvent. Cooperative ion-dipole and weak C-H⋯O interactions between DMS and Pyr13 + regulate the free-solvent reservoir, while TFSI- (bis(trifluoromethanesulfonyl)imide) and DFOB- enrich the primary Li+ coordination shell. Variable-temperature 7Li NMR, Raman, and molecular dynamics simulations show that solvent-separated ion pairs, contact ion pairs, and aggregates remain nearly invariant from -60°C to 60°C, unlike the strongly temperature-responsive Pyr13DFOB-free electrolyte. This locked anion-rich solvation structure reduces solvent coordination around Li+, mitigates solvent-derived interfacial decomposition and gas evolution, and promotes LiF- and borate-rich interphases on Li metal and NMC811. Consequently, Li||NMC811 cells deliver discharge capacity at -85°C and operate up to 120°C, while pouch cells remain functional after cooling to -122.9°C. A 6.6 Ah Li||Ni90 pouch cell further achieves 565 Wh kg-1 under lean-electrolyte conditions, establishing solvation-equilibrium locking as a molecular design principle for lithium metal batteries operating over a broad temperature range.

PMID 42876209
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PubMedFrontiers in plant science2026-10-15

Partitioning photoperiod- and chilling-driven cold hardiness in a Vitis riparia × V. vinifera F1 population.

Delavar Hava H, Kaya Ozkan O, Riaz Summaira S, Hatterman-Valenti Harlene H

Grapevine cold hardiness governs cultivar distribution and winter survival, and is a key constraint on viticulture in cold regions. We evaluated bud cold hardiness in a Vitis riparia × Vitis vinifera F1 population by differential thermal analysis across three environments (a California vineyard, an NDSU field, and an NDSU greenhouse), sampled nine times through the 2023-2024 dormant season. Mean low-temperature exotherms (LTEs) differed significantly among sampling times, and hierarchical clustering separated the genotypes into five hardiness classes defined by mean LTE, from very hardy (≤ -21.4 °C) to very susceptible (≥ -13.4 °C). Field vines reached a midwinter maximum of -22.7 °C, whereas greenhouse vines were most susceptible (-14.6 °C), and nine genotypes were hardier than the tender parent. Genotype accounted for only 7% of the phenotypic variance, giving a low single-observation heritability (H²i = 0.07) but a moderate entry-mean heritability (H²c = 0.49), which are distinct statistics reported separately. The seasonal trajectory was well described by logistic and response-surface models (R² = 0.99) and, on an accumulated-chilling axis, by a Weibull model (half-hardening at 184 chilling degree-days). A state-space model estimated the chilling contribution at ≈6.7 °C and identified three genotypes (536-078, 539-127, 536-142) that attained most of their hardiness under the short-day, moderate-cooling greenhouse regime without sub-zero exposure; because that regime combined shortening photoperiod with a 4 °C decline, these are described as short-day/low-temperature responsive rather than photoperiod-responsive. Mean hardiness and plasticity were uncorrelated, providing no evidence of a hardiness-stability trade-off. The December field and greenhouse samplings exposed the greatest among-genotype variance and are the most informative conditions for future QTL mapping; the nine genotypes hardier than the tender parent, and a hardy, stable subset, are identified as parents for cold-hardiness introgression.

PMID 42876794
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PubMedFrontiers in pain research (Lausanne, Switzerland)2026-10-15

Comparative evaluation of the antipyretic and analgesic efficacy and safety of a fast-release paracetamol 650 mg formulation vs. conventional paracetamol formulations in adults with acute febrile or febrile-pain conditions: a multicenter randomized controlled trial.

Mondal Susobhan S, Ikbal S K Ashik SKA, Agrawal Sumit S, Raykantiwar Amar A et al.

Paracetamol is widely used for management of fever/pain. With increasing emphasis on rapid symptom relief, this study compared the response following a single 650 mg oral dose of four commercially available tablets in acute febrile and febrile-pain conditions. This multicenter, open-label trial (CTRI/2025/12/098995) included adults (18-60 years) with oral temperature ≥38 °C (with/without pain) and symptom onset within ≤72 h. Consenting participants were randomized (1:1:1:1) to receive a single dose of the test fast release test paracetamol (A) and conventional paracetamol (B, C, D) drug. Oral body temperature(digital thermometer) and pain (numerical rating scale (NRS) were assessed at predefined intervals till 90 ± 2 min. Outcomes included magnitude and onset of antipyretic and analgesic effects, adverse events (AEs), and patient satisfaction. Among 220 febrile participants (55% women; mean temperature 38.51 °C), 169 reported pain (mean NRS score 7.31). At 90 ± 2 min, fast release paracetamol demonstrated significantly greater reduction in temperature (1.54 °C), along with the fastest rate of decline (1.03 °C/hr), and the shortest restricted mean time to defervescence (84.27 min), resulting in majority of participants (60.0%) experiencing defervescence (temperature ≤37 °C). Pain reduction was also significantly greater with fast release test paracetamol (5.2 units; 3.4 units/hr), with onset of analgesia (≥30% reduction in NRS score) after a comparatively shorter median time (30 min; conventional, 60-90 min). By 90 ± 2 min, pain resolved (NRS score = 0) in 23.2% (A), 22.5% (B), 11.9% (C), and 6.8% (D) participants, with restricted mean times to resolution being 90.00, 89.25, 89.29, and 90.00 min, respectively. Overall, 82.2% participants reported treatment satisfaction, with likelihood highest for fast-release test paracetamol (A). Four participants reported unrelated, mild/moderate AEs. All evaluated paracetamol 650 mg formulations demonstrated antipyretic and analgesic activity within 90 min, while the fast-release formulation showed earlier and, for several assessed outcomes, greater reductions in temperature and pain. These findings may support consideration of formulation choice when rapid early symptomatic relief is desired. CTRI/2025/12/098995.

PMID 42876821
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PubMedHuman mutation2026-10-15

Rapid and Sensitive Detection of USP26 Cluster Variants Based on CRISPR/Cas12a.

Li Ning N, Huo Yongkun Y, Zhao Yanan Y, Liu Chao C et al.

USP26 gene variants have been reported to be associated with male infertility, such as non-obstructive azoospermia (NOA), oligozoospermia, and asthenoteratozoospermia, and may be associated with altered sperm sex chromosome segregation patterns. Among the reported variants, USP26 cluster variants (c.370_371insACA/c.494 T > C/c.1423C > T) represent a frequently reported variant pattern in certain populations. Rapid and convenient detection of USP26 cluster variants may serve as a powerful tool for male infertility-associated cohorts. Here, we develop a CRISPR/Cas12a-based assay to rapid detection USP26 variants in human samples. Candidate CRISPR RNAs (crRNAs) and RPA primers were screened and optimized, followed by incorporation of restriction enzymes to reduce wild-type-derived amplification interference. Using controlled artificial DNA mixtures, the assay detected mutant-template fractions down to 5% under the tested conditions. The complete workflow could be performed within 60 min using basic laboratory equipment. The results of the CRISPR/Cas12a system are consistent with Sanger sequencing in 91 male infertility research samples. Overall, our study establishes a rapid molecular detection method for detecting USP26 cluster variants and provides an alternative approach for genetic studies of male infertility-associated cohorts.

PMID 42876898
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PubMedRenal failure2026-10-15

Association of the triglyceride-to-high-density lipoprotein cholesterol ratio with kidney stone status: cross-sectional and machine-learning analyses.

Liang Hu H, Hu Dekai D, Zhang Junzhi J, Yi Xincheng X et al.

This study investigated the association between triglyceride-to-high-density lipoprotein cholesterol ratio (TG/HDL-C) and kidney stone status and evaluated its contribution to multivariable classification models. A total of 1,174 patients from the First Affiliated Hospital of Anhui Medical University were included, with kidney stone status confirmed by urological imaging. Multivariable analyses were used to assess the association between TG/HDL-C and kidney stone status. Supplementary population-based analyses were conducted using weighted data from the National Health and Nutrition Examination Survey (NHANES). Seven machine-learning models were developed and internally evaluated within the clinical cohort, and SHapley Additive Explanations (SHAP) were used to interpret model outputs. In the clinical cohort, a higher TG/HDL-C ratio was associated with greater odds of kidney stone status after multivariable adjustment (OR, 2.16; 95% CI, 1.73-2.70). The association was generally consistent across subgroups defined by age, sex, body mass index, hypertension, and diabetes, with no significant interactions observed. A directionally similar association was identified in the weighted NHANES analysis (OR, 1.04; 95% CI, 1.01-1.07). Among the evaluated machine-learning models, the random forest model achieved the highest area under the receiver operating characteristic curve in the internal validation set (AUROC, 0.818; 95% CI, 0.775-0.859). SHAP analysis identified the TG/HDL-C ratio as an important contributor to model classification. These findings indicate that the TG/HDL-C ratio is an accessible metabolic marker associated with kidney stone status. However, the observational design precludes causal inference, and prospective studies with external model validation are warranted.

PMID 42876265
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