Sumitomo Pharma Co., Ltd. · Small Molecule · Small Molecule
miriplatin hydrate is a small molecule developed by Sumitomo Pharma Co., Ltd.. It is approved for therapeutic indications via injectable (others) or intraarterial injection.
| Brand Names | miriplatin hydrate, SMP 11355, Miripla |
| Company | Sumitomo Pharma Co., Ltd. |
| Drug Class | Small Molecule |
| Route | Injectable (Others), Intraarterial Injection |
| Status | Approved |
miriplatin hydrate is developed for 1 unique indication across 1 therapeutic area.
| Therapeutic Area | Condition | Phase |
|---|---|---|
| Neoplasms benign, malignant and unspecified (incl cysts and polyps) | Hepatic cancer | ✓ Approved |
Jiang Chenyu C, Xu Yunlong Y, Zhong Jiafeng J, Wu Junyan J et al.
[This corrects the article DOI: 10.3389/fnmol.2022.934167.].
Song Zhuoran Z, Zhang Haoqi H, Yang Xiaoqin X, Rao Xiaoping X et al.
As a key chemical raw material, hydrazine hydrate (N2H4) is widely used in chemical manufacturing, aerospace propulsion and pharmaceuticals synthesis. However, excessive N2H4 causes serious harms to the environment and organisms. Herein, a ratiometric fluorescence probe CDP has been designed and synthesized from p-hydroxycinnamic acid. Upon interaction with N2H4, the major fluorescence emission peak at 570 nm is blue-shifted to 455 nm, accompanied by a fluorescence color change from pale orange to blue. The detection limit of CDP for N2H4 is determined as 17.08 nM. Experimental data further indicate that probe CDP can effectively detect N2H4 across a broad pH range (5-12). More notably, probe CDP demonstrates significant potential for imaging N2H4 in living cells and mice models. Moreover, probe CDP can be employed for the detection of N2H4 in soil samples and water samples. This work describes a versatile fluorescence probe for detecting N2H4, underscoring its considerable potential in environmental analysis and public health monitoring.
Bouzouaid Samia S, Charrak Hicham H, Belakhdar Ahmed Rafik AR, Rekbi Fares Mohammed Laid FML et al.
Sabkha soils, widely distributed in arid coastal regions, are characterized by high salinity, metastable structure, and low bearing capacity, posing significant challenges for geotechnical applications. Although sustainable stabilization methods have been increasingly explored, the application of alkali-activated waste glass powder (WGP) to highly saline sabkha soils, with emphasis on linking engineering performance to microstructural characteristics, remains insufficiently investigated. This study investigates the effectiveness of alkali-activated WGP as a sustainable and environmentally beneficial stabilizer for sabkha soil. WGP was incorporated at 10-30% by dry soil mass and activated using a sodium silicate-sodium hydroxide solution (Na₂SiO₃: NaOH = 2:1). The treated soils were evaluated through Standard Proctor compaction, California Bearing Ratio (CBR) under soaked and unsoaked conditions, and unconfined compressive strength (UCS) at curing periods up to 90 days, complemented by Scanning Electron Microscopy coupled with Energy Dispersive Spectroscopy (SEM-EDS) analysis. The results reveal a property-dependent optimum WGP content. The highest CBR was achieved at 10% WGP (290% under soaked conditions and 180% under unsoaked conditions), while maximum UCS was obtained at 20% WGP, reaching 3550 kPa at 90 days. Although the untreated sabkha soil exhibited relatively high soaked CBR due to temporary salt-induced bonding, alkali activation provided a more stable cementation mechanism, resulting in improved mechanical performance. This distinction indicates that bearing resistance and compressive strength are governed by different mechanisms of stabilization. Excess WGP content (30%) led to reduced performance due to incomplete activation and disruption of particle interlocking. SEM-EDS observations indicated the development of a denser and better-bonded matrix that is consistent with the possible formation of sodium aluminosilicate hydrate (N-A-S-H) gel, accompanied by reduced pore connectivity and improved load transfer. The findings demonstrate that alkali-activated WGP provides an effective and more sustainable approach for stabilizing highly saline sabkha soils, highlighting the importance of property-dependent binder optimization for ground improvement in saline environments.
Gambe Yoshiyuki Y, Ohno Saneyuki S, Honma Itaru I
Lithium croconate molecules (C5O5Li2), a 4 V-class high-voltage organic cathode material, offer a possibility to develop high-energy-density, rare-metal-free, and environmentally friendly organic secondary batteries. However, organic molecules generally have a serious problem of dissolution into electrolytes, leading to poor cycling performance. Here, we demonstrate the water-based hydrate-melt electrolyte for improving cycling performance of organic batteries and evaluate the relationship between battery performance and solubility behavior of croconate molecules into the electrolytes. Hydrate-melt electrolyte Li(TFSI)0.7(BETI)0.3(H2O)2 effectively suppresses the dissolution of pristine C5O5Li2 and C5O5 molecules (in their two-electron charged state), leading to improved cycling performance and coulombic efficiency. This result can be ascribed to the unique solution structure having less free-water in hydrate-melt electrolytes. Moreover, a C5O5Li2/Li4Ti5O12 cell with hydrate-melt electrolyte exhibits an ultrafast redox reaction with no capacity fading at higher C-rate up to 10 C. This insight is beneficial to construct high-power and high-energy-density croconate-based storage systems.
Han Youmin Y, Zhao Yunlong Y, Han Beiping B, Jiang Li L et al.
This study experimentally investigated the stabilization mechanisms and structure formation models of high-water-content soft soils (>70%) treated with ordinary Portland cement, sulfur aluminate cement, gypsum, and lime. Fifteen single- and composite-stabilizer systems were evaluated using unconfined compressive strength (UCS) tests and microstructural analyses, including SEM, XRD, TG-DTG, and FTIR analyses. The results show that stabilized soils containing cementitious components exhibit significantly higher strength due to the formation of calcium silicate hydrate (C-S-H) gel, which effectively binds soil particles. The addition of sulfur aluminate cement, gypsum, and lime promotes rapid hydration and generates abundant ettringite (AFt) crystals with strong water absorption capacity, contributing to early strength development. Based on these findings, a composite stabilizer (ECS) combining cement with appropriate proportions of sulfur aluminate cement, gypsum, and lime is proposed, achieving substantial improvements in both early and long-term strength. The stabilization process proceeds in two stages: rapid AFt formation absorbs free water and fills large pores to form a three-dimensional network, and then C-S-H gel cementation integrates the soil-AFt framework into a dense and coherent structure. The study provides mechanistic insight and a theoretical basis for stabilizing high-water-content soft soils in coastal and riparian engineering applications.
Wang Wei W, Zhou Shidong S, Li Xiaoyan X, Liu Haode H et al.
Gas hydrate formation and deposition in deepwater-oil and gas pipelines is a major threat to flow assurance. The adhesion between hydrate particles and the pipe wall is a key factor governing the hydrate deposition and blockage. Condensed water is ubiquitous on pipeline walls under practical operating conditions, yet its' influence on the hydrate formation and deposition remains unclear. In this study, the adhesion between cyclopentane hydrate particles and different carbon steel surfaces was studied in a micromechanical adhesion test apparatus. The adhesion behaviors of hydrate particles were compared on bare carbon steel, corroded carbon steel, epoxy-coated carbon steel, and epoxy-coated carbon steel with HKUST-1 loading, with emphasis on the roles of surface wettability and liquid bridges. The results show that the presence of condensed water increased the adhesion between hydrate particles and the wall from approximately 3.6 mN/m to 21.7-29.6 mN/m, depending on the corrosion degree of the surfaces. On epoxy-coated surfaces, the adhesion was reduced to 18.2 mN/m under the same condensed water condition, while further loading with HKUST-1 lowered it to 12.7 mN/m, representing a 30-57% reduction compared to uncoated corroded surfaces. The surface corrosion of carbon steel modified the wettability, which facilitated the retention of condensed water, resulting in the formation of a stable liquid layer on the surface of carbon steel. Thus, the liquid-bridge interactions were strengthened, and the adhesion was improved. When a liquid layer was present, the epoxy coating markedly reduced the adhesion by weakening liquid-bridge forces. On the surface of the epoxy coating, the further loading of HKUST-1 could reduce the thickness of the liquid layer, thereby reducing liquid-bridge forces and making the antiadhesion performance of carbon steel more stable. This work provides experimental evidence for selecting and designing surface-protection materials to prevent gas hydrate deposition and blockage in deepwater pipelines.
+9996 more articles available with a free account
Sign up free to view all articles →