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miriplatin hydrate (miriplatin hydrate / SMP 11355 / Miripla)

✓ Approved

Sumitomo Pharma Co., Ltd. · Small Molecule · Small Molecule

What is miriplatin hydrate?

miriplatin hydrate is a small molecule developed by Sumitomo Pharma Co., Ltd.. It is approved for therapeutic indications via injectable (others) or intraarterial injection.

Drug Profile

Brand Namesmiriplatin hydrate, SMP 11355, Miripla
CompanySumitomo Pharma Co., Ltd.
Drug ClassSmall Molecule
RouteInjectable (Others), Intraarterial Injection
StatusApproved
Sources: ClinicalTrials.gov, Sumitomo Pharma Co., Ltd.

Therapeutic Indications

miriplatin hydrate is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Neoplasms benign, malignant and unspecified (incl cysts and polyps)Hepatic cancer✓ Approved

Related Research Articles

PubMedRSC advances2026-08-28

A redox additive gel-polymer electrolyte and vanadium oxide hydrate electrode material for quasi-solid state asymmetric supercapacitor.

Arumugam Gowdhaman G, Mathan Stanleydhinakar S, Dhandapani Elumalai E, Murugesan Vijayan V et al.

Herein, we prepared layered vanadium oxide hydrate (VOH), a vanadium pentoxide-based electrode material for supercapacitor applications. The VOH electrode showed a specific capacity of 77.6 C g-1 at 4 A g-1 in a 3 M KOH electrolyte solution. Furthermore, the enhancement of the electrochemical performance of the VOH was achieved by adding K3[Fe(CN)6] to the electrolyte as a redox additive. Among the various concentrations, the VOH electrode showed a specific capacity of 1085.9 C g-1 at 4 A g-1 in a 3 M KOH containing 75 mM K3[Fe(CN)6] electrolyte. The performance enhancement was attributed to the eased diffusion of ferricyanide species into the hydrated, enlarged interlayer structure of the active material. Additionally, the [Fe(CN)6]3-/[Fe(CN)6]4- redox pair contributed to the charge-storing process through reversible redox reactions in the electrolyte. Moreover, a quasi-solid-state asymmetric supercapacitor was constructed by employing VOH as positive electrode, activated charcoal (AC) as negative electrode, and PVA/KOH/K3[Fe(CN)6] as gel-polymer electrolyte (GPE). The constructed device displayed a specific capacity of 105.2 C g-1 at 1 A g-1 and delivered a maximum energy density of 24.8 Wh kg-1 at 850 W kg-1 power density with a cell voltage of 1.7 V. The outcomes of this work suggest a viable strategy for the rational design of next-generation high-performance energy storage systems.

PMID 42662591
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PubMedJournal of clinical medicine2026-08-27

Adjunctive Fasudil Use and Outcomes After Clazosentan Treatment for Aneurysmal Subarachnoid Hemorrhage: A Multicenter DCI Japan Registry Study.

Matsuda Shingo S, Katsuki Masahito M, Inoue Yusuke Y, Hidaka Toshikazu T et al.

Background/Objectives: Subarachnoid hemorrhage (SAH) is frequently complicated by cerebral vasospasm (VS). Clazosentan reduces VS, and fasudil hydrochloride hydrate (Fasudil) is widely used for VS prevention in Japan. However, the benefit of adding Fasudil to clazosentan remains unclear. We investigated whether adjunctive Fasudil was associated with VS-related and functional outcomes in clazosentan-treated aneurysmal SAH. Methods: We retrospectively analyzed data from the multicenter "Database of Cohort Study for Outcome of SAH in Japan," collected from 2020 to 2024. Patients with aneurysmal SAH who underwent surgical clipping or endovascular coiling within 4 days of onset and completed 14 days of clazosentan treatment were included. Outcomes were compared between clazosentan plus Fasudil and clazosentan alone. Multivariable logistic regression assessed factors associated with angiographic vasospasm (AVS), cerebral infarction, and poor functional outcome (modified Rankin Scale 3-6) at discharge and 6 months. Results: Among 341 patients, 100 (29.3%) received adjunctive Fasudil and 241 (70.7%) clazosentan alone. AVS occurred in 58/329 (17.6%), cerebral infarction in 58/327 (17.7%), poor functional outcome at discharge in 142/341 (41.6%), and poor functional outcome at 6 months in 82/325 (25.2%). Adjunctive Fasudil was independently associated with higher odds of AVS (adjusted odds ratio [aOR] 2.41, 95% confidence interval [CI] 1.21-4.81), cerebral infarction (aOR 2.10, 95% CI 1.08-4.09), and poor 6-month outcome (aOR 2.88, 95% CI 1.08-7.71), but not with poor functional outcome at discharge (aOR 1.37, 95% CI 0.62-3.03). Conclusions: In clazosentan-treated aneurysmal SAH, adjunctive Fasudil use was not associated with additional benefit and was associated with higher odds of AVS, cerebral infarction, and poor functional outcome at 6 months.

PMID 42652828
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PubMedInternational journal of molecular sciences2026-08-27

Comprehensive Phytochemical Characterization of Echinophora tenuifolia subsp. sibthorpiana Reveals Radical Scavenging, Antimicrobial, and Antiproliferative Activities Associated with Apoptosis and G2/M Cell Cycle Accumulation.

Uğur Yılmaz Y, Kolaç Turgay T, Dündar Muhammed M, Zengin Rukiye R et al.

Echinophora tenuifolia subsp. sibthorpiana is an aromatic and traditionally used plant whose phytochemical diversity and pharmacological potential remain incompletely characterized. This study aimed to integrate comprehensive chemical profiling with antioxidant, antimicrobial, and antiproliferative evaluations of an acidified methanolic extract prepared from its aerial parts. Phenolic constituents, volatile compounds, and fatty acids were characterized using LC-MS/MS, GC-MS, and GC-FID, respectively. Antioxidant capacity was assessed using DPPH and ABTS assays, antimicrobial effects were evaluated by disc diffusion and broth microdilution methods, and antiproliferative activity was investigated in six human cancer cell lines and non-cancerous BEAS-2B cells. Apoptosis induction and cell-cycle alterations were further examined by flow cytometry. The extract contained a high total phenolic content of 181.78 ± 5.03 mg GAE/g and exhibited substantial DPPH and ABTS radical scavenging activities of 333.65 ± 2.94 and 262.18 ± 6.80 mg TE/g, respectively. LC-MS/MS analysis identified rutin hydrate, quinic acid, chlorogenic acid, narcissin, and vicenin-2 as the predominant non-volatile constituents. The essential oil was dominated by methyl eugenol (51.10%) and Δ-3-carene (32.23%), whereas lauric acid (29.71%) was the major fatty acid. The extract also exhibited measurable antimicrobial activity and concentration-dependent cytotoxicity, with the greatest sensitivity observed in MCF-7 breast cancer cells (IC50 = 32.96 ± 4.80 μg/mL), followed by A549 and MDA-MB-231 cells. However, the relatively close IC50 values observed in cancer and non-cancerous BEAS-2B cells indicated limited cancer-cell selectivity under the tested conditions. Flow-cytometric analyses demonstrated marked apoptosis induction in MCF-7 cells, reaching 57.93 ± 1.80%, together with a cell-line-dependent accumulation in the G2/M phase. Collectively, these findings indicate that E. tenuifolia subsp. sibthorpiana is a chemically diverse source of plant-derived bioactive compounds with notable radical scavenging and measurable antimicrobial and cytotoxic effects. Further bioactivity-guided fractionation and mechanistic studies are required to identify the active constituents and clarify their pharmacological relevance and selectivity.

PMID 42653387
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PubMedJournal of colloid and interface science2026-08-26

Tunable tetrahydrofuran saturation governs pore-scale wetting and storage-pathway control in hydrate-based hybrid hydrogen storage systems.

Chen Lijin L, Zhang Yuxuan Y, Shannon Mark M, Krebsz Melinda M et al.

Hydrogen storage in activated carbons (ACs) via hydrate-based hybrid systems is governed by pore-scale wetting and interfacial phenomena rather than pore structure alone. We hypothesize that tetrahydrofuran (THF) saturation controls capillary-driven liquid redistribution across micro-, meso-, and macropores, thereby modulating interfacial accessibility and governing the redistribution of H2 among adsorption, pore-confined gas-phase compression, and hydrate-associated contributions. Three ACs with distinct pore hierarchies (RLY-1700, CY-1500, and MES-80) were systematically loaded with 5.56 mol% THF solution at saturation levels ranging from 0 to 1. Hydrogen storage experiments were conducted at 9 MPa and 273.8 K. Pressure-time evolution, combined with pore-scale occupancy analysis and morphology observations, was used to resolve storage contributions and to map structure-saturation-performance relationships. THF saturation induces a transition in pore-scale wetting from dispersed nanoclusters to semi-continuous films and finally to fully connected liquid domains, fundamentally altering interfacial accessibility and mass transport. At low saturation (0.25), an optimal balance is achieved through enhanced gas-liquid-solid interfacial area and preserved gas accessibility. For RLY-1700, adsorption, pore-confined gas-phase compression, and hydrate-associated contributions account for 46%, 34%, and 20% of the total H2 uptake, with 28.42 mol% conversion of water to hydrate and 0.19 wt% gravimetric hydrate-based storage capacity. Increasing saturation progressively suppresses adsorption and compression through pore flooding, while promoting hydrate-dominated regimes at high saturation. These results establish THF saturation as a pore-wetting switch that governs interfacial processes and pathway competition in confined hydrogen storage systems, providing a framework for designing colloidally structured porous media for energy storage applications.

PMID 42648091
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PubMedNanomaterials (Basel, Switzerland)2026-08-26

Carbon Black Nanoparticle-PP Fiber Interfacial Engineering for Piezoresistive Self-Sensing Cementitious Nanocomposites.

Fu Xianyang X, Hao Yongchun Y

Carbon black (CB) nanoparticles (~20 nm) offer high specific surface area and conductivity for self-sensing cementitious composites, but strong interparticle van der Waals forces drive agglomeration in alkaline pore solutions, limiting sensing reliability. This study introduces a nanoscale interfacial engineering strategy in which CB nanoparticles are adsorbed onto polypropylene (PP) fiber surfaces as spatially organized conductive elements, with EDS evidence of enhanced hydrate coverage at the fiber-matrix interface. Three CB dosages (0.5%, 1.0%, and 1.5% by binder mass) with 0.5% PP fiber were investigated. Nanoparticle coating and interfacial micro-structure were characterized by SEM-EDS, while FTIR was used to verify that the fiber backbone remained chemically unmodified; piezoresistive response and durability were assessed via cyclic compression, DIC, and hygrothermal cycling. The 1.0% CB nanocomposite lies within the effective percolation window (~0.9-1.2%), showing high linearity, a stable gauge factor (~100), and distinct FCR acceleration for early-warning sensing. The 1.5% CB composite yields higher sensitivity but scattered responses due to nanoparticle clustering; 0.5% CB remains below the percolation threshold with a discontinuous network. After 60 hygrothermal cycles, the 1.0% nanocomposite retains >93% of its gauge factor with minimal resistance drift. The nano-engineered CB-PP fiber architecture offers a scalable route integrating crack bridging, percolation networking, and durable self-sensing in cementitious nanocomposites for structural health monitoring.

PMID 42646408
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PubMedAudiology research2026-08-26

Dexmedetomidine and Chloral Hydrate Sedation on ABR Indices in Children.

Wang Lan L, Li Qiong Q, Zhang Bin B, Wang Shaohan S et al.

Background/Objectives: The study was aiming to determine the test-retest repeatability of DEX or CH as single sedative agents on ABR indices by analyzing data from initial test and retest. We also preliminarily explored the correlation between sleep deprivation and onset time of sedation in group DEX and group CH, respectively. Methods: We collected data from two groups of children sedated with either DEX (n = 20, 40 ears) or CH (n = 20, 40 ears). Paired- samples t-tests and Bland-Altman plots were used to evaluate repeatability between the initial test and retest. Pearson correlation analysis was used to measure the relationship between the average onset time of sedation and the average duration of sleep deprivation in both groups. Results: Within each sedative group, no significant differences were observed in ABR indices between the initial test and retest. Additionally, in group DEX, the mean onset time was 12.15 ± 4.40 min and the mean sleep deprivation duration was 442.80 ± 85.91 min, with no correlation between them (r = 0.01, p = 0.96). In group CH, the mean onset time was 27.55 ± 15.70 min and the mean sleep deprivation duration was 455.10 ± 90.94 min, showing a significant negative correlation (r = -0.97, p = 0.00). Conclusions: ABR indices exhibited high repeatability when DEX and CH were used as a sedative in pediatric ABR examinations. The choice of sedative agent in clinical practice should be individualized, taking into account institutional protocols and clinical requirements.

PMID 42645129
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