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colistimethate sodium (ColiFin / ColiFinair)

✓ Approved

EnBiotix · therapeutic agent

What is colistimethate sodium?

colistimethate sodium is a therapeutic agent developed by EnBiotix. It is approved for therapeutic indications via inhaled.

Drug Profile

Brand NamesColiFin, ColiFinair
CompanyEnBiotix
RouteInhaled
StatusApproved
Sources: ClinicalTrials.gov, EnBiotix

Therapeutic Indications

colistimethate sodium is developed for 1 unique indication across 1 therapeutic area.

Therapeutic AreaConditionPhase
Infections and infestationsPneumonia pseudomonal✓ Approved

Related Research Articles

PubMedEvidence-based dentistry2026-10-15

How do different topical fluoride applications affect salivary and plaque fluoride levels for young children with dental caries?

Timms Laura L, Marshman Zoe Z

Asavalertpalakorn C, Jirarattanasopha V, Nakornchai S, Horsophonphong S. Plaque and salivary fluoride levels in preschoolers following applications of silver diamine fluoride, sodium fluoride varnish, and their combination: a randomized clinical trial. Int J Paediatr Dent. 2026;36:81-9. https://doi.org/10.1111/ipd.70030 . A three-arm randomised controlled trial compared the salivary and plaque fluoride levels for young children, following application of different fluoride prevention and treatment procedures (silver diamine fluoride, sodium fluoride varnish and silver diamine fluoride and sodium fluoride varnish together), in child development centres in Thailand. Children aged 3-6 were selected who had at least one carious tooth reaching dentine in the primary dentition. Included children were considered healthy and co-operative. Children who had received professional fluoride application within the last three months were excluded, or those with a known allergy to any component. Twenty children were randomised to each group. Group 1 received silver diamine fluoride application (1 drop) to dentinal carious lesions; group 2 received sodium fluoride varnish application (0.25 ml) to all erupted primary teeth; group 3 received both the silver diamine fluoride and sodium fluoride varnish interventions. Fluoride applications were not applied to pulpally involved teeth. Plaque and saliva samples were collected at baseline (prior to fluoride application), at 5, 30 and 60 minutes, and at 24 and 48 hours. Kruskal-Wallis and Friedman tests were used to compare the 3 groups at the various time points. A Bonferroni correction was applied to account for the multiple comparisons. In total, 60 children were randomised, data were analysed for 50 children's salivary samples and 49 children's plaque samples. The mean age was 3.7 months, with children having a mean of 7.6 decayed, missing or filled teeth. At the shorter-term (5, 30 and 60 minute) time points, the salivary fluoride levels were significantly higher in the sodium fluoride varnish alone and silver diamine fluoride with sodium fluoride varnish groups than in the silver diamine fluoride alone group. There was no difference in the silver diamine fluoride with sodium fluoride varnish and sodium fluoride varnish alone groups for both salivary and plaque fluoride levels. Considering fluoride levels in plaque, the sodium fluoride varnish group had significantly higher levels at 5 and 60 minutes than the silver diamine fluoride group and the silver diamine fluoride with sodium fluoride varnish group was significantly higher at 30 and 60 minutes in comparison to silver diamine fluoride alone. At 60 minutes, the silver diamine fluoride and sodium fluoride varnish groups had returned to baseline; this was at 24 hours for the silver diamine fluoride with sodium fluoride varnish group for salivary fluoride. For plaque levels, the return to baseline was at 60 minutes for the silver diamine fluoride group, and 24 hours for the sodium fluoride varnish and silver diamine fluoride with sodium fluoride varnish groups. Children receiving sodium fluoride varnish and silver diamine fluoride had higher plaque and salivary fluoride levels than those treated with silver diamine fluoride alone in the short term. Plaque and salivary fluoride levels returned to baseline at 24 hours for all groups.

PMID 42875550
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PubMedFrontiers in medicine2026-10-15

Risk factors for recurrent variceal bleeding after TIPS in cirrhotic patients with esophagogastric variceal hemorrhage: a single-center retrospective study.

Chen Zhiliang Z, Gou Yi Y, Li Wenke W, Yu Daowu D et al.

Transjugular intrahepatic portosystemic shunt (TIPS) effectively reduces portal pressure but post-procedural rebleeding remains a major clinical challenge. Risk factors for rebleeding are not fully defined. This single-center retrospective cohort study included 114 cirrhotic patients who underwent TIPS for EGVB (2019-2024). Patients were categorized into rebleeding (n = 35) and non-rebleeding (n = 79) groups based on 1-year post-TIPS rebleeding. Clinical, laboratory, procedural, prior endoscopic treatment history and follow-up data were analyzed. Univariate and multivariate Cox proportional hazards models were used to identify risk factors. Cumulative rebleeding incidence was compared between serum sodium groups (<135 vs. ≥135 mmol/L) using Kaplan-Meier analysis with log-rank test. The 1-year rebleeding rate was 30.7% (35/114). Multivariate Cox regression identified lower serum sodium (HR = 0.85; 95% CI: 0.77-0.93; P < 0.001) and shunt dysfunction (HR = 4.60; 95% CI: 2.21-9.58; P < 0.001) as independent risk factors for rebleeding. Stent type was not independently associated after adjustment. The low sodium group (<135 mmol/L) showed a significantly higher cumulative rebleeding incidence than the high sodium group (log-rank P = 0.041). Conclusion: Serum sodium preoperatively and post-TIPS shunt dysfunction are independent risk factors for 1-year rebleeding. Optimizing serum sodium preoperatively and implementing regular surveillance for shunt dysfunction may help reduce rebleeding risk in these patients.

PMID 42876481
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PubMedAngewandte Chemie (International ed. in English)2026-10-15

Rotation-Coupled Guest Anions Stabilize Polymer Solid-State Sodium-Metal Batteries.

Li Yi Y, Wang Lifeng L, Ling Fangxin F, Wang Ziyang Z et al.

Polymer solid-state sodium-metal batteries are constrained by sluggish Na+ migration and unstable sodium-metal interfaces, both of which are closely associated with poorly regulated solvation chemistry. Here we report a rotation-coupled guest-anion strategy in a poly(vinylidene fluoride-co-hexafluoropropylene)-based solid-state electrolyte (PHSE) using Mg(OTf)2. Mg2+ preferentially coordinates DMF and TFSI-, weakening Na+-TFSI- association and limiting solvent-derived reactions at the sodium metal anode. OTf- enters the Na+ solvation shell as a mobile guest anion. Its C─S rotational axis and equivalent oxygen coordination sites allow conformational rotation to synchronize with Na+ hopping along polymer chains. This anchor-rotator chemistry reorganizes Na+ coordination, lowers the migration barrier, and promotes an inorganic-rich, Mg─O-containing interphase. The optimized electrolyte enables Na3V2(PO4)3||Na cells to retain 94.2% capacity after 1100 cycles at 2C and supports a 94 mAh pouch cell with stable cycling. It also enables high-voltage Na3V2(PO4)2O2F||Na cells to retain 93.6% capacity after 1000 cycles at 0.5C over 2.5-4.2 V. Comparative evaluation across a total of 20 polymer electrolyte systems with varied polymer matrices and anion structures identifies anion symmetry, rotational periodicity, and finite rotational barriers as molecular criteria for designing stable polymer solid-state sodium-metal batteries.

PMID 42875829
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PubMedFrontiers in veterinary science2026-10-15

Comparative analysis of feeding probiotic and exogenous buffer on growth performance, nutrient utilization, blood biochemistry, rumen fermentation pattern and carcass characteristics of crossbred lambs reared under feedlot.

Sahib Qazi Shehriyar QS, Ahmed Haidar Ali HA, Aafaq Ifla I, Farooq Javid J et al.

Feedlot nutrition is formulated to maximize growth rate and feed efficiency for high-quality meat production; however, high-grain diets can disrupt rumen function and cause digestive disorders, the inclusion of non-nutritive feed additives helps counter these effects, thereby enhancing growth performance and overall feed efficiency. The present study was carried out to delineate the effect of feeding Saccharomyces cerevisiae strain 1,026 as probiotic and sodium bicarbonate as exogenous buffer on performance of feedlot crossbred lambs. Fifteen crossbred lambs were selected and divided equally into three treatment groups viz., FT, FT-P and FT-SB. In FT group, animals were fed feedlot diet only; while in FT-P and FT-SB groups, Saccharomyces cerevisiae and sodium bicarbonate were offered as feed additives, respectively. A 74-days feeding trial was conducted, including 10-days metabolism trial at the end. No effect (p > 0.05) was observed in dry matter intake (DMI), body weight indices, feed conversion ratio (FCR), digestibility coefficients of nutrients and haemato-biochemical parameters. Rumen pH was significantly (p < 0.05) higher in FT-P group than FT group. Dressing percentage showed significantly (p < 0.05) higher values in FT-P group. The present experiment validates that feeding of Saccharomyces cerevisiae had more beneficial effect than sodium bicarbonate feeding on the performance of feedlot lambs.

PMID 42876503
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PubMedPhysiologia plantarum2026-10-15

Sodium Hydrosulfide Delays Postharvest Softening of Sand Pear Fruit in Association With Altered Ethylene Production and Cell Wall Metabolism.

Gao Jie J, Ren Hai-Ying HY, Wang Peng-Yuan PY, Wang Chun-Lei CL et al.

Sodium hydrosulfide (NaHS), a hydrogen sulfide donor, has been reported to regulate postharvest senescence and quality maintenance in horticultural crops. However, its role in sand pear softening and the underlying physiological basis remain unclear. Mature fruits of the climacteric sand pear cultivar "Sucui No. 1" were treated with NaHS and stored at 20°C to evaluate its effects on postharvest quality, ethylene production, cell wall metabolism, and softening-related gene expression. Treatment with 1 mmol L-1 NaHS delayed firmness loss and reduced ethylene production, with limited effects on fruit color, weight loss, and total soluble solids during storage. NaHS-treated fruit retained significantly higher firmness than control fruit from Day 15 onward, with the largest difference between treatments being 3.25 N on Day 15. NaHS-treated fruit retained higher levels of cellulose, hemicellulose, covalently soluble pectin, and ionically soluble pectin, and accumulated less water-soluble pectin, indicating delayed cell wall polysaccharide disassembly. Consistently, NaHS suppressed the activities of several cell wall-modifying enzymes, including cellulase, β-glucosidase, xyloglucan endotransglucosylase/hydrolase, polygalacturonase, and pectin methylesterase. RNA sequencing and qRT-PCR analyzes showed that NaHS modulated the expression of genes associated with cell wall remodeling, ethylene biosynthesis, sulfur-related metabolism, and transcriptional regulation, particularly during the early-to-middle storage stage. Transient silencing assays further indicated that the XTH gene (gene11051) was associated with cellulose-hemicellulose remodeling, whereas the two PME genes (gene26382 and gene8920) were associated with pectin solubilization. These results suggest that the delay in postharvest softening following NaHS treatment was associated with coordinated changes in ethylene production and cell wall disassembly.

PMID 42875954
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PubMedACS applied materials & interfaces2026-10-15

Ca2+-Triggered Reinforcement of Polyacrylamide/Sodium Alginate Composite Nanogel Spheres for Regulating Multiphase Transport in Low-Permeability Heterogeneous Porous Media.

Zhou Shuai S, Lu Xukang X, Lin Yuxuan Y, Lu Xi X et al.

Low-permeability heterogeneous porous media commonly exhibit preferential flow through high-permeability channels and persistent residual-oil trapping in small pores and dead-end regions, limiting effective multiphase transport and residual-oil mobilization. Herein, Ca2+-responsive polyacrylamide/sodium alginate nanogel spheres (PAM/SA NSGs) were developed as an environment-responsive nanogel system for Ca2+-rich porous media. In simulated formation water, SA-Ca2+ coordination increased the apparent elastic modulus from 1.35 MPa for PAM NSGs to 3.45 MPa for PAM/SA NSGs and enabled the composite nanogel spheres to retain their morphology after hydrothermal aging at 60 °C for 14 days. The PAM/SA NSG emulsion dispersion reduced the crude-oil/water interfacial tension from approximately 32 to 12.6 mN·m-1 and produced smaller and more stable emulsified droplets than the PAM control. Microfluidic visualization showed that PAM/SA NSGs generated stronger pressure fluctuations, promoted flow redistribution toward less-swept pores, and increased displacement efficiency from 46.8% after water flooding to 65.3%. Post-displacement observations revealed stripe-like accumulation, surface deposition, and localized bridging without complete pore blockage, interfacial enrichment, and downstream migration of emulsified oil droplets, supporting the coupling of local flow regulation with in situ macroemulsion formation. Core flooding further showed that PAM/SA NSGs maintained stronger flow-resistance regulation after aging and achieved a final oil recovery of 48.7%, representing a 13.5-percentage-point increase over water flooding. These results establish an environment-responsive nanogel strategy in which Ca2+, conventionally regarded as detrimental to chemical flooding, is repurposed as an environmental trigger for nanogel reinforcement to couple mechanical stability, interfacial regulation, and multiphase transport in low-permeability heterogeneous porous media.

PMID 42876091
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