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S-

S-amlodipine gentisate (Nexad / Nexad TAb)

✓ Approved

SK Chemicals · CACNA1C · Small Molecule

What is S-amlodipine gentisate?

S-amlodipine gentisate is a small molecule developed by SK Chemicals. It is approved for therapeutic indications via oral (po).

Drug Profile

Brand NamesNexad, Nexad TAb
CompanySK Chemicals
Drug ClassSmall Molecule
Molecular TargetCACNA1C
RouteOral (PO)
StatusApproved
Sources: ClinicalTrials.gov, SK Chemicals

Mechanism of Action

Molecular Targets

S-amlodipine gentisate acts on 1 molecular target:

CACNA1Ccalcium voltage-gated channel subunit alpha1 C (CACNL1A1, CACNA1C-IT2)
Want deeper analysis?Noah AI can explain complex mechanisms and compare to similar drugs.

Therapeutic Indications

S-amlodipine gentisate is developed for 2 unique indications across 2 therapeutic areas.

Therapeutic AreaConditionPhase
Cardiac disordersAngina pectoris✓ Approved
Vascular disordersHypertension✓ Approved

Related Research Articles

PubMedInternational journal of pediatric otorhinolaryngology2026-07-17

Evaluation of anatomical and ultrasonographic parameters to predict difficult airway in pediatric patients.

Altun Demet D, Canbaz Mert M, Dinçer Müşerref Beril MB, Demirel Ebru Emre EE et al.

Predicting a difficult airway in pediatric patients remains challenging due to unique anatomical and physiological characteristics. Traditional bedside predictors show inconsistent accuracy in children, and ultrasonography has emerged as a promising, objective tool for airway evaluation. This study aimed to assess the diagnostic performance of anatomical and ultrasonographic parameters in predicting difficult intubation in pediatric patients. In this prospective, double-blind observational study, children aged 1-12 years undergoing elective surgery with endotracheal intubation were evaluated. Clinical assessments included anthropometric measurements and airway tests (Mallampati, thyromental distance (TMD), sternomental distance (SMD), hyomental distance (HMD)). Sonographic measurements-skin-epiglottis distance (S-ED) and skin-hyoid distance (S-HD)-were obtained preoperatively. Difficult intubation was defined as Intubation Difficulty Score (IDS) > 5. ROC curve analyses were used to evaluate diagnostic performance; logistic regression identified independent predictors. A total of 240 children were included, with a difficult-intubation incidence of 20%. S-ED demonstrated the highest predictive accuracy (AUC 0.941), followed by S-HD (AUC 0.912), HMD (AUC 0.898), and Mallampati classification (AUC 0.860). TMD and SMD showed moderate predictive ability. Combining significant clinical and sonographic parameters improved diagnostic performance, with S-ED + S-HD yielding an AUC of 0.961. Multivariable regression identified S-ED (OR 4.61), S-HD (OR 1.76), Mallampati ≥ III, and facial anomalies as independent predictors of difficult intubation. The final model correctly classified 95.4% of cases. Ultrasonographic parameters, particularly S-ED and S-HD, are highly accurate predictors of difficult intubation in children and outperform traditional clinical tests. Combining sonographic with anatomical assessments significantly enhances diagnostic performance. Airway ultrasound provides an objective, reproducible, and non-cooperation-dependent tool that can improve preoperative risk stratification in pediatric anesthesia.

PMID 42462582
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PubMedThe Journal of clinical endocrinology and metabolism2026-07-17

Identifying TMEM127-deficient pheochromocytomas/paragangliomas via RET overexpression by immunohistochemistry.

Estrada-Zuniga Cynthia M CM, Liang Rui R, Landry Bethany B, Alvarez Andrea A et al.

Pheochromocytomas and paragangliomas (PPGLs) are rare, genetically diverse tumors originating from the adrenal medulla or extra-adrenal paraganglia, respectively. Knowledge of the pathogenic status of genetic variants, especially in the 35-40% of patients with germline changes, impacts management and family surveillance. However, interpreting variants of uncertain significance (VUS) remains challenging, particularly for poorly characterized genes such as TMEM127, and often requires additional testing. We recently reported that TMEM127 loss promotes RET accumulation by reducing its degradation. We evaluated RET expression by immunohistochemistry (IHC) as a potential aid to highlight TMEM127 dysfunction in PPGLs carrying TMEM127 germline variants. We performed RET IHC in 104 formalin-fixed and paraffin-embedded (FFPE) sections of clinically and genetically diverse PPGLs and generated histochemical scores (H-S) manually for membrane (MH-S), cytoplasm (CH-S) and their sum (total TH-S), and digitally for CH-S and TH-S. Tumors driven by TMEM127 variants carried the highest RET expression scores (151.8 ± 62), predominantly MH-S, when compared with other PPGL genotypes, including RET pathogenic disruptions (69.9 ± 96.8, adjusted p = 0.03) or tumors of undefined genotype (40.8 ± 69, adjusted p = 0.0001). Digital scoring showed high correlation with manual H-S (0.74 and 0.80 for C-HS and TH-S, respectively). RET membrane immunoreactivity also distinguished PPGLs carrying likely damaging from non-disrupting TMEM127 variants. These findings point to increased RET membrane expression as a promising biomarker for loss-of-function TMEM127 variants in PPGLs. If validated in independent cohorts, RET IHC could be an effective tool for assessing the functional implications of PPGLs from patients carrying TMEM127 VUS.

PMID 42464758
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PubMedAngewandte Chemie (International ed. in English)2026-07-17

Taming a Blue Gas-Structure and Chemistry of Hexafluorothioacetone.

Günther Hennes H, Karttunen Antti J AJ, Xie Xiulan X, Tambornino Frank F

Hexafluorothioacetone (1), a blue gas at r.t. and unusually prone to dimerization, was synthesized and characterized by single‑crystal x‑ray diffraction, NMR spectroscopy, and density functional theory (DFT) calculations. The C═S bond lengths in 1 were determined to be 1.583-1.595 Å, representing the shortest C═S bond lengths reported for a non-cumulene system. DFT calculations indicate an only mildly polar covalent C═S bond. Furthermore, due to the strongly electron withdrawing CF3 groups, the polarity of the C═S bond is reversed to Cδ-═Sδ+, running contrary to their electronegativities. The 13C NMR spectrum of neat 1 collected at 193 K shows resonances at 205.4 ppm (2JCF = 37.7 Hz) and 116.7 ppm (1JCF = 278.7 Hz), with the thiocarbonyl resonance shifted unusually far up-field, further underscoring the inverted polarity of the C═S bond. Nickel complexes with 1 as side-on ligand (η2) and ancillary ligands (COD, pyridine, TMEDA) were obtained, in which the nickel atom adopts a pseudo square‑planar geometry. The C-S bond lengths in these complexes (1.735-1.762 Å) lie between typical single (1.78 Å) and double (1.61 Å) bonds.

PMID 42464510
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PubMedInternational microbiology : the official journal of the Spanish Society for Microbiology2026-07-17

Metabolomics study of the inhibitory effects of tubuloside A on Streptococcus suis biofilm.

Che Ruixiang R, Sun Yiyang Y, Zhao Jianjun J

Streptococcus suis (S. suis) is an important zoonotic pathogen. Biofilm formation contributes to persistent and chronic infections, increases the difficulty of bacterial eradication, and may pose a threat to public health. Clinically, S. suis infection is mainly treated with antibacterial drugs. However, biofilm-forming S. suis exhibits enhanced drug tolerance, and conventional drugs are often unable to eradicate established biofilms effectively. At present, screening traditional Chinese medicine monomer drugs to interfere with the formation of biofilms has become a promising strategy for controlling S. suis biofilms. In this study, the antibiofilm effect of tubuloside A (TA) on S. suis ATCC700794 and the associated metabolic changes were investigated using untargeted metabolomics. The minimum inhibitory concentration (MIC) of TA against S. suis ATCC700794 was determined by the broth microdilution method. The effects of TA were studied using crystal violet staining. The morphology of TA treated ATCC700794 cells was observed by scanning electron microscopy. Differentially abundant metabolites were screened using metabolomics and bioinformatics analyses. The MIC of TA was 64 µg/mL, whereas 1/2 MIC (32 µg/mL) of TA significantly inhibited biofilm formation without markedly affecting bacterial growth under the tested conditions and reduced biofilm structural formation. After treatment with 1/2 MIC of TA, 65 annotated metabolites met the screening criteria, including 23 upregulated and 42 downregulated metabolites. Bioinformatic analysis showed that the metabolic changes in S. suis ATCC700794 after TA treatment were mainly associated with glycine, serine and threonine metabolism, purine metabolism, cysteine and methionine metabolism, alanine, aspartate and glutamate metabolism, the citrate cycle, arginine and proline metabolism, and pyruvate metabolism. This study provides preliminary metabolomic evidence that TA-mediated inhibition of S. suis biofilm formation is associated with alterations in amino acid metabolism and central carbon metabolism, offering candidate metabolic clues for future mechanistic studies.

PMID 42463619
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PubMedMicrobial cell factories2026-07-17

Establishment of SRLC: a multiplex genome editing technology for Saccharomyces cerevisiae and its application in metabolic engineering of malonyl-CoA pathway.

Zheng Wentao W, Wang Miao M, Tu Qiang Q, Bian Xiaoying X et al.

The development of advanced genome engineering tools is crucial for optimizing metabolic pathways in Saccharomyces cerevisiae and achieving efficient biomanufacturing. This study proposes an enhancing multiplex genome editing strategy in S. cerevisiae by employing Escherichia coli-derived single-stranded annealing proteins (SSAPs) combined with S. cerevisiae-derived homologous recombinases (Rad51 and Rad52). The strategy utilizes an SSAP-Rad-Linearized CRISPR (SRLC) platform, which supports efficient simultaneous editing of multiple genomic loci without constructing complex multi-gRNA expression vectors. Co-overexpressing Rad51/Rad52 and E. coli SSAP proteins significantly enhances homologous recombination (HR), allowing precise multi-locus genome editing mediated by short homologous arms. Furthermore, SRLC employs a linearized CRISPR-Cas system to stimulate homologous recombination and enable counter-selection in S. cerevisiae, thereby improving precise multiplex genome editing efficiency. We applied SRLC to engineer the malonyl-CoA metabolic pathway in S. cerevisiae. Through a single round of editing and screening, we constructed a chassis strain with 9 targets simultaneously modification and achieved a 9.6-fold increase in intracellular malonyl-CoA. Using this chassis, 3-hydroxypropionic acid production increased 4.5-fold relative to wild-type S. cerevisiae. This platform offers a robust and scalable tool for S. cerevisiae manipulation and a practical pathway-engineering strategy for building for malonyl-CoA-derived factories.

PMID 42464282
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PubMedAngewandte Chemie (International ed. in English)2026-07-17

Dynamic Ion-Pair Networks Enable Selective Li+ Transport for Stable and Efficient Solid-State Lithium-Sulfur Batteries.

Xiong Haoyang H, Wang Jiayi J, Li Qingying Q, Nie Yihang Y et al.

Solid-state lithium-sulfur (Li-S) batteries are intrinsically constrained by persistent Li+-anion coordination in polymer electrolytes, which couples Li+ migration to anion motion and limits both interfacial stability and sulfur redox kinetics. Here, we show that incorporating an ionic liquid modified ZIF-67 (IL@ZIF-67) into a polymer solid electrolyte enables deliberate reorganization of ion coordination and reconfiguration of Li+ transport pathways at the molecular level. ZIF-67 sites preferentially anchor TFSI-, while confined ionic liquid domains reshape Li+ coordination, establishing a dynamic ion-pair network with weakened Li+-anion coupling and spatially restricted anions. This coordination reorganization decouples long-range Li+ transport from anion migration, lowers the Li+ migration energy barrier, and homogenizes Li+ flux across the electrolyte. Consequently, a stable LiF/Li2S-rich solid electrolyte interphase forms at the lithium metal interface, while continuous Li+ supply mitigates solid-solid interfacial polarization and accelerates reversible S─C/S─S bond conversion and Li2S nucleation/decomposition kinetics in SPAN cathodes. As a result, the solid-state Li-S batteries deliver a high reversible capacity of 1004.97 mAh g-1 after 150 cycles at 0.2 C, prolonged cycling stability over 500 cycles at 1 C with a decay rate of ∼0.06% per cycle, highlighting ion-pair regulation via ionic-liquid-engineered MOF fillers as an effective pathway toward high-performance solid-state Li-S batteries.

PMID 42464479
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